Clinical trials: Prilocaine
Spinal Anesthesia, Cardiac Toxicity
Cardiovascular Effects of Intrathecal Hyperbaric Prilocaine or Bupivacaine in Surgery Under Spinal Anesthesia
Spinal anesthesia remains a mainstay in lower limbs- as in day-case surgeries as well. It consists in injecting a local anesthetic drug into the intrathecal space of a patient's spinal canal.
- Trial name
- NCT05751148
- Testing
- Hyperbaric bupivacaïne, Hyperbaric prilocaïne
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Spinal Anesthesia, Hyperbaric
Spinal Anesthesia by Hyperbaric Prilocaine in Day-Case Perianal Surgery
The aim of this study is to evaluate the effect of spinal anesthesia by hyperbaric prilocaine in day-case perianal surgery.
- Conditions
- Spinal Anesthesia, Hyperbaric, Prilocaine, Day-Case
- Trial name
- NCT06600048
- Testing
- Hyperbaric prilocaine, Hyperbaric bupivacaine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Anesthesia; Adverse Effect, Spinal and Epidural
Comparative Study Between Bilateral and Unilateral Spinal Anaesthesia
The purpose of this study is to compare unilateral spinal anesthesia using hyperbaric Prilocaine with "classical bilateral spinal anesthesia" using plain Prilocaine according to block characteristics and quality of micturition…
- Trial name
- NCT01877356
- Testing
- bilateral spinal anesthesia, unilateral spinal anesthesia
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- University Hospital, Antwerp
Cervical Incompetence in Pregnancy as Antepartum Condition
Hyperbaric Prilocaine Compared With Hyperbaric Bupivacaine in Cervical Cerclage?
Patients that have a "cervical stitch" (cervical cerclage) require an anaesthetic. The most common choice is a spinal block. This is an injection in the back that makes the lower half of the body become temporarily numb and weak.
- Trial name
- PRILOCC (NCT04394533)
- Testing
- Prilocaine (Hyperbaric 2%), Bupivacaine (Hyperbaric 0.5%)
- Where
- United Kingdom
- Volunteers
- 129 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Premature Ejaculation
Efficacy, Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment Premature Ejaculation
The purpose of this study is to evaluate the effectiveness, safety and tolerability of the investigational drug, PSD502 in subjects with premature ejaculation (PE) The study drug, PSD02, is a metered dose (measured dose), topical…
- Trial name
- NCT00556478
- Testing
- PSD502, contains a mixture of lidocaine and prilocaine
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- Plethora Solutions Ltd
Brachial Plexus Blockade
Concentration-Volume Relationship in Infraclavicular Block
This prospective, randomized, double blind study aims to determine the optimal volume for adequate sensorial and motor blockade following an infraclavicular block. Patients will be randomized into three groups.
- Trial name
- NCT02820688
- Testing
- Bupivacaine 0.25%, Prilocaine 1%, Infraclavicular Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Bozyaka Training and Research Hospital
Three Different Doses of Intrathecal Hyperbaric Prilocaine With Fentanyl
A Comparative Study on Three Different Doses of Intrathecal Hyperbaric Prilocaine With Fentanyl for Optimal Dose to be Used in Elderly Patients Undergoing Day Case Lower Abdominal and Urologic Surgeries.
To compare the effects of using different doses of intrathecal hyperbaric prilocaine 2% combined with fentanyl 25 µg in patients scheduled for a day-case lower abdominal and urologic surgery in the geriatric patient population.
- Trial name
- NCT05726968
- Testing
- Pilocaine 2% (1.5 ml) and 25 ug fentany
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pacemaker Implantation, Pain
Effect of Local Anesthetic EMLA (Lidocaine 2.5% and Prilocaine 2.5%) Cream and Reduction in Dose, Pain and Intravenous Analgesic During Permanent Pacemaker Implantation
The investigators believe that the local anesthetic EMLA (Lidocaine 2.5% and Prilocaine 2.5%) cream will lessen pain and reduce the need for anesthesia and analgesia, when implanting a permanent pacemaker.
- Trial name
- NCT02016976
- Testing
- EMLA Analgesic Cream, Dormicum 2.5 mg and Pethidine 25 mg
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Hillel Yaffe Medical Center
Premature Ejaculation
A Safety and Tolerability Study of Administration of PSD502
A Phase I, Single-Centre, Double-Blind, Randomised, Placebo-Controlled, Parallel Group, Pharmacokinetic and Safety Study to Evaluate Systemic Exposure and Local Vaginal Exposure to Lidocaine and Prilocaine and the Metabolites 2,6…
- Trial name
- NCT01183208
- Testing
- Intervention A, Intervention B, Intervention C
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Plethora Solutions Ltd
Office Hysteroscopy
Pain Management During Diagnostic Office Hysteroscopy in Postmenopausal Women: a Randomized Study
To assess the effectiveness of lidocaine-prilocaine spray versus placebo in minimizing the pain experienced by postmenopausal patients during diagnostic office hysteroscopy and to assess the ease of insertion of hysteroscope as…
- Trial name
- NCT06767085
- Testing
- Lidocaine-Prilocaine Topical, Saline spray
- Volunteers
- 106 people
- Sponsor
- Cairo University
Hemodynamic Stability
Selective Spinal Anaesthesia With Hyperbaric Prilocain With 2%Provides Better Perioperative Hemodynamic Stability for Patients With Peripheral Vascular Disease and Cardiac Dysfunction in Lower Limb Surgery
to compare the safety and efficacy of spinal anesthesia using Hyperbaric Prilocaine 2% versus Hyperbaric Bupivacaine 0.5% for patients with peripheral vascular disease and cardiac dysfunction.
