Clinical trials: Preventive Intervention
Colorectal Carcinoma, Colorectal Neoplasm
Testing a Combination of Vaccines for Cancer Prevention in Lynch Syndrome
This phase IIb trial tests whether Tri-Ad5 in combination with N-803 works to prevent colon and other cancers in participants with Lynch syndrome.
- Conditions
- Colorectal Carcinoma, Colorectal Neoplasm, Lynch Syndrome
- Trial name
- NCT05419011
- Testing
- Adenovirus 5 CEA/MUC1/Brachyury Vaccine Tri-Ad5, Biopsy Procedure, Biospecimen Collection
- Where
- 14 sites in United States, Puerto Rico
- Volunteers
- 186 people
- Sponsor
- National Cancer Institute (NCI)
Chemotherapy-Induced Peripheral Neuropathy in Breast Cancer
Efficacy of Auricular Acupuncture Therapy in the Prevention of CIPN in Breast Cancer
Evaluate the Efficacy of Auricular Acupuncture Therapy via the Seirin Pyonex Needles in the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Breast Cancer
- Trial name
- NCT07092111
- Testing
- Auricular acupuncture treatment
- Where
- China
- Volunteers
- 110 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
HIV Pre-exposure Prophylaxis, PrEP
HIV Pre-Exposure Prophylaxis (PrEP) Linkage With Immediate Medications in the Emergency Department Study
Our primary objective is to increase HIV pre-exposure prophylaxis (PrEP) awareness and uptake among people who want, need, or would benefit from PrEP in Dallas, TX through a pilot program of immediate PrEP prescribing in the…
- Trial name
- PrEP ED (NCT07462611)
- Testing
- PrEP Uptake with Rapid Start, Pre-Exposure Prophylaxis (PrEP) Persistence
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Juvenile Justice Involvement, Drug Abuse
Prevention Program for Problem Behaviors in Girls in Foster Care
This study will determine the efficacy of a parent-involved intervention in preventing problem behavior in middle school girls who are currently in foster care.
- Trial name
- NCT00239837
- Testing
- Middle School Success Intervention (MSS)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Oregon Social Learning Center
Obesity
Family-based Outcome Results
Many obesity related risk factors are strikingly apparent in minority populations. Mexican-American children have the highest rates of overweight.
- Trial name
- NCT04132245
- Testing
- behavioral intervention, Obesity prevention intervention trial
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Colon Cancer, Lung Cancer
Effectiveness of Electronic Health Record-Based Interventions for Improving Follow-Up in Primary Care
Diagnostic delays in ambulatory care are often due to breakdowns of related care processes. Electronic systems can improve follow-up and reduce delays by detecting missed appointments or incomplete procedures so that patients are…
- Conditions
- Colon Cancer, Lung Cancer, Prostate Cancer
- Trial name
- NCT01346839
- Testing
- Contact Intervention
- Where
- 2 sites in United States
- Volunteers
- 1,256 people
- Sponsor
- Baylor College of Medicine
Transplantation, Kidney
VEL-101 to Prevent Rejection After Kidney Transplantation
This study will evaluate the safety and efficacy of VEL-101 compared with tacrolimus in patients undergoing kidney transplantation.
- Trial name
- RENGEVITY-201 (NCT07290777)
- Testing
- Tacrolimus (TAC), VEL-101
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Veloxis Pharmaceuticals
Breast Neoplasms
Know Your Risk: Assessment at Screening for Breast Cancer - Pilot Study
The purpose of this pilot study is to evaluate a decision support website (RealRisks) designed to inform patients about breast cancer chemoprevention.
- Trial name
- KYRAS (NCT02954900)
- Testing
- RealRisks, BNAV
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Columbia University
Suicide Risk, Suicide Ideation
Momentary Assessment.Tracking Suicidal Ideation
The goal of this observational study is to increase the knowledge base about fluctuations in suicide ideation and its association with relational and contextual factors after hospital discharge in patients with high risk of…
- Conditions
- Suicide Risk, Suicide Ideation, Suicide Prevention, Ecological Momentary Assessment
- Trial name
- NCT05955807
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Vestre Viken Hospital Trust
Thrombocytopenia
A Study of PN20 for the Prevention of Chemotherapy-induced Thrombocytopenia in Lymphoma or Solid Tumor Patients
The main aim of this clinical trial is to assess the safety and tolerability of PN20 in adult patients with chemotherapy-induced thrombocytopenia (CID).
- Trial name
- NCT06521931
- Testing
- PN20
- Where
- 6 sites in China
- Volunteers
- 24 people
- Sponsor
- Chongqing Peg-Bio Biopharm Co., Ltd.
