Clinical trials: Preterm Rupture of Membranes
Fetal Growth Restriction (FGR), Preterm Birth
Enhancing Prediction of Adverse Pregnancy Outcomes in Africa Through Partnerships and Innovation
Pregnancy complications such as pre-eclampsia (high blood pressure during pregnancy), poor fetal growth, unexplained stillbirth, and spontaneous preterm birth are major causes of illness and death for mothers and babies in…
- Conditions
- Fetal Growth Restriction (FGR), Preterm Birth, Still Births, Abruptio Placentae
- Trial name
- EPAPOA (NCT07844876)
- Where
- 2 sites in Uganda
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Makerere University
Premature Rupture of Fetal Membranes
Oxytocin vs. Prostaglandin for Induction of Labor in Primiparas With Prelabor Rupture of Membrane and Low Bishop
The purpose of the study is to compare between oxytocin to prostaglandin (PGE2), regarding time from induction of labor (IOL) to delivery among primiparas at term with prelabor rupture of membrane (PROM) and an unfavorable cervix.
- Trial name
- NCT02801227
- Testing
- Oxytocin, Prostaglandin E2
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Preterm Membrane Rupture, Neonatal Sepsis
Comparison of the Effectiveness of Two Different Antibiotic Regimens of the Treatment of Pregnant Women With Preterm Rupture of Membranes
There is no consensus around the world on the treatment of preterm rupture of membranes, which is one of the important causes of early neonatal sepsis and one of the common causes of prematurity.
- Trial name
- NCT04528251
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Maternal Infection During Pregnancy (Diagnosis), Neonatal Infection
Immediate Versus Delayed Induction in Term-PROM Using or Not Antibiotic Prophylaxis
The primary aim of this study is to determine if antibiotics combined with immediate induction can significantly reduce the rate of maternal and neonatal infection compared with immediate induction alone in women presenting with…
- Trial name
- NCT02985086
- Testing
- Cefoxitin, oxytocin/misoprostol
- Where
- 2 sites in Portugal
- Volunteers
- 568 people, healthy volunteers welcome
- Sponsor
- Hospital de Santa Maria, Portugal
Preterm Premature Rupture of Membranes
The Relation Between Serum Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes
To study the association between maternal serum vitamin C concentration in women with preterm premature rupture of membranes (PPROM) and women without PPROM.
- Trial name
- NCT02635451
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Previous; Cesarean Section, Cicatricial, Complicating Pregnancy or Childbirth, Affecting Fetus or Newborn, Prelabor Rupture of Membranes
Balloon Induction of Labor in PROM for TOLAC
A prospective randomized controlled trial to evaluate the safety and efficacy of labor induction with a double balloon catheter (Atad Ripener Device) in women desiring TOLAC (trial of labor after cesarean) with PROM (pre labor…
- Trial name
- BILROM-TOLAC (NCT03399266)
- Testing
- Double Balloon catheter for induction of labor
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Preterm Premature Rupture of Membrane
Effect of Progesterone on Latent Phase Prolongation in Patients With Preterm Premature Rupture of Membranes
The aim of the study is to assess the efficacy of 17-hydroxyprogesterone caproate (17P) therapy on the latency period in pregnant women with Preterm premature rupture of membranes.
- Trial name
- NCT04807543
- Testing
- 17-hydroxyprogesterone caproate, Castor Oil
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Rupture of Membranes; Premature
Urea and Creatinine Level in Vaginal Fluid as a Predicator for Length of Latency Period in Prelabour Membranes Rupture
This study aims to investigate the relation between the concentration of urea and creatinine in vaginal fluid and length of latency period in women with PROM between 32 and 35 weeks gestation.
- Trial name
- NCT03213535
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Covid19, Pregnancy Complications
Spanish Registry of Pregnant Women With COVID-19
Study title Spanish Registry of Pregnant Women with COVID-19 Protocol number and version Number 55/20. Version V8. Sponsors This registry is a project promoted by Dr.
- Conditions
- Covid19, Pregnancy Complications, Premature Rupture of Membrane, Abruptio Placentae
- Trial name
- OBS COVID (NCT04558996)
- Where
- Spain
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Puerta de Hierro University Hospital
Chorioamnionitis, Cerebral Palsy
Early Identification of Brain Insult in Chorioamnionitis
Premature breaking of the amniotic fluids during pregnancy caries high risk for infection of the amniotic fluid. One of the results of chorioamnionitis is brain injury of the fetus.
