Clinical trials: Preterm Birth
Postpartum Depression, Small for Gestational Age at Delivery
Happy Mother-Healthy Baby: An Anxiety-focused Early Prenatal Intervention
In the proposed study the investigators will develop an early prenatal preventive intervention targeting anxiety and conduct a randomized controlled trial in Pakistan to test its efficacy in reducing generalized anxiety disorder…
- Conditions
- Postpartum Depression, Small for Gestational Age at Delivery, Preterm Birth, Anxiety
- Trial name
- HMHB (NCT03880032)
- Testing
- Cognitive Behavioral Therapy Intervention for Anxiety
- Where
- Pakistan
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Infectious Diseases
Severe Necrotizing Enterocolitis in Preterm Newborns <1500g Using Probiotics
The purpose of this study is to know the effects of probiotics on the incidence of Necrotizing Enterocolitis (NEC) in preterm infants less than 1500 g.
- Trial name
- EPP (NCT02226263)
- Testing
- probiotics Lactobacillus acidophilus boucardii
- Where
- Mexico
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Newborn, Infant
Placing Preterm Infants in Polyethylene Bags Immediately After Birth
Primary objective: To determine if placing preterm infants in a polyethylene bag (PB) immediately after birth, before the umbilical cord is clamped, will increase the number of preterm infants with a normal temperature on…
- Conditions
- Newborn, Infant, Hypothermia, Premature
- Trial name
- NCT04463511
- Testing
- Polyethylene bag before the umbilical cord is clamped
- Where
- Ireland
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Preterm Labor Without Delivery, Pregnancy Preterm
The Treatment of Magnesium Sulfate and Nifedipine in Preterm Labor Threat
Comparison of the effects of Nifedipine and MgSO4 therapies on maternal and fetal blood flow.
- Trial name
- MgSO4 (NCT05520021)
- Testing
- Nifedipine, Magnesium sulfate
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Konya Meram State Hospital
Mothers, Premature
Empowering Mothers Whose Babies Are Hospitalized in the Neonatal Intensive Care Unit
Family Integrated Care is designed to eliminate the barriers between parents and their infants in the NICU by involving parents of premature infants in their care.
- Conditions
- Mothers, Premature, Empowerment
- Trial name
- NCT06958458
- Testing
- Mother Integrated Care
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Yalova
Stress, Psychological, Preterm Infants
Multimedia Admission Orientation in NICU
The effect of a multimedia admission orientation on the parental stress, uncertainty, and knowledge of primary caregivers of high-risk infants in a neonatal intensive care unit: a quasi-randomized controlled trial study.
- Conditions
- Stress, Psychological, Preterm Infants, Intensive Care Units, Neonatal, Education
- Trial name
- NCT05214248
- Testing
- a multimedia admission orientation
- Where
- Taiwan
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Preterm Birth, Low Birth Weight <2500 Grams
Reducing Preterm Births in Underserved Pregnant Women
Timely screening and management of modifiable conditions can reduce preterm births, yet providing effective prenatal risk management systems to meet the unique needs of medically underserved populations is complex.
- Conditions
- Preterm Birth, Low Birth Weight <2500 Grams, Verylow Birthweight <1500 Grams
- Trial name
- NCT01344616
- Testing
- lifestyle support
- Where
- United States
- Volunteers
- 482 people, healthy volunteers welcome
- Sponsor
- PHCC LP
Vulvodynia, Mycoses
Prospective Data Bank Creation to Study Vaginal Conditions
The purpose of this study is to identify and elucidate the pattern and perhaps role of atypical proteins, cytokines and vaginal microbial flora in the pathogenic mechanisms involved in the development of vulvodynia, recurrent…
- Conditions
- Vulvodynia, Mycoses, Bacterial Vaginosis, Preterm Labor
- Trial name
- CRIPB-13-002 (NCT01829204)
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Congenital Uterine Anomalies
Prevalence of Congenital Uterine Malformations
Aims: We plan to investigate how common uterine malformations are in high-risk women (with history of miscarriage or preterm delivery), by analysing different characteristics in these groups.
- Trial name
- PUMA (NCT01487616)
- Where
- United Kingdom
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Respiratory Distress Syndrome, Newborn
LISA Catheter With Marked vs. Unmarked Tip in Extremely Low Birth Weight Infants With RDS
This is an unblinded, randomized, controlled, crossover (AB/BA) trial of surfactant treatment with LISA catheter with a marked tip vs.
- Trial name
- NCT05399628
- Testing
- Surfactant administration with less invasive surfactant administration (LISA) marked tip catheter, Surfactant administration with less invasive surfactant administration (LISA) unmarked tip catheter
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital Padova
Obstetric Labour, Premature, Premature Ejaculation
A Study To Assess The Pharmacokinetics Of Different Modified Release Formulations Of GSK221149 In Healthy Adult Subjects
PreTerm Labor (prior to 37 weeks gestation) is the largest single cause of infant morbidity and mortality and is frequently associated with long-term disability. Oxytocin is a hormone produced by the body during labor.
