Clinical trials: Preterm Infants
Adiposity, Insulin Resistance
PREterM FOrmula Or Donor Breast Milk for Premature Babies
In order to address this crucial question, central to preterm newborn care, a multicentre United Kingdom (UK) -wide study randomising 4000 preterm babies would be necessary to achieve sufficient power to evaluate the impact on…
- Conditions
- Adiposity, Insulin Resistance, Metabolomic Profile, microRNA Profile
- Trial name
- PREMFOOD (NCT01686477)
- Testing
- Unfortified Human donor Milk used to make up any shortfall in mother's own milk, Fortified Human donor Milk used to make up any shortfall in mother's own milk, Preterm Formula used when there is a shortfall in mother's own milk
- Where
- United Kingdom
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Chronic Lung Disease
Using Parent Engagement to Improve the Wellbeing of Black Premature Infants With Chronic Lung Disease
The goal of this pilot study is to test the feasibility and acceptability of a collaborative goal setting intervention to improve parent engagement of Black preterm infants with chronic lung disease in primary care.
- Trial name
- NCT06474767
- Testing
- P-CGS (Pediatric Collaborative Goal Setting)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Pain, Acute, Neonatal Intensive Care Unit
Non-pharmacological Methods in Pain Managment During Heel Stick in Preterm Infants
Aims and objectives: This study was performed to examine the effects of Non-nutritive sucking, breast milk odor, and Facilitated tucking on preterm infant pain before, during, and after heel-stick procedures.
- Trial name
- (pain) (NCT05281367)
- Testing
- Breast milk odor group, Facilitated tucking group, Non-nutritive sucking group
- Where
- Iran
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Negarin Akbari
Prematurity
Bridging the Docosahexaenoic Acid (DHA) Gap: The Effects of Omega-3 Fatty Acid Supplementation in Premature Infants
The purpose of this study is to understand if the "DHA gap" can be corrected by giving a daily dose of DHA oil to preterm babies. DHA is an essential omega-3 fatty acid, which means our body cannot make DHA.
- Trial name
- NCT01908907
- Testing
- DHA oil, (MCT) Control oil
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sanford Health
Anatomic Abnormality, Internal Jugular Vein
Ultrasound Measurement of RIJV in Patients Between 0-2 Years
After obtaining parental consent ultrasonographic evaluation of right internal jugular vein will be performed in pediatric patients undergoing elective surgeries between 0-2 years of age.
- Conditions
- Anatomic Abnormality, Internal Jugular Vein, Neonates, Infants, Premature
- Trial name
- NCT03604094
- Testing
- Ultrasonographic evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Respiratory Syncytial Virus Infection
Efficacy and Safety of Clesrovimab (MK-1654) in Infants (MK-1654-004)
The primary objectives of this phase 2b/3 double-blind, randomized, placebo-controlled study are to evaluate the efficacy and safety of clesrovimab in healthy pre-term and full-term infants.
- Trial name
- CLEVER (NCT04767373)
- Testing
- Clesrovimab
- Where
- 217 sites in United States, Argentina and 22 more
- Volunteers
- 3,632 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Bronchopulmonary Dysplasia
IVIG Trial for the Treatment of Bronchopulmonary Dysplasia
It is intended to examine the efficacy and safety of intravenous immunoglobulin(IVIG) for the bronchopulmonary dysplasia in preterms.
- Trial name
- NCT06925360
- Testing
- intravenous immunoglobulin
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- International Peace Maternity and Child Health Hospital
Low Birthweight, Preterm Birth
Low Birthweight and Preterm Infant Feeding Trial and Supportive Care Package: Implementation Research
Low Birthweight and Preterm Infant Feeding Trial and Supportive Care Package (LIFT-UP) aims to improve feeding and growth outcomes among low birthweight (LBW; <2.5kg) or preterm (<37 weeks gestational age) infants admitted to…
- Trial name
- LIFT-UP (NCT06390943)
- Testing
- Facility-based feeding support package plus (FB-FSP+), Transition-to-home feeding support package plus (TTH-FSP+)
- Where
- 5 sites in India, Malawi and 1 more
- Volunteers
- 632 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Premature, Feeding Behavior
Facilitated Tucking Position and Reiki Efficacy in Orogastric Tube Insertion
The aim of this study is to determine the effects of faciliated tucking and reiki given manually during orogastric tube insertion in preterm infants treated in the NICU on stress, pain and physiological parameter (heartbeat…
- Conditions
- Premature, Feeding Behavior, Infant, Premature, Diseases
- Trial name
- NCT05801640
- Testing
- Facilitated Tucking Position, Reiki
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sibel Küçükoğlu
Very Premature Baby
Attention Control Training (ACT) and Very Preterm Infants
Infants' attention control, defined as the ability to select what to pay attention to, is a fundamental building block for developing learning abilities and behaviour self-regulation.
