Clinical trials: Presymptomatic Disease
Cardiovascular Diseases, Asymptomatic Condition
Cardiovascular Screening in Asymptomatic South Asians
Cardiovascular disease (CVD) is the leading cause of morbidity, mortality and healthcare costs in the United Kingdom. Ethnic minorities like South Asians (SA) have a 3-5 times higher incidence of CVD as predicted by various risk…
- Conditions
- Cardiovascular Diseases, Asymptomatic Condition, South Asian
- Trial name
- NCT06765785
- Testing
- CTCA
- Volunteers
- 50 people
- Sponsor
- Sandwell & West Birmingham Hospitals NHS Trust
Asymptomatic Condition
Instrument Assisted Soft Tissue Mobilization Effect on Blood Flow
This study is designed to evaluate the short term change in blood flow in the superficial human tissue layers after the application of 3 min Graston instrumented assisted soft tissue mobilization on the plantar aspect of the foot…
- Trial name
- NCT04785079
- Testing
- Graston Instrument assisted Soft tissue Mobilization
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Florida Gulf Coast University
Aged, Asymptomatic Condition
Classification of the Sagittal Profile of the Spine in Asymptomatic Elderly Subjects
Principal aim The main purpose of the study is to describe the distribution of the sagittal profile in elderly subjects in order to bridge the gap present in this type of screening, evaluated in the literature for adults only…
- Trial name
- EOS60 (NCT03237039)
- Testing
- X-ray examination, fall-risk assessment, gait cycle analysis
- Where
- Italy
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Colonization, Asymptomatic, Colonization
Probiotic Delivered to the Small Intestine Changes Microbiota
This study will determine whether encapsulation of probiotic bacteria using natural plant protein can enhance bacterial colonisation.
- Trial name
- Probiotic (NCT07510282)
- Testing
- Probiotic containing L.rhamnosus R0011 strain, 200 ml yogurt drink
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Amyotrophic Lateral Sclerosis (ALS)
Developing New Ways to Detect Respiratory Impairment Early in ALS
The goal of this observational study is to develop new ways to detect early changes associated with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.
- Trial name
- NCT07844590
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
Prolonged Monitoring to Detect Ventricular Arrhythmias in Presymptomatic Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Patients
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is an inherited condition characterized by life threatening heart racing, presenting with palpitations, cardiac arrest (collapse requiring an ambulance) or sudden death.
- Trial name
- PREPARE (NCT01271816)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Presymptomatic Huntington Disease
Assessment of the Psychological, Cognitive and Social Resources of Applicants for Huntington's Disease and Presymptomatic Genetic Testing
The purpose of this study is to assess the psychological, cognitive and social resources of applicants for Huntington's Disease and Presymptomatic Testing.
- Trial name
- PREHUNT (NCT02134561)
- Testing
- psychological interview, MRI, cognitive tests
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Angers
Asymptomatic State, Temporomandibular Joint
Ultrasounds Evaluation of Asymptomatic Perimandibular Muscles Treated With Dry Needling
The articular disc of temporomandibular joint and three muscles of the cervico-facial region (temporal, masseter, sternocleidomastoid) are evaluated by means of sonographic images to observe and measure their dimensions' changes…
- Conditions
- Asymptomatic State, Temporomandibular Joint, Masticatory Muscles
- Trial name
- NCT04578626
- Testing
- dry needling
- Where
- Spain
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Poliambulatorio Physio Power
Phenylketonuria
Announcement of Rare Metabolic Diseases in Systematic Newborn Screening: the Phenylketonuria Experience.
The aims of this collaborative, interdisciplinary research project are to understand and describe the psychological impact of the announcement of a rare, serious disease present since birth and detected in the context of the…
- Trial name
- ANNPHE (NCT06289348)
- Testing
- socio-psychological questionnaire, revised event impact scale (IER-S), Non directive interview
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asymptomatic Condition
Effects of Mulligan Bent Leg Raise With and Without Bowen Therapy on Hamstring Tightness in Asymptomatic Adults
Hamstring tightness is a common problem caused by a sedentary lifestyle and can have negative effects on posture and musculoskeletal function.
- Trial name
- NCT06197945
- Testing
- Mulligan bent leg raise, Mulligan bent leg raise with Bowen therapy
- Where
- Pakistan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Colonization, Asymptomatic
Decolonization of Carbapenem-resistant Enterobacterales (CRE) in Patients With Faecal Carriage of CRE With Neomycin
Rates of antimicrobial resistance are increasing worldwide. There is increasing evidence that physiological gut microbiota is a large reservoir of antibiotic-resistance genes.
- Trial name
- NCT05593601
- Testing
- Neomycin
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Chlamydia Trachomatis Infection, Neisseria Gonorrheae Infection
Clinical Evaluation of the ID NOW™ CT/NG Test
The objective of this study is to determine the performance of the ID NOW™ CT/NG test in male urine, female urine, and self-collected vaginal swabs when tested by intended users (i.e., untrained operators).
