Clinical trials: Prevention of Pregnancy
Acute Kidney Injury
Safety & Efficacy of BCT197 in Patients Undergoing Cardiac Surgery
This study will assess the safety and efficacy of BCT197 on acute kidney injury in patients undergoing cardiac surgery with cardiopulmonary bypass.
- Trial name
- NCT01336959
- Testing
- BCT197 Part A, BCT197 Part B
- Where
- 13 sites in United States, Israel and 1 more
- Volunteers
- 91 people
- Sponsor
- Mereo BioPharma
GDM, Preterm Preeclampsia
Advancing Stillbirth Prevention Through Innovative Risk Evaluation (ASPIRE) Clinical Study
ASPIRE will be a multi-site, prospective, two-part longitudinal, noninterventional observational cohort study of nulliparous singleton pregnant women to evaluate biomarkers from blood and ocular imaging for prediction of…
- Conditions
- GDM, Preterm Preeclampsia, Preeclampsia, Fetal Growth Restriction (FGR)
- Trial name
- ASPIRE (NCT07669935)
- Testing
- None (this is an observational study with no intervention)
- Where
- 2 sites in United States
- Volunteers
- 5,500 people, healthy volunteers welcome
- Sponsor
- Medicines360
Type 2 Diabetes, Pregnancy
Motivational Interviewing With Focus on Diet and Weight Gain in Pregnant Women With Type 2 Diabetes
The primary goal of this case control study is to investigate the effect of implementation of motivational interviewing with focus on diet and weight gain in addition to the routine treatment on prevention of excessive…
- Trial name
- NCT02883127
- Testing
- Motivational interviewing
- Where
- Denmark
- Volunteers
- 189 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hemorrhage; Complicating Delivery
Combined Use of Oxytocin and Misoprostol in the Prevention of Post Partum Haemorrhage
To demonstrate that the combined used of oxytocin and misoprostol prevent from post partum haemorrhage better than oxytocin alone, following vaginal birth at 36 to 42 weeks.
- Trial name
- CYTOCINON (NCT01113229)
- Testing
- Misoprostol
- Where
- France
- Volunteers
- 1,721 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury
Prevention of Acute Kidney Injury Through Biomarker-guided Nephrological Intervention
This study examines the clinical relevance of early biomarkers to detect and prevent acute kidney injury. High-risk patients for developing acute kidney injury will be screened at initial presentation (emergency department and…
- Trial name
- NCT02730637
- Testing
- Early nephrologist consultation
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Robert Bosch Medical Center
Cervical Cancer Screening, Cervical Cancer
Development of Systems and Education for Cervical Cancer Prevention (DOSE-CC)
Cervical cancer disproportionately impacts those who have not accessed screening or follow-up. Universal screening has the potential to decrease the overall burden of cervical cancer.
- Trial name
- DOSE-CC (NCT07226037)
- Testing
- DOSE-CC Intervention: Educational Sessions
- Volunteers
- 80,000 people
- Sponsor
- Boston Medical Center
Preeclampsia
Optimizing the Use of Aspirin for the Prevention of Preeclampsia
Pregnant women at higher risk for preeclampsia (PE) are currently recommended to take low-dose aspirin (acetylsalicylic acid, ASA) daily from the first trimester until 36 weeks of gestation.
- Trial name
- Optim-PRE (NCT07665853)
- Testing
- Discontinuation of Acetylsalicilic acid 150 mg/day at 24-28 weeks of gestation
- Where
- 38 sites in Austria, Bulgaria and 5 more
- Volunteers
- 15,160 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Hyperkalemia, Heart Failure
Evaluation of Patiromer in Heart Failure Patients
The purpose of this study was to assess the effects of patiromer on serum potassium participants with heart failure. This study also assessed the safety and tolerability of patiromer in participants with heart failure.
- Trial name
- PEARL-HF (NCT00868439)
- Testing
- patiromer
- Where
- 33 sites in United States, Czechia and 5 more
- Volunteers
- 120 people
- Sponsor
- Relypsa, Inc.
Pregnant Women, Stretch Mark
Prevention of Stretch Marks in Expectant Mothers
PRIME Mothers is a national observational trial designed to evaluate patient outcomes with Stratamark® for the prevention of stretch marks during pregnancy and the postpartum period.
