Clinical trials: Prevention of Heart Disease
Type 2 Diabetes, Coronary Heart Disease
NMR Metabolomics-Based Risk Assessment and Stratified Digital Health Interventions in Middle-Aged Adults (PREMAP)
PREMAP invites residents of the Eloisa region (South Savo, Finland) turning 45, 50, or 55 years of age in 2026 to undergo a blood-based NMR metabolomics risk assessment for five interlinked cardio-renal-metabolic conditions (type…
- Conditions
- Type 2 Diabetes, Coronary Heart Disease, Myocardial Infarction, Cerebrovascular Disease
- Trial name
- PREMAP (NCT07820800)
- Testing
- Digital health interventions
- Where
- Finland
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Atrial Fibrillation
High-intensity Interval Training in Patients With Atrial Fibrillation
A key characteristic of the heart is its regular rhythm. When the heart is exposed to irregular electric impulses, such as with atrial fibrillation (AF), detrimental effects can occur affecting the ability of the heart to pump…
- Trial name
- HIIT-AF (NCT05354271)
- Testing
- High-intensity interval training, Moderate-intensity continuous training
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Liverpool John Moores University
Delirium
A Research Study to Evaluate the Effectiveness of Dexmedetomidine in Preventing Delirium After Heart Surgery
The purpose of this study is to evaluate the efficacy and safety of dexmedetomidine in the prevention of postoperative delirium in subjects undergoing heart valve surgery with or without coronary artery bypass surgery (CABG)…
- Trial name
- NCT00464763
- Testing
- Dexmedetomidine
- Where
- 11 sites in United States
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Heart Defect, Triscupid Atresia
International Multi Centre Randomized Clinical Trial Of Anticoagulation In Children Following Fontan Procedures
Compare heparin/warfarin to ASA for thromboembolic prophylaxis in the first two years following Fontan procedures.
- Trial name
- NCT00182104
- Testing
- Warfarin vs ASA
- Where
- 7 sites in Australia, Canada
- Volunteers
- 111 people
- Sponsor
- Hamilton Health Sciences Corporation
Acute Myocardial Infarction (AMI), Stable Angina
Prospective Lifespan Cohort of Myocardial Infarction
This prospective cohort study aims to establish a lifespan cohort of myocardial infarction and build a standardized, multidimensional, and shareable disease-specific database by systematically integrating clinical phenotypes…
- Conditions
- Acute Myocardial Infarction (AMI), Stable Angina, Unstable Angina
- Trial name
- NCT07471763
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Fujian Provincial Hospital
Heart Failure, Congestive
PREVENT-HF: Prevention of Heart Failure Events With Impedance Cardiography Testing
The purpose of this study is to determine whether outpatient therapeutic management guided by impedance cardiography (ICG), in addition to standard clinical assessment, will result in a longer time in days to the first heart…
- Trial name
- NCT00409916
- Testing
- BioZ Dx
- Where
- 3 sites in United States
- Volunteers
- 500 people
- Sponsor
- CardioDynamics
Lipoprotein(a)
Heart CT Imaging to Detect Early Coronary Artery Disease in First-Degree Relatives With High or Low Lipoprotein(a) Identified Through Family Screening
Lipoprotein(a), or Lp(a), is a type of cholesterol that can increase the risk of heart and blood vessel disease. Many people are unaware they have high Lp(a), since it is not routinely measured and usually causes no symptoms on…
- Trial name
- IMAGE-LPA (NCT06995183)
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- E.S.stroes
Atrial Fibrillation
Real-world Comparative Effectiveness of Stroke Prevention in Patients With Atrial Fibrillation Treated With Factor Xa Non-vitamin-K Oral Anticoagulants (NOACs) vs. Phenprocoumon
Existing real-world studies have provided evidence that novel oral anticoagulants (NOACs) in general and rivaroxaban in particular are more effective and at least as safe as warfarin in non-valvular atrial fibrillation (NVAF)…
- Trial name
- ReLoaDeD (NCT03563937)
- Testing
- Phenprocoumon, Apixaban, Rivaroxaban (Xarelto, BAY59-7939)
- Where
- Germany
- Volunteers
- 64,920 people
- Sponsor
- Bayer
Breast Cancer Stage 2 and 3
Evaluation of Possible Safety and Efficacy of Fenofibrate in the Prophylaxis of Doxorubicin Induced Cardiotoxicity in Breast Cancer Patients
This study aims at evaluating the possible safety and efficacy of fenofibrate in attenuating doxorubicin related cardiac toxicity in breast cancer patients.
- Trial name
- NCT06155331
- Testing
- Fenofibrate, Doxorubicin, Cyclophosphamide
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Tanta University
Acute Kidney Failure
BNP (Nesiritide) vs. Placebo to Protect Kidney Function in Patients Undergoing Heart Bypass Surgery.
Use of BNP (nesiritide) vs placebo to help protect kidney function in patients undergoing heart bypass surgery.
