Clinical trials: Preventive Cardiology
Venous Thromboembolism
Optimal Prophylactic Method of Venous Thromboembolism (VTE)
This study is to define the optimal method of prophylaxis for patients with gastrectomy in Korea and the investigators hypothesized only mechanical method would be enough for preventing VTE on perioperative period.
- Trial name
- NCT01448746
- Testing
- low molecular weight heparin
- Where
- South Korea
- Volunteers
- 682 people
- Sponsor
- The Catholic University of Korea
Venous Thromboembolism
A Comparison of Extended Versus Conventional Duration of Enoxaparin Prophylaxis (i.e., Preventive Treatment) for Venous Thromboembolism (VTE, i.e., Blood Clots in the Veins) and Bleeding Event Risk in a Population With Acute Medical Illness
Venous Thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is associated with an increase in risk of mortality and long-term disability and is a major contributor to global disease burden.
- Trial name
- NCT05819112
- Where
- United States
- Volunteers
- 14,799 people
- Sponsor
- Sanofi
Subarachnoid Hemorrhage
Lumbar Drain With Intrathecal Nicardipine in Aneurysmal Subarachnoid Hemorrhage
The purpose of this study is to determine the effectiveness of prophylactic administration of intra-thecal nicardipine though lumbar cerebrospinal fluid drain in prevention of symptomatic vasospasm in patients with subarachnoid…
- Trial name
- NCT07246629
- Testing
- Normal Saline, Nicardipine
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- Wake Forest University Health Sciences
Aortic Valve Stenosis
A Trial to Assess the Safety and Efficacy of Prophylactic TicagrelOr With Acetylsalicylic Acid Versus CLopidogrel With Acetylsalicylic Acid in the Development of Cerebrovascular EMbolic Events During TAVI
Ticagrelor administered with Acetylsalicylic Acid (ASA) will provide better cerebral protection from microembolization in the cerebral circulation during Transcatheter Aortic Valve Implantation (TAVI) and 30 days afterwards, than…
- Trial name
- PTOLEMAIOS (NCT02989558)
- Testing
- Ticagrelor plus ASA, Clopidogrel plus ASA
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- University of Athens
Cardiac Arrest
The Benefit of Prophylactic Anticonvulsant in Post Cardiac Arrest Syndrome With Induced Mild Hypothermia
Cardiac arrest is a leading cause of sudden death, but the survival rate of cardiac arrest is only 5-35%. Although, the first resuscitation of cardiac arrest patient would be success, the hypoxic brain injury after cardiac arrest…
- Trial name
- NCT01083784
- Testing
- Use of prophylactic anticonvulsants (valproate, clonazepam), Control group
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Type 2 Diabetes, Coronary Heart Disease
NMR Metabolomics-Based Risk Assessment and Stratified Digital Health Interventions in Middle-Aged Adults (PREMAP)
PREMAP invites residents of the Eloisa region (South Savo, Finland) turning 45, 50, or 55 years of age in 2026 to undergo a blood-based NMR metabolomics risk assessment for five interlinked cardio-renal-metabolic conditions (type…
- Conditions
- Type 2 Diabetes, Coronary Heart Disease, Myocardial Infarction, Cerebrovascular Disease
- Trial name
- PREMAP (NCT07820800)
- Testing
- Digital health interventions
- Where
- Finland
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
COVID-19
PROphylaxis for paTiEnts at Risk of COVID-19 infecTion
The PROTECT open-label randomised basket trial will assess the effectiveness of hydroxychloroquine (HCQ) as chemoprophylaxis against COVID-19 in multiple vulnerable populations in the United Kingdom.
- Trial name
- PROTECT (NCT04389359)
- Testing
- Hydroxychloroquine Sulfate 200 MG
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Hereditary Angioedema Types I and II
A Study to Evaluate the Long-term Clinical Safety and Efficacy of Subcutaneously Administered C1-esterase Inhibitor in the Prevention of Hereditary Angioedema
The aim of this study is to assess the long-term safety of C1-esterase inhibitor (C1-INH) in preventing hereditary angioedema (HAE) attacks when it is administered under the skin of subjects with HAE.
- Trial name
- NCT02316353
- Testing
- C1-esterase inhibitor
- Where
- 32 sites in United States, Australia and 9 more
- Volunteers
- 126 people
- Sponsor
- CSL Behring
Venous Thromboembolism
Prophylactic Use of Sodium Enoxaparin for Venous Thromboembolism in High-Risk Abdominal Surgery
The purpose of this study is to compare the safety and security and efficacy of sodium enoxaparin Cristália Produtos Químicos Farmaceuticos Ltda - Endocris with Clexane (Sanofi-Aventis) to prevent Venous Thromboembolism in…
- Trial name
- NCT01308528
- Testing
- Sodium enoxaparin, Sodium Enoxaparin clexane
- Where
- 9 sites in Brazil
- Volunteers
- 243 people
- Sponsor
- Cristália Produtos Químicos Farmacêuticos Ltda.
Atrial Fibrillation
Prophylactic Pulmonary Vein Isolation Study
This study is being done to learn the effects of the Pulmonary Vein Isolation in patients that are at high risk to developing, but do not have a documented history of atrial fibrillation.