- Trial name
- PRIME (NCT07467837)
- Testing
- Stratamark
- Where
- Australia
- Volunteers
- 10,000 people
- Sponsor
- Stratpharma AG
Chorioamnionitis, Puerperal Endometritis
Antibiotic Prophylaxis in Prelabor Rupture of Membranes at Term
The aims of this study are to determine whether antibiotics administered routinely in women presenting with premature rupture of membranes later than the 37+0 weeks of gestation can alter the rate of maternal and neonatal…
- Conditions
- Chorioamnionitis, Puerperal Endometritis, Neonatal Early Onset Sepsis, Neonatal Meningitis
- Trial name
- NCT01633294
- Testing
- Ampicillin + gentamicin
- Where
- Portugal
- Volunteers
- 161 people
- Sponsor
- Hospital de Santa Maria, Portugal
Anemia
Prevention of Transfusion Related Acute Gut Injury (TRAGI) in Extremely Low Gestational Age Neonates (ELGANs) Using iNO
The investigators seek to determine whether providing inhaled nitric oxide (iNO; a vasodilator) will improve the delivery of oxygen to the brain, kidney and intestines of preterm neonates during and after the subject receives a…
- Trial name
- iNO-TRAGI (NCT02851472)
- Testing
- Inhaled Nitric Oxide
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- New York Medical College
Vitamin D Deficiency
Nutritional Requirements for Vitamin D in Pregnant Women
Randomised, placebo-controlled dose-response intervention study with vitamin D3 in pregnant women.
- Trial name
- DMAT (NCT02506439)
- Testing
- 10 mcg Vitamin D3, 20 mcg Vitamin D3
- Where
- 2 sites in Ireland
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University College Cork
Necrotizing Enterocolitis
Necrotizing Enterocolitis (Nec) and B. Lactis in Premature Babies
The purpose of the trial is to demonstrate the effect of B. lactis in reducing the incidence of Necrotizing Enterocolitis (NEC) compared to placebo in preterm infants.
- Trial name
- NCT00977912
- Testing
- Probiotic supplementation
- Where
- 3 sites in South Africa
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Uremia; Chronic, Cardiovascular Diseases (CVD)
Prevention and Management of Cardiovascular and Cerebrovascular Complications in Maintenance Hemodialysis (MHD) Patients
Background and Purpose: This clinical study aims to explore and validate two innovative treatment strategies to address two major challenges faced by patients on maintenance hemodialysis (uremia): the high incidence of…
- Conditions
- Uremia; Chronic, Cardiovascular Diseases (CVD), Cerebrovascular Disorders, Intradialytic Hypotension
- Trial name
- NCT07335471
- Testing
- Continuous High-Glucose Infusion and Regular Hemoperfusion in Maintenance Hemodialysis
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Suzhou Municipal Hospital of Anhui Province
Urinary Tract Infections
Cranberry Juice for the Prevention of Recurrent Urinary Tract Infections
This study will determine whether cranberry juice is effective in reducing recurrent urinary tract infections (UTIs) in women who have had a UTI within the past year.
- Trial name
- NCT00128128
- Testing
- Cranberry juice cocktail
- Where
- 2 sites in United States
- Volunteers
- 176 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Post Partum Hemorrhage, Fibrinolysis; Hemorrhage
Tranexamic Acid for Prevention of Hemorrhage in Cesarean Delivery
The investigators prepared a novel study of tranexamic acid (TXA) designed to estimate the quantity of blood loss in women undergoing elective repeat cesarean deliveries.
- Conditions
- Post Partum Hemorrhage, Fibrinolysis; Hemorrhage, Blood Loss
- Trial name
- TXA (NCT03856164)
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Preeclampsia Postpartum
Guideline-directed Management and Therapy (GDMT) for the Prevention of Postpartum Cardiac Dysfunction in Preeclamptic African American Women
This is a single-center, open-label pilot study looking at how Guideline-directed management and therapy (GDMP) in post-partum women with preeclampsia can improve Global Longitudinal Strain (GLS).
- Trial name
- GDMT For PE (NCT05534932)
- Testing
- Remote Patient Monitoring
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Preterm Labour, Cervical Insufficiency
Intramuscular vs Rectal Progesterone in Preventing Preterm Labour After Cervical Cerclage
Preterm labour is a major cause of neonatal morbidity and mortality worldwide. Progesterone supplementation is known to help reduce the risk of preterm birth in high-risk women.
- Conditions
- Preterm Labour, Cervical Insufficiency, Pregnancy, High-Risk
- Trial name
- PROCER (NCT07307092)
- Testing
- Intramuscular Progesterone, Rectal Progesterone
- Where
- Pakistan
- Volunteers
- 820 people
- Sponsor
- Hina Mukhtar
Pregnancy in Adolescence, Sexually Transmitted Diseases
Wrap It Up Rigorous Evaluation
Unintended pregnancy rates among teenagers are higher in rural counties than urban or suburban counties. Wrap It Up (WIU) is a sexual health education "booster" program for older high school students attending school in rural…
- Trial name
- WIU (NCT06574321)
- Testing
- Wrap It Up (WIU)
- Where
- United States
- Volunteers
- 1,120 people, healthy volunteers welcome
- Sponsor
- ETR Associates
Surgical Site Infection, Vaginal Cuff Cellulitis
Prevention of Vaginal Cuff Infection After Hysterectomy by Addition of Vaginal Clindamycin
This study seeks to determine ways to reduce the hospitals surgical site infection rate during hysterectomy operations.
- Conditions
- Surgical Site Infection, Vaginal Cuff Cellulitis, Bacterial Vaginosis
- Trial name
- NCT07888101
- Testing
- Clindamycin Vaginal Gel
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- Baylor Research Institute