Clinical trials: Preventive Cardiology
Subarachnoid Hemorrhage, Intracerebral Hemorrhage
Prophylactic Antibiotics Useful With Antibiotic Impregnated External Ventricular Drains (EVDs)?
The principal objective of this study is to compare the incidence of ventriculostomy related infections (VRIs) in patients who receive twenty-four hours of antibiotics, beginning no more than sixty minutes prior to EVD placement…
- Conditions
- Subarachnoid Hemorrhage, Intracerebral Hemorrhage, Ventriculitis, Cerebral, Hydrocephalus
- Trial name
- NCT05001750
- Testing
- Long term (continuous) prophylactic antibiotics, 24 hours antibiotics
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Montefiore Medical Center
Hypotension, Anesthesia; Adverse Effect, Spinal and Epidural
ONDANSETRON AND EFFECTIVE DOSE IN 50% OF SUBJECTS OF PROPHYLACTIC NOREPINEPHRINE INFUSIONS FOR PREVENTING SPINAL ANESTHESIA-INDUCED HYPOTENSION DURING CESAREAN DELIVERY
Spinal anesthesia is the preferred technique for elective cesarean section as per ASA guidelines. Hypotension is the main complication of this technique and is secondary to both sympatholysis and its associated decrease in…
- Conditions
- Hypotension, Anesthesia; Adverse Effect, Spinal and Epidural, Cesarean Section
- Trial name
- NCT04703088
- Testing
- Ondansetron 4 MG, 0.9% Saline
- Volunteers
- 60 people
- Sponsor
- Laval University
Health Services Accessibility, Rural Health
Health Ahead Comparative Effectiveness Study
The Health Ahead Comparative Effectiveness Study is a pragmatic, parallel-arm interventional platform that systematically compares successive changes to preventive health screening on the path toward a fully automated screening…
- Conditions
- Health Services Accessibility, Rural Health, Medically Underserved Area, Preventive Health Services
- Trial name
- HACE (NCT07669168)
- Testing
- AI-Assisted Screening Interpretation (AI Reads), Human-Only Screening Interpretation
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- William Brandenburg, MD
Coronary Artery Disease
Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Change in Cardiovascular Health
The goal of this randomized controlled trial is to assess the impact of disclosing a high polygenic risk result for coronary artery disease on change in cardiovascular health over one year.
- Trial name
- PROACT 1 (NCT05819814)
- Testing
- Disclosure of high polygenic risk result for coronary artery disease
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Massachusetts General Hospital
Preventive Medicine, Hypertension
ThumpThump Pilot Study
Brain disease and heart disease are the leading causes of death and disability in the US; at least 60% of cases can be attributed to modifiable risk factors such as hypertension, dyslipidemia, and poor-quality diet.
- Trial name
- ThumpThump (NCT07865247)
- Testing
- : Implementation strategy to improve hypertension care in geopolitically defined communities
- Where
- United States
- Volunteers
- 3,680 people, healthy volunteers welcome
- Sponsor
- Yale University
Postpartum Hemorrhage
Tranexamic Acid and Thromboelastography During Cesarean Delivery
The aim of this study is to characterize the coagulation changes, using thromboelastography (TEG), after prophylactic tranexamic administration during cesarean delivery.
- Trial name
- TA TEG (NCT02026297)
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Atrial Flutter Typical, Heart Failure
Pulmonary Vein Isolation in Typical Atrial Flutter and Heart Failure
This study, called the PVI-AFL-HF Trial, investigates two treatments for patients with typical atrial flutter (AFL) and heart failure (HF).
- Trial name
- PVI-AFL-HF (NCT06817447)
- Testing
- Pulmonary vein isolation plus cavo-tricuspid isthmus ablation, Cavo-tricuspid isthmus ablation
- Volunteers
- 168 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Stress Disorders, Post-Traumatic, Myocardial Infarction
Myocardial Infarction - Stress Prevention Intervention
Posttraumatic Stress Disorder (PTSD) is a mental disorder that may occur after someone experiences a traumatic event. Between 10-20% of patients may develop PTSD in response to the traumatic experience of myocardial infarction…
- Trial name
- MI-SPRINT (NCT01781247)
- Testing
- Minimal behavioral intervention, Control intervention
- Where
- Switzerland
- Volunteers
- 190 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Myocardial Infarction, Coronary Artery Disease
A Randomized Evaluation of First-dollar Coverage for Post-MI Secondary Preventive Therapies
The objective of this randomized trial is to evaluate the effect of providing full prescription drug coverage (i.e. no co-pays, co-insurance or deductibles) for statins, beta-blockers, angiotensin converting enzyme inhibitors and…
- Trial name
- MI FREEE (NCT00566774)
- Testing
- Full drug coverage, Usual coverage
- Where
- United States
- Volunteers
- 5,860 people
- Sponsor
- Brigham and Women's Hospital
Negative-Pressure Wound Therapy, Amputation
The Effect of Negative Pressure Wound Therapy on Wound Healing in Major Amputations of the Lower Limb
The socioeconomic costs of problematic and delayed wound healing following lower limb amputations are enormous to the society. Lower limb amputations is one of the longest known surgical treatments, but also one of the least…
- Conditions
- Negative-Pressure Wound Therapy, Amputation, Wound Heal
- Trial name
- NCT04618406
- Testing
- PICO VAC, Standard care
- Where
- Denmark
- Volunteers
- 158 people
- Sponsor
- University of Southern Denmark
Deep Vein Thrombosis
Prophylactic Anticoagulation for Preventing Deep Vein Thrombosis After Total Hip Arthroplasty
Deep vein thrombosis (DVT) remains a life-threatening complication of arthroplasty. It remains controversial for anticoagulation strategies after total hip arthroplasty (THA).
