Clinical trials: Preventive Cardiology
Intracranial Aneurysm
Perioperative Neuroprotection of Stellate Ganglion Block
To investigate whether stellate ganglion block is helpful to brain protection during cranial aneurysm surgery
- Trial name
- NCT02275247
- Testing
- Stellate Ganglion Block
- Where
- China
- Volunteers
- 40 people
- Sponsor
- General Hospital of Ningxia Medical University
Vision Impairment and Blindness, Glaucoma
Developing and Testing a Model to Identify Preventive Vision Loss Among Older Patients in General Practice
In this cohort study, the investigators will test vision screenings in Danish general practice for patients over 70 years of age with minimum one chronic condition.
- Conditions
- Vision Impairment and Blindness, Glaucoma, Age-Related Macular Degeneration, Cataract
- Trial name
- DETECT (NCT07015034)
- Testing
- focus on vision impairment in older patients in general practice
- Where
- 2 sites in Denmark
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Long QT Syndrome Type 3
Long Term Prophylactic Therapy of Congenital Long QT Syndrome Type III (LQT3) With Ranolazine
The purpose of this study is to determine whether ranolazine will reduce the risk of arrhythmic events in patients with long QT syndrome type 3.
- Trial name
- NCT01728025
- Testing
- Ranolazine
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Hemophilia A
Single-Arm Study To Evaluate The Efficacy and Safety of Valoctocogene Roxaparvovec in Hemophilia A Patients (BMN 270-301)
This Phase III clinical study will assess the impact of BMN 270 (compared to FVIII prophylaxis) on the number of bleeding episodes irrespective of exogenous FVIII replacement treatment in the efficacy evaluation period (EEP)…
- Trial name
- BMN 270-301 (NCT03370913)
- Testing
- valoctocogene roxaparvovec
- Where
- 49 sites in United States, Australia and 11 more
- Volunteers
- 144 people
- Sponsor
- BioMarin Pharmaceutical
Pregnancy, Cesarean Delivery
Crystalloid Versus Colloid Rapid Co-load for Cesarean Delivery Under Spinal Anesthesia
The study aims to compare crystalloid co-loading and colloid co-loading in parturients receiving prophylactic phenylephrine infusion during cesarean delivery in terms of the incidence of hypotension.
- Conditions
- Pregnancy, Cesarean Delivery, Hypotension
- Trial name
- NCT03729076
- Testing
- Crystalloid, Colloid
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Tricuspid Valve Insufficiency
Prophylactic Tricuspid Valve Annuloplasty in Patients Undergoing Mitral Valve Surgery
De novo or progressive tricuspid regurgitation (TR) is not uncommonly observed following mitral valve surgery and associated with worse outcome.
- Trial name
- NCT01580436
- Testing
- Tricuspid Valve Annuloplasty
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- Hasselt University
Venous Thromboembolism, Embolism and Thrombosis
Factor IX Inhibition in Thrombosis Prevention (The FIXIT Trial)
The purpose of this study is to determine whether TTP889 prevents venous thromboembolism following surgery to repair hip fracture.
- Conditions
- Venous Thromboembolism, Embolism and Thrombosis, Hip Fractures
- Trial name
- NCT00119457
- Testing
- TTP889
- Where
- 21 sites in Czechia, Denmark and 2 more
- Volunteers
- 300 people
- Sponsor
- vTv Therapeutics
Cardiovascular Morbidity, Cardiovascular Risk Assesment
A Hospital-Based Registry of Preventive Cardiology Clinics
More research is needed to articulate the most effective ways to use these tools as screening tests in cardiovascular risk assessments and how they ultimately affect CVD mortality and morbidity outcomes.
- Conditions
- Cardiovascular Morbidity, Cardiovascular Risk Assesment, Primary Prevention CVD
- Trial name
- PREVENT-CARD (NCT06503341)
- Testing
- Cardiovascular risk assesment
- Where
- Pakistan
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiovascular Diseases, Pakistan
Heart Disease Risk Factors, Healthy Lifestyle
Healthy Communities: A Healthy City Preventive Program on Cardiovascular Health and Well-being (HC)
Healthy Communities is a multidisciplinary health-promotion initiative. The objective of the present study is to determine whether such an intervention will be efficacious to improve cardiovascular health compared to the current…
- Conditions
- Heart Disease Risk Factors, Healthy Lifestyle, Health Behavior
- Trial name
- HC (NCT05974826)
- Testing
- the SI! Program for Secondary Schools (NCT03504059), the Fifty-Fifty Program (NCT02367963)
- Where
- Spain
- Volunteers
- 2,000 people
- Sponsor
- Foundation for Science, Health and Education, Spain
Healthy
The Role of L-arginine in the Endothelial Dysfunction
Acute cardiac and vascular events, like heart attack and sudden cardiac death manifest a clear surge in the early morning hours around the time of waking, so that their peak onset is between 6AM and 11AM.
