Clinical trials: Prevention of Heart Disease
Intellectual Disability, Neurodevelopmental Disorders
Physical Activity and Community EmPOWERment Project
Purpose: Conduct a wait-list randomized controlled trial (RCT) of an inclusive physical activity program called PACE for adults with intellectual disability (ID) who are not yet showing signs of Alzheimer's Disease…
- Conditions
- Intellectual Disability, Neurodevelopmental Disorders, Autism Spectrum Disorder, Down Syndrome
- Trial name
- PACE (NCT06740162)
- Testing
- PACE Program
- Where
- 2 sites in United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Beta-Thalassemia, Iron Overload
Amlodipine as Adjuvant Treatment to Iron Chelation for Prevention of Cardiac Iron Overload in Thalassemia Patients
This is a randomized, open label, two arms superiority trial of a representative population of patients with a primary diagnosis of transfusion dependent thalassemia with evidence of moderate cardiac iron overload, defined as an…
- Trial name
- CANALI (NCT02474420)
- Testing
- Amlodipine, Deferasirox
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Kevin H.M. Kuo, MD, MSc, FRCPC
Myocardial Injury, Myocardial Infarction
Prevention of Myocardial Injury in Non-cardiac Surgery
Worldwide, more than 200 million patients have major non-cardiac surgery annually and a significant proportion of these patients suffer major cardiovascular complications (e.g.
- Trial name
- PIXIE (NCT02344797)
- Testing
- Remote ischemic preconditioning
- Where
- 3 sites in Denmark
- Volunteers
- 573 people
- Sponsor
- Zealand University Hospital
Fibrillation, Atrial
Prevention Of Recurrence Of Atrial Fibrillation
The purpose of this study is to determine whether the study drug is effective in preventing the recurrence of atrial fibrillation (an abnormal heart rhythm).
- Trial name
- NCT00041496
- Testing
- SB-207266
- Volunteers
- 520 people
- Sponsor
- GlaxoSmithKline
Atrial Fibrillation (Prevention of Stroke), Arrythmia, Cardiac
Pharmacy-based Opportunistic Atrial Fibrillation Screening Integrated With Emergency Services (NUMAPLUS-FA)
This study evaluates the feasibility and fidelity of an opportunistic atrial fibrillation (AF) screening programme conducted in 38 community pharmacies in Seville (Spain), using the Kardias® 6-lead portable ECG device…
- Conditions
- Atrial Fibrillation (Prevention of Stroke), Arrythmia, Cardiac, Mass Screening, Pharmacies
- Trial name
- Numaplus_FA (NCT07598903)
- Testing
- Integrated pharmacy-based AF screening circuit
- Where
- Spain
- Volunteers
- 380 people
- Sponsor
- Centro de Emergencias Sanitarias 061 Andalucía
Atrial Fibrillation
Dronedarone Pattern of Use in Patients Scheduled for Elective Cardioversion (ELECTRA)
Primary Objective: To determine whether daily administration of dronedarone started 5-7 days before cardioversion is superior to dronedarone started only after cardioversion with respect to the absence of symptomatic, ECG…
- Trial name
- NCT01026090
- Testing
- Dronedarone
- Where
- 43 sites in Canada
- Volunteers
- 292 people
- Sponsor
- Sanofi
Cardiovascular Diseases, Heart Diseases
STORIES-Stories to Communicate Risk About Tobacco
The purpose of this study is to develop and test an intervention based on literacy-appropriate electronic tools, tailored to the demographics and readiness for change of the user, to promote tobacco smoking cessation in a…
- Trial name
- NCT00101491
- Testing
- Health Communication DVD video
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Atrial Fibrillation, Stroke, Ischemic
Use of Oral Anticoagulants and Symptoms in Patients With Atrial Fibrillation in Örebro County
Atrial fibrillation (AF) is the most common sustained arrhythmia and the number of patients with AF is expected to increase substantially in the coming decades.
- Trial name
- NCT04233515
- Testing
- Oral anticoagulant
- Where
- Sweden
- Volunteers
- 11,964 people
- Sponsor
- Region Örebro County
Periodontitis, Coronary Disease
Periodontal Therapy in a Primary Prevention of Cardiovascular Disease
Cardiovascular diseases (CVD) are still considered the main cause of mortality and morbidity all over the world. In the last years, efforts have been made to define more effective therapeutic and preventive strategies.Periodontal…
- Trial name
- NCT02081976
- Testing
- Integrated Care Group, Standard Care Group
- Where
- India
- Volunteers
- 57 people
- Sponsor
- Macmillan Research Group UK
Ischemic Stroke, Cryptogenic, Transient Ischemic Attack
Smartwatches for Detection of Atrial Fibrillation (AFib) in Secondary Prevention of Cryptogenic Stroke
Scientific Background: In secondary prevention of ischemic stroke, detection of atrial fibrillation (AFib) and subsequent anticoagulation therapy reduce the risk of recurrent stroke by approximately 60%.
- Conditions
- Ischemic Stroke, Cryptogenic, Transient Ischemic Attack, Atrial Fibrillation
- Trial name
- WATCH AFib (NCT06005233)
- Testing
- Smartwatch
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Technical University of Munich
Heart Failure, Cardiovascular Risk Factor
Feasibility of the Implementation of Tools for Heart Failure Risk Prediction
The purpose of this study is to gather information to develop a heart failure screening and prevention program.
