Clinical trials: Preventive Intervention
Low Back Pain
Active Management for Low Back Pain for 6 to 8 Year Old Schoolchildren
The objective is to assess the effectiveness of a prevention campaign promoting active management in shifting beliefs in 6 to 8 year old schoolchildren.
- Trial name
- NCT00809640
- Testing
- Education (Back Comic-Book)
- Where
- Spain
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Kovacs Foundation
Behavior
Handheld Mirror to Improve Child's Behavior During Dental Treatment
The purpose of this study is to determine whether a handheld mirror helps to reduce child behavior problems during dental treatment. It will be tested by randomized crossover design.
- Trial name
- NCT02366520
- Testing
- handheld mirror
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Radial Artery Occlusion
Comparison of the Systematic Versus the Selective Use of Heparin for the Prevention of Radial Artery Occlusion
Randomized study comparing the systematic use of heparin (standard of care) against an elective use of heparin to prevent radial artery occlusion after a percutaneous catheterization using a dual-artery compression system.
- Trial name
- EASY-Heparin (NCT06981624)
- Testing
- No heparin
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Olivier F. Bertrand
Multiple Sclerosis
Functional Balance Intervention in Multiple Sclerosis
This project involves two sub-parts: Study 1: Effect of lab-based Functional Balance Intervention (FBI) for physical and cognitive symptoms of Multiple Sclerosis.
- Trial name
- FBIinMS (NCT06341023)
- Testing
- Functional Balance Intervention, Stretching
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Illinois Chicago
Breast Cancer
Plant-derived Nutrients in the Prevention and Prognosis of Breast Cancer in Women.
This study evaluates the impact of plant-derived nutritional interventions on inflammation, immune function-related indicators, and quality of life in healthy women and breast cancer patients based on real-world data, providing…
- Trial name
- Plant (NCT07868159)
- Testing
- Curcumin
- Where
- China
- Volunteers
- 639 people, healthy volunteers welcome
- Sponsor
- Keda Yu
Infection Wound
Negative Pressure Wound Therapy for Prevention of Groin Infection Following Vascular Surgery
Surgical site infection in vascular surgery is a relatively common event with reported incidence as high as 43%. When considering the groin alone, the incidence is around 20% (30% when considering any wound complication).
- Trial name
- PICO (NCT03460262)
- Testing
- Standard cutiplast®, PICO®
- Where
- Belgium
- Volunteers
- 160 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Anal High Grade Squamous Intraepithelial Lesion, Anal Precancerous Condition
Artesunate Suppositories for the Treatment of HIV-negative Patients With Intra-anal HSIL
This is a phase II double blind, placebo-controlled, randomized study of Artesunate suppositories for the treatment of HIV-negative men and women who have anal high grade squamous intraepithelial lesions (anal HSIL)
- Conditions
- Anal High Grade Squamous Intraepithelial Lesion, Anal Precancerous Condition, AIN 2/3, HPV Infection
- Trial name
- anal HSIL HIV- (NCT05555862)
- Testing
- Artesunate
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Frantz Viral Therapeutics, LLC
Leukemia, Myeloid
γδ T Cell Therapy for Relapse Prevention in High-Risk AML Post-Transplant
This is a prospective, double-arm, single-center, randomized controlled single-blind clinical study
- Conditions
- Leukemia, Myeloid, Acute
- Trial name
- NCT07123662
- Testing
- Gamma-Delta T cell injection, Standard prophylactic treatment
- Sponsor
- Guangzhou Bio-gene Technology Co., Ltd
Iron Deficiency
Nutritional Education and the Prevention of Iron Depletion in Children 9 Months to 2 Years
Iron depletion in young children is common and may progress to iron deficiency anemia which is associated with irreversible neurodevelopmental effects. Efforts to prevent iron depletion are key to preventing these effects.
- Trial name
- NCT00907088
- Testing
- Healthy milk intake, Standard nutrition counselling
- Where
- Canada
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
COVID-19
Allocetra-OTS in COVID-19
This is a multi-center, open-label study evaluating the safety of Allocetra-OTS, in 5 subjects with severe COVID-19 and respiratory dysfunction. Subjects, who will be identified as suffering from COVID-19, will be recruited.
