Clinical trials: Preventive Intervention
Prevention
Adaptive Intervention to Facilitate PrEP Uptake/Adherence Among Transgender Women
"PrEP N' Shine" is a two-stage randomized controlled pilot trial which utilizes a behavioral intervention to optimize the uptake and adherence of Pre-exposure Prophylaxis (PrEP) in Transgender women (TGW).
- Trial name
- NCT05016232
- Testing
- PrEP N' Shine: Strength Based Case Management (Stage 1), PrEP N' Shine: Stepped Adherence Training and Counseling (Stage 2)
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Prevention of Shivering With Spinal Anaesthesia
Could Ephedrine Replace Dexmedetomidine Fordexmedetomidine Prevention of Shivering in Women Undergoing Cesarean Section Under Spinal Anaesthesia
Could ephedrine replace dexamedetomidine for prevention of shivering in women undergoing Cesarean section Under spinal anaesthesia
- Trial name
- NCT06233032
- Testing
- Ephedrine, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Injury, Knee, Injury, Ankle
Prevention of Patellar and Achilles Tendinopathies in Youth Basketball
This study seeks to determine the prevalence of knee and ankle tendinopathies in youth basketball players, as well as determine the efficacy of a Basketball specific Neuromuscular training warm-up in reducing injuries.
- Conditions
- Injury, Knee, Injury, Ankle, Tendinopathy, Sports Injuries in Children
- Trial name
- NCT04363398
- Testing
- Comprehensive Follow-up, Standard Follow-up
- Where
- Canada
- Volunteers
- 441 people, healthy volunteers welcome
- Sponsor
- Sport Injury Prevention Research Centre
HIV Infection
Connect to Protect (C2P): Building a Community-Based Infrastructure for HIV Prevention
The proposed study seeks to continue the implementation of Connect to Protect® (C2P), a community mobilization intervention, which entails developing coalitions to plan for and bring about structural changes for purposes of…
- Trial name
- NCT01752504
- Testing
- Community Mobilization
- Where
- 5 sites in United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Childcare Quality, Child Development
THRIVE BY 3 Daycare to Promote Development/ Mental Health in 1&2 Year-olds
This study evaluates a preventive, knowledge enhancement and tailored quality building intervention to promote development and mental health in 1 and 2 year-olds.
- Trial name
- Tb3 (NCT03879733)
- Testing
- Thrive by Three, Treatment as usual (TAU)
- Where
- 3 sites in Norway
- Volunteers
- 1,531 people, healthy volunteers welcome
- Sponsor
- Regionsenter for barn og unges psykiske helse
Malaria
Insecticide Treated Polyethylene Sheeting for Prevention of Malaria in Emergencies
A Phase III malaria prevention trial was conducted in two camps of Liberian refugees in Sierra Leone using Insecticide Treated Polyethylene Sheeting (ITPS) or untreated polyethylene sheeting (UPS) randomly deployed to defined…
- Trial name
- NCT01456858
- Testing
- Insecticide Treated Polyethylene Sheeting, Untreated Plastic Sheeting
- Where
- Sierra Leone
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- The Mentor Initiative
Otitis Media, Pneumococcal Infections
Efficacy Trial of Two Pneumococcal Conjugate Vaccines (PncCRM and PncOMPC) for Prevention of Acute Otitis Media Due to Vaccine Serotypes
This was a randomized, double-blinded multicenter cohort study of Finnish children aged 2 to 24 months. The study was designed to evaluate the efficacy of two 7-valent pneumococcal conjugate vaccines (PncCRM and PncOMPC)…
- Trial name
- NCT00378417
- Testing
- 7-valent pneumococcal-CRM197 conjugate vaccine, 7-valent pneumococcal-OMPC conjugate vaccine
- Where
- 5 sites in Finland
- Volunteers
- 3,075 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Human Papillomavirus-Related Cervical Carcinoma
Single-Dose HPV Vaccination for the Prevention of Cervical Cancer in Young Adult Women in Costa Rica, The PRISMA ESCUDDO Trial
This phase IV trial tests whether a single dose of the human papillomavirus (HPV) vaccine works in preventing cervical cancer in young women in Costa Rica.
