Clinical trials: Prevention of Dental Caries
Dental Caries Extending Into Dentin
Comparison of Conventional Versus Conservative Caries Removal in Primary Teeth
The sample will be, at least, 90 primary molars, randomly distributed into three groups: Group 1: IPC; Group 2: SE; Group 3: SCR.
- Trial name
- Caries_removal (NCT03650647)
- Testing
- Carious dentin removal
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Caries,Dental
Birth to Three - Cavity Free
Early childhood caries (ECC) is a potentially painful and debilitating disease, which represents a significant public health problem among young children.
- Trial name
- BTCF (NCT05756413)
- Testing
- Self-determination theory
- Where
- 16 sites in United States
- Volunteers
- 1,268 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Dental Caries
Fluoride Varnish For Childsmile Nursery School Attenders
The study will compare the effectiveness of Duraphat® fluoride varnish in preventing any further dental decay among 3-4 year old children in nursery schools.
- Trial name
- PT@3 (NCT01674933)
- Testing
- Duraphat® Fluoride Varnish, treatment as usual
- Where
- 4 sites in United Kingdom
- Volunteers
- 1,610 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Caries,Dental
Evaluation of Caries Prevention Based on Genetic Etiology and Risk.
Dental caries affects billions of people worldwide and involves saliva immunodeficiency, commensal pathogen and exposure (lifestyle) causal subtypes of the disease.
- Trial name
- PRECARIES (NCT05600517)
- Testing
- Fluoride
- Where
- Sweden
- Volunteers
- 520 people
- Sponsor
- Umeå University
Dental Caries
Comparative Evaluation of Hydrophilic and Hydrophobic Sealants in Partially Erupted First Molars
This randomized controlled clinical trial aims to evaluate and compare the retention, caries prevention, microleakage, and fluoride release of three types of pit and fissure sealants-hydrophilic, nanofilled hydrophobic, and…
- Trial name
- NCT07052526
- Testing
- Prevention, Prevention of caries, Prevention therapy
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Tooth Decay
Impact of Fluoride Vanish Application in Dental Prevention for Elderly
This study questions the interest of fluoride varnish dental application in preventing tooth decay in a population of institutionalised elderly people.
- Trial name
- VERNIS (NCT01038817)
- Testing
- Duraphat
- Where
- France
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dental Caries
Effect of Erythritol and Xylitol on Dental Caries Prevention in Children
This study aims at demonstrating the effect of erythritol and xylitol lozenges on preventing the new caries lesions and the possible remineralization effect of both polyols on incipient caries lesions.
- Trial name
- NCT01062633
- Testing
- A, erythritol, xylitol, C, sorbitol
- Where
- Estonia
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Tartu
Prevention of Dental Caries
Effect of Bioactive Glass Varnish on Salivary Parameters in Children: Randomized Controlled Trial
This study is a two-arm parallel randomized controlled trial led by Principal Investigator Inas Karawia at the Faculty of Dentistry, designed to evaluate and compare the short-term (immediatly) and sustained (over 6 months)…
- Trial name
- NCT07875387
- Testing
- Bioactive glass topical varnish, Fluoride varnish
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pharos University in Alexandria
Dental Caries
The Relation Between Pregnancy,Birth Outcome, Feeding , Oral Hygiene Habits and Early Childhood Caries Development.
200 children between ages 36 to 48 months will be invited for a regular dental examination Parameters to be investigated 1. Pregnancy history 2. Birth outcome 3. Child's general health 4. Feeding habits 5. Oral hygiene habits 6.
- Trial name
- NCT00334087
- Testing
- feeding habits
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Tooth Decay
Preventive Treatment Approach of Early Caries Lesions With Contemporary Methods of Remineralization
The purpose of this study is to evaluate 1. the additional therapeutic benefit of Curodont Repair for the treatment early occlusal carious lesions on permanent teeth in children compared fluoride varnish alone 2.
- Trial name
- NCT03780270
- Testing
- Fluoride Varnish, Curodont Repair, Curodont Protect
- Volunteers
- 90 people
- Sponsor
- University Dentistry Clinical Center of Kosovo
Dental Caries in Children, Satisfaction
Comparison of Caries Arrested & Prevented Among SDF, NaF Varnish and Combination in Children
Tooth decay is one of the most common chronic infectious disease found in children worldwide and if left untreated, is rapidly progress.
