Clinical trials: Preterm Premature Rupture of the Membranes
Preterm Parturation, Preterm Premature Rupture of Membranes (PPROM)
Preterm Parturation Study
In this study (study group) non-invasively measured fetal parameters in pregnant patients with preterm premature rupture of membranes (PPROM) or preterm parturation (cervical dilation before 37+0 weeks of gestation) will be…
- Trial name
- PrePart (NCT07869160)
- Testing
- Fetal ultrasound, blood draw, vaginal swab
- Where
- Austria
- Volunteers
- 300 people
- Sponsor
- Medical University of Graz
PPROM, Preterm Premature Rupture of Membrane
Trans-perineal Ultrasound in Assessment of PPROMs
Accurate and timely diagnosis of preterm pre-labor rupture of membranes (PPROM) is important to prevent adverse maternal and fetal outcomes.
- Trial name
- NCT06443788
- Testing
- transperineal ultrasound
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Preterm Premature Rupture of Membranes (PPROM)
Treatment of ppROM With Erythromycin vs. Azithromycin Trial
Preterm premature rupture of membranes (PPROM) complicates 4% of pregnancies annually. This pregnancy complication is a major contributor to preterm births and results in neonatal morbidity and mortality.
- Trial name
- TREAT (NCT03060473)
- Testing
- Azithromycin, Erythromycin, Ampicillin
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Bacterial Vaginosis, Fetal Membranes, Premature Rupture
Perinatal Infections in Pakistan
There are large differences in health outcomes related to pregnancy and birth between developed and developing countries. This study will investigate how infections, medical history, health care behavior and psychosocial issues…
- Conditions
- Bacterial Vaginosis, Fetal Membranes, Premature Rupture, Chorioamnionitis, Pregnancy
- Trial name
- NCT00070746
- Where
- Pakistan
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Preterm Premature Rupture of Membrane, Amniotic Fluid Leakage
The Accuracy of Amniotic Fluid Ferning in the Second Trimester in the Diagnosis of Preterm Prelabor Rupture of Membranes
Although much investigation has been done on the use of ferning in the second and third trimesters, particularly with the development of rapid protein clinical assays, there appears to be lower ferning rates in clinical practice…
- Trial name
- NCT04963465
- Testing
- Ferning on microscopy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Albany Medical College
Premature Rupture of Membrane
Preterm Premature Rupture of Fetal Membranes: Cervical Ultrasound and Biological Markers to Diagnose Prematurity (RECHOBIOL)
Our main hypothesis is to consider that the detection of biomarkers on admission combined with the length of the cervix would improve the prediction of the latency period in case of preterm premature rupture of membranes (pPROM).
- Trial name
- RECHOBIOL (NCT04237142)
- Testing
- Vaginal secretions collection, Blood sample
- Where
- France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Clermont-Ferrand
Preterm Premature Rupture of Membranes (PPROM), Premature Rupture of Membranes (PROM)
Effects of Emotional Freedom Technique and Music Therapy in High-Risk Pregnancy
Pregnancy is a physiological process; however, it is also a dynamic period during which obstetric and medical complications that may threaten maternal and fetal health can occur.
- Conditions
- Preterm Premature Rupture of Membranes (PPROM), Premature Rupture of Membranes (PROM), High-Risk Pregnancy
- Trial name
- NCT07559071
- Testing
- Emotional Freedom Technique (EFT), Music Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 177 people
- Sponsor
- Selcuk University
Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture), Rupture of Membranes; Premature
Latency Antibiotics in Previable PPROM, 18 0/7- 22 6/7 WGA
This study is a non-blinded, prospective, randomized controlled trial designed to compare the effect of outpatient oral antibiotics (i.e., amoxicillin and azithromycin) on the length of time (days) that pregnancy continues after…
- Conditions
- Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture), Rupture of Membranes; Premature, Rupture of Membranes; Premature, Affecting Fetus, Preterm Birth
- Trial name
- NCT04047849
- Testing
- Antibiotics, oral Azithromycin and oral Amoxicillin
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Woman's
Premature Rupture of Membranes
Rapid Immunoassay Tests for the Detection of Ruptured Membranes
The aim of the study is to demonstrate substantial equivalence of IGFBP-1/AFP tests with the "predicate device" Amnisure® in detecting pre labor rupture of membranes.
- Trial name
- NCT02495441
- Testing
- Use of Rapid Immunoassay Tests for the Detection of PROM
- Where
- Sri Lanka
- Volunteers
- 100 people
- Sponsor
- De Soysa Hospital for Women
Prelabor Rupture of Membranes
Impact of Early Rupture of the Residual Membrane on Latency Before Labour Begins
Approximately 25% of patients experience premature rupture of membranes before labour. Of these patients, 82% will give birth within 24 hours and 97% within 48 hours.
- Trial name
- RESIRUPT (NCT07301957)
- Testing
- Additional rupture of the residual membrane
- Where
- 2 sites in France
- Volunteers
- 130 people
- Sponsor
- Centre Hospitalier le Mans
Abortion, Second Trimester, PPROM
Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial
When time allows, administration of mifepristone prior to second trimester induction of labor decreases total labor time. However, in the setting of many pregnancy complications, decreasing time from diagnosis of nonviable…
- Conditions
- Abortion, Second Trimester, PPROM, Rupture, Spontaneous, Fetal Demise
- Trial name
- MIST (NCT05322252)
- Testing
- Mifepristone, Misoprostol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Preterm Labor, Preterm Birth
The FLIP-1 Study: Vaginal Lactobacillus Supplementation in Women at High Risk of Preterm Birth
Preterm birth (PTB) is the primary cause of infant death worldwide. It has been shown that a vaginal microbiota deplete in Lactobacillus species is a risk factor for preterm labour.
- Conditions
- Preterm Labor, Preterm Birth, Preterm Premature Rupture of Membrane, Cervical Incompetence
- Trial name
- NCT03992534
- Testing
- LACTIN-V
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Imperial College London
Premature Birth
Impact of a Booster Course of Antenatal Steroids on Neonatal Outcome in Patients With Premature Rupture of the Membranes
This trial hopes to prospectively evaluate the impact of one versus two courses of antenatal steroids on the incidence of major neonatal morbidity in pregnant women with pre-labor premature rupture of the membranes.
- Trial name
- ACSinPROM (NCT02469519)
- Testing
- Betamethasone - ACTIVE
- Where
- 9 sites in United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Pediatrix
Preterm Premature Rupture of Membrane
Domiciliary Versus Hospital Management of PPROM
This study is designed to compare efficacy \& safety of planned domiciliary versus hospital care for women with preterm prelabor rupture of the membranes (PPROM) on fetal, neonatal and maternal outcome.
- Trial name
- PPROM (NCT04413019)
- Testing
- Clinical follow up
- Where
- Egypt
- Volunteers
- 3,662 people
- Sponsor
- Ahmed Mohammed Selim
Preterm Labor, Preterm Birth
Use of Placental Alpha Microglobulin-1(PAMG-1) to Diagnose Premature Rupture of Membranes in Pregnant Women
The study is to evaluate the accuracy of a test device called "PAMG-1" to see if a pregnant women has ruptured membranes in comparison to standardly used testing methods.
- Trial name
- PAMG-1 (NCT03715530)
- Testing
- PAMG-1 immunoassay
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Mark Santillan
Preterm Premature Rupture of Membranes
Matrix Metalloproteinase 14, Neopterin, and Orosomucoid 1 Levels in PPROM
Introduction: To evaluate the maternal blood serum matrix metalloproteinase 14, neopterin, and orosomucoid 1 levels in pregnant women complicated by preterm premature rupture of membranes (PPROM) and to compare the results with…
- Trial name
- MMP-14&PPROM (NCT04532021)
- Testing
- matrix metalloproteinase 14, neopterin, and orosomucoid 1 measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Cengiz Gokcek Women's and Children's Hospital
PPROM, Preterm
Preterm Rupture of Membranes Optimising Antibiotics Trial
The goal of this clinical trial is to learn which antibiotic regimen works best to prevent infection in pregnant women whose waters break early (preterm, pre-labour rupture of membranes, or PPROM) and assess the health outcomes…
- Trial name
- PROMOAT (NCT06906757)
- Testing
- Erythromycin 250mg and Amoxicillin 500mg
- Volunteers
- 3,900 people
- Sponsor
- University of Melbourne
Preterm Premature Rupture of Membranes
Indomethacin Versus Placebo in Women With Preterm Premature Rupture of Membranes (PPROM)
The purpose of this study is to determine if the short term use of indomethacin will reduce the number of women delivering within 48 hours when given to women with preterm premature rupture of membranes (PPROM) between 24- 32…
- Trial name
- NCT00466128
- Testing
- indomethacin
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Pregnancy, Preterm Labor
Biomarkers in Obstetrical Complications
Objective: To study the natural history of normal pregnancy and the most frequent pregnancy complications responsible for the excessive rate of perinatal morbidity and mortality, in order to develop models to predict the…
- Conditions
- Pregnancy, Preterm Labor, Maternal Fetal Factors, Preterm Birth
- Trial name
- NCT03480139
- Where
- United States
- Volunteers
- 746 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Pregnancy, Premature Rupture of Membranes
Cervical Ripening in Premature Rupture of Membranes
Premature rupture of membranes (PROM) is diagnosed by demonstrating amniotic fluid in the vaginal canal before the onset of labor.
- Conditions
- Pregnancy, Premature Rupture of Membranes, Preterm Premature Rupture of Membranes, Unfavorable Cervix
- Trial name
- NCT02314728
- Testing
- Misoprostol, Oxytocin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center