Clinical trials: Prescription
Prescription Opioid Misuse
Reducing High School Athletes' Prescription Opioids Misuse and Diversion Through the Student Athlete Wellness Portal
The goal of this study is to prevent prescription opioid misuse among high school athletes by developing, demonstrating the feasibility, and evaluating the outcomes of an innovative digital intervention.
- Trial name
- NCT05209191
- Testing
- Student Athlete Wellness Portal
- Where
- 5 sites in United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Real Prevention, LLC
Opioid-Related Disorders, Drug Overdose
Prescribe to Save Lives
The U.S. is in the midst of an epidemic of opioid overdose deaths. The common use of opioids among persons living with HIV, along with their common use of benzodiazepines, has resulted in high rates of opioid overdose among this…
- Trial name
- PTSL (NCT03175640)
- Testing
- Implementation intervention
- Where
- 2 sites in United States
- Volunteers
- 294 people
- Sponsor
- Baystate Medical Center
Constipation, Bowel Dysfunction
Study Of Alvimopan Drug For Treatment Of Constipation Due To Prescription Pain Medication
A multicenter study to evaluate the effectiveness and safety of multiple dosage regimens of an investigational drug for the treatment of constipation due to prescription pain medication in subjects with cancer pain.
- Trial name
- NCT00101998
- Testing
- alvimopan
- Where
- 162 sites in United States, Argentina and 24 more
- Volunteers
- 233 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
End Stage Kidney Disease
The Reducing Adverse Outcomes in Dialysis by Adjusting the pRescription for Dialysate Potassium Trial
This will be a randomized controlled pilot trial comparing usual care to a precision approach to dialysis potassium prescribing.
- Trial name
- RADAR-K (NCT07051447)
- Testing
- PKRxHD, Dialysis
- Volunteers
- 120 people
- Sponsor
- NYU Langone Health
Type 2 Diabetes
Pathway for Produce Prescriptions in Diabetes Management
Fruit and vegetable (FV) intake decrease the risk of type 2 diabetes (T2D) and is important for T2D management but is difficult to achieve in adequate amounts for those with a low- income.
- Trial name
- PPT2D (NCT06058338)
- Testing
- Produce Prescription
- Where
- 5 sites in United States
- Volunteers
- 600 people
- Sponsor
- Gretchen Swanson Center for Nutrition
Opioid Use Disorder
A Pragmatic Randomized Control Trial Comparing Models of Care in the Management of Prescription Opioid Misuse
This trial evaluates two standard of care treatments for opioid addiction: methadone and buprenorphine/naloxone. In order to improve patient care, the study will address real-world treatment conditions, including strict…
- Trial name
- OPTIMA (NCT03033732)
- Testing
- Methadone, Buprenorphine-Naloxone
- Where
- 7 sites in Canada
- Volunteers
- 272 people
- Sponsor
- Didier Jutras Aswad
Patient Compliance, Medication Adherence
Impact of Information Prescriptions on Medication Adherence in Emergency Department (ED) Patients
The main objectives of this research are: 1. To identify factors that influence medication adherence rates in Emergency Department (ED) patients. 2.
- Conditions
- Patient Compliance, Medication Adherence, Medication Non-Adherence
- Trial name
- NCT01174706
- Testing
- Information prescriptions
- Where
- 3 sites in United States
- Volunteers
- 3,940 people
- Sponsor
- Johns Hopkins University
Type 2 Diabetes Mellitus, Exercise
Project Diabetes: Prescription for Healthy Living
Health disparities related to obesity, pre-diabetes and Type 2 diabetes in the United States represent public health concerns. Given the benefit of exercise in disease prevention and management, evidence-based, cost-effective…
- Conditions
- Type 2 Diabetes Mellitus, Exercise, Obesity, Behavioral Research
- Trial name
- NCT00775216
- Testing
- Behavioral counseling plus "telephone helpline"
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Acute Kidney Injury, Kidney Replacement
Proactive Prescription-based Fluid Management vs Usual Care in Critically Ill Patients on Kidney Replacement Therapy
A pilot randomized clinical trial comparing a protocol-based fluid management strategy to usual care in critically ill patients receiving kidney replacement therapy.
- Conditions
- Acute Kidney Injury, Kidney Replacement, Critical Illness
- Trial name
- Probe-Fluid (NCT05473143)
- Testing
- Protocol-based fluid management, Usual care
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Food Insecurity
Reducing Food Insecurity During COVID-19
This study aims to compare the effectiveness of two interventions to address food insecurity among low-income families with young children during the COVID pandemic.