- Conditions
- Dental Caries in Children, Satisfaction, Cost Effectiveness, Oral Health
- Trial name
- NCT03480516
- Testing
- SDF, Fluoride varnish
- Where
- Thailand
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Dental Caries
Caries-preventive Effect of a Dentifrice Containing 5,000 Ppm Fluoride in Orthodontic Patients
AIM: To evaluate the efficacy of daily tooth brushing with high concentrated fluoride dentifrice on white spot lesion (WSL) formation in adolescents during treatment with fixed orthodontic appliances (FOA).
- Trial name
- NCT01768390
- Testing
- toothpaste containing 5,000 ppm fluoride, 1450 GCP
- Where
- Sweden
- Volunteers
- 500 people
- Sponsor
- University of Copenhagen
Dental Caries in Children, Cariostatic Agent
Cariostatic and Remineralizing Effects of Three Different Dental Varnishes
This study is a randomly, controlled, prospective in vivo study. The objective of this study is: To evaluate the cariostatic and re-mineralizing effects of Nano silver fluoride, Nano Hydroxyapatite and sodium fluoride varnishes…
- Conditions
- Dental Caries in Children, Cariostatic Agent, Resistance, Dental Caries, Fluoride Varnishes
- Trial name
- NCT04887389
- Testing
- Nano Silver Fluoride varnish, nano-hydroxyapatite varnish, sodium Fluoride Varnish
- Where
- Egypt
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Nisreen Ibrahim khan
Caries, Dental
Remineralization Effects of Hydroxyapatite Toothpaste
The objective of this in situ clinical study is to determine whether a toothpaste containing hydroxyapatite microclusters is as effective as a fluoridated kid's toothpaste in promoting remineralization of early caries lesions and…
- Trial name
- NCT03681340
- Testing
- Hydroxyapatite toothpaste, Fluoridated toothpaste
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Dr. Joachim Enax
Dental Caries
Effectiveness of Resin Sealants: Retrospective Cohort Study
This retrospective cohort study assessed sealant clinical success applied to pit and fissure by dental undergraduate students at Piracicaba Dental School - Brazil.
- Trial name
- NCT02649816
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Fernanda Miori Pascon
Dental Caries, Fluor
Efficacy of Fluor Protector S in the Prevention in Adolescents
Purpose of the study is to evaluate the effectiveness of Fluor Protector S in preventing tooth decay in adolescents and to isolate factors that reduce its effectiveness.
- Trial name
- NCT03720379
- Testing
- Fluor Protector S
- Where
- Poland
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Dental Hygiene, Probiotics, Periodontitis
Probiotic Nanofiber Floss and Subgingival Pathogen Suppression
This randomized, double-blind, crossover clinical trial evaluated the effect of a probiotic-containing nanofiber dental floss on subgingival red complex periopathogens and gingival health in periodontally healthy individuals.
- Conditions
- Dental Hygiene, Probiotics, Periodontitis, Prevention of Dental Caries, Gingivitis and Periodontal Diseases
- Trial name
- NCT07149493
- Testing
- Probiotic nanofiber floss
- Where
- Czechia
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Dental Caries, Dental Caries of Root Surface
Silver Diamine Fluoride for Caries Prevention in Removable Partial Dentures Wearers
This study measures and compares the effect of silver diamine fluoride (SDF) on caries increment in removable partial denture wearers. Half of the participants will SDF and while the other half will receive placebo.
- Trial name
- NCT03185104
- Testing
- Silver Diamine Fluoride, Distilled Water
- Volunteers
- 196 people
- Sponsor
- The University of Hong Kong
Preterm Birth, Periodontal Disease
Saving Lives at Birth: Primary Prevention of Periodontal Disease in Relation to Preterm Birth in Malawi
The hypothesis of the investigators' project is that comprehensive primary preterm birth prevention, inclusive of maternal oral health with xylitol chewing gum (the intervention), will reduce the rate of periodontal disease and…
- Conditions
- Preterm Birth, Periodontal Disease, Caries, Dental
- Trial name
- PPaX (NCT02333227)
- Testing
- Xylitol gum
- Where
- United States
- Volunteers
- 10,069 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Caries,Dental
Fluoride Caries-control Effectiveness/Feasibility in Children
The aim of this study is to compare the effectiveness and feasibility of using silver diamine fluoride solution (SDF) vs. sodium fluoride varnish (NaF) for caries management in children from Bogotá (and its suburban areas) and…
- Trial name
- NCT06690008
- Testing
- Experimental group
- Where
- 2 sites in Colombia
- Volunteers
- 814 people, healthy volunteers welcome
- Sponsor
- Universidad El Bosque, Bogotá