Clinical trials: Prevention
Pre-exposure Prophylaxis, HIV Prevention
UNCPM 22314 - Pregnancy, Infant and Maternal Health Outcomes Study
The primary purpose of this study is to assess the safety of long-acting injectable cabotegravir (CAB-LA) and oral pre-expose prophylaxis (PrEP) (FTC/TDF or 3TC/TDF) for the prevention of HIV during pregnancy and breastfeeding…
- Conditions
- Pre-exposure Prophylaxis, HIV Prevention, Pregnancy Related
- Trial name
- PrIMO (NCT06158126)
- Testing
- Initiating daily oral PrEP during pregnancy, Already using daily oral PrEP at the time of pregnancy diagnosis, Initiating injectable PrEP during pregnancy
- Where
- Malawi
- Volunteers
- 621 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Human Immunodeficiency Virus (HIV), HIV Pre-Exposure Prophylaxis
A Clinical Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-011)
Researchers are looking for new medicines to prevent HIV-1 (Human Immunodeficiency Virus Type 1) infection. The goals of this study are to learn: If taking MK-8527 once a month works to prevent HIV-1 infection as well as or…
- Trial name
- NCT07044297
- Testing
- MK-8527, FTC/TDF
- Where
- 81 sites in United States, Argentina and 14 more
- Volunteers
- 4,390 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Rheumatic Heart Disease, Rheumatic Heart Disease in Children
Effectiveness of a School-centered Prevention Program on Prevalence of Latent Rheumatic Heart Disease
The overall objective is to evaluate the effectiveness of a school-centered primary and secondary prevention program on the prevalence of latent rheumatic heart disease among schoolchildren in Nepal, and to investigate the role…
- Trial name
- NEPAL4 (NCT05504928)
- Testing
- School nurse program
- Where
- Nepal
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Aging Well, Aging Problems
Aquatic Exercise for Cognition and Mobility in Older Adults
The purpose of this study is to assess the effects of an aquatic exercise program on cognition and physical function of older adults.
- Conditions
- Aging Well, Aging Problems, Cognitive Change, Gait, Unsteady
- Trial name
- NCT05501249
- Testing
- Aquatic Integrated Cognitive Motor Training
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Emily Dunlap
Mental Stress, Hypertension
Impact of a Health and Mental Health Promotion Intervention Among Jordanians and Syrians.
Given the heightened risk of NCDs and mental health issues, it is critical for Jordanians and Syrian refugees to have access to prevention based health services.
- Conditions
- Mental Stress, Hypertension, Diabetes
- Trial name
- NCT03721848
- Testing
- Healthy community clinic NCD+MH, Healthy community clinic NCD
- Where
- Jordan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Elective Cesarean Section
Antibiotic Prophylaxis Before Surgery Versus After Cord Clamping in Elective Cesarean Delivery - a Double-blind, Prospective, Randomized Placebo-controlled Trial
In this prospective, randomized, placebo controlled trial the investigators were able to demonstrate the usefulness of prophylactic cefazolin in elective caesarean section versus placebo, irrespective of the timing of…
- Trial name
- NCT01248078
- Testing
- Keflex, saline solution
- Where
- Austria
- Volunteers
- 1,112 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Smoking
Evaluation of a School-based Smoking Prevention and Cessation Programme in Negeri Sembilan
School-based smoking cessation programmes stretched longer than a year had 12% reduction in preventing smoking uptake. With regards to smoking intervention programme among adolescents, there is a lack of evidences regarding its…
- Trial name
- NCT04378725
- Testing
- School-based smoking prevention and cessation program (The KOTAK program)
- Where
- Malaysia
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Injury;Sports
Post-exercise Recovery of DOMS in Recreational Athletes
The main goal of this study was to investigate the effectiveness of cryo-sauna in preventing the development of DOMS in the lower extremity.
- Trial name
- NCT05757518
- Testing
- Cryosauna
- Where
- Poland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Wroclaw University of Health and Sport Sciences
Chronic Disease, Mental Health
Alaska Alliance for Community Engagement Phase II: Partnership for Action Toward Health
The AK ACE-PATH Phase II study aims to pilot and implement a novel intervention, Tools for Arctic Health Promotion (TAHP), to address Alaska Native (AN) community priorities related to local health and community-level resilience.
