Clinical trials: Preterm Birth
Premature Birth
Prophylactic DR-CPAP on Late Preterm Infants Born by C-section: an RCT
A Pragmatic Randomized Controlled Pilot Trial to Evaluate the Impact of Early Prophylactic Continuous Positive Airway Pressure with or without Supplemental Oxygen in Spontaneously Breathing Late Preterm Newborn Infants Born by…
- Trial name
- PLANT (NCT05204719)
- Testing
- Prophylactic Delivery Room Continuous Positive Airway Pressure
- Where
- 5 sites in United States, Canada and 1 more
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Cerebral Palsy
ePrime: Evaluation of Magnetic Resonance (MR) Imaging to Predict Neurodevelopmental Impairment in Preterm Infants
Preterm infants face an uncertain future because premature birth often leads to problems with brain development and can cause cerebral palsy.
- Trial name
- ePrime (NCT01049594)
- Where
- 13 sites in United Kingdom
- Volunteers
- 625 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Amblyopia, Child
Early Vision Screening in High-risk Children
To evaluate the effect of early vision screening with automated photorefraction device in high risk children
- Trial name
- NCT02678468
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Prematurity
Fact-based Nutrition for Infants and Lactating Mothers
Human milk (HM) is the ideal source of nutrients for infants, but its composition is highly variable. When not enough own mother's milk (OMM) is available, the administration of pasteurized donor human milk (DHM) is considered…
- Trial name
- NUTRISHIELD (NCT05646940)
- Where
- Spain
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Cerebral Oxygenation, Premature
Evaluation of Cerebral Oxygenation Results in Premature Infant
The general purpose of this project is; Evaluation of cerebral oxygenation results in premature infants. These results will be evaluated in two different applications.
- Conditions
- Cerebral Oxygenation, Premature, Kangaroo Care, Facilitated Tucking
- Trial name
- NCT04725435
- Testing
- Kangaroo care, Facilitated Tucking Position
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Preterm Birth
Preventing Preterm Birth With a Pessary
The primary objective of this study, is to determine the effect of a Cup pessary, a device that is currently readily available in the USA and similar in design to the Arabin pessary, on the incidence of delivery prior to 37 weeks…
- Trial name
- PrePPy (NCT01380158)
- Testing
- Cup pessary (Bioteque America, Inc)
- Where
- 3 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Birth Defect, Pregnancy Loss
B-vitamin Levels and Adverse Pregnancy Outcomes
This prospective nested case-control study aims to examine the effects of blood vitamin B levels in first-trimester pregnant women on the pregnancy outcomes
- Conditions
- Birth Defect, Pregnancy Loss, Pregnancy Complications, Pregnancy Induced Hypertension
- Trial name
- NCT05073978
- Testing
- No intervention
- Where
- China
- Volunteers
- 7,500 people, healthy volunteers welcome
- Sponsor
- Westlake University
Cesarean Delivery Affecting Fetus, Preterm Labor
Baby Smell Visual Stimulus Program Cortical and Breast Oxygenation Milk Amount Mother-Infant Attachment
In this study, the effect of infant odor and visual stimulus program applied to mothers who had delivered by cesarean section and whose babies were taken to the NICU on cortical and breast oxygenation (rSO2), amount of breast…
- Trial name
- NCT06058208
- Testing
- Olfactory stimulation, Visual stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Premature Infants, Stool Bacterial Composition
Effects of Probiotic and Prebiotic Combinations on Premature Infants
The purpose of this study is to see how oral preparations containing both probiotics and prebiotics impact the growth, bacterial colonization of the intestines, and fecal short chain fatty acid content in premature infants.
