Clinical trials: Primary
Post-traumatic Stress Disorder
Increasing Engagement in Evidence-Based PTSD Therapy for Primary Care Veterans
The purpose of this study is to implement an evidence-based Referral Management System that will address patient and system-level barriers to the uptake of evidence-based psychotherapy for PTSD by Veterans Affairs primary care…
- Trial name
- NCT01984515
- Testing
- Referral Management System
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- VA Office of Research and Development
Total Hip Arthroplasty (THA), Hemiarthroplasty
Post-Market Clinical Follow-Up (PMCF) Study Evaluating the Safety and Efficacy of Tıpmed™ Primary Hip Prosthesis System
This is a multicenter, prospective, observational, post-market clinical follow-up (PMCF) study designed to evaluate the safety and clinical performance of the Tipmed™ Primary Hip Prosthesis System in adult subjects undergoing…
- Conditions
- Total Hip Arthroplasty (THA), Hemiarthroplasty, Osteoarthritis (OA) of the Hip, Femoral Neck Fractures
- Trial name
- NCT07651735
- Testing
- Tipmed™ Primary Hip Prosthesis System
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- TIPMED Medical Device Manufacturing Ltd. Co.
Cluster Headache
Evaluation of Efficacity and Safety of Deep Brain Stimulation (DBS) in Chronic and Treatment-Resistant Cluster Headache(CH)
The aim of this study is to evaluate the efficacy and safety of deep brain stimulation (DBS) in chronic and treatment-resistant CH.
- Trial name
- NCT00662935
- Testing
- setting-up of an electrode in deep brain
- Volunteers
- 12 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Patient Safety
Non-COVID Patient-safety Incidents Reported by Primary Care Professionals in Time of Lockdown: Protocol for a Cross-sectional Descriptive Study
The COVID-19 epidemic is causing a global health crisis. In France, it has imposed a major reorganization of the healthcare system. This emergency reorganization is unprecedented. It involved first, second and third line care.
- Trial name
- PSI-RECORd-XP (NCT04348552)
- Testing
- Primary care professionals reports of potential patient safety incidents, non-COVID-19 related
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nantes University Hospital
PrEP Education
Encouraging Multiple PrEP Options for Women Engaged in PRimary Care
This study will address the significant yet often overlooked problem of HIV among cisgender women. To do this, researchers will adapt and test a multilingual technology-based strategy supporting informed decision-making for PrEP…
- Trial name
- EMPOWER (NCT06785038)
- Testing
- EMPOWER Strategy, Attention Control
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Northwestern University
Multiple System Atrophy
Fluoxetine in Multiple System Atrophy Patients
This is a French national trial, conducted using a double-blind, placebo-controlled, randomised design involving 15 centers and 88 patients of both sexes.
- Trial name
- MSA-Fluox (NCT01146548)
- Testing
- FLUOXETINE
- Where
- 14 sites in France
- Volunteers
- 87 people
- Sponsor
- University Hospital, Toulouse
Migraine
Biomarker and Genetic Predictors of Erenumab Treatment Response
To explore the relationship between clinical response to erenumab and genetic biomarkers
- Trial name
- INTERROGATE (NCT04265755)
- Testing
- Erenumab
- Where
- 2 sites in Denmark, Iceland
- Volunteers
- 1,406 people
- Sponsor
- Amgen
Obesity
Measuring the Weight Status, Primary Care Usage and Dietary Intake in the Pediatric Emergency Department
Childhood obesity is a major area of concern for health care and public health. Overweight children are more likely overweight and obese adults.
- Trial name
- NCT02265185
- Where
- United States
- Volunteers
- 484 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Patients in Complex Situations
A Quality Rating Scale for Patients in Complex Situations
The prevalence of multimorbid patients and complex care is increasing in France and elsewhere in the world. It concerns 60% of the over 65 years old.
- Trial name
- Qualsoprim_2 (NCT03886285)
- Testing
- Questionnaire
- Where
- 12 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Brest
Visceral Leishmaniasis
Pharmacokinetics/Safety of Miltefosine Allometric Dose for the Treatment of Visceral Leishmaniasis in Children in Eastern Africa
This is a multicenter, non-comparative, open-label clinical trial to assess the Pharmacokinetics (PK) and safety of miltefosine using an allometric dose algorithm in the treatment of children with primary Visceral Leishmaniasis…
- Trial name
- NCT02431143
- Testing
- Miltefosine
- Where
- 2 sites in Kenya, Uganda
- Volunteers
- 30 people
- Sponsor
- Drugs for Neglected Diseases
Episodic Cluster Headache, Chronic Cluster Headache
Sumatriptan 4 mg Statdose in the Acute Treatment of Cluster Headache
This study's hypothesis is the 4mg StatDose sumatriptan is effective for the acute treatment of cluster headache and provides good safety and tolerability across multiple doses of the study medication as well as across multiple…
- Trial name
- NCT00399243
- Testing
- Sumatriptan 4mg Statdose injection
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Diamond Headache Clinic
Chronic Migraine, Chronic Migraine, Headache
A Study to Evaluate the Efficacy and Safety of TNX-1900 in Patients With Chronic Migraine
This is a phase 2, double-blind, randomized, multicenter, placebo-controlled, three arm parallel study to evaluate the efficacy and safety of two different dosages (30 IU daily and 60 IU daily) of TNX-1900 in patients with…
- Conditions
- Chronic Migraine, Chronic Migraine, Headache, Chronic Migraine Without Aura, Aura Migraine
- Trial name
- PREVENTION (NCT05679908)
- Testing
- TNX-1900
- Where
- 26 sites in United States
- Volunteers
- 88 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Non-inflammatory Degenerative Joint Disease
A Trial Evaluating TKR Compared to BKR Performed Using Stryker's Mako Robot
A prospective, randomised controlled trial evaluating Total Knee Replacement with the Stryker Triathlon Primary Total Knee System, compared to Bicompartmental Knee Replacement with Restoris MCK Multicompartmental Knee System…
- