Clinical trials: Prescription
Overdose, Substance Use
Permanent Supportive Housing Overdose Prevention+ Study
This community-partnered study examines a technical assistance intervention designed to help permanent supportive housing agencies implement evidence-based practices to prevent tenant overdose and improve tenant health.
- Trial name
- POP+ (NCT07214519)
- Testing
- TA Intervention
- Where
- United States
- Volunteers
- 2,940 people
- Sponsor
- NYU Langone Health
Breast Cancers, Triple Negative Breast Cancer (TNBC)
Personalizing the Use of Pembrolizumab for Patients Who Have a Strong Response in Early Triple Negative Breast Cancer
OPT-PEMBRO trial is a pragmatic, multicentre, international, prospective, non-inferiority, two-arms, randomised (1:1), open-label, Phase III clinical study.
- Trial name
- OPT-PEMBRO (NCT06606730)
- Testing
- Pembrolizumab, Deescalation
- Where
- 2 sites in Belgium, France
- Volunteers
- 2,454 people
- Sponsor
- UNICANCER
Drug Overdose
A Pilot Study of the Bioavailability of Nasal Naloxone
The overall is aim of this pilot study is to give a preliminary estimation of key parameters of the pharmacokinetics of a proper formulation of intranasal naloxone.
- Trial name
- NCT01939444
- Testing
- naloxone intranasal, naloxone intravenous
- Where
- Norway
- Volunteers
- 5 people
- Sponsor
- Norwegian University of Science and Technology
Opioid Use Disorder
A Pragmatic Randomized Control Trial Comparing Models of Care in the Management of Prescription Opioid Misuse
This trial evaluates two standard of care treatments for opioid addiction: methadone and buprenorphine/naloxone. In order to improve patient care, the study will address real-world treatment conditions, including strict…
- Trial name
- OPTIMA (NCT03033732)
- Testing
- Methadone, Buprenorphine-Naloxone
- Where
- 7 sites in Canada
- Volunteers
- 272 people
- Sponsor
- Didier Jutras Aswad
Prostate Cancer
Consensus Method to Evaluate the Conformity of Prescription of a Chemotherapy
Cabazitaxel is a second line chemotherapy drug recently approved for the treatment of metastatic castration-resistant prostate cancer.
- Trial name
- CABOBS (NCT02882178)
- Volunteers
- 18 people
- Sponsor
- Institut Bergonié
Non-cancerous Chronic Pain
Comparison of Standard Opioid Prescription Versus Prescription Guided by Pharmacogenetic Analysis in Patients With Non-cancerous Chronic Pain.
The investigators hypothesize that opioid prescription guided by patient pharmacogenetic profile will diminish opioid-associated undesirable effects by 50% and improve medication compliance.
- Trial name
- AlgoPGx (NCT03498014)
- Testing
- Pharmacogenetic analysis allowing personalized opioid prescription, Standard opioid prescription
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Overdose
SOONER Feasibility Study Protocol
Opioid Overdose Education and Naloxone Distribution programs (OEND) involve training and equipping people who are likely to be bystanders to opioid overdose to recognize and respond to opioid-related emergencies by activating…
- Trial name
- SOONER (NCT03821649)
- Testing
- SOONER Training and Naloxone Kit Kit, Community or Hospital-Based Training
- Where
- 4 sites in Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
End Stage Renal Disease
Effect of Changes in Dialysate Bicarbonate on Serum Calcification Propensity and Calciprotein Particles in Hemodialysis Patients
This is a single-center, prospective, proof-of-priciple, pilot study in 24 end-stage renal disease patients on chronic hemodiaysis.
- Trial name
- D-Bic-T50-HD (NCT06084858)
- Testing
- Dialysate bicarbonate modification
- Where
- Austria
- Volunteers
- 26 people
- Sponsor
- Prim. Priv. Doz. Dr. Daniel Cejka
Opioid Overdose
Tailoring Overdose Education for Black Churches
Church-based interventions are culturally acceptable, reduce access barriers, and can be brought to scale in under-resourced communities.
- Trial name
- NCT05645016
- Testing
- COEST
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Depression Chronic, Depressed
Evaluation of Dalia Solution For Depressed Patient
The goal of this superiority clinical investigation, prospective, multicenter, controlled, randomized, open-label is to evaluate the clinical impact of the Dalia medical telemonitoring device on the management of depressive…
- Conditions
- Depression Chronic, Depressed, Depressed Mood, Depression and Quality of Life
- Trial name
- DaliaMonitorin (NCT07211984)
- Testing
- Dalia Monitoring, Conventional healthcare
- Where
- France
- Volunteers
- 644 people
- Sponsor
- Dalia Care
Chronic Pain
Pain Catastrophizing and Prescription Opioid Craving
Adherence to prescription opioid and opioid tapering as indicated are critical for safe chronic opioid therapy for chronic pain, but this can be difficult for patients experiencing prescription opioid craving.