- Conditions
- Chlamydia Trachomatis Infection, Neisseria Gonorrheae Infection, Asymptomatic Condition
- Trial name
- NCT06395675
- Testing
- ID NOW™
- Where
- United States
- Volunteers
- 7,100 people, healthy volunteers welcome
- Sponsor
- Abbott Rapid Dx
Aortic Valve Stenosis, Asymptomatic Conditions
Prognostic Impact of Myocardial Longitudinal Strain in Asymptomatic Aortic Stenosis: a Meta-Analysis
In patients with asymptomatic aortic stenosis (AS), the prognostic value of reduced left ventricular (LV) ejection fraction is well known.
- Conditions
- Aortic Valve Stenosis, Asymptomatic Conditions, Left Ventricular Function
- Trial name
- NCT02608567
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- European Association of Cardiovascular Imaging
Asymptomatic Diseases
The Efficiency of Postoperative Antibiotics in Orthognathic Surgery
Orthognathic surgery is the state of art of the maxillofacial surgery, it fix and normalize facial abnormalities and create a harmony between the different tissues compounding the face (bone, soft tissue and dental structures).
- Trial name
- NCT02740647
- Testing
- Amoxicillin Clavulanate
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Parkinson Disease
Effect of Cognitive Training on Gait in Parkinson's Disease
Physiotherapy and targeted rehabilitation are routinely performed in order to influence disorders of posture, gait and stability in Parkinson´s disease (PD), but their effects have been controversial (Keus et al.
- Trial name
- NCT05514379
- Testing
- cognitive training
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- General University Hospital, Prague
Alzheimer Disease, Mild Cognitive Impairment
Evaluation of a Computerized Complex Instrumental Activities of Daily Living Marker (NMI)
The proposed study is designed to evaluate the performance of the ALTOIDA™ System as a tool to assist physicians in diagnosing Alzheimer's Disease (AD) in real-world clinical settings.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Memory Disorders, Cognitive Impairment
- Trial name
- AltoidaML (NCT02843529)
- Testing
- Altoida: neuropsychological, MRI, EEG and CSF biomarkers
- Volunteers
- 548 people, healthy volunteers welcome
- Sponsor
- Altoida
Uncomplicated Malaria, Asymptomatic Condition
A Study to Determine Safety, Tolerability, and Pharmacokinetics of Different Orally Administered Regimens of the Combination ZY19489-Ferroquine in Adult Asymptomatic Plasmodium Falciparum Carriers
Malaria is caused by protozoan parasites of the genus Plasmodium and it is the most important parasitic disease in terms of mortality and morbidity.
- Conditions
- Uncomplicated Malaria, Asymptomatic Condition, Falciparum Malaria
- Trial name
- ZYFER-1 (NCT05911828)
- Testing
- ZY19489 + Ferroquine (FQ)
- Where
- Gabon
- Volunteers
- 36 people
- Sponsor
- Zydus Lifesciences Limited
Colonization, Asymptomatic, Probiotic Intervention
Probiotic in Fruit Snack
The aim of this study is to investigate whether a fruit snack containing probiotic ''Lactobacillus rhamnosus'' can survive and establish itself more effectively in the gut when it is protected inside a natural plant-protein…
- Conditions
- Colonization, Asymptomatic, Probiotic Intervention, Gut Microbiota Diversity and Composition, Gut-brain Axis
- Trial name
- Probiotics (NCT07679490)
- Testing
- Microencapsulated Lactobacillus rhamnosus Fruit Snack
- Where
- Ireland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Asymptomatic Condition, Infection Viral
ScreenNC, a Study to Determine the Number of Asymptomatic Individuals Who Have Antibodies to the Virus That Causes COVID-19
Purpose: To determine the number of asymptomatic individuals who have antibodies to SARS-CoV-2, the virus which causes COVID-19
- Conditions
- Asymptomatic Condition, Infection Viral, Coronavirus Infections, Severe Acute Respiratory Syndrome Coronavirus 2
- Trial name
- NCT04367740
- Testing
- To assess for development of IgG antibodies against SARS-CoV2
- Where
- United States
- Volunteers
- 6,313 people
- Sponsor
- University of North Carolina, Chapel Hill
Asymptomatic Condition
Influence of Muscle Stretching and Neural Mobilizations on Lower Limbs Range of Motion in Asymptomatic Subjects.
First, this study aims to use the straight leg raising test (SLR) and the knee angle extension test (KEA) test associated to a structural differentiation to determine the limitation of the lower limb (muscular or nervous) in…
- Trial name
- NCT05899244
- Testing
- muscle streching exercice, Slider, Tensioner
- Where
- Belgium
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- University of Liege