Clinical trials: Preventive Intervention
Anxiety Disorders, Depression
Pharmacogenomics of Antidepressant Response in Children and Adolescents
This study will identify variations in genes that may be involved in the development of suicidal events or certain behaviors in youth who are exposed to antidepressant medications.
- Conditions
- Anxiety Disorders, Depression, Eating Disorders, Obsessive-Compulsive Disorder
- Trial name
- PARCA (NCT00516932)
- Where
- United States
- Volunteers
- 211 people
- Sponsor
- Duke University
Esophagus Disorder, Esophageal Achalasia
Impact of Antibiotic Prophylaxis in Per-oral Endoscopic Myotomy for Esophageal Motor Disorders
No recommendation regarding antibiotic prophylaxis and preparation modalities are available for patients with esophageal motor disorders who benefit from Per-Oral Endoscopic Myotomy (POEM).
- Trial name
- NCT03944863
- Testing
- Antibiotics
- Volunteers
- 252 people
- Sponsor
- Société Française d'Endoscopie Digestive
Cirrhosis, Liver, Portal Hypertension
Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of Oesophageal Varices Trial.
Research has proven that large varices can be treated with beta-blockers (a type of anti-hypertensive medication) to reduce the pressure in the veins. The management of small varices is still uncertain.
- Conditions
- Cirrhosis, Liver, Portal Hypertension, Variceal Hemorrhage, Varices, Esophageal
- Trial name
- BOPPP (NCT05872698)
- Testing
- Carvedilol
- Where
- United Kingdom
- Volunteers
- 763 people
- Sponsor
- King's College Hospital NHS Trust
Suicide Prevention, Suicide
Brief Skills for Safer Living (Brief-SfSL)
The goal of this project is to assess the efficacy of Brief-Skills for Safer Living (Brief-SfSL) in a randomized control trial. The investigators will be testing 150 participants Canada-wide, half of which will be randomized to…
- Conditions
- Suicide Prevention, Suicide, Suicide and Self-harm
- Trial name
- NCT06571916
- Testing
- Brief-SfSL
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Unity Health Toronto
Radiotherapy Side Effect, Mucositis
Adjunctive Treatments for the Prevention of Radiotherapy-Induced Mucositis
Radiation therapy (RT) is used in at least 50% of cancer patients and is critical in treating and palliating tumor-related symptoms.
- Trial name
- NCT06117904
- Testing
- MEBO ointment, Symptomatic treatment only
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
Cirrhoses, Liver, Oesophageal Varices
Beta-blockers for Oesophageal Varices
To determine if carvedilol reduces the rate of variceal haemorrhage in patients with cirrhosis and small oesophageal varices
- Trial name
- BOPPP (NCT03776955)
- Testing
- Carvedilol
- Where
- 4 sites in United Kingdom
- Volunteers
- 1,200 people
- Sponsor
- King's College Hospital NHS Trust
Atrial Fibrillation, Stroke
Canadian Community Utilization of Stroke Prevention Study - Emergency Department
Atrial fibrillation (AF) is a common heart condition, and increases the risk of stroke by six times. There are several medications (blood thinners) that can prevent strokes in AF patients.
- Trial name
- C-CUSP ED (NCT02358655)
- Testing
- Retrospective review of OAC prescription, Prescription of OAC in ED, Community AF clinic
- Where
- 5 sites in Canada
- Volunteers
- 360 people
- Sponsor
- Population Health Research Institute
Herpes Zoster
A Study to Test GlaxoSmithKline's (GSK) Candidate Vaccine-GSK1437173A for Prevention of Shingles in Children With Kidney Transplant
The purpose of this study is to evaluate the reactogenicity, safety and immunogenicity of 2 doses of PED-HZ/su, GSK's vaccine candidate for the prevention of Herpes Zoster (HZ) in immunocompromised paediatric renal transplant…
- Trial name
- NCT04006808
- Testing
- PED-HZ/su
- Where
- 31 sites in Belgium, France and 4 more
- Volunteers
- 184 people
- Sponsor
- GlaxoSmithKline
Heavy Smokers, Lung Cancer Screening
Akershus Cardiac Examination (ACE) 5 Study
Individuals with extensive smoking history have 2- to 3-fold increased risk of dying prematurely compared to age- and gender-matched peers.
- Conditions
- Heavy Smokers, Lung Cancer Screening, Cardiovascular Risk Profile, Cardiovascular Disease Prevention
- Trial name
- ACE5 (NCT07301489)
- Testing
- Lung Cancer Screening Plus Program, Standard of Care
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Akershus
Age-related Macular Degeneration
Prophylactic Ranibizumab for Exudative Age-Related Macular Degeneration
To evaluate Ranibizumab as prophylaxis against the conversion to neovascular Age-Related Macular Degeneration
- Trial name
- PROTECT (NCT02302989)
- Testing
- Ranibizumab 0.5mg
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Leonard Feiner, MD, PhD
Cervical Cancer, Human Papilloma Virus
Research in Ethno-Medicine and Education (REMED)
The purpose of this study is to gain information about intravaginal practices, like intravaginal "twalet deba", among Haitian women living in South Florida.