- Trial name
- NCT00449709
- Testing
- GSK221149
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Premature Birth, Premature Labor
Electrical Inhibition (EI): A Preliminary Study To Inhibit Preterm Labor And Preterm Birth
An electrical-inhibition (EI) uterine pacemaker device similar to an electrical heart pacemaker delivers a weak electrical current to the human uterus during active preterm labor to rapidly and safely inhibit the unwanted…
- Trial name
- EI (NCT02569216)
- Testing
- Electrical Inhibition (EI)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- NYU Langone Health
Patent Ductus Arteriosus in Preterm Infants, Patent Ductus Arteriosus After Premature Birth
Prophylactic IV Paracetamol in Extremely Premature Infants
Purpose of the research Everyone is born with an opening between the chambers of the heart, called a ductus arteriosus. In most people, it closes on its own, but in infants born at less than 30 weeks or less than 1250 grams…
- Conditions
- Patent Ductus Arteriosus in Preterm Infants, Patent Ductus Arteriosus After Premature Birth, Patent Ductus Arteriosus (PDA), Patent Ductus Arteriosus in Premature Infants
- Trial name
- NCT07067177
- Testing
- Paracetamol (drug)
- Where
- 3 sites in Palestinian Territories
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Al-Quds University
Bronchopulmonary Dysplasia
Early Predictors of Bronchopulmonary Dysplasia in Extremely Preterm Infants
Bronchopulmonary dysplasia (BPD) remains one of the most common complications in extremely preterm infants despite advances in neonatal intensive care.
- Trial name
- EPIRESP (NCT07771387)
- Where
- Austria
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Breastfeeding, Postnatal Depression
Mother and Late Preterm Lactation Study
Breastfeeding has various benefits for the mother and infant. It has the capability of reducing the risk of short term and long term problems for the infant, such as gastroenteritis, respiratory infections, type II diabetes and…
- Conditions
- Breastfeeding, Postnatal Depression, Stress, Psychological, Preterm Infant
- Trial name
- MAPLeS (NCT03791749)
- Testing
- Breastfeeding Support
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University College, London
Sepsis, Necrotizing Enterocolitis
Circulating Markers in Preterm Infants With Perinatal and Neonatal Inflammation
Circulating markers to diagnose complications (sepsis, necrotizing enterocolitis) in preterm infants are often inaccurate, partly due to the lack of comprehensive studies with temporal evaluation from birth until a disease onset.
- Conditions
- Sepsis, Necrotizing Enterocolitis, Chorioamnionitis, Feeding Intolerance
- Trial name
- NEOINFLAM (NCT03320785)
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Per Torp Sangild
Breast Feeding, Exclusive, Enteral Feeding
Tactile/kinesthetic Stimulus Program
The study will be carried out as a prospective randomized controlled clinical study to determine the effect of tactile/kinesthetic stimulus program on preterm infants on transition time to full sucking, sucking success and…
- Conditions
- Breast Feeding, Exclusive, Enteral Feeding, Hospital Stay
- Trial name
- NCT05486663
- Testing
- Tactile/kinesthetic Group
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Gonca Karatas Baran
Premature Infants, Necrotizing Enterocolitis
PREMAPROB. Probiotics to Prevent Necrotizing Enterocolitis
The main objective of this study is to assess the impact of two different doses of a mixture of probiotics from two strains isolated in human milk on the incidence of severe necrotizing enterocolitis (NEC) and death among preterm…
- Trial name
- NCT06501404
- Testing
- High dose group, Low dose group
- Where
- Spain
- Volunteers
- 583 people, healthy volunteers welcome
- Sponsor
- José Antonio Hurtado Suazo
Preterm Birth, Tube Feeding
Maternal Role in Oral Feed Establishment in Preterm Neonates
Hypothesis Preterm babies who receive sensory motor stimulation from their mothers as compared to trained nurses will 1. Start taking oral feed at the same time as compared to control group 2.
- Conditions
- Preterm Birth, Tube Feeding, Swallowing Disorder, Maternal Care Patterns
- Trial name
- NCT05484726
- Testing
- perioral sensory motor stimulation
- Where
- Pakistan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Fatima Memorial Hospital
Preterm Birth, Antenatal Corticosteroids
India Dexamethasone and Betamethasone
An open label, randomized, two-period, crossover, study to compare the pharmacokinetics and pharmacodynamics of single dose Dexamethasone and Betamethasone administered orally and intramuscularly in 48 healthy, adult, female…
- Trial name
- NCT03668860
- Testing
- Dexamethasone 4 mg/ml, Betamethasone 4 mg/ml, Celestone Soluspan 6Mg/Ml Suspension for Injection
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
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