- Trial name
- NCT04513470
- Testing
- Allocetra-OTS
- Where
- Israel
- Volunteers
- 5 people
- Sponsor
- Hadassah Medical Organization
Emesis
Aprepitant in the Prevention of Delayed Emesis Induced by Cyclophosphamide Plus Anthracyclines in Breast Cancer Patients
The aim of the study is to compare efficacy and tolerability of aprepitant versus dexamethasone in the prevention of delayed emesis induced by moderately emetogenic chemotherapy (cyclophosphamide plus anthracyclines) in breast…
- Trial name
- NCT00869973
- Testing
- Aprepitant, dexamethasone
- Where
- Italy
- Volunteers
- 580 people
- Sponsor
- S. Maria Hospital, Terni
Candidiasis
Pharmacokinetics of Fluconazole IV as Prophylaxis or Therapy to ICU Patients
The pharmacokinetics of fluconazole are expected to be different in ICU patients compared to non-ICU patients. The investigators will determine fluconazole and free fluconazole concentrations in 20 ICU patients, who will get…
- Trial name
- PACIFIC (NCT02666716)
- Testing
- fluconazole
- Where
- 3 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Hematopoietic Stem Cell Transplantation
Oral Hygiene Management of Hematologic Patients Undergoing Auto-transplantation
This study assessed the effectiveness of a preventive protocol that included oral hygiene measures, patient education, and motivational strategies in individuals eligible for hematopoietic stem cell transplantation (HSCT).
- Trial name
- NCT06755333
- Testing
- Oral hygiene motivation
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- University of Pisa
Diabetic Retinopathy
The Diabetic Retinopathy Screening, Prevention and Control Program
The greatest harm of diabetes is various acute and chronic complications, especially diabetic retinopathy(DR), leading to extremely high rates of disability and blindness.
- Trial name
- NCT04240652
- Where
- 2 sites in China
- Volunteers
- 500,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Body Weight
Health Effects of Substituting Sugary Beverages With Artificially-sweetened Beverages or Water
Sugar-sweetened beverages (SSBs) contribute an alarming ~7% of calories in the US diet among adults, making SSBs the single largest source of added sugar.
- Trial name
- SUB-POP (NCT04567108)
- Testing
- Maintain usual SSBs, Substitute to non-SSBs, Study app
- Where
- United States
- Volunteers
- 461 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Cervical Cancer
Web-Based Education Program and Educational Booklet Developed on Cervıcal Cancer
Cervical cancer is the fourth most common cancer type among women worldwide and ranks ninth in Turkey, making it the second most common gynecological cancer.
- Trial name
- NCT06705309
- Testing
- Web-Based Education
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Post-traumatic Stress Disorder
Effectiveness of a Blended Care Parenting Intervention for Parents With PTSD (KopOpOuders-PTSD)
KopOpOuders-PTSD is a new preventive blended care intervention for parents with PTSD. The purpose of this study is to evaluate its effectiveness in improving parenting and preventing child mental health problems.
- Trial name
- NCT05237999
- Testing
- KopOpOuders-PTSD
- Where
- Netherlands
- Volunteers
- 142 people
- Sponsor
- Arkin
Anxiety Disorders
Duloxetine Compared With Placebo in the Prevention of Relapse in Generalized Anxiety Disorder
This is a clinical trial assessing the time to relapse of anxiety symptoms among patients with generalized anxiety disorder who have responded to duloxetine therapy.
- Trial name
- NCT00122863
- Testing
- Duloxetine Hydrochloride
- Where
- 47 sites in United States, Austria and 5 more
- Volunteers
- 380 people
- Sponsor
- Eli Lilly and Company
HIV Infections
A Peer-Driven Intervention to Increase PrEP Uptake Among Minority MSM
The objective of this study is to develop an effective peer-driven intervention (PDI) approach and assess its feasibility and efficacy on pre-exposure prophylaxis (PrEP) uptake among men who have sex with men.
- Trial name
- NCT05161663
- Testing
- Peer-driven intervention
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Bone Demineralization
Alendronate for Prevention of AntiRetroviral Therapy-associated Bone Loss
Antiretroviral therapy (ART) initiation is associated with a significant loss of bone mineral density (BMD), characterised by increases in bone turnover, which is largely limited to the first 48 weeks of therapy.
- Trial name
- APART (NCT02322099)
- Testing
- Alendronate, calcium carbonate and colecalciferol, Tenofovir disoproxil
- Where
- 2 sites in Ireland
- Volunteers
- 53 people
- Sponsor
- University College Dublin
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