Metabolic Syndrome, Insulin Resistance
An Antiinflammatory Diet as Modulator of Cardiometabolic Risk and Body Weight in Healthy Subjects
Main scientific question: A previous intervention with an anti-inflammatory multifunctional dietary portfolio (MFD) showed remarkable reductions in cardiometabolic (CM) risk markers compared with a well-designed control diet.
- Conditions
- Metabolic Syndrome, Insulin Resistance, Overweight
- Trial name
- NCT02148653
- Testing
- Multifunctional diet (MFD), Control diet
- Where
- Sweden
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Lund University
Breast Cancer
The Effects of Radiation in Reconstructed Breasts
The primary objective of this study is to use LR imaging to evaluate the effects of adjuvant radiation therapy on reconstructed breasts.
- Trial name
- NCT01292772
- Testing
- contract-enhanced MRI, Unilateral Adjuvant Radiation Therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Suicide
Suicide Prevention Intervention for At-Risk Individuals in Transition
The four year SPIRIT Trial, or Suicide Prevention Intervention for at-Risk Individuals in Transition, will recruit 800 pretrial jail detainees at risk for suicide.
- Trial name
- SPIRIT (NCT02759172)
- Testing
- Safety Planning Intervention
- Where
- 2 sites in United States
- Volunteers
- 800 people
- Sponsor
- Michigan State University
Ankle Fracture
Ankle Syndesmosis Fixation by Antibiotic Releasing Bioabsorbable Screw
This single-center randomized trial evaluates the efficacy and safety of a new bone screw (antibiotic releasing bioabsorbable screw) in fixation of syndesmosis in patients with Weber C-type ankle fractures.
- Trial name
- NCT01729195
- Testing
- A ciprofloxacin containing bioabsorbable PLGA bone screw
- Where
- Finland
- Volunteers
- 17 people
- Sponsor
- Turku University Hospital
Athlete, Eating Disorder Prevention
Cross-cultural Adaptation and Validation of the French Version of the Athletic Disordered Eating Scale (ADE)
Assessing disordered eating is crucial in athlete health monitoring. However, existing tools are not tailored to athletes' specific needs. In 2024, Buckley et al.
- Conditions
- Athlete, Eating Disorder Prevention, Eating Disorders Symptoms
- Trial name
- ADE-Fr (NCT07617701)
- Testing
- The French version of the Athletic Disordered Eating (ADE-Fr) Scale
- Where
- France
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Dyskinesia, Medication-Induced, Parkinson's Disease
Prevention of Levodopa-induced Dyskinesias by Transcranial Static Magnetic Field Stimulation (tSMS)
This is a randomized sham-controlled double-blind study to test the hypothesis that transcranial static magnetic field stimulation (tSMS) of the motor cortex improves levodopa-induced dyskinesias in patients with Parkinson's…
- Trial name
- NCT02657681
- Testing
- tSMS
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundación de investigación HM
Chronic Migraine or Episodic Migraine
Study to Evaluate the Efficacy and Safety of AMG 301 in Migraine Prevention
To evaluate the effect of AMG 301 compared to placebo on the change from the baseline period in monthly migraine days in subjects with migraine.
- Trial name
- NCT03238781
- Testing
- AMG 301
- Where
- 49 sites in United States, Austria and 6 more
- Volunteers
- 343 people
- Sponsor
- Amgen
Norepinephrine, Glypressin, Tourniquet Deflation, Hypotension
Noradrenaline Versus Glypressin for Prevention of Hypotension After Deflation of Tourniquet in Knee Arthroplasty
Pneumatic tourniquet is usually used in orthopedic surgeries, as it helps to decrease operative bed bleeding, and thus, maintaining a clean and dry surgical field allowing easy and clear identification of the anatomical…
- Trial name
- NCT05774067
- Testing
- Saline, Norepinephrine, glypressin
- Where
- Egypt
- Volunteers
- 135 people
- Sponsor
- Tanta University
Ebola Virus Disease, Marburg Virus Disease
Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults
Primary Objective: To evaluate the safety and tolerability of cAd3-EBO-S and cAd3 Marburg vaccines when administered Intramuscular (IM) at a dose of 1 x 10^11 particle units (PU) to healthy adults.
- Trial name
- NCT04723602
- Testing
- cAd3-Marburg, cAd3-EBO-S
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Respiratory Distress Syndrome, Adult, Ventricular Dysfunction, Right
The Value of Combined Critical Care Ultrasound and PAC Monitor Oriented Therapy Protocol to Patients of ARDS With ACP
We hypothesize that combined critical care ultrasound and PAC monitoring-oriented therapy protocol (CUP protocol), would improve prognosis of patients of ARDS with right ventricular dysfunction.
- Trial name
- NCT03971331
- Testing
- PAC catheter and critical care ultrasound examination
- Volunteers
- 236 people
- Sponsor
- Kang Yan
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