- Conditions
- Chronic Disease, Mental Health, Caridovascular Disease, Stress
- Trial name
- AK ACE-PATH (NCT07801989)
- Testing
- Tools for Arctic Health Promotion
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Alaska Fairbanks
Vitamin D Deficiency
OASIS Study: Vitamin D Deficiency Prevention Among Older Adults in Ireland
Vitamin D deficiency is common. It is caused by limited sun availability together with a low supply of vitamin D in the food system. There is a high prevalence of low vitamin D status around the world.
- Trial name
- OASIS (NCT06705582)
- Testing
- Fortified Bread, Unfortified bread
- Where
- 2 sites in Ireland
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University College Cork
Alcohol Use, Underage
JUNTOS Familia Preventive Intervention
The primary objective of this study is to develop and pilot-test a family-based Latino youth alcohol use preventive intervention for Latino youth (ages 14-16) and one of their parents.
- Trial name
- Juntos (NCT05863182)
- Testing
- Juntos Familia Family based intervention
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Severe Hemophilia A Without Inhibitor, Joint Bleed
Comparison of Outcomes Between Low Dose Emicizumab and Factor VIII in Clinically Severe Hemophilia A
To outcome between low dose Emicizumab and low dose prophylaxis with FVIII concentration To study pharmacokinetic, side effect of low dose Emicizumab
- Trial name
- NCT06155955
- Testing
- "Emicizumab", "HEMLIBRA®"
- Where
- Thailand
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Malaria, Pregnancy
Efficacy and Safety of IPTp-DP Versus IPTp-SP in Malawi
This study aims to compare the efficacy of monthly IPTp-DP with monthly IPTp-SP to determine if IPTp-DP is associated with a reduction in malaria infection at delivery among HIV-negative women in an area with high levels of SP…
- Trial name
- STOPMIP-MW (NCT03009526)
- Testing
- Sulfadoxine-pyrimethamine, dihydroartemisinin-piperaquine
- Where
- Malawi
- Volunteers
- 602 people, healthy volunteers welcome
- Sponsor
- Kamuzu University of Health Sciences
PreDiabetes
Behavioral Nudges for Diabetes Prevention (BEGIN) Trial in Primary Care
A large body of research has demonstrated that intensive lifestyle interventions and metformin are effective treatments to prevent or delay diabetes among high-risk adults, yet neither treatment is routinely used in practice.
- Trial name
- BEGIN (NCT04869917)
- Testing
- Decision Aid intervention, Text Messaging intervention, Usual Care
- Where
- United States
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Northwestern University
HIV/AIDS
Developing a Patient Navigation Intervention for PrEP Continuum of Care Among Young Latino MSM (PrEParate)
This study aims to help young Latino gay and bisexual men access sexual health information, including PrEP. Participants will be randomly assigned to either the patient navigation or the usual care condition and followed for 6…
- Trial name
- NCT04048382
- Testing
- Patient Navigation, Usual Care
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Prevention
RCT-Consumer Perceptions of Cannabidiol (CBD) Health Claims
Cannabidiol (CBD) cannot be marketed as having therapeutic benefits (without FDA's approval), be false or misleading to consumers, or convey the products are approved or endorsed by the FDA.
- Trial name
- RCT (NCT06800066)
- Testing
- Purchase Behavior - (Non-CBD ads), Purchase Behavior - (CBD ads)
- Where
- United States
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Family
Validation and Reliability of the Parents Assessment of Protective Factors Survey
Neglect and abuse, which have a devastating effect on children, can be prevented with community-based education programs aimed at strengthening families.
- Trial name
- NCT05066295
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Marmara University
Obesity Prevention
A Web-Based Healthy Living Training for Promotores
The goal of this clinical trial is to test a new web-based promotora de salud/ community health worker (CHW) training. This training is designed to provide CHWs with the knowledge and skills to effectively implement a healthy…
- Trial name
- NCT06627439
- Testing
- Comadres Saludables, Control
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- ISA Associates, Inc.
Hypertension
Implementation of a Beauty Salon-Based Strategy for Blood Pressure Management Among Women
CROWN is a two-arm, cluster-randomized pilot trial testing the feasibility and preliminary efficacy of a salon-based cardiovascular intervention - training stylists as Heart Health Stylists to conduct in-salon blood pressure…
- Trial name
- CROWN (NCT07042386)
- Testing
- CROWN Intervention, Enhanced Usual Care
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Heart Failure Risk Factors in Healthy Individuals
Cleveland Heart and Metabolic Prevention Study
The purpose of this research study is to investigate the role of chemical reactions, such as inflammation and oxidation, in the cause of cardiac dysfunction (the heart does not function properly).
- Trial name
- CHAMPS (NCT03012022)
- Where
- United States
- Volunteers
- 1,208 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
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