Clinical trials: Preterm Labor, Premature Birth
Preterm Birth
Efficacy Study of a Cervical Pessary Containing Progesterone for the Prevention of Preterm Delivery
Assess the efficacy of 2 Cervical Pessaries containing 6.3 g and 7.7 g micronized progesterone for the prevention of preterm delivery, established through spontaneous birth before gestation weeks 32 (31 weeks and 6 days) and 34…
- Trial name
- PCP002 (NCT02225353)
- Testing
- Progesterone Cervical Pessary 6.3 g, Progesterone 200 mg vaginal capsules, Progesterone Cervical Pessary 7.7 g
- Where
- 4 sites in Chile
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Persistent Ductus Arteriosus
Betamethasone and Closure of Ductus Arteriosus
The ductus arteriosus (DA) normally closes after birth as a result of exposure to oxygen. Its persistence of DA (PDA) occurs in 20 to 50% of very preterm infants and is associated with significant morbidity and mortality…
- Trial name
- CELESTE (NCT05987202)
- Testing
- DA closure in a population of premature infants
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Hospices Civils de Lyon
Adverse Pregnancy Outcome
Using Placental Pathology to Prevent Recurrent Adverse Pregnancy Outcomes: A Pilot Project
The goal of this randomized clinical trial is to evaluate if we can use placental pathology in a prior pregnancy which had an adverse outcome, such as early delivery, stillbirth, a baby born smaller than expected, or severe forms…
- Trial name
- NCT06004674
- Testing
- Lovenox 40mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Endeavor Health
Premature
Study of Applying Acupressure in Low-birth Weight Premature
The purpose of this study is to investigate the effects of acupressure application in very low birth weight premature.
- Trial name
- NCT03061968
- Testing
- acupressure
- Volunteers
- 60 people
- Sponsor
- Li-Li Chen
Cerebral Oxygenation
Neonatal Cerebral Oxygenation and Changes in CPAP Flow Pressure - Evaluation With INVOS Oximeter
Due to the increased risk of brain damage, continuous monitoring of the cerebral oxygenation is interesting. We will evaluate the capability of the INVOS Oximeter to detect induced changes in the cerebral regional saturation.
- Trial name
- NCT01684618
- Testing
- Cerebral NIRS Oximetry + CPAP
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Developmental Disabilities
Recombinant Human Erythropoietin Improve Neurodevelopmental Outcomes in Extremely Preterm Infants
In the ELGAN (Extremely Low Gestational Age Newborn) study, abnormal brain structure and function were associated with intermittent or sustained systemic inflammation (ISSI).
- Trial name
- EPO (NCT02745990)
- Testing
- Recombinant human erythropoietin, Normal saline
- Volunteers
- 440 people
- Sponsor
- Huiqing Sun
Bronchopulmonary Dysplasia
Respiratory Management of Preterm Infants and Bronchopulmonary Dysplasia
This observational study evaluates the impact of respiratory management modifications implemented in our institution on the intubation rates and the death or Bronchopulmonary Dysplasia (BPD) outcome.
- Trial name
- NCT03411018
- Testing
- Mechanical ventilation exposure
- Where
- Spain
- Volunteers
- 600 people
- Sponsor
- Manuel Sanchez Luna
Anxiety Fear, Prenatal Depression
Mentors Offering Maternal Support (M-O-M-S™): A Prenatal Program for Decreasing Maternal Anxiety and Depression
The M-O-M-S project evaluates the effectiveness of the M-O-M-S program for improving birth outcomes and maternal-infant attachment and role satisfaction in a large military sample.
- Conditions
- Anxiety Fear, Prenatal Depression, Infant, Low Birth Weight, Preterm Birth
- Trial name
- M-O-M-S (NCT03393637)
- Testing
- Mentors Offering Maternal Support (M-O-M-S)
- Where
- 3 sites in United States
- Volunteers
- 1,717 people, healthy volunteers welcome
- Sponsor
- University of the Incarnate Word
Preterm Birth, Twin Dichorionic Diamniotic Placenta
Vaginal Progesterone in Twin With Short Cervix
Aim of the work The aim of this study is to assess the efficacy of the use of vaginal progesterone as a method of prevention of preterm labour in twin gestations with short cervix .
- Trial name
- NCT02697331
- Testing
- Progesterone
- Where
- Egypt
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
no Conditions
Lung Ultrasound as a Predictor for Successful Extubation in Preterm Infants
unit (NICU); however prolonged MV is known to be associated with serious complications including ventilator associated pneumonia, blood stream infections, bronchopulmonary dysplasia (BPD) and periventricular leukomalacia.
- Trial name
- LUSE (NCT05628753)
- Testing
- Lung Ultrasound (LUS)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Royal University Hospital, Saskatoon
Preterm Birth, Obstetric Labor, Premature
Azithromycin to Improve Latency in Exam Indicated Cerclage Control Trial
Azithromycin is an antibiotic that is effective against bacteria that been associated with preterm birth (PTB). The purpose of this study is to evaluate if the addition of azithromycin prior to exam indicated cerclage prolongs…
- Conditions
- Preterm Birth, Obstetric Labor, Premature, Obstetric Labor Complications, Pregnancy Complications
- Trial name
- ALEC (NCT05132829)
- Testing
- Azithromycin 1 gram IV, Cefazolin and indomethacin
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Children Born to Mothers Enrolled in the TOCOPROM Trial
6-year Outcomes in Children After Nifedipine vs Placebo for Preterm Prelabor Rupture of Membranes at 22-33 Weeks
The purpose of this study is to evaluate the neurodevelopment at age 6 of children born to women with preterm prelabor rupture of membranes at 22 to 33 weeks of gestation, after antenatal exposure to nifedipine vs placebo.
- Trial name
- TOCOKIDS (NCT07146451)
- Testing
- Self-administered parental questionnaire, A short psychological assessment performed online
- Where
- France
- Volunteers
- 480 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breast Milk, Premature
The Effect of the Message Left by Mothers Whose Babies Are in the Neonatal Intensive Care Unit
Newborn babies may need to stay in neonatal intensive care units (NICU) immediately after birth for many reasons such as premature birth, low birth weight, respiratory distress, infection, jaundice.
- Trial name
- NCT06741176
- Testing
- Experimental, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Semra Kose
Premature Infant, Developmental Delay
A Parent Administered Sensorimotor Intervention and Developmental Outcome of Preterm Infants
Advances in medical technologies over the last three decades have increased survival rates in infants born preterm . Preterm infants are at high risk of developing developmental delays.
- Trial name
- NCT03836326
- Testing
- Sensorimotor intervention, Control, Story telling attention refocusing intervention
- Where
- Canada
- Volunteers
- 94 people
- Sponsor
- Dr. Sandra Fucile
Prematurity, Extreme Prematurity
Use Of Nfant(R) Technology Feeding System For Infants Less Than 30 Weeks GA
The purpose of the study is to utilize the objective data provided by the nfant® suite of products, along with current NICU visual assessment and cue-based feeding practices, in order to determine if feeding performance outcomes…
- Trial name
- NCT04256889
- Testing
- nfant(R) feeding system
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Woman's
Kangaroo Care, Premature Birth
Evaluating the Effects of Kangaroo Care in the NICU
The main hypothesis of this study is that Kangaroo Father Care (KFC) will positively impact acute physiologic and long-term behavioral outcomes in infants, fathers, and families.
- Conditions
- Kangaroo Care, Premature Birth, Fathers
- Trial name
- NCT04727125
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Premature Neonates
Investigation of the Effect of muSic on the Stress of Preterm neONates Through innovATive Applications (SONATA)
The goal of this prospective randomized clinical trial is to investigate the effect of music intervention on the stress of live born preterm neonates requiring admission to a Neonatal Intensive Care Unit, through the measurements…
- Trial name
- SONATA (NCT06650189)
- Testing
- Music intervention
- Where
- 2 sites in Greece
- Volunteers
- 70 people
- Sponsor
- University of West Attica
Retinopathy of Prematurity (ROP)
Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care
Retinopathy of prematurity (ROP) is a disorder of development of the retina and its vasculature that can impact vision in vulnerable preterm neonates for a lifetime.
- Trial name
- (BabySTEPS3) (NCT07738874)
- Testing
- Ultra-widefield Optical Coherence Tomography (UWF-OCT), Wide-field ophthalmic imaging system
- Where
- 2 sites in United States
- Volunteers
- 175 people
- Sponsor
- Duke University
Premature Birth
Population PK/PD of Off Label Drugs in Premature Neonates
This study will provide information on the pharmacokinetics, safety and effectiveness of off--label drugs used in critically ill premature infants: doxapram, fentanyl, midazolam, paracetamol, phenobarbital, sildenafil…
- Trial name
- DINO (NCT02421068)
- Where
- 4 sites in Netherlands
- Volunteers
- 246 people
- Sponsor
- Sinno H.P. Simons
Prematurity, Neonatal Screening
Amino Acid and Acylcarnitine Profiles in Premature Neonates
Primary Hypotheses of the study include: Metabolic profiles are influenced by gestational age, chronological age, type and degree of nutritional support and illness Metabolic profiles differ between neonates who receive…
- Conditions
- Prematurity, Neonatal Screening, Parenteral Nutrition
- Trial name
- NCT00865150
- Where
- 2 sites in United States
- Volunteers
- 1,003 people, healthy volunteers welcome
- Sponsor
- Pediatrix
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