Clinical trials: Preventive Cardiology
Heart Failure, Caregivers
Heart Failure Resilience Intervention for Caregivers
Heart failure (HF) patients with supportive caregivers have better physical health, emotional health, and quality of life. But caregivers have an increased risk of caregivers' own worsening health and often feel a sense of burden…
- Trial name
- HEROIC (NCT03963583)
- Testing
- HEROIC
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cardiovascular Diseases, Cardiovascular Risk Factor
Digital Nudges to Improve Heart Health Actions After Community Screening in Malaysia (NADI-MyHeartRisk)
This is a pragmatic, risk-stratified, individually randomized controlled trial testing whether personalised WhatsApp-based digital behavioural nudges can improve completion of cardiovascular preventive actions after community…
- Trial name
- NADI-MHR (NCT07879144)
- Testing
- Personalised Digital Behavioural Nudges (NADI-MyHeartRisk Enhanced Pathway)
- Where
- 2 sites in Malaysia
- Volunteers
- 6,588 people, healthy volunteers welcome
- Sponsor
- Cardiovascular Advancement and Research Excellence Institute
Type 2 Diabetes, Coronary Heart Disease
NMR Metabolomics-Based Risk Assessment and Stratified Digital Health Interventions in Middle-Aged Adults (PREMAP)
PREMAP invites residents of the Eloisa region (South Savo, Finland) turning 45, 50, or 55 years of age in 2026 to undergo a blood-based NMR metabolomics risk assessment for five interlinked cardio-renal-metabolic conditions (type…
- Conditions
- Type 2 Diabetes, Coronary Heart Disease, Myocardial Infarction, Cerebrovascular Disease
- Trial name
- PREMAP (NCT07820800)
- Testing
- Digital health interventions
- Where
- Finland
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Subarachnoid Hemorrhage, Aneurysmal
Safety and Efficacy Study of Etanercept for Aneurysmal Subarachnoid Hemorrhage
Subarachnoid hemorrhage (SAH) is a special type of stroke that typically results from a ruptured intracranial aneurysm, a weakening in the wall of a blood vessel.
- Trial name
- NCT01865630
- Testing
- Etanercept
- Where
- Canada
- Sponsor
- Unity Health Toronto
Type-2 Diabetes, Cardiovascular Diseases
Feasibility of a Preventive Program Against Lifestyle Related Diseases
The continuously increasing prevalence of cardiovascular diseases, type-2 diabetes, and COPD is a major health problem in developed countries and is mainly caused by an unhealthy lifestyle.
- Conditions
- Type-2 Diabetes, Cardiovascular Diseases, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT02797392
- Testing
- Lifestyle intervention
- Where
- 6 sites in Denmark, Norway and 1 more
- Volunteers
- 9,400 people
- Sponsor
- University of Southern Denmark
Ischemic Stroke
Impact of a Pluriprofessional Intervention to Improve Medication Adherence (Secondary Preventive Medication) in Patients After Ischemic Stroke
Medication adherence is a major factor to prevent vascular recurrence after a first ischemic stroke. Nevertheless, it is suboptimal and the implementation of specific interventions are needed to improve it.
- Trial name
- ADMED-AVC (NCT02611440)
- Testing
- Pharmaceutical care
- Where
- 6 sites in France
- Volunteers
- 182 people
- Sponsor
- Hospices Civils de Lyon
Fibrinogen, Spine Deformity
Effect of Prophylactic Fibrinogen Concentrate In Scoliosis Surgery
EFISS is a prospective, randomized, placebo-controlled trial testing the feasibility, safety and efficacy of prophylactic administration of fibrinogen in paediatric spinal surgery.
- Conditions
- Fibrinogen, Spine Deformity, Coagulopathy, Consumption, Bleeding
- Trial name
- EFISS (NCT05391412)
- Testing
- Fibrinogen Concentrate Human
- Where
- Czechia
- Volunteers
- 32 people
- Sponsor
- Brno University Hospital
Cardiac Disease
Edoxaban for Prevention of Blood Vessels Being Blocked by Clots (Thrombotic Events) in Children at Risk Because of Cardiac Disease
A committee will judge the safety and effectiveness of edoxaban and the regular treatment (standard of care). All children in the study will receive free treatment.
- Trial name
- NCT03395639
- Testing
- Edoxaban, Standard of Care (SOC)
- Where
- 48 sites in United States, Austria and 12 more
- Volunteers
- 168 people
- Sponsor
- Daiichi Sankyo
Atherosclerosis
Preventive Arterial Wall Phenotype and Low-dose Fluvastatin/Valsartan Combination
The study was designed to test whether short-term treatment with a very low-dose combination of fluvastatin and valsartan could induce improvement of endothelial function, arterial stiffness, vascular inflammation, oxidative…
- Trial name
- AGE-ZT (NCT03393377)
- Testing
- fluvastatin 10 mg and valsartan 20 mg
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Central Retinal Vein Occlusion, Choroidal Neovascularization
A Research Study to Evaluate the Effects of Repeated Intravitreal Injections on Bacteria Around the Eye
This is a research study to evaluate the effects of repeated intravitreal injections on bacteria around the eye.