- Trial name
- NCT01778725
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Chorioamnionitis
Intrapartum Study of Sterile and Clean Gloves
The purpose of this study is to determine whether the use of sterile or clean gloves during labor exams affects the rate of chorioamnionitis. Chorioamnionitis is an infection of the membranes around the baby.
- Trial name
- NCT01852188
- Testing
- Type of glove used for intrapartum vaginal exams
- Where
- United States
- Volunteers
- 507 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Labor Long, Nulliparity
HIDRATA Study: Efficacy of a Hydration Protocol in Nulliparous Women During Labor
Aim. To evaluate the efficacy of optimizing hydration during labor in nulliparous women with respect to reducing the duration of dilation and the second stage of labor, lowering the incidence of Cesarean sections and fever, and…
- Conditions
- Labor Long, Nulliparity, Premature Rupture of Membrane, Pregnancy, Prolonged
- Trial name
- HYDRATA (NCT03607929)
- Testing
- optimal, variability
- Where
- Spain
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Puerta de Hierro University Hospital
Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture), Rupture of Membranes; Premature
Latency Antibiotics in Previable PPROM, 18 0/7- 22 6/7 WGA
This study is a non-blinded, prospective, randomized controlled trial designed to compare the effect of outpatient oral antibiotics (i.e., amoxicillin and azithromycin) on the length of time (days) that pregnancy continues after…
- Conditions
- Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture), Rupture of Membranes; Premature, Rupture of Membranes; Premature, Affecting Fetus, Preterm Birth
- Trial name
- NCT04047849
- Testing
- Antibiotics, oral Azithromycin and oral Amoxicillin
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Woman's
Pathology of Pregnancy
Maternal Plasmatic Regulatory T Cells and Th17 as Possible Diagnosis Markers of Acute Chorioamnionitis
The purpose of this study is to evaluate if regulator T cells (Treg) and Th17 level modifications in maternal blood and placenta could be correlated to a chorioamnionitis, in women hospitalized for PPROM.
- Trial name
- ICAR (NCT01610258)
- Testing
- Blood and placenta samples
- Where
- 2 sites in France
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Premature Rupture of Membranes
FOLCROM Trial: Foley Catheter in Rupture of Membranes
Multicenter randomized clinical trial comparing oxytocin versus oxytocin and foley catheter for induction in women who present with premature rupture of membranes who are not in labor.
- Trial name
- FOLCROM (NCT01973036)
- Testing
- Foley Catheter, Oxytocin
- Where
- 5 sites in United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Pregnancy Related, Remote Monitoring
Feasibility of Remote eCTG Monitoring Home@Hospital in Complicated Pregnancies
The objective of this single center, interventional cohort study is to evaluate the feasibility of remote electrophysiological cardiotocography (eCTG) monitoring in complicated pregnancies in a home@hospital setting.
- Conditions
- Pregnancy Related, Remote Monitoring, Feasibility
- Trial name
- HASTA (NCT06859177)
- Testing
- Remote eCTG
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maxima Medical Center
PROM, Preterm (Pregnancy)
Outcome of Conservative Management in Cases of Pre Mature Rupture of Membranes (PROM) Between 20 and 28 Weeks of Pregnancy in Sohag City Hospitals
Prospective observational study
- Trial name
- NCT06271863
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Pregnancy Related, Fever
Assessment of Labour Progress by Intrapartum Ultrasound
Assessment of labor progress via digital exams is considered the standard of care in most delivery rooms. However, this method can be stressful, painful and imprecise and multiple exams increase the risk for chorioamnionitis.
- Conditions
- Pregnancy Related, Fever, Chorioamnionitis, Labor Complication
- Trial name
- NCT04651309
- Testing
- Transperineal Ultrasound
- Where
- Israel
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Kaplan Medical Center
Preterm Premature Rupture of Membrane
Azithromycin Versus Erythromycin For Preterm Prelabor Rupture of Membranes
Aim 1. To examine the latency period according to antibiotic regimens (erythromycin iv for two days followed by orally for 5 days vs. azithromycin iv for 2 days followed by 5 days orally). Aim 2.
- Trial name
- NCT05328817
- Testing
- Antibiotics
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Eastern Virginia Medical School
PROM (Pregnancy)
PROM by AmnioQuick Duo+ in Egyptian Women
Preterm premature rupture of the membranes (PPROM) is responsible for one-third of all preterm births. Optimum treatment relies on accurate diagnosis and gestational age.
- Trial name
- NCT03435965
- Testing
- AmnioQuickDuo+
- Where
- 2 sites in Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Aljazeera Hospital