Clinical trials: Preoperative Sedation
Preoperative Anxiety
Lavender Oil on Preoperative Anxiety and Sedation Requirement in General Anaesthesia
Assessment of how Lavender oil reduces preoperative anxiety and subsequently influences requirement of induction agents for general anesthesia.
- Trial name
- NCT03460145
- Testing
- Lavender Oil on Nasal Strip (Lx), Strip without Lavender Oil (Px), Propofol 1 % Injectable Suspension
- Where
- Malaysia
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Anxiety, Preoperative Anxiety
Comparing the Effect of Melatonin, Diazepam, and Placebo on Decreasing the Level of Anxiety Preoperatively
The goal of this clinical trial is to compare the effect of melatonin, diazepam, and placebo on the level of anxiety in patients undergoing surgery.
- Trial name
- NCT06103188
- Testing
- Diazepam, Melatonin
- Where
- Jordan
- Volunteers
- 87 people
- Sponsor
- University of Jordan
Anesthesia, Sedation
The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes
Perioperative fasting has historically been viewed as a low-risk intervention. However, preliminary data indicate that perioperative loss of nutrition and fluids is likely harmful.
- Conditions
- Anesthesia, Sedation, Monitored Anesthesia Care, Procedure
- Trial name
- MACS (NCT07022951)
- Testing
- Preoperative fasting
- Where
- United States
- Volunteers
- 1,200,000 people
- Sponsor
- Massachusetts General Hospital
Gastric Ultrasound, Gastric Ultrasound in Chronic Opioid Use (≥2 Weeks)
Does Pre-operative Gastric Ultrasound Influence Anaesthetic Decision-Making in Chronic Pain Patients? A Prospective Observational Cohort.
Gastric POCUS has been validated and shown to be an accurate diagnostic tool in both healthy individuals and medically complex patient populations.
- Conditions
- Gastric Ultrasound, Gastric Ultrasound in Chronic Opioid Use (≥2 Weeks), Gastric Ultrasound in Poorly Controlled Acute-on-chronic Pain, Gastric Ultrasound in Acute Opioid Administration Within 24 Hours Prior to the Procedure
- Trial name
- NCT07537582
- Where
- United Arab Emirates
- Volunteers
- 140 people
- Sponsor
- Danat Al Emarat Hospital
Sedation, Conscious
Intranasal Midazolam in Children as a Pre-Operative Sedative
The purpose of this study is to see if adding a numbing medicine, xylocaine, to the nasal midazolam makes giving the midazolam easier and more comfortable without affecting how the midazolam works as a sedative.
- Trial name
- NCT02314546
- Testing
- Midazolam, xylocaine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Bassett Healthcare
Remimazolam, Dexmedetomidine
Application of Remimazolam, Dexmedetomidine, and Esketamine in Pediatric Preoperative Sedation
By comparing the application effects of three drugs in pediatric preoperative sedation, this study explores the optimal medication regimen, aiming to provide safer, more effective, and more personalized medication options for…
- Conditions
- Remimazolam, Dexmedetomidine, Esketamine
- Trial name
- NCT07050212
- Testing
- remimazolam group, dexmedetomidine group, esketamine group
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Maternal and Child Health Hospital of Hubei Province
Clinical Trial
Optimal Dosage of Melatonin for Preoperative Sedation in FESS
To determine the optimal dosage of Melatonin for preoperative sedation in patients undergoing FESS.
- Trial name
- FESS (NCT07550751)
- Testing
- Melatonin
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Aswan University Hospital
Preoperative Sedation of Children
A Trial of Dexmedetomidine Hydrochloride Nasal Spray in Preoperative Sedation of Children
The study is being conducted to evaluate the efficacy, and safety of dexmedetomidine hydrochloride nasal spray for preoperative sedation in children.
- Trial name
- NCT05111431
- Testing
- Dexmedetomidine Hydrochloride Nasal Spray, Dexmedetomidine hydrochloride nasal spray blank preparation
- Where
- China
- Volunteers
- 159 people
- Sponsor
- Shanghai Hengrui Pharmaceutical Co., Ltd.
Agitation on Recovery From Sedation
Preoperative Use of Alprazolam and Hydroxyzine in Anxiety
Patients will be divided into three groups. Group H patients will be given 100 mg Hydroxyzine orally 1 hour before surgery while group A patients will receive 0.5 mg Alprazolam orally. group P will be placebo group.
- Trial name
- NCT04184141
- Testing
- Hydroxyzine Hydrochloride, Alprazolam tablet
- Volunteers
- 90 people
- Sponsor
- Istanbul Medeniyet University
Dream, Day, Ketamine Adverse Reaction
The Impact of Preoperative Suggestion on Dreaming
Recent studies have shown that positive preoperative suggestions can significantly influence the quality of dreams and reduce the incidence of unpleasant dreams during sedation with agents like ketamine and propofol.
