Clinical trials: Prescription Drug Abuse and Dependency
PTSD, Psychiatric Illness
Killing Pain - Use of Analgesic, Sedative and Anxiolytic Medication and the Development of Psychiatric Illness in Adolescents
Prescription of analgesic, sedative, and anxiolytic medication for children and adolescents is increasing in Western countries. In recent decades, rates have also increased in Norway, despite a relatively restrictive prescription…
- Conditions
- PTSD, Psychiatric Illness, Prescription Drug Dependence, Addiction
- Trial name
- NCT04336605
- Testing
- Age & Development, Socioeconomy, Traumatic Events
- Where
- Norway
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Norwegian Center for Violence and Traumatic Stress Studies
Opiate Substitution Treatment
Buprenorphine and Substance Abuse Services for Prescription Opioid Dependence
This is a randomized trial of two group-based models of care for buprenorphine/naloxone (bup/nx) patients in Substance Use (SU) specialty treatment: Standard Medical Management (SMM) and Intensive Outpatient Treatment (IOT).
- Trial name
- NCT02496403
- Testing
- Standard Medical Management (SMM)
- Where
- United States
- Volunteers
- 239 people
- Sponsor
- Kaiser Permanente
Opioid Use, Opioid-Related Disorders
Addressing Origins of the Opioid Epidemic by Improving Prescribing for Opioid-Naive Patients
Risk of long-term opioid dependence increases with initial opioid dose/duration, but despite recent Centers for Disease Control and Prevention (CDC)-endorsed minimum doses for initial opioid prescription, primary care providers…
- Conditions
- Opioid Use, Opioid-Related Disorders, Opioid Abuse, Prescription Drug Abuse and Dependency
- Trial name
- NCT03377855
- Testing
- Default Prescribing Change
- Where
- 2 sites in United States
- Volunteers
- 948 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Drug Overdose, Opioid-Related Disorders
A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid Overdoses
This project will further develop and test the Tailored Telephone Intervention delivered by Peers to Prevent Recurring Opioid Overdoses (TTIP-PRO), a promising, low-cost, intervention to facilitate entry into medication assisted…
- Conditions
- Drug Overdose, Opioid-Related Disorders, Drug Addiction, Drug Abuse
- Trial name
- TTIP-PRO (NCT02922959)
- Testing
- Peer Intervention, naloxone nasal spray kit, Personally-tailored opioid overdose prevention education (information packet)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Cincinnati
Narcolepsy
Observational Study to Evaluate Risks of Side Effects, Drug Abuse and Dependence in Patients Who Received Xyrem ® on Prescription
Patients will be followed up for max 18 months. Information on the Adverse Events and potential misuse or abuse of Xyrem ® will be collected.
- Trial name
- NCT00244465
- Where
- 41 sites in Austria, Belgium and 7 more
- Volunteers
- 750 people
- Sponsor
- UCB Pharma
Drug Dependence
Improving Treatment Outcomes for Prescription Opioid Dependence
Overall, this proposal seeks to improve treatment strategies for the significant public health problem of prescription opioid dependence by determining whether gabapentin, a non-narcotic pharmaceutical agent with minimal abuse…
- Trial name
- GBN (NCT02543944)
- Testing
- Gabapentin, Buprenorphine, Clonidine
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- University of Arkansas
Marijuana Dependence
The Effect of Marijuana and Prescription Medications in Mood, Performance and Sleep
Heavy marijuana users report experiencing trouble sleeping when they try to quit, but this has not been carefully studied. This research is being done to learn more about sleep function in heavy marijuana users, and to determine…
- Trial name
- NCT00893269
- Testing
- eszopiclone, ramelteon, zolpidem
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Opioid-use Disorder, IV Drug Usage
AWAITS: A Web-based E-health Application for Active Illicit Opioid Users
The purpose of this research study is to: 1. assess how participants like the AWAITS e-health application as measured by their feedback on the intervention 2.
- Conditions
- Opioid-use Disorder, IV Drug Usage, Overdose, Drug Addiction
- Trial name
- AWAITS (NCT03402672)
- Testing
- self-administered, e-health application
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Cincinnati
Alcohol Use Disorder, Alcoholism
fNIRs-based Neurofeedback to Reduce Relapse in pOUD/AUD
This study will examine the impact of functional near-infrared spectroscopy-based neurofeedback to a region within the brain's prefrontal cortex involved with self-regulation of resisting craving in alcohol use and prescription…
- Conditions
- Alcohol Use Disorder, Alcoholism, Prescription Drug Dependence, Opioid-use Disorder
- Trial name
- NCT03595293
- Testing
- fNIRs-based Neurofeedback
- Sponsor
- Milton S. Hershey Medical Center
Opioid Use, Prescription Drug Abuse and Dependency
No Opioids PrescrIptions On Discharge After Surgery
Opioid analgesics are routinely prescribed for these patients for post-operative pain control. Even a short exposure to opioids in opioid-naïve patients following minor or major surgery has been associated with de novo habitual…
- Conditions
- Opioid Use, Prescription Drug Abuse and Dependency, Surgery, Postoperative Pain
- Trial name
- NOPIOiDS (NCT04469868)
- Testing
- No opioids at discharge
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Albany Medical College
Anxiety, Prescription Drug Abuse and Dependency
Prescription of Benzodiazepines by General Practitioners: Characteristics of Prescribing Trend and Implementation of an Online Educational Program
Portugal has the highest benzodiazepine utilization compared to other European countries. The high utilization of benzodiazepines has been a concern due to reported side effects of long-term use and dependence.
- Trial name
- NCT04925596
- Testing
- ePrimaPrescribe online educational program, ComunicaSaudeMental online educational program
- Where
- Portugal
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent)
An Opioid Prescribing Nudge
Analyze baseline concurrent opioid prescribing metrics at the individual prescriber level in the Duke Health System on the identified three main outcome measures.
- Conditions
- Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent), Prescription Drug Abuse and Dependency, Health Behavior
- Trial name
- OHS (NCT04069403)
- Testing
- Automated Reports on prescription patterns for their patients
- Where
- United States
- Volunteers
- 427 people, healthy volunteers welcome
- Sponsor
- Duke University
Overdose, Opioid-related Disorders
Phone Interview to Prevent Recurring Opioid Overdoses
There has been a dramatic rise in opioid overdose (OOD) deaths in recent years. Attempts to ameliorate the problem have largely focused on increasing the accessibility of naloxone, an opioid antagonist that is effective in OOD…
- Conditions
- Overdose, Opioid-related Disorders, Drug Addiction, Drug Abuse
- Trial name
- TTIP-PRO (NCT02282306)
- Testing
- TTIP-PRO
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati