Clinical trials: Preterm Delivery
Premature Infants, Necrotizing Enterocolitis
PREMAPROB. Probiotics to Prevent Necrotizing Enterocolitis
The main objective of this study is to assess the impact of two different doses of a mixture of probiotics from two strains isolated in human milk on the incidence of severe necrotizing enterocolitis (NEC) and death among preterm…
- Trial name
- NCT06501404
- Testing
- High dose group, Low dose group
- Where
- Spain
- Volunteers
- 583 people, healthy volunteers welcome
- Sponsor
- José Antonio Hurtado Suazo
Preterm Infants, Metabolic Bone Disease
Calciuric Effect and Cyclic Parenteral Nutrition in Preterm Infants
The aim of our work is to study the effect of total parenteral nutrition (TPN) cycling in preterm infants on hypercalcuria (excessive calcium excretion in urine).
- Trial name
- NCT00711763
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Pain, Acute, Preterm Infant
Olfactive Stimulation Interventions With Mothers' Milk on Preterm Pain Response
Repeated and untreated pain can lead to long-term consequences in preterm infants, such as pain hypersensitivity and impaired motor and intellectual development.
- Conditions
- Pain, Acute, Preterm Infant, Breast Milk
- Trial name
- NCT04062513
- Testing
- Olfactive stimulation intervention with familiarization, Olfactive stimulation intervention, Standard care
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Depression, Child Development
Improving Preterm Outcomes by Safeguarding Maternal Mental Health
The investigators' goal is to optimize the developmental outcomes of preterm infants by preventing depression and improving functioning among their mothers during the critical first year of life.
- Trial name
- NCT01892982
- Testing
- Problem Solving Education tailored to NICU
- Where
- 4 sites in United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Preterm Premature Rupture of Fetal Membranes
Core-temperature Monitoring in Patients With PPROM
The most common reason for preterm prelabor rupture of membrane (PPROM) is an ascendance of infection. Moreover PPROM is one of the main risk factors for chorioamnionitis.
- Trial name
- NCT02125708
- Testing
- OvulaRing®
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Post-Abortion, Hemorrhage, Obstetric
Oxytocin Receptor Expression in Pregnancy
This study aims to determine when during gestation oxytocin receptor (OXTR) expression increases in the myometrium, which will contribute new insight to the management of obstetric hemorrhage and our understanding of normal and…
- Trial name
- NCT03907735
- Testing
- Myometrial tissue sample collection
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Premature Infant
Effect of a Mixture of New Probiotic Strains in Preterm Infants
An interventional, randomized, double-blind, placebo-controlled study will be conducted to investigate the effect of a new probiotic strain Lactobacillus PS11603 \& Bifidobacterium PS10402 in premature infants from 28 weeks + 0…
- Trial name
- PREBIOMA (NCT03701906)
- Testing
- Lactobacillus PS11603 & Bifidobacterium PS10402
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ProbiSearch SL
Infectious Diseases
Prevention of Necrotizing Enterocolitis of Premature Newborns Under Less Than 1500 g Using Probiotics
The purpose of this study is to evaluate the incidence of necrotizing enterocolitis and its effect over the secreting immunoglobulin A in the feces with the use of probiotics of the strain Lactobacillus acidophilus boucardii vs.
- Trial name
- (PEPP) (NCT02245815)
- Testing
- use probiotics boucardii, use probiotics Multi-species
- Where
- Mexico
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Growth Failure, Atopy
The PREWEAN Study. Weaning of Preterm Infants During the First Year of Life.
In this Austrian observational study preterm infants born with a birth weight <1500 g and a gestational age <32 weeks will be investigated at the neonatal outpatient clinic.
- Conditions
- Growth Failure, Atopy, Adiposity, Cognitive Impairment
- Trial name
- PREWEAN (NCT02936219)
- Where
- Austria
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Enterocolitis, Necrotizing, Infant, Premature
Role of Urinary Claudin-2, Caveolin-1, and EGF as Diagnostic Biomarkers of Necrotizing Enterocolitis in Preterm Neonates
Our study aims to determine the differences in the concentration of urinary claudin-2, caveolin-1, and epidermal growth factor (EGF) as non-invasive biomarkers in the diagnosis of Necrotizing Enterocolitis (NEC).
- Trial name
- NCT05335577
- Testing
- Urinary Claudin-2, Urinary Caveolin-1, Urinary EGF
- Where
- Indonesia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Brawijaya
Hypovitaminosis D
Vitamin D Status and the Adequacy of Vitamin D Intake in Early Preterm Infants
Vitamin D is an essential nutrient. Deficiency of vitamin D is widespread. The prevalence of vitamin D deficiency in early preterm infants is unknown.
- Trial name
- NCT01793402
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Acute Kidney Injury, Chronic Kidney Disease
Outcomes of Neonatal Acute Kidney Injury In Premature Infants
The objective of this protocol is to investigate the impact of prematurity, with or without associated acute kidney injury (AKI), on the future risk of chronic kidney disease (CKD) by establishing a patient registry and…
- Trial name
- NCT02375854
- Testing
- Observation
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Preterm Labor
Transabdominal Cervical Length Predict Preterm Labor During Routine Antenatal Screening
Sonographically, cervical length measurement is widely used in obstetrics. Studies have revealed that early detection of short cervix can be a predictor of predicting preterm labor.
- Trial name
- NCT04313673
- Testing
- second trimester ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Short Cervix, Preterm Delivery
A Randomized Trial of Pessary in Singleton Pregnancies With a Short Cervix
The purpose of the study is to determine whether the Arabin pessary is a useful intervention of preterm birth at less than 37 weeks in women with a singleton gestation and a short cervix.
- Trial name
- TOPS (NCT02901626)
- Testing
- Arabin Cervical Pessary
- Where
- 12 sites in United States
- Volunteers
- 544 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Premature Babies
BEADI - The Bliss Cluster Randomised Control Trial on the Effects of Active Dissemination of Information (BEADI)
BEADI is a dissemination trial, on standards of care of premature babies. The main objective of BEADI is to assess whether an innovative 'active' strategy for the dissemination of neonatal information (evidence reviews…
- Trial name
- BEADI (NCT00831168)
- Testing
- Effects of Active Dissemination
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Confidential Enquiry into Maternal and Child Health
Preterm Birth, Artificial Intelligence (AI) in Diagnosis
Does AI Make Clinicians More Appropriately Confident? A Randomized Study in Preterm Birth Prediction
The goal of this randomized questionnaire-based study is to evaluate how different presentations of artificial intelligence (AI) decision support influence clinical judgment among medical doctors working in obstetrics and…
- Trial name
- NCT07402668
- Testing
- AI prediction (binary), AI risk estimate (%)
- Where
- 18 sites in Denmark
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Preterm Birth
Maternal Gut Microbiome (MGM) Study of Diet, the Gut Microbiome and Preterm Birth
The purpose of this study is to determine whether diet and the gut microbiome play a role in spontaneous preterm birth (SPTB), namely delivery of the fetus prior to 37 weeks gestation.
- Trial name
- MGM (NCT02560246)
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Premature Newborn
Influence of the Use of Hearing Protection in the Salivary Cortisol Level and in the Sleep of Premature Infants
The aim of this study was to investigate the influence of the use of headphones in salivary cortisol levels in newborns (NB) during periods of nap aimed at noise reduction, brightness and handling NB, measure the concentrations…
- Trial name
- NCT02781168
- Testing
- use of earmuffs
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Premature Infants, Stool Bacterial Composition
Effects of Probiotic and Prebiotic Combinations on Premature Infants
The purpose of this study is to see how oral preparations containing both probiotics and prebiotics impact the growth, bacterial colonization of the intestines, and fecal short chain fatty acid content in premature infants.
- Conditions
- Premature Infants, Stool Bacterial Composition, Growth
- Trial name
- NCT00282113
- Testing
- ProBioPlus, Culturelle
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Cardiovascular Diseases
Continuation of the nuMoM2b Heart Health Study
Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in U.S. women at all ages, and large knowledge gaps exist in CVD predictive and preventative strategies for women.
- Trial name
- nuMoM2b-HHS2 (NCT05472597)
- Where
- 14 sites in United States
- Volunteers
- 4,048 people, healthy volunteers welcome
- Sponsor
- RTI International
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