- Trial name
- ACT (NCT03896490)
- Testing
- Attention Control Training, Control
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Docosahexaenoic Acid Content of the Participants, Docosahexaenoic Acid Content of the Breast Milk
Effectiveness of Nutritional Resources for Milk Donors
Maternal diet influences breast milk nutritional profile; however, a national survey undertaken by the researchers revealed that non-for-profit donor milk banks in the U.K. do not provide specific dietary information to donors.
- Trial name
- VITAMIN (NCT07042009)
- Testing
- Nutritional resources, Milk docosahexaenoic acid levels
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Roehampton
Respiratory Distress Syndrome, Newborn, Respiratory Distress Syndrome in Premature Infant
Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting
The purpose of this study is to analyze the gastric fluid aspirated from the stomachs of neonates receiving routine post-delivery care to predict the need for prolonged respiratory support (>6 hours of life).
- Conditions
- Respiratory Distress Syndrome, Newborn, Respiratory Distress Syndrome in Premature Infant, Transient Tachypnea of the Newborn, Meconium Aspiration Syndrome
- Trial name
- NCT07344714
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pregnancy, Stress, Psychological
Happy Mommy! Happy Baby! Study
The purpose of this study is to determine how difficult life-events that women experienced during their childhood might affect their babies.
- Conditions
- Pregnancy, Stress, Psychological, Stress, Physiological, Maternal-fetal Relations
- Trial name
- FAP (NCT01700374)
- Where
- 4 sites in United States
- Volunteers
- 1,506 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Premature Birth
Theory of Mind in Preschool Children, School Children, Youths and Adults Born Preterm or Full-term
This study tests preschoolers, school children, youths and young adults, who were born preterm or full-term, in their theory of mind abilities.
- Trial name
- NCT02628015
- Where
- Germany
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Face, Newborn
Fitting of Commonly Available Face Masks for Late Preterm and Term Infants
Around ten percent of newborn infants require positive pressure ventilation (PPV) in the delivery room. This is most commonly delivered using a round or anatomically shaped face mask attached to a T-piece device, self-inflating…
- Conditions
- Face, Newborn, Preterm Infant
- Trial name
- CAFF (NCT03369028)
- Testing
- 2D and 3D image of infants´ faces
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Infant, Premature, Infant, Low Birth Weight
Global Survey on Newborns' HOspitalisation and Parental Experiences - the HOPE Study
This study aims to explore parents' experiences and emotional burdens related to their newborn's hospital stay using an online survey.
- Conditions
- Infant, Premature, Infant, Low Birth Weight, Parents, Life Change Events
- Trial name
- HOPE (NCT06827028)
- Testing
- N/A, no intervention, participation in survey
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Global Foundation for the Care of Newborn Infants
Neonatal Respiratory Distress Syndrome
Association of SCNN1A Single Nucleotide Polymorphisms With Neonatal Respiratory Distress Syndrome
Lung fluid absorption disorders are largely mediated by transepithelial Na+ reabsorption through alpha epithelial sodium channels (α-ENaCs) in alveolar epithelial cells.
- Trial name
- NCT02333669
- Testing
- no intervention
- Where
- China
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Bronchopulmonary Dysplasia, Preterm Birth
Bronchopulmonary Dysplasia: From Neonatal Chronic Lung Disease to Early Onset Adult COPD
The investigators will apply xenon-129 (129Xe) and non-contrast enhanced magnetic resonance imaging (MRI) acquisition and analysis methods in 50 subjects aged between 20 and 29 years born pre-term (with and without a diagnosis of…
- Trial name
- NCT02723513
- Testing
- Hyperpolarized Xenon-129
- Where
- Canada
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Respiratory Illness
NICU Asthma Education and Secondhand Smoke Reduction Study
Premature infants have a significantly increased risk for developing respiratory illnesses and asthma. Secondhand smoke (SHS) also is clearly associated with increased breathing problems in children, thus exposure to smoke makes…
- Trial name
- NCT00499915
- Testing
- Secondhand Smoke Reduction and Smoking Cessation Counseling, Asthma Education
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Preterm Birth, Premature Birth
Exposure to Plasticisers in the Neonatal Intensive Care Unit
Neonatal intensive care relies on indwelling plastic medical devices fundamental in respiratory support, intravenous catheterization, and nutrition.
- Conditions
- Preterm Birth, Premature Birth, Neurodevelopmental Disorders, Pulmonary Disease
- Trial name
- PLASTIC-NICU (NCT05404815)
- Where
- Belgium
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp