Clinical trials: Preterm Labor, Premature Birth
Enterocolitis, Necrotizing, Premature Infant
NEC Screening Abdominal Radiograph vs Bowel Ultrasound in Preemies
The overall primary objective is to establish the feasibility and pilot the design and delivery of a diagnostic randomized controlled trial (RCT) of BUS (bowel ultrasound) for NEC evaluation which will lead to a successful…
- Trial name
- NCT03963011
- Testing
- Bowel Ultrasound
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Children's Mercy Hospital Kansas City
Ventilation
Neurally Adjusted Ventilatory Assist (NAVA) in Ventilatory Care of Premature Infants
The purpose of this study is to find out, whether it is possible to improve the ventilatory care of premature infants by using Neurally adjusted ventilatory assist (NAVA).
- Trial name
- NCT01156467
- Testing
- Neurally adjusted ventilatory assist, i-Servo, Maquet Nordic (Solna, Sweden), Control group, ventilation with i-Servo or Stephanie
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- University of Oulu
Preterm, Birth Weight
Impact of Modified Feeding Protocol on Neonatal Outcomes
The goal of this clinical trial is to compare modified feeding protocol and current feeding protocol on neonatal outcomes in preterm infants who born with weight less than 2kg.
- Conditions
- Preterm, Birth Weight, Feeding Disorder Neonatal
- Trial name
- NCT06246032
- Testing
- Modified feeding Protocol
- Where
- Saudi Arabia
- Volunteers
- 30 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Congenital Heart Disease, Prematurity
Prediction of Feeding Problems in Prostaglandin-dependent Prematurely Born Infants With Congenital Heart Disease
Prematurely born infants with ductal-dependent congenital heart disease (CHD) are at increased risk to develop necrotizing enterocolitis (NEC).
- Conditions
- Congenital Heart Disease, Prematurity, Necrotizing Enterocolitis
- Trial name
- NCT01126372
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Utah
Cholestasis, Liver Diseases
Omegaven for Compassionate Use in the Treatment of Parenteral Nutrition-Associated Liver Disease
This is a compassionate use protocol of an investigational new drug (IND). The overall purpose of the treatment is to offer alternative treatment to children who developed parenteral nutrition-associated liver disease (PNALD) and…
- Trial name
- NCT03072667
- Testing
- Omegaven
- Where
- United States
- Sponsor
- Catherine Cibulskis, MD
Infant, Premature, Congenital Heart Disease
Splanchnic and Renal Tissue Oxygenation During Enteral Feedings in Neonates With Patent Ductus Arteriosus
Patent ductus arteriosus (PDA) is a common problem in the neonatal intensive care unit and can be secondary to prematurity or congenital heart disease (CHD).
- Conditions
- Infant, Premature, Congenital Heart Disease, Patent Ductus Arteriosus, Necrotizing Enterocolitis
- Trial name
- NCT03551600
- Testing
- Near-infrared spectroscopy (NIRS)
- Where
- 3 sites in United States
- Volunteers
- 64 people
- Sponsor
- University of Utah
Premature Infant
Evaluation of the Risks and Benefits of Abdominal Massage Treatment in Neonatalogy in Premature Children
Premature birth creates difficulties for the child in starting his diet and digestion. The immaturity of the major vital functions complicates the abdominal transit.
- Trial name
- PREMASS (NCT03681782)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Caen
Pregnancy Complications, Endothelial Dysfunction
Oxidative Stress and Endothelial Function in Pregnancy Complications
Pregnancy complications like pre-eclampsia (PE), pregnancy induced hypertension (PIH), intra-uterine growth restriction (IUGR) and preterm labor (PTL), (i.e.
- Trial name
- ENDOPREG (NCT02603913)
- Where
- Belgium
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Infant, Newborn, Infant, Small for Gestational Age
Vitamin E for Extremely Preterm Infants
The purpose of this pilot trial is to test the safety and efficacy of administering one dose of vitamin E, via a tube into the stomach, to extremely preterm infants (less than 27 weeks gestation and less than 1000 grams birth…
- Conditions
- Infant, Newborn, Infant, Small for Gestational Age, Infant, Very Low Birth Weight, Infant, Premature
- Trial name
- NCT01193270
- Testing
- Vitamin E
- Where
- 16 sites in United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Preterm Birth
Oral Progesterone for Prevention of Preterm Birth
To evaluate whether daily oral micronized progesterone is effective in preventing recurrent spontaneous preterm birth (RSPB) and whether micronized progesterone use increases maternal serum progesterone levels.
- Trial name
- NCT01180296
- Testing
- oral micronized progesterone
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Fetal Medicine Foundation
Premature, Phototherapy
Effectiveness of Aluminum Foil vs White Linen Reflectors in Phototherapy for Neonatal Hyperbilirubinemia
Background: Indirect hyperbilirubinemia (IHB) is a common neonatal condition, affecting over 60% of term and 80% of preterm infants.
- Conditions
- Premature, Phototherapy, Neonatal Intensive Care Unit, Neonatal Hyperbilirubinemia
- Trial name
- NCT07266246
- Testing
- reflective material
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Kubra Nur Kabakcı Sarıdağ
Bronchopulmonary Dysplasia, Respiratory Tract Infections
Long-term Safety and Efficacy Follow-up Study of PNEUMOSTEM® in Patients Who Completed PNEUMOSTEM® Phase-I Study
This is a 5-year long-term follow-up study of open label, single-center, phase I clinical trial to evaluate the safety and efficacy of PNEUMOSTEM® in premature infants with bronchopulmonary dysplasia.
- Conditions
- Bronchopulmonary Dysplasia, Respiratory Tract Infections, Premature Birth of Newborn
- Trial name
- NCT02023788
- Testing
- PNEUMOSTEM
- Where
- South Korea
- Volunteers
- 8 people
- Sponsor
- Medipost Co Ltd.
Preterm Birth, Respiratory Distress Syndrome
Sustained Lung Inflation and Pulmonary Mechanics in Preterm Infant
Lung protection should start in the delivery room where, from the first breaths, the preterm infant can be helped to clear the lung fluid and to recruit alveolar spaces and establish the functional residual capacity (FRC).
- Conditions
- Preterm Birth, Respiratory Distress Syndrome, Lung Diseases
- Trial name
- NCT02493920
- Testing
- Sustained lung inflation, mask using a T-piece system (Fabian,Acutronic Medical Systems AG, Switzerland).
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Premature Birth
The Impact of NICU Music Therapy for Preterm Infants and Caregivers
This study aims to provide initial evidence for the use of music therapy in the NICU in a UK context. In other countries, such as the US and the Netherlands, music therapy is routinely provided in the NICU and research has…
- Trial name
- NCT06844396
- Testing
- Music Therapy
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Anglia Ruskin University
Preterm Birth, Cervical Insufficiency
Bed Rest With a Short Cervix on Preterm Birth
Maternal AR has long been used to prevent PTB. However, definitions of AR vary widely, ranging from complete bed rest to partial limitation of physical activity for one or more hours daily.
- Conditions
- Preterm Birth, Cervical Insufficiency, Bed Rest, Pregnancy Complications
- Trial name
- BEWISE (NCT07577388)
- Testing
- Activity Restriction, No Activity Restriction
- Volunteers
- 6,000 people
- Sponsor
- Julie Glavind
Premature Birth of Newborn
Improving Preterm Infant Outcomes With Family Integrated Care and Mobile Technology
The purpose of this study is to compare the standard of care in the neonatal intensive care unit (NICU), known as Family Centered Care, to a new model of care, called mobile enhanced Family Integrated Care.
- Trial name
- mFI-Care (NCT03418870)
- Testing
- Family Integrated Care
- Where
- 6 sites in United States
- Volunteers
- 347 people
- Sponsor
- University of California, San Francisco
Premature Delivery
Effect of Intelligent Intervention Strategies on Self-efficacy and Hospital Readiness of Parents of Preterm Infants
1. Construct intelligent management intervention plan for parents of preterm infants from hospital to family based on the medical and health system suitable for China's national conditions. 2.
- Trial name
- NCT06635473
- Testing
- Information support, Stress and coping, Specialist guidance
- Volunteers
- 84 people
- Sponsor
- Shantou University Medical College
Very Low Birth Weight Infant, Respiratory Distress Syndrome in Premature Infant
Enteral Nutrition Tolerance And REspiratory Support (ENTARES)
This research study aims to evaluate the relation between non-invasive ventilation and feeding tolerance in preterms with respiratory distress syndrome (RDS).
- Conditions
- Very Low Birth Weight Infant, Respiratory Distress Syndrome in Premature Infant, Enteral Feeding Intolerance
- Trial name
- ENTARES (NCT03548324)
- Testing
- HHHFNC, NCPAP
- Where
- 13 sites in Italy
- Volunteers
- 280 people
- Sponsor
- University of Turin, Italy
Preterm Birth, Caffeine
Caffeine for Infants Born at 28 to 34 Weeks Receiving Respiratory Support
The goal of this pilot clinical trial is to test if it is possible to conduct a larger study on the use of caffeine in preterm infants who need help with their breathing.
- Conditions
- Preterm Birth, Caffeine, Neonatal Outcomes
- Trial name
- CARES-Pilot (NCT07456670)
- Testing
- Caffeine
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- Queen's University
Human Milk, Premature Birth of Newborn
Noninferiority Trial of Liquid Human Milk Fortifier (HMF) Hydrolyzed Protein Versus Liquid HMF With Supplemental Liquid Protein
Breast milk is readily accepted as the ideal source of nutrition for almost all infants, including premature or very low birth weight infants.
- Trial name
- NCT03001479
- Testing
- Similac Human Milk Fortifier Hydrolyzed Protein Concentrated Liquid
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- St. Louis University
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