- Trial name
- NCT01446887
- Testing
- prophylactic anticoagulation
- Where
- China
- Sponsor
- JIANG Qing
Ischemic Cardiomyopathy, Heart Failure
Evaluation of Prophylactic Use of a Preoperative IABP in High-Risk Coronary Artery Bypass Graft Surgery
Background: The intra-aortic balloon balloon pump (IABP) has been used as a method of percutaneous circulatory assistance high surgical risk patients undergoing coronary artery bypass graft surgery (CABG); Although its…
- Trial name
- IABP-HR (NCT03857906)
- Testing
- Intra-Aortic Ballon Pump insertion
- Volunteers
- 129 people
- Sponsor
- CMN "20 de Noviembre"
Chronic Kidney Disease stage3, Chronic Kidney Disease stage4
The Effect of Prophylactic Hemodialysis on the Morbidity and Mortality of the Patients With Chronic Kidney Disease Stages 3-4 Undergoing Coronary Artery Graft Bypass
Coronary artery disease is a major cause of death in patients with renal dysfunction Among patients who undergo coronary artery bypass grafting ,renal dysfunction is known To be a major predictor of in-hospital and remote…
- Conditions
- Chronic Kidney Disease stage3, Chronic Kidney Disease stage4, Coronary Artery Disease
- Trial name
- NCT01410617
- Testing
- hemodialysis
- Where
- Iran
- Volunteers
- 120 people
- Sponsor
- Imam Khomeini Hospital
Covid19
Prophylactic Versus Therapeutic Dose Anticoagulation In COVID-19 Infection at the Time of Admission To Critical Care Units
This is a multi-center, retrospective, study to determine if therapeutic dose anticoagulation (High dose group) improves inpatient mortality in severely ill patients with COVID-19 compared to prophylactic dose anticoagulation…
- Trial name
- NCT04829552
- Where
- United States
- Volunteers
- 704 people
- Sponsor
- Corewell Health East
Abdominal Aortic Aneurysm
Prophylactic Mesh Implantation After Abdominal Aortic Aneurysm Repair
AIDA Study is a prospective, multicentre, randomized, controlled clinical investigation with patients undergoing median laparotomy for Abdominal Aortic Aneurysm (AAA) repair.
- Trial name
- NCT01353443
- Testing
- Optilene® Mesh Elastic
- Where
- 9 sites in Germany
- Volunteers
- 282 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Angioedema, Hereditary, Types I and II
A Trial to Evaluate the Efficacy and Safety of Different Doses of KVD824 for Prophylactic Treatment of HAE Type I or II
A study to assess whether different doses of KVD824 are effective in preventing attacks of Hereditary Angiodedema Type I or Type II.
- Trial name
- KVD824-201 (NCT05055258)
- Testing
- KVD824
- Where
- 33 sites in United States, Australia and 11 more
- Volunteers
- 33 people
- Sponsor
- KalVista Pharmaceuticals, Ltd.
Healthy
The Role of L-arginine in the Endothelial Dysfunction
Acute cardiac and vascular events, like heart attack and sudden cardiac death manifest a clear surge in the early morning hours around the time of waking, so that their peak onset is between 6AM and 11AM.
- Trial name
- NCT00583388
- Testing
- L-arginine, Ultrasound
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cardiovascular Morbidity, Cardiovascular Risk Assesment
A Hospital-Based Registry of Preventive Cardiology Clinics
More research is needed to articulate the most effective ways to use these tools as screening tests in cardiovascular risk assessments and how they ultimately affect CVD mortality and morbidity outcomes.
- Conditions
- Cardiovascular Morbidity, Cardiovascular Risk Assesment, Primary Prevention CVD
- Trial name
- PREVENT-CARD (NCT06503341)
- Testing
- Cardiovascular risk assesment
- Where
- Pakistan
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiovascular Diseases, Pakistan
Peripheral Arterial Disease, Asymptomatic Diseases
The Effect of a Multimodal Preventive Intervention in Patients With Asymptomatic Peripheral Artery Disease
This pilot study, the PilotPreAPAD study, will be carried out to check whether the key parts of the planned Prevention in asymptomatic Arterial Disease (PreAPAD) study will work in practice.
- Conditions
- Peripheral Arterial Disease, Asymptomatic Diseases, Ankle Brachial Index (0.9 or Less)
- Trial name
- PilotPreAPAD (NCT07897396)
- Testing
- Multimodal intervention
- Where
- 2 sites in Sweden
- Volunteers
- 16 people
- Sponsor
- Värmland County Council, Sweden
Ovarian Cancer, Ovarian Carcinoma
Exercise as a Preventive Agent to Combat Immobility in Patients With Ovarian or Endometrial Cancers Receiving Chemotherapy
The purpose of this research is to determine whether a 16-week virtually supervised aerobic and resistance exercise program is feasible in patients receiving first-line chemotherapy after surgery for ovarian or endometrial cancer…
- Conditions
- Ovarian Cancer, Ovarian Carcinoma, Ovarian Cancer Stage IV, Ovarian Cancer Stage III
- Trial name
- NCT04997096
- Testing
- Exercise, Attention Control
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Dana-Farber Cancer Institute