- Conditions
- Central Retinal Vein Occlusion, Choroidal Neovascularization, Age-related Macular Degeneration, Branch Retinal Vein Occlusion
- Trial name
- NCT01531842
- Testing
- Conj flora Antibiotic resistance
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mid Atlantic Retina
Physical Activity
Exercise is Medicine at Emory Seavey Internal Medicine Clinic
Implementation of physical activity promotion in routine health care delivery is low because of multiple barriers including insufficient health system support, care team coordination, and scarcity of community resources for…
- Trial name
- EIM (NCT03416634)
- Testing
- App, Wearable Device, Automated Motivational Message
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Emory University
Multiple Myeloma, Total Knee Replacement
Comparison of the Effects of Apixaban on Thrombin Generation in Patients With de Novo Multiple Myeloma
Patients with multiple myeloma (MM) are at high risk of venous thromboembolism (VTE) and these patients require adequate thromboprophylaxis.
- Trial name
- ProApix (NCT06474182)
- Testing
- Blood sampling, Apixaban
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Heart Failure, Arrhythmia, Ventricular
Preventive Catheter Ablation for Ventricular arrhythmiaS in Patients With End-sTage Heart faiLure
CASTLE-VT is a randomized evaluation of prophylactic ablative treatment of arrhythmogenic ventricular scar in patients referred for HTx evaluation and diagnosed with ICM.
- Conditions
- Heart Failure, Arrhythmia, Ventricular, Cardiomyopathy Ischemic, Catheter Ablation
- Trial name
- CASTLE-VT (NCT06556485)
- Testing
- Catheter ablation, Medical therapy
- Where
- Germany
- Volunteers
- 160 people
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Hypertension
Knowledge on Preventive Measures of Hypertension
Hypertension among children and adolescents is on the rise in both developed and developing countries. Childhood and adolescent obesity, a key factor for hypertension in this population results largely from unhealthy dietary and…
- Trial name
- NCT04554017
- Testing
- Education/Training
- Where
- Ghana
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- Garden City University College
Heart Attack
The Role of Genetic Factors in the Development of Myocardial Infarction in the Kazakh Population
This is a GWAS study that aims to identify possible candidate genes associate to heart attack by exploring single nucleotide polymorphism (SNP) in a group of heart attack, in the Kazakh population.
- Trial name
- NCT05090618
- Testing
- DNA analysis
- Where
- Kazakhstan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Asfendiyarov Kazakh National Medical University
Hypertension, Pregnancy Induced, Hypertension Complicating Pregnancy
Optimizing Cardiovascular Preventive Care for Women Following Hypertensive Disorders of Pregnancy
Cardiovascular disease is the leading cause of death among women in the United States, and women with hypertensive disorders of pregnancy have a 2-fold higher risk for cardiovascular disease later in life compared to women with…
- Conditions
- Hypertension, Pregnancy Induced, Hypertension Complicating Pregnancy, Preeclampsia, Cardiovascular Diseases
- Trial name
- NCT05826925
- Testing
- Decision aid
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Utah
Spinal Ischemia, Stroke
The Darbepoetin Alfa for Ischemic Surgical Complications (DISC) Dose Finding Trial
Numerous neuroprotectants have been effective when given prior to ischemic stroke in animals, yet they have all have failed when given after ischemic stroke in humans. A novel approach to ischemic neuroprotection is needed.
- Conditions
- Spinal Ischemia, Stroke, Neuroprotection
- Trial name
- DISC (NCT00647998)
- Testing
- Darbepoetin alfa, Standard care
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Pennsylvania
Cardiovascular Disease
Improving Aspirin Use Among Adults at Risk for Cardiovascular Disease (CVD)
The investigators' aim is to implement an intervention to increase aspirin prophylaxis use among patients that is patient initiated, optimizes use of physician and staff time, appropriately compensates staff, provides clinicians…
- Trial name
- NCT00981032
- Testing
- Pre-visit Summary, Clinical Decision Sharing Tool
- Where
- 3 sites in United States
- Volunteers
- 884 people
- Sponsor
- Geisinger Clinic
Diabetic Neuropathies
Effects of Foot Muscle Strengthening in Daily Activity in Diabetic Neuropathic Patients
The main objective of this trial is to investigate the effects of foot muscle strengthening in daily activity of patients with diabetic neuropathy.
- Trial name
- NCT02790931
- Testing
- Intervention Group
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- University of Sao Paulo General Hospital
Prevention Harmful Effects, Health Maintenance
Lifewise Preventive Video Education in Primary Care
It is widely accepted that prevention is far more impactful than curative medicine and must be included in primary care. In a previous pilot study, we evaluated passive video preventive lifestyle education in the emergency…
- Conditions
- Prevention Harmful Effects, Health Maintenance, Preventive Health Care, Dietary Habits
- Trial name
- NCT06730737
- Testing
- Video preventive education
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Trinity Health-Livonia