- Trial name
- NCT00587899
- Testing
- Pulmonary Vein Isolation
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Mayo Clinic
Arthritis, Diabetes
Arthritis Foundation Exercise Program & "10 Keys" to Healthy Aging--Prevention Research Center
Older adults are at high risk for loss of independence because of age-related chronic health conditions. Of these chronic conditions, arthritis accounts for the largest proportion of the disability in the community.
- Conditions
- Arthritis, Diabetes, Hypertension, Preventive Behaviors
- Trial name
- AFEP+10 Keys (NCT01616433)
- Testing
- AFEP, "10 Keys" to Healthy Aging
- Where
- United States
- Volunteers
- 462 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Atrial Fibrillation, Cardiac Surgery
Prevention of Atrial Fibrillation by Low-dose Landiolol Administration After Cardiac Surgery
Postoperative atrial fibrillation (POAF) is a common complication that occurs in 30-50% of patients after cardiac surgery and increases morbidity and mortality and hospital length of stay.
- Trial name
- LANDIPROTEC (NCT04607122)
- Testing
- Landiolol, Saline
- Where
- 3 sites in France
- Volunteers
- 400 people
- Sponsor
- CMC Ambroise Paré
Hereditary Angioedema
Long-term Safety and Efficacy of CSL312 (Garadacimab) in the Prophylactic Treatment of Hereditary Angioedema Attacks
This phase 3b study will evaluate long-term safety and efficacy of CSL312 (also known as garadacimab) when administered subcutaneously (SC)
- Trial name
- NCT04739059
- Testing
- CSL312
- Where
- 44 sites in United States, Australia and 12 more
- Volunteers
- 171 people
- Sponsor
- CSL Behring
Arterial Hypertension, Atherosclerosis Occlusive Disease
Gut Microbiota in Chronic Noncommunicable Diseases
It is an observational study in patients with chronic noncommunicable diseases (i.e. cardiovascular diseases, diabetes mellitus, non-alcoholic fatty liver disease, chronic obstructive pulmonary disease and asthma ) and control…
- Conditions
- Arterial Hypertension, Atherosclerosis Occlusive Disease, Heart Failure With Preserved Ejection Fraction, Heart Failure With Reduced Ejection Fraction
- Trial name
- NCT04820556
- Where
- 2 sites in Russia
- Volunteers
- 1,084 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Abdominal Aortic Aneurysms, Peripheral Arterial Disease
Randomized Preventive Vascular Screening Trial of 65-74 Year Old Men in the Central Region of Denmark
Well-documented health benefits may be achieved through prophylactic screening for cardiovascular disease. The advantages are fewer premature deaths and a reduction in the number of hospital admissions and amputations.
- Conditions
- Abdominal Aortic Aneurysms, Peripheral Arterial Disease, Hypertension
- Trial name
- NCT00662480
- Testing
- Screening for hypertension, lower limb atherosclerosis and abdominal aortic aneurysm
- Where
- Denmark
- Volunteers
- 40,000 people
- Sponsor
- Central Jutland Regional Hospital
Aging, Mortality
Human Observatory Study
The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level.
- Conditions
- Aging, Mortality, All-cause Mortality, Life Expectancy
- Trial name
- HOS (NCT07646782)
- Testing
- Multi-Domain Ecological and Clinical Data Linkage
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Thrombosis; Catheter, Infusion Catheter (Vascular)
Electromuscular Stimulation Therapy as a Prophylactic Method to Reduce Thromboses Related to PICC Catheters
Introduction: The placement of a peripheral inserted central catheter (PICC) is a common practice in the hospital setting. However, despite all the advances reported, venous devices are not free of complications and…
- Trial name
- ECOEMS (NCT06135857)
- Testing
- Protocol ECOEMS
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Cardiovascular Diseases
Stair Instead of Elevator Use at Work: Cardiovascular Primary Preventive Effects on Hospital Employees.
This is an intervention study which evaluates the cardiovascular primary preventive effects of using stairs instead of elevators at the worksite during a 12-weeks period.
- Trial name
- NCT00520195
- Testing
- Physical activity
- Where
- Switzerland
- Volunteers
- 77 people
- Sponsor
- University Hospital, Geneva
Ventricular Tachycardia, Ischemic Cardiomyopathy
Impact of PREVENTIVE Substrate Ablation of Coronary Chronic Total Occlusion on Implantable cardioVerTer-Defibrillator Interventions
The aim of this study is to assess whether preventive substrate ablation of chronic total occlusion infarct-related artery (CTO-IRA) area in heart failure (HF) patients correlates with lower appropriate implantable cardiac…
- Trial name
- PREVENTIVE VT (NCT03421834)
- Testing
- Catheter ablation of ventricular tachycardia, Optimal medical treatment
- Where
- 5 sites in Croatia, Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Bone Metastases, Lymphoma
Post-Op Pain Control for Prophylactic Intramedullary Nailing.
Nationally, the opioid crisis has become a major epidemic with increasing mortality rates each year. Orthopedic surgeons routinely prescribe narcotics instead of NSAIDs for post-op pain control because of risk of delayed healing…
- Conditions
- Bone Metastases, Lymphoma, Multiple Myeloma, Opioid Use
- Trial name
- NCT03823534
- Testing
- Ketorolac, Normal saline, Acetaminophen
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- St. Louis University