Clinical trials: Preventive Measures
Neoplasms
A Study to Evaluate the Efficacy and Safety of Rivaroxaban Venous Thromboembolism (VTE) Prophylaxis in Ambulatory Cancer Participants
The purpose of this study is to demonstrate that rivaroxaban is superior to placebo for reducing the risk of the primary composite outcome as defined by objectively confirmed symptomatic lower extremity proximal deep vein…
- Trial name
- NCT02555878
- Testing
- Rivaroxaban
- Where
- 151 sites in United States, Belgium and 8 more
- Volunteers
- 841 people
- Sponsor
- Janssen Research & Development, LLC
Migraine, Headache
Long-term Atogepant in Real-world Practice
This prospective multicentre observational study aims to evaluate the long-term effectiveness, safety, tolerability, and treatment persistence of atogepant for migraine prevention in routine clinical practice.
- Conditions
- Migraine, Headache, Headache (Migraine), Migraine Disease
- Trial name
- GEMA PROJECT (NCT07699549)
- Testing
- Atogepant 60 mg, Headache diary, Patient-reported outcome measures
- Where
- Spain
- Volunteers
- 513 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Severe Aplastic Anemia (SAA), Hypo-Plastic Myelodysplastic Syndrome (MDS)
Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH Using Peripheral Blood Stem Cells and Post-transplant Cyclophosphamide for GVHD Prophylaxis
Background: Severe aplastic anemia (SAA), and myelodysplastic syndrome (MDS), and paroxysmal nocturnal hemoglobinuria (PNH) cause serious blood problems.
- Conditions
- Severe Aplastic Anemia (SAA), Hypo-Plastic Myelodysplastic Syndrome (MDS), Paroxysmal Nocturnal Hemoglobinuria (PNH)
- Trial name
- NCT03520647
- Testing
- Cyclophosphamide, Peripheral Blood Stem Cells
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Diabetic Retinopathy
The Diabetic Retinopathy Screening, Prevention and Control Program
The greatest harm of diabetes is various acute and chronic complications, especially diabetic retinopathy(DR), leading to extremely high rates of disability and blindness.
- Trial name
- NCT04240652
- Where
- 2 sites in China
- Volunteers
- 500,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Myeloid Malignancies
Post Transplant High-Dose Cy as GvHD Prophylaxis in 1 HLA Mismatched Unrelated HSCT for Myeloid Malignancies
The experimental treatment consists in the application of a therapeutic strategy with post Transplant High-Dose Cyclophosphamide as GvHD Prophylaxis in Patients Receiving 1-Antigen/Allele HLA Mismatched (7/8 matched) Unrelated…
- Trial name
- GITMO-PHYLOS (NCT03270748)
- Testing
- GvHD prophylaxis
- Where
- 33 sites in Italy
- Volunteers
- 78 people
- Sponsor
- Gruppo Italiano Trapianto di Midollo Osseo
Vascular Headaches, Migraine
A Study of the Effectiveness and Safety of Topiramate for the Prevention of Migraine
The primary purpose of this study is to evaluate the effectiveness and safety of topiramate (an epilepsy medication) compared with placebo in the prevention of migraine.
- Trial name
- NCT00253175
- Testing
- topiramate
- Volunteers
- 211 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Prevention and Control
PrOVE QUERI Project #1
The overall goal of this project is to test two strategies for implementing a shared decision making tool to be used by providers while talking to patients about lung cancer screening.
- Trial name
- NCT02765412
- Testing
- Webinar, Promotion, and Tool Access, LEAP, Audit and Feedback
- Where
- 8 sites in United States
- Volunteers
- 17,033 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Abdominal Neoplasms
Japanese Efficacy and Safety Study of Enoxaparin in Patients With Curative Abdominal Cancer Surgery
The primary objective of this study is to evaluate the effects of enoxaparin on venous thromboembolism incidence and bleeding rate (major and minor bleeding) in patients undergoing curative abdominal cancer surgery.
- Trial name
- NCT00723216
- Testing
- enoxaparin, Physical prophylaxis
- Where
- Japan
- Volunteers
- 151 people
- Sponsor
- Sanofi
Epstein-Barr Virus Infections, Lymphoproliferative Disorders
Prevention and Treatment of Epstein-Barr Virus (EBV) Lymphoma Following a Solid Organ Transplant Using EBV Specific Cytotoxic T Lymphocytes (CTLs).
Patients who may have been infected with EBV (Epstein-Barr Virus) before or after the time of their transplant have a higher risk of developing Lymphoproliferative Disease (LPD) or may already have a form of this disease.
- Trial name
- EUCLID (NCT00058604)
- Testing
- Intravenous injection of EBV specific CTLs
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Baylor College of Medicine
Migraine Prophylaxis
Comparison of Propranolol, Flunarizine and Their Combination in Preventing Migraine in Adults in a Tertiary Care Hospital in Bangladesh
Migraine is a common and disabling neurological condition that affects quality of life, work productivity, and daily functioning.