- Trial name
- NCT00583388
- Testing
- L-arginine, Ultrasound
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Ondansetron in Preventing Nausea and Vomiting in Patients Undergoing Stem Cell Transplant
RATIONALE: Ondansetron may help lessen or prevent nausea and vomiting in patients undergoing stem cell transplant. PURPOSE: This phase II trial is studying how well ondansetron works in preventing nausea and vomiting in patients…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Trial name
- NCT00795769
- Testing
- ondansetron, survey administration, management of therapy complications
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Fred Hutchinson Cancer Center
Atrial Fibrillation
Prophylactic Pulmonary Vein Isolation Study
This study is being done to learn the effects of the Pulmonary Vein Isolation in patients that are at high risk to developing, but do not have a documented history of atrial fibrillation.
- Trial name
- NCT00587899
- Testing
- Pulmonary Vein Isolation
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Mayo Clinic
Hereditary Angioedema
Autonomic Nervous System Profile in Hereditary Angioedema
The goal of this study is to compare the autonomic nervous system control of patients with hereditary angioedema to healthy individuals.
- Trial name
- ANS-HAE (NCT06408805)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Ischemic Stroke, Hemorrhagic Stroke
Improved Prevention of Stroke in Primary Care in Stockholm, Sweden (Förbättrad Prevention av Stroke)
Stroke is a devastating disease. The acute mortality in Sweden is 20 % and 25 % of all patients relapse. Secondary prevention is proven efficient but observational studies have shown that a number of patients are lost to follow…
- Conditions
- Ischemic Stroke, Hemorrhagic Stroke, TIA, Atrial Fibrillation
- Trial name
- NCT01942031
- Testing
- structured collegial feed back
- Where
- Sweden
- Volunteers
- 204 people
- Sponsor
- Karolinska Institutet
Coronary Heart Disease
Pharmaceutical Follow-up of Coronary Heart Disease (CHD) Patients
Objectives To explore the impact of a clinical pharmacist-led 12 month lasting follow-up program for patients with established coronary heart disease (CHD) discharged from the North Norway University Hospital.
- Trial name
- NCT01115608
- Testing
- Pharmacist follow-up
- Where
- Norway
- Volunteers
- 102 people
- Sponsor
- Hospital Pharmacy of North Norway Trust
Sports Cardiology, Preventive Cardiology
Deep Learning ECG Evaluation and Clinical Assessment for Competitive Sport Eligibility
The goal of this observationl study is to evaluate the possibility of building a Deep Learning (DL) model capable of analyzing electrocardiographic traces of athletes and providing information in the form of a probability…
- Conditions
- Sports Cardiology, Preventive Cardiology, Electrocardiogram, Artificial Intelligence
- Trial name
- VALETUDO (NCT06285084)
- Where
- Italy
- Volunteers
- 531 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Depression, Acute Ischemic Stroke
Prophylactic Effects of Agomelatine for Poststroke Depression
The incidence of depression in stroke patients with frontal lobe involvement was reported to be as high as 42%. Agomelatin, a type 1/2 melatonin receptor agonist and serotonin 2C receptor antagonist, is effective in treatment of…
- Trial name
- PRAISED (NCT05426304)
- Testing
- Agomelatine
- Volunteers
- 420 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Anesthesia
Tachycardia as an Indication for Prophylactic Phenylephrine Injection in Caesarean Section Under Spinal Anesthesia; an Observational Study
The value of phenylephrine administration in response to tachycardia in preventing hypotension after spinal anesthesia in elective cesarean section.
- Trial name
- NCT06220942
- Testing
- Phenylephrine
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
SVT, Thrombosis
A Pilot Trial Comparing Full Dose Rivaroxaban to Prophylactic Dose Rivaroxaban in Patients With Superficial Vein Thrombosis in the Leg
The goal of this clinical trial, called a pilot study or a feasibility study, is to test the study plan and to find out whether enough participants will join a larger study and accept the study procedures.
- Conditions
- SVT, Thrombosis, Superficial Vein Thrombosis
- Trial name
- RIVA-SVT (NCT06965998)
- Testing
- Full dose rivaroxaban, Low dose rivaroxaban
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Ottawa Hospital Research Institute
Cardiovascular Risk Factors, Insulin Resistance
Pilot Validation of the STELA Preventive Medicine Platform to Reduce Modifiable Health Risk Factors in Adults (CPM-STELA)
This study evaluates a comprehensive digital health platform called STELA, developed at the Center for Preventive Medicine (CPM) of AGEL Hospital Trinec-Podlesi in Czechia.
- Conditions
- Cardiovascular Risk Factors, Insulin Resistance, Obesity, Dyslipidemias
- Trial name
- CPM-STELA (NCT07551960)
- Testing
- STELA Digital Preventive Medicine Platform, Comprehensive Preventive Health Assessment
- Where
- Czechia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nemocnice AGEL Trinec-Podlesi a.s.