- Trial name
- NCT00252200
- Testing
- Neseritide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Acute Coronary Syndrome, Venous Thrombosis
Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Sweden)
This prospective cohort study will provide information about: Characteristics of Rivaroxaban use in patients who are prescribed Rivaroxaban for the first time compared to patients who are prescribed standard of care for the first…
- Conditions
- Acute Coronary Syndrome, Venous Thrombosis, Pulmonary Embolism, Atrial Fibrillation
- Trial name
- NCT02468102
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Standard of care drugs
- Where
- Sweden
- Volunteers
- 99,999 people
- Sponsor
- Bayer
Atrial Fibrillation
Effect of 3 Years of Exercise on Development of Atrial Fibrillation
This is a substudy of "Generation 100". In that study, 4000 healthy persons between 70 and 75 will be randomised to a moderate intensity training group, a high intensity training group or control group, with 3 years of exercise.
- Trial name
- NCT01680302
- Testing
- High intensity exercise, Moderate intensity exercise, Control
- Where
- Norway
- Volunteers
- 1,567 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Cardiovascular Diseases, Atherosclerosis
Aspirin Dose and Atherosclerosis in Patients With Heart Disease
The purpose of the study is to test higher versus lower doses of aspirin on markers of atherosclerosis in patients who have had a heart attack.
- Conditions
- Cardiovascular Diseases, Atherosclerosis, Myocardial Infarction
- Trial name
- TAD (NCT00272337)
- Testing
- Aspirin
- Where
- 2 sites in United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Florida Atlantic University
Atrial Fibrillation
A Study Evaluating Safety and Tolerability of YM150 Compared to Warfarin in Subjects With Atrial Fibrillation
The purpose of this study is to investigate the optimal daily dose and dose regimen of YM150 in subjects with non-valvular atrial fibrillation (NVAF), primarily based on safety and tolerability data.
- Trial name
- OPAL-2 (NCT00938730)
- Testing
- YM150, Warfarin
- Where
- 170 sites in Australia, Austria and 21 more
- Volunteers
- 1,280 people
- Sponsor
- Astellas Pharma Inc
Atrial Fibrillation
COmparison of Bleeding Risk Between Rivaroxaban and Apixaban in Patients With Atrial Fibrillation
Atrial Fibrillation (AF) affects 200,000 Canadians and increases risk of stroke, morbidity and mortality. Having a stroke can affect a patient's ability to speak, eat, walk, work, care for themselves, and interact with others.
- Trial name
- COBRRA-AF (NCT04642430)
- Testing
- Apixaban, Rivaroxaban
- Where
- 8 sites in Canada
- Volunteers
- 3,018 people
- Sponsor
- Ottawa Hospital Research Institute
Dementia, Inflammation
Anthocyanins as Dementia Prevention?
The aim of this project is to study the safety and efficacy of anthocyanins in improving key dementia-related mechanisms and cognitive functioning in older people at risk for dementia.
- Conditions
- Dementia, Inflammation, Mild Cognitive Impairment, Coronary Artery Disease
- Trial name
- ACID (NCT03419039)
- Testing
- Anthocyanins
- Where
- Norway
- Volunteers
- 212 people
- Sponsor
- Helse Stavanger HF
Heart Failure, Sudden Death
MIBG Scintigraphy as a Tool for Selecting Patients Requiring Implantable Cardioverter Defibrillator (ICD)
The aim of the study is to assess the cardiac innervation in patients with heart failure to better select candidates for an implantable cardioverter defibrillator.
- Trial name
- MISTIC (NCT01185756)
- Testing
- MIBG for diagnostic purpose
- Where
- France
- Volunteers
- 330 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atrial Fibrillation
Satisfaction/Quality of Life With Rivaroxaban in SPAF (Stroke Prevention in Atrial Fibrillation) Indication
National, multicenter, prospective, observational, non-interventional study. The objective is to determine if the switch from Vitamin K antagonists (VKA) to Xarelto in subjects treated with VKA with issues for stroke prevention…
- Trial name
- SAFARI (NCT01805531)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939)
- Where
- France
- Volunteers
- 411 people
- Sponsor
- Bayer
Rheumatic Heart Disease
GOALIE: Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent RHD Trial
The goal of this clinical trial is to determine if twice daily oral penicillin prophylaxis is non-inferior to monthly IM penicillin prophylaxis in preventing latent Rheumatic Heart Disease Progression in children between the ages…
- Trial name
- NCT05693545
- Testing
- phenoxymethyl penicillin, intramuscular benzathine penicillin G (BPG) prophylaxis
- Where
- Uganda
- Volunteers
- 1,004 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Atrial Fibrillation (AF)
Randomized Interventional Clinical Trial on the Prevention of Atrial Fibrillation Using Colchicine, Amiodarone And a Posterior Pericardiotomy.
The goal of this clinical trial is to learn if a bundle of three treatments can prevent atrial fibrillation, a heart rhythm disorder often observed in adults following heart surgery.
- Trial name
- PREV-AF (NCT07887022)
- Testing
- Colchicine, Amiodarone, Posterior pericardiotomy
- Where
- 3 sites in France
- Volunteers
- 636 people
- Sponsor
- Elsan