- Trial name
- NCT04652596
- Testing
- Produce prescription program, Grocery store gift cards
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Knee Arthroscopy, Shoulder Arthroscopy
Non-Opioid Prescriptions After Arthroscopic Surgery in Canada (NO PAin)
This is a randomized controlled trial of 200 patients between the ages of 18 and 65 years undergoing outpatient knee or shoulder arthroscopy. Patients will be evaluated clinically at 2 and 6 weeks post-operatively.
- Trial name
- NO PAin (NCT04566250)
- Testing
- Non-Opioid Prescription and Infographic
- Where
- 3 sites in Canada
- Volunteers
- 200 people
- Sponsor
- McMaster University
Delirium
The Effect of Clonidine-enhanced Sedation on Delirium in Ventilated Critically Ill Patients
Rationale: Delirium is highly prevalent in the ICU. GABA-ergic anaesthetics may provoke delirium. Alpha-2-adrenergic agonists may lead to a reduction of the total amount of GABA-ergic anaesthetics and reduction of delirium.
- Trial name
- CATAPRES (NCT01876355)
- Testing
- Clonidine, SodiumChloride
- Where
- Netherlands
- Volunteers
- 115 people
- Sponsor
- Deventer Ziekenhuis
Prescription, Physical Activity
Implementation and Effectiveness of a Community-based Exercise on Prescription Program for Adults With Chronic Diseases
The objectives were (1) to evaluate the characteristics of the patients referred, and (2) the effect of a community-based Exercise on Prescription program on their physical capacities and their quality of life.
- Conditions
- Prescription, Physical Activity, Chronic Disease
- Trial name
- SSOCaen (NCT04919889)
- Testing
- Exercise prescription
- Where
- France
- Volunteers
- 330 people
- Sponsor
- University Hospital, Caen
Gait, Medication Induced Gait Disturbances
BioButton Among Nursing Home Residents
This pilot study will explore the use of the BioIntellisense BioButton, a remote wearable multi-parameter monitor, to identify gait disturbances that occur as a side effect of polypharmacy.
- Trial name
- NCT06665685
- Testing
- BioButton Device, Providing Clinical Care with BioButton Device
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Charles Lin
Chronic Pain
Pain Catastrophizing and Prescription Opioid Craving
Adherence to prescription opioid and opioid tapering as indicated are critical for safe chronic opioid therapy for chronic pain, but this can be difficult for patients experiencing prescription opioid craving.
- Trial name
- NCT04097743
- Testing
- Coping Statement
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Stanford University
Allergic Rhinitis, Asthma
Integrating Targeted MedlinePlus Health Prescriptions Into Clinic Practice Workflow
The specific aim of this proposed project is to implement a standard process for integrating MedlinePlus health information prescriptions into the clinic workflow.
- Conditions
- Allergic Rhinitis, Asthma, Back Pain, Benign Prostatic Hypertrophy
- Trial name
- NCT00634608
- Testing
- Health Information Prescription
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
End Stage Renal Disease
Effect of Changes in Dialysate Bicarbonate on Serum Calcification Propensity and Calciprotein Particles in Hemodialysis Patients
This is a single-center, prospective, proof-of-priciple, pilot study in 24 end-stage renal disease patients on chronic hemodiaysis.
- Trial name
- D-Bic-T50-HD (NCT06084858)
- Testing
- Dialysate bicarbonate modification
- Where
- Austria
- Volunteers
- 26 people
- Sponsor
- Prim. Priv. Doz. Dr. Daniel Cejka
Prostate Cancer
Consensus Method to Evaluate the Conformity of Prescription of a Chemotherapy
Cabazitaxel is a second line chemotherapy drug recently approved for the treatment of metastatic castration-resistant prostate cancer.
- Trial name
- CABOBS (NCT02882178)
- Volunteers
- 18 people
- Sponsor
- Institut Bergonié
Chronic Disease, Sedentary Lifestyle
Evidence-Based Lifestyle Prescription Program: Pilot Study
The HealtheSteps™ (HeS) Program is an evidence-based, community-focused, lifestyle prescription (Rx) program, supported by in-person coaching and innovative health technologies.
- Conditions
- Chronic Disease, Sedentary Lifestyle, Overweight
- Trial name
- HeSP (NCT02413385)
- Testing
- HealtheSteps Program
- Where
- Canada
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Opioid Overdose
Pharmacokinetics (PK) and Safety of Multiple Doses of Intranasal Naloxone in Healthy Adults
This study will be a Phase 1, single-center, open-label, randomized cross-over study to evaluate the PK of a new AP003 device which delivers two sprays of 4 mg naloxone hydrochloride intranasally.
- Trial name
- NCT05377255
- Testing
- 16 mg naloxone AP003, 8 mg naloxone NARCAN Nasal Spray
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
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