- Conditions
- Premature Infants, Stool Bacterial Composition, Growth
- Trial name
- NCT00282113
- Testing
- ProBioPlus, Culturelle
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Preterm Birth
Impact of Pessary Treatment on Cervical Stiffness Measurement and Birth Outcomes in Patients at Risk for Preterm Birth
Background: A preterm birth remain a worldwide important socioeconomic burden since prematurity has been consistently implicated in a wide range of health medical problems affecting newborn child and contributed in up to more…
- Trial name
- NCT05267717
- Testing
- Non-interventional study, all patients being tested with AG Pregnolia System to assess the values of the Cervical Stiffness
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Asklepios proresearch
Infant, Newborn, Infant, Low Birth Weight
Benchmarking Initiative to Reduce Bronchopulmonary Dysplasia
This study tested whether Neonatal Intensive Care Unit (NICU) teams trained in benchmarking -- comparing care practices between different NICUs to see which practices prevent bronchopulmonary dysplasia (BPD) -- and quality…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- Benchmarking (NCT00067613)
- Testing
- Benchmarking Management Practices, Standard Management Practices
- Where
- 17 sites in United States
- Volunteers
- 4,095 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Premature Birth, Maternal Distress - Delivered
Heart Rate Variability and Prematurity
Mothers who deliver prematurely (<37 weeks of gestational age) experience intense stress and anxiety given that their child's survival and development might be compromised.
- Conditions
- Premature Birth, Maternal Distress - Delivered, Stress, Anxiety
- Trial name
- NCT03565874
- Testing
- Heart rate variability biofeedback
- Where
- Switzerland
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Premature Birth, Bacterial Vaginosis
Effect of Probiotic Lactobacilli on Vaginal Flora of Pregnant Women at High Risk for Preterm Delivery
Purpose of the study is to determine the effect of probiotic lactobacilli on the vaginal flora and cytokine profile during pregnancy, and the incidence of preterm labour in women at high risk for preterm birth.
- Trial name
- NCT00217308
- Testing
- Lactobacilli GR-1 and RC-14
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Parental Anxiety Following Premature Birth
Impact of Preterm Birth on Symptoms of Anxiety and Depression in Parents, and on the Precursors of Cognition, Including Social Cognition in Their Child
In 2018, the World Health Organization (WHO) counted no less than 15 million preterm births each year worldwide, or more than one in ten children.
- Trial name
- PréDANPa (NCT05734768)
- Testing
- State-Trait Anxiety Inventory - Y ou STAI-Y
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Osteopenia Prematurity
Effect of Assisted Exercise on Musculoskeletal System and Growth in Preterm Infants
The primary aim of this study is to assess whether physical activity programs in preterm infants improve bone mineralization as well as growth and reduce the risk of fractures.
- Trial name
- NCT03354988
- Testing
- Physical exercise group, Control group
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
HIE - Hypoxic - Ischemic Encephalopathy, Perinatal Anoxic-ischemic Brain Injury
Biomarkers Study in Infants With Prior Neonatal Brain Injury
This research focuses on the long-term cognitive development of children, including healthy infants and those who had a perinatal brain injury.
- Conditions
- HIE - Hypoxic - Ischemic Encephalopathy, Perinatal Anoxic-ischemic Brain Injury, Premature Birth, Healthy Participants
- Trial name
- NCT07413900
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Respiratory Distress Syndrome, Newborn
LISA Catheter With Marked vs. Unmarked Tip in Extremely Low Birth Weight Infants With RDS
This is an unblinded, randomized, controlled, crossover (AB/BA) trial of surfactant treatment with LISA catheter with a marked tip vs.
- Trial name
- NCT05399628
- Testing
- Surfactant administration with less invasive surfactant administration (LISA) marked tip catheter, Surfactant administration with less invasive surfactant administration (LISA) unmarked tip catheter
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital Padova
Preterm Birth Infants
Effect of Antenatal Dexamethasone on Postnatal Adrenal Hormones in Preterm Neonates
This study is designed to evaluate the effect of antenatal dexamethasone administration on postnatal adrenal hormone levels in preterm neonates.
- Trial name
- NCT07916142
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sohag University
Premature
The Effect of the Finger Feeding Method Premature Babies
This study aimed to determine the effect of the finger feeding method applied by fathers on the transition time to oral feeding and sucking success in premature babies.
- Trial name
- NCT06204263
- Testing
- finger feeding
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Preterm Rupture of Membranes
Identification of Microbial DNA in Maternal Plasma After PPROM
This study evaluates the use of metagenomic next generation sequencing in identifying microbial DNA in plasma samples of patients with preterm premature rupture of membranes.
- Trial name
- NCT04318470
- Testing
- mNGS
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
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