- Conditions
- Dream, Day, Ketamine Adverse Reaction, Propofol Adverse Reaction
- Trial name
- NCT06609538
- Testing
- Control Group, Suggestion Group
- Where
- South Korea
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Wonkwang University Hospital
Anesthesia, Sedation
Comparison of Intranasal Dexmedetomidine and Short Video Viewing in the Preoperative Anxiety
This observational study aims to compare the effects of short video viewing and intranasal dexmedetomidine administration-both of which are part of routine clinical practices in the pediatric endoscopy unit-on preoperative…
- Conditions
- Anesthesia, Sedation, Anxiety
- Trial name
- NCT07077200
- Testing
- Intranasal dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Samsun University
Delirium, Sedation Complication
The Relationship Between Fasting Time and Delirium
We investigated the relationship between fasting times and delirium in children undergoing MRI under anesthesia. Paediatric Anaesthesia Emergence Delirium (PAED) scale, last oral intake time and type of food (solid-liquid) and…
- Conditions
- Delirium, Sedation Complication, Magnetic Resonance Imaging, Fasting
- Trial name
- NCT05567718
- Testing
- Paediatric Anaesthesia Emergence Delirium scale
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Preoperative Biliary Drainage, Recovery Period, Anesthesia
Do Preoperative Bilirubin Levels Affect Recovery and Hospital Stay After Sedation Anesthesia?
There are still complexities regarding the effects of anesthetic drugs on bilirubin metabolism. The aim of the study was to investigate whether preoperative serum bilirubin levels are associated with the length of hospital stay…
- Conditions
- Preoperative Biliary Drainage, Recovery Period, Anesthesia, Hospital Length of Stay
- Trial name
- NCT06849661
- Where
- Turkey (Türkiye)
- Volunteers
- 360 people
- Sponsor
- Naime Yalçın
Anxiety
Cranial Electro Therapy Stimulation in Reducing Perioperative Anxiety
Cranial electro stimulation (CES) provides safe, adequate, side-effect free sedation without excessive drowsiness in preoperative settings.
- Trial name
- NCT00928772
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of Oklahoma
Behavior, Child, Anxiety
Impact of Pre-Sedation Virtual Reality Game on Post-Discharge Negative Behaviors in the Pediatric Emergency Department
The purpose of this study is to evaluate if a virtual reality (VR) distraction game played prior to procedural sedation for long bone fracture reduction will improve post-discharge negative behavior changes following discharge…
- Trial name
- NCT03980067
- Testing
- Virtual Reality Game
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Medical College of Wisconsin
Magnetic Resonance Imaging
Prospective Study Assessing the Validity of Y-PAS (Yale Preoperative Anxiety Scale) to Predict Patients Undergoing Magnetic Resonance Imaging Without the Use of Sedation/General Anesthesia
The mYPAS (Modified Yale Preoperative Anxiety Scale) is a quick, easy, validated and "gold standard" assessment tool to measure pediatric anxiety in the perioperative period.
- Trial name
- NCT02586103
- Testing
- MRI simulation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Arlyne Thung
Preoperative Sedation
Nebulized vs. Oral Midazolam Sedation in Pediatric Anesthesia: A Randomized Comparative Study
This study is to be carried out to compare nebulized and oral midazolam in achievement of a satisfactory level of sedation, Ramsey Sedation Score (RSS) of 4, within 30 mins of midazolam administration in pediatrics.
- Trial name
- NCT04760041
- Testing
- Midazolam nebulized, Midazolam oral solution
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cairo University
Peripheral Nerve Block, Anxiety
Music vs Midazolam During Preop Nerve Block Placement - Part 2 Study On Anxiolytic Options Before Peripheral Nerve Blocks
This study is evaluating music vs midazolam as a means of anxiolysis for preoperative single-shot nerve block placement.
- Conditions
- Peripheral Nerve Block, Anxiety, Preoperative Anxiety
- Trial name
- NCT05610969
- Testing
- Music, Midazolam
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Pennsylvania
Gastric Content Aspiration Risk, Gastrointestinal Endoscopy
BBCMADE Nomogram Validation for High-Risk Gastric Content in Sedative Endoscopy
This prospective observational study aims to validate the BBCMADE nomogram (Body Mass Index, Brain infarction, Cirrhosis, Male sex, Age, Diabetes, Esophageal reflux) for predicting high-risk gastric content in patients undergoing…
- Conditions
- Gastric Content Aspiration Risk, Gastrointestinal Endoscopy, Anesthesia Complications
- Trial name
- BBCMADE (NCT07638917)
- Testing
- BBCMADE Nomogram, Endoscopic Gastric Volume and pH Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 533 people
- Sponsor
- Fusun Gozen
Preoperative Sedation, Postoperative Pain
Preemptive Analgesia for Post Tonsillectomy Pain With IV Morphine in Children
In this double blind study, after taking an informed consent, 60 children aged between 7 and 12 years old assigned for tonsillectomy with or without adenoidectomy will be randomly divided into three groups.
- Trial name
- NCT02995304
- Testing
- Morphine premedication, Midazolam premedication
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Dr. Soliman Fakeeh Hospital