- Trial name
- NCT05877690
- Testing
- Bupivacaine 0.5% Injectable Solution, Prilocaine Hydrochloride 2% Injection
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Infertility, Female
Lidocaine Prilocaine Spray in Reducing Pain During Hysterosalpingography in Women With Primary Infertility
We aim to assess the Safety and Efficacy of Cervical Lidocaine Prilocaine Spray in Reducing Pain During Hysterosalpingography in women with primary infertility
- Trial name
- NCT06769204
- Testing
- EMLA SPRAY
- Volunteers
- 90 people
- Sponsor
- Cairo University
Anesthesia
Clinical Use of Prilocaine Chlorhydrate Among a General Surgical Population
Observation of the effects of an administration of prilocaine chlorhydrate hyperbare in rachianesthesia among a general surgical population.
- Trial name
- NCT02282280
- Testing
- Prilocaine Chlorhydrate
- Where
- Belgium
- Volunteers
- 380 people
- Sponsor
- Astes
Pregnant Women
Estimation of the ED95 of Intrathecal Hyperbaric Prilocaine 2% With Sufentanyl for Scheduled Cesarean Delivery
Hyperbaric bupivacaine 0.5% associated with opioids is the local anesthetic the most commonly used for spinal injection in cesarean section.
- Trial name
- NCT03036384
- Testing
- HB Prilocaine 2% (varying dose), HB Prilocaine 2%, Sufentanil
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Anesthesia
Dosing of Carcinogenic Complexes After Anesthesia With Intrathecal Hyperbaric Prilocaine.
The prilocaine is a very common local anesthetic that has the disadvantage of being metabolized to o-toluidine, a human carcinogen.
- Trial name
- NCT03642301
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Cesarean
Prilocaine or Bupivacaine for Spinal Anesthesiain Pregnant
The planned cesarean section is an intervention with a standard operating time of less than 40 minutes in trained teams. Hyperbaric Bupivacaine is the local anesthetic (LA) reference for these operations.
- Trial name
- Césarcaïne (NCT03433976)
- Testing
- spinal anesthesia
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
IUD, Endometrial Biopsy
2.5% Lidocaine/2.5% Prilocaine Cream for IUD Insertion and Endometrial Biopsy
The aim of this study is to determine if 5g of self-administered topical 2.5% lidocaine/2.5% prilocaine cream, reduces pain during IUD insertion and/or endometrial biopsy.
- Trial name
- NCT07768059
- Testing
- 2.5% lidocaine/2.5% prilocaine topical cream, VersaPro Cream Base for Compounding
- Where
- Canada
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Healthy
Bioequivalence Study of Lidocaine and Prilocaine Cream in Healthy Chinese Subjects
The test formulation (Lidocaine and Prilocaine Cream, Haisco Pharmaceutical Group Co., Ltd.) and the reference formulation (EMLA®, AstraZeneca) were applied to healthy adult subjects under fasting conditions to evaluate the…
- Trial name
- NCT07551713
- Testing
- Tested Lidocaine and Prilocaine Cream, Reference Lidocaine and Prilocaine Cream (EMLA®)
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Lidocaine Adverse Reaction, Prilocaine Adverse Reaction
Efficacy of a Topical Anesthetic Containing Lidocaine and Prilocaine in Treatment With CO2 Fractional Laser
This is a study aimed at evaluating the efficacy of a topical anesthesia (test product) compared to placebo in adult patients of phototypes I to III, with indication of treatment of CO2 fractional laser in the forehead.
- Trial name
- CO2 (NCT03366246)
- Testing
- Lidocaine / Prilocaine Cream
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Galeno Desenvolvimento de Pesquisas Clínicas
Itch
Inhibition of Non-histaminergic Pruritus Applied Using 3 Different Pruritogens
With this experiment, we want to use to investigate whether repeated application of EMLA cream as a tool to modulate non-histaminergic itching, which is produced using small needles from the plant mucuna pruriens (it is known…
- Trial name
- NCT04858360
- Testing
- Emla 1 hour, EMLA 3 hours, Vehicle cream for 1 hour
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Aalborg University