- Trial name
- NCT07655700
- Testing
- Propranolol 80 mg, Flunarizine 10 mg, Propranolol 40 mg + Flunarizine 10mg
- Where
- Bangladesh
- Volunteers
- 177 people
- Sponsor
- Chittagong Medical College
Venous Thromboembolism, Digital Health
Smart Technology Facilitated Patient-centered Venous Thromboembolism Management
Smart technologies, such as wearable devices, mobile technologies, and artificial intelligence, are being investigated for use in health management.
- Conditions
- Venous Thromboembolism, Digital Health, Health Education
- Trial name
- SmaVTE-COR (NCT06350344)
- Testing
- mobile venous thromboembolism application (mVTEA)
- Where
- China
- Volunteers
- 2,353 people
- Sponsor
- Navy General Hospital, Beijing
Post Spinal Anesthesia Shivering
Nebulized vs. IV Ketamine in Preventing Shivering Post Spinal Anesthesia
Shivering is an involuntary muscle activity, often triggered by hypothermia, that can occur after anesthesia. This is known as postanesthetic shivering (PAS) and is a common issue that increases oxygen demand, raises the risk of…
- Trial name
- NCT07055828
- Testing
- Ketamine, Intranasal ketamine, Normal Saline
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Tanta University
Spinal Induced Hypotension, Elderly
Norepinephrine Versus Phenylephrine for Preventing Spinal Anesthesia Induced Hypotension in Elderly
Various regimens were used for prevention of hypotension; most of these regimens included the use of vasopressors. Ephedrine is commonly used vasopressor for management and prophylaxis of hypotension; however, ephedrine is…
- Trial name
- NCT04195321
- Testing
- Norepinephrine, phenylephrine
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Kasr El Aini Hospital
Stem Cell Transplantation
A Study to Assess 7/8 HLA-matched Hematopoietic Stem Cell Transplantation Participants Treated With or Without Abatacept in Combination With a Calcineurin Inhibitor and Methotrexate
The purpose of this study is to estimate overall survival (OS) for participants treated with abatacept versus those not treated with abatacept prior to hematopoietic stem cell transplantation (HSCT).
- Trial name
- NCT05421299
- Where
- United States
- Volunteers
- 378 people
- Sponsor
- Bristol-Myers Squibb
Sex Work, Pre-Exposure Prophylaxis
Centering Those Engaged in Transactional Sex: A PrEP Innovation for Getting To Zero
Using a participatory implementation science framework, I will test whether an adapted and community empowered group healthcare model, Centering PrEP+, is a feasible and acceptable health system intervention to improve the health…
- Trial name
- C-PrEP+ (NCT05929521)
- Testing
- C-PrEP+
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Implant Infection
Long-term Coated and Non-coated Tibia Nails
For this retrospective cohort study, medical records of patients treated between 2005 to 2019 with the UTN PROtect and/or ETN PROtect for tibia fractures or tibia revision cases will be examined.
- Trial name
- NCT04576052
- Where
- Germany
- Volunteers
- 397 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Cancer of Cervix
Prevention and Control of Neoplasms Associated With HPV in High-risk Groups in Mexico City: The Condesa Study
Objective: To evaluate the effectiveness of a combined strategy of human papillomavirus virus (HPV) vaccination and high-risk HPV screening to reduce the occurrence of neoplasms in the anogenital region and oral cavity among men…
- Trial name
- CONDESA (NCT05149248)
- Testing
- Gardasil® [Quadrivalent Human Papillomavirus (Types 6,11,16,18) Recombinant vaccine], Two dose, Control group
- Where
- Mexico
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Salud Publica, Mexico
Gastrointestinal Hemorrhage (Clinically Important, Upper)
Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial
Patients who are critically ill in the in the Intensive Care Unit (ICU), especially those who need a breathing machine, can develop ulcers in the stomach that bleed.
- Trial name
- REVISE (NCT03374800)
- Testing
- Pantoprazole
- Where
- 67 sites in United States, Australia and 6 more
- Volunteers
- 4,800 people
- Sponsor
- McMaster University
Allogeneic Disease, GVHD,Acute
Wharton Jelly Mesenchymal Stromal Cells as GVHD Prophylaxis
Despite progress in chemotherapy, targeted therapy and immunotherapy, allogeneic hematopoietic stem cell transplantation (allo-SCT) is still the only curative procedure for some hematological malignancies.
- Conditions
- Allogeneic Disease, GVHD,Acute, Graft Failure
- Trial name
- HAPLO-GEL (NCT05855707)
- Testing
- WJ-MSC infusion
- Volunteers
- 12 people
- Sponsor
- Central Hospital, Nancy, France
Acute Mountain Sickness, High Altitude
CO2 Supplement for Treatment of Acute Mountain Sickness
It was reported that up to 76% people who rapidly ascend to the altitude higher than 4500 m without sufficient acclimatization will have AMS which often develops 6-8 hours after reaching at high altitude.
- Conditions
- Acute Mountain Sickness, High Altitude, Inhalation; Gas
- Trial name
- NCT06393998
- Testing
- Breathing with CO2 during daytime and night at high altitude, Sleep and doing exercise test under inhalation of air
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- State Key Laboratory of Respiratory Disease
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