- Trial name
- PRISMA (NCT05237947)
- Testing
- Diphtheria Toxoid/Tetanus Toxoid/Acellular Pertussis Vaccine Adsorbed, Questionnaire Administration, Recombinant Human Papillomavirus Bivalent Vaccine
- Where
- Costa Rica
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Oral Pre-exposure Prophylaxis (PrEP), Long-acting Injectable Cabotegravir for PrEP
PathToScale: The PERSIST Trial
The purpose of this study is to identify the effectiveness of a bundle of strategies to support continuation of clients on pre-exposure prophylaxis, including long-acting injectable cabotegravir and oral pre-exposure prophylaxis…
- Trial name
- NCT07221747
- Testing
- Standard of Care (SoC), Enhanced continuation support package
- Where
- Malawi
- Volunteers
- 9,900 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Substance Abuse, Substance Use Disorders
Testing Strategies to Improve Substance Misuse Prevention Research Use in State Policy Contexts
If science is to inform effective substance misuse prevention policy and ultimately improve public health, the field needs an effective strategy for directly supporting policymakers' use of research evidence, yet our field lacks…
- Conditions
- Substance Abuse, Substance Use Disorders, Prevention, Legislation
- Trial name
- NCT06856148
- Testing
- Intervention: RPC Group, Active Comparator: Control Group
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Penn State University
Urinary Tract Infection, Bacteriuria
Cranberry Juice for Preventing Bacteria in Urine During Pregnancy
The purpose of this study is to determine the amount of cranberry juice that is most effective in preventing a condition in pregnant women that often leads to urinary tract infections (UTIs).
- Trial name
- NCT00093938
- Testing
- Cranberry juice
- Where
- 2 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Coronavirus Infections
Comparative Study of Hydroxychloroquine and Ivermectin in COVID-19 Prophylaxis
We have to be aware of the challenge and concerns brought by 2019-nCoV to our healthcare workers. Front-line healthcare workers can become infected in the management of patients with COVID-19; the high viral load in the…
- Trial name
- NCT04384458
- Testing
- Hydroxychloroquine, Ivermectin
- Where
- Brazil
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara
Surgical Wound Infection
Circular pOlyethylene Drape in preVention of Surgical Site infEction: A Randomized Controlled Trial
This study is to evaluate the effectiveness of the plastic ring wound retractor to reduce the rate of surgical site infection in patients who undergo open abdomen surgery for gastrointestinal tract.
- Trial name
- COVER (NCT03170843)
- Testing
- use of plastic ring wound retractor
- Where
- 13 sites in South Korea
- Volunteers
- 457 people, healthy volunteers welcome
- Sponsor
- Saint Vincent's Hospital, Korea
Sharps Injuries
A Study of VAX-ID® 2200, a New Device for Intradermal Injections
The researchers are doing this study to find out whether the VAX-ID® 2200 device is safe and easy to use for healthcare professionals who give intradermal injections.
- Trial name
- NCT07898111
- Testing
- VAX-ID® 2200
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Healthcare Workers, COVID-19
TAF/FTC for Pre-exposure Prophylaxis of COVID-19 in Healthcare Workers (CoviPrep Study)
A randomized parallel double-blinded placebo-controlled clinical trial to evaluate the effect of Emtricitabine/Tenofovir alafenamide (FTC/TAF) compared with placebo on the risk of developing SARS-CoV-2 disease (COVID-19) in…
- Conditions
- Healthcare Workers, COVID-19, SARS-CoV 2
- Trial name
- NCT04405271
- Testing
- Emtricitabine/Tenofovir Alafenamide 200 MG-25 MG Oral Tablet
- Where
- Argentina
- Volunteers
- 1,378 people, healthy volunteers welcome
- Sponsor
- Hospital Italiano de Buenos Aires
Malaria in Pregnant HIV + Patients
A Comparative Study of Mefloquine and S-P as Prophylaxis Against Malaria in Pregnant HIV + Patients
Randomized controlled single blind prospective comparative study.
- Trial name
- NCT02524444
- Testing
- Mefloquine, Sulphadoxine-Pyrimethamine
- Where
- Nigeria
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- ORIYOMI OMOTOYOSI AKINYOTU
Cardiovascular Disease
Prevention of Cardiovascular Disease With Med or Veg Diets
The study is a randomized, open, cross-over trial designed to test whether a vegetarian diet would benefit the cardiovascular risk profile of the participants, compared with a Mediterranean diet.
- Trial name
- CARDIVEG (NCT02641834)
- Testing
- Vegetarian diet, Mediterranean diet
- Where
- Italy
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Musculoskeletal Injury
Running Online Injury Prevention Feasibility Study
The main purpose of this study is to test the feasibility of a larger scale interventional study. The investigators want to understand whether data can be reliably collected data various different streams while participants…
- Trial name
- ROIPF (NCT06538363)
- Testing
- Education, Generic Education
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Cardiovascular Diseases
Seton Hill University--Personal Empowerment Program
It is widely acknowledged that cardiovascular disease prevention requires intervention as early in the human lifespan as practical.
- Trial name
- SHU-PEP (NCT02476604)
- Testing
- health coaching and electronic messaging
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Opioid Misuse
Prevention of Opioid Misuse and Overdose Deaths Among Hispanic/Latinx Adolescents: A Family-based Perspective
The purpose of this study is to develop culturally-competent family-focused educational modules targeting opioid knowledge and attitudes (including targeting safe storage and prevention of accidental opioid overdose in adolescent…
- Trial name
- NCT06303804
- Testing
- Educational videos
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.