- Conditions
- Cervical Cancer, Human Papilloma Virus, HPV, Human Papillomavirus Infection
- Trial name
- REMED (NCT05907187)
- Testing
- Cervical Cancer Prevention Education
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Miami
Prevention Program, Wait List Control
School-Based Eating Disorder Prevention
This is a cluster randomized controlled trial with two assessment points (baseline and 24-week follow-up) comparing the Claudia Carraro prevention program to a no-intervention control group.
- Trial name
- NCT07158593
- Testing
- Claudia carraro prevention program
- Where
- Italy
- Volunteers
- 1,205 people
- Sponsor
- Villa Garda Hospital
Cytomegalovirus Infections
Breakthrough CMV Lung Transplant -Multicentre
Cytomegalovirus (CMV) infection is the most common opportunistic infection in lung transplantation leading to direct and indirect effects that can result in life threatening complications.
- Trial name
- NCT04439916
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Subconjunctival Hemorrhage
Topical Tranexamic Acid After Intravitreal Injections
We aim to investigate whether topical administration of Tranexamic acid can reduce the occurence of subconjunctival hemorrahge after routine intravitreal injections for retinal conditions.
- Trial name
- NCT04400916
- Testing
- Tranexamic acid, Balanced Salt Solution
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
HIV Infections
Workplace-based HIV Self-testing Among Men in Uganda (WISe-Men)
This study seeks to determine whether workplace delivery of HIV self-testing will lead to an increase in uptake of HIV testing and subsequent linkage to care or prevention services among men in Uganda.
- Trial name
- NCT04164433
- Testing
- Oral HIV Self-Test (OraQuick)
- Where
- 2 sites in Uganda
- Volunteers
- 548 people, healthy volunteers welcome
- Sponsor
- Makerere University
Cancer
Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer
RATIONALE: Cyproheptadine hydrochloride may prevent weight loss caused by cancer or cancer treatment. It is not yet known whether cyproheptadine is more effective than a placebo in preventing weight loss in young patients…
- Trial name
- NCT01132547
- Testing
- cyproheptadine hydrochloride
- Where
- 14 sites in United States
- Volunteers
- 22 people
- Sponsor
- University of South Florida
Obsessive - Compulsive Disorder
Transcranial Magnetic Stimulation and Psychotherapy for Treating Obsessive-Compulsive Disorder
This study will test how people with OCD respond to a type of noninvasive brain stimulation, repetitive Transcranial Magnetic Stimulation (rTMS), when it is combined with psychotherapy.
- Trial name
- NCT07146438
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), Supportive Therapy (ST), Exposure and Response Prevention (ERP) Therapy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Adam Frank
Head and Neck Tumors
Effectiveness of autoHYpnosis in the Prevention of Anxiety During Radiotherapy of Head and Neck Tumors (HYMACO)
HYMACO is a monocentric, randomized comparative pilot study with a total duration of 25 months. The purpose of this study is to evaluate the effectiveness of autoHYpnosis by anchoring in the prevention of anxiety related to…
- Trial name
- HYMACO (NCT04671485)
- Testing
- Standard care, Autohypnosis, Musicotherapy
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Institut de Cancérologie de Lorraine
Memory Loss (Excluding Dementia), Lifestyle (Sedentary Behavior and Physical Activity)
Pilot Study of a Brain Health Program in Senior Centers
The investigators will evaluate a brain health programs in older adults with subjective cognitive decline. The primary aim of the study is to determine the credibility, expectancy, feasibility, acceptability, appropriateness…
- Conditions
- Memory Loss (Excluding Dementia), Lifestyle (Sedentary Behavior and Physical Activity), Lifestyle Risk Reduction, Healthy Lifestyle Behaviors
- Trial name
- NCT07424443
- Testing
- My Healthy Brain
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Intravascular-catheter Colonization, Catheter Failure
Chlorhexidine-Alcohol Versus Povidone Iodine-Alcohol, Combined or Not With Use of a Bundle of New Devices, for Prevention of Intravascular-catheter Colonization and Catheter Failure
Short peripheral intravenous catheters (PVC) are the most frequently used invasive medical devices in hospitals. Unfortunately, PVCs often fail before the end of treatment due to the occurrence of complications, which can be…
- Trial name
- CLEAN3 (NCT03757143)
- Testing
- Povidone-Iodine-Alcohol, Chlorhexidine-Alcohol, Insyte Autoguard BC Winged
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Poitiers University Hospital
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