- Trial name
- FIT-HF (NCT04684264)
- Testing
- Heart Failure Prevention Clinic
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Northwestern University
Unexpected Hospital Mortality, Death, Sudden, Cardiac
Prevention of Serious Adverse Events in Acute Care Hospitals by Afferent Limb and Response Method Intervention - the ALARM Intervention Study.
1. Summary Growing evidence suggests that a significant proportion of in-hospital patient deaths occur after serious adverse events (SAE's).
- Conditions
- Unexpected Hospital Mortality, Death, Sudden, Cardiac, Unplanned Intensive Care Unit Admission
- Trial name
- ALARM (NCT01949025)
- Testing
- ALARM intervention
- Where
- Belgium
- Volunteers
- 69,656 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Atrial Fibrillation
Efficacy and Safety of Rivaroxaban for the Prevention of Stroke in Subjects With Non-Valvular Atrial Fibrillation
This is a clinical study evaluating the efficacy and safety of rivaroxaban for stroke prevention in patients with atrial fibrillation (originally described in Japanese).
- Trial name
- NCT00494871
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Warfarin
- Where
- 165 sites in Japan
- Volunteers
- 1,280 people
- Sponsor
- Bayer
Heart Failure With Preserved Ejection Fraction
Optimizing Exercise Training in Prevention and Treatment of Diastolic Heart Failure
Aim of the clinical multicenter study (OptimEx-CLIN) is to assess the optimal exercise intervention in patients with Heart Failure with preserved Ejection Fraction (HFpEF; also termed diastolic heart failure) that will best…
- Trial name
- OptimEx-Clin (NCT02078947)
- Testing
- High Intensity Exercise, Moderate Continuous Exercise, Usual Care
- Where
- 4 sites in Belgium, Germany
- Volunteers
- 180 people
- Sponsor
- Technical University of Munich
Hyperlipidemia, Coronary Artery Disease
Evaluation of Pharmacist Interventions in Lipid Management for Secondary Prevention
The primary objective of this research project is to compare the effect of pharmacist interventions versus usual care in the implementation of guideline directed lipid lowering therapies for secondary prevention.
- Trial name
- NCT06647238
- Testing
- Pharmacist Intervention in lipid therapy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Wake Forest University Health Sciences
Atrial Fibrillation, Catheter Ablation
Efficacy of Pulmonary Vein Isolation Alone in Patients With Persistent Atrial Fibrillation
This study examines non-inferiority of pulmonary vein isolation (PVI) for persistent atrial fibrillation (AF) to extensive ablation; and reveals the effect of the presence or origin of AF trigger on outcomes of catheter ablation.
- Conditions
- Atrial Fibrillation, Catheter Ablation, Recurrence
- Trial name
- EARNEST-PVI (NCT03514693)
- Testing
- PVI, PVI plus additional ablation
- Volunteers
- 512 people
- Sponsor
- Osaka Cardiovascular Conference
Atrial Fibrillation
S.I.F.A. II: Prevention Of Thromboembolic Events In Patients With Nonrheumatic Atrial Fibrillation
Evaluate efficacy and safety of Indobufen v. Aspirin in preventing thromboembolic events in patients at high risk of CV events such as patients suffering from nonrheumatic atrial fibrillation.
- Trial name
- SIFA (NCT00244426)
- Testing
- indobufen, aspirin
- Where
- 132 sites in Italy
- Volunteers
- 1,372 people
- Sponsor
- Pfizer
Rheumatic Heart Disease in Children, Latent Rheumatic Heart Disease
Determining the Impact of Penicillin in Latent RHD: The GOAL Trial
Rheumatic heart disease (RHD) affects at least 32.9 million people, mostly children living in low-resource settings. Long-term intramuscular benzathine penicillin G (BPG) prophylaxis is proven to prevent progression of chronic…
- Conditions
- Rheumatic Heart Disease in Children, Latent Rheumatic Heart Disease, Rheumatic Heart Disease, Heart Diseases
- Trial name
- GOAL (NCT03346525)
- Testing
- intramuscular benzathine penicillin G (BPG) prophylaxis
- Where
- Uganda
- Volunteers
- 807 people
- Sponsor
- Children's National Research Institute
Ischemic Heart Disease, Obesity
Copenhagen Study of Obese Patients With Ischemic Heart Disease Undergoing Low Energy Diet or Interval Training
The purpose of the study is to make a head-to-head comparison of weight loss and interval training as methods of secondary prevention in overweight patients with ischemic heart disease.
- Trial name
- CUT-IT (NCT01724567)
- Testing
- Interval Training, Weight Loss
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Eva Prescott
Prevention of Thromboembolic Events, Atrial Fibrillation
An Observational Study (Called RETAF-PS) Using a Patient Survey to Learn More About Treatment Outcomes in Patients With Irregular and Often Rapid Heartbeat (Atrial Fibrillation) Treated With Apixaban in a Real World Setting
This is an observational study in which data from people with atrial fibrillation who received or are currently receiving the drug apixaban to prevent thromboembolic events (blood clots that travel through the blood stream to…
- Trial name
- NCT05471830
- Testing
- Apixaban
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Bayer