- Trial name
- NCT04097743
- Testing
- Coping Statement
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Stanford University
Asthma, Chronic Obstructive Pulmonary Disease
Analysis of Inhaled Corticoid Prescriptions in General Medicine
Chronic obstructive pulmonary disease (COPD) and asthma are frequent and disabling pathologies. The general practitioner is often at the front line vis-a-vis screening, diagnosis and treatment of these pathologies.
- Trial name
- COMEGE (NCT03179826)
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Montpellier
Hypernatremia, Hyponatremia
Plasma Sodium and Sodium Administration in the ICU
Patients in the Intensive Care Unit often present with low levels of plasma sodium and are therefore often administered high amounts of sodium, both as an additive to intravenous glucose solutions and as a constituent of various…
- Conditions
- Hypernatremia, Hyponatremia, Critical Illness
- Trial name
- NCT06037928
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- University Hospital, Linkoeping
Covid-19
Long COVID Kids DK - Investigating Long-term Covid-19
During the COVID-19 pandemic children have been perceived as a group not being especially affected, with less being infected, low symptom burden and low mortality.
- Trial name
- NCT04786353
- Testing
- LongCOVIDkidsDK
- Where
- Denmark
- Volunteers
- 330,000 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Community-acquired Acute Lower Respiratory Infection
Advanced Diagnostics for Enhanced QUality of Antibiotic Prescription in Respiratory Tract Infections in Emergency Rooms
This study is a randomized controlled trial where participants are randomly assigned in a 1:1 ratio to either a rapid test group or a control group. Standard care is provided in the control group.
- Trial name
- ADEQUATE (NCT04781530)
- Testing
- BioFire FilmArray Respiratory Panel 2.1 plus (RP2.1plus)
- Where
- 6 sites in Germany, Greece and 3 more
- Volunteers
- 522 people
- Sponsor
- PENTA Foundation
Prescription Drug Problems
SCOSI-M: Preventing Prescription Drug Problems
Brandeis University and University of South Carolina (USC) have joined together to develop the South Carolina Opioid Safety Initiative - Military (SCOSI-M), to develop an academic detailing (medical education) intervention for…
- Trial name
- NCT02210936
- Testing
- Educational Intervention
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Brandeis University
Depressive Symptoms, Depressive Disorder
Improving Depressive Symptoms Through Personalised Exercise and Activation
The purpose of the present study is to evaluate the changes on mental and physical health deriving from a blended intervention merging psychological intervention aimed at increasing activity and exercise with a personalised…
- Trial name
- IDEA (NCT04857944)
- Testing
- IDEA program (Improving depressive symptoms through personalised exercise and activation), IDEApp
- Where
- Spain
- Volunteers
- 121 people
- Sponsor
- Hospital del Mar Research Institute (IMIM)
Heart Arrest, Out-Of-Hospital, Opioid Overdose
Naloxone for Opioid Associated Out of Hospital Cardiac Arrest
The investigator's long-term goal is to conduct Naloxone for Opioid Associated out of Hospital Cardiac Arrest (NOPACA), a randomized, double blind, controlled trial to determine the efficacy of naloxone vs.
- Conditions
- Heart Arrest, Out-Of-Hospital, Opioid Overdose, Naloxone
- Trial name
- NOPACA (NCT06251609)
- Testing
- Naloxone 2 MG, Saline 2ml
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of California, San Francisco
Arthroplasty, Replacement, Hip
Home-based Rehabilitation Following a Total Hip Replacement
In this study we will investigate the relation between performed exercise dose and recovery after total hip replacement (THA). A dose-response relationship is hypothesized.
- Trial name
- PHETHAS-1 (NCT03109821)
- Testing
- Home-based exercise
- Where
- Denmark
- Volunteers
- 94 people
- Sponsor
- Central Jutland Regional Hospital
Pseudomonas
Impact of Modifications to the Rendering of the Antibiogram on the Prescriptions of Meropenem in Pseudomonas Bacteremia
Modification of the rendering of the antibiogram at the Strasbourg University Hospital in November 2019 with the appearance of the concept of "standard dose" or "high dose" sensitivity.
- Trial name
- Mero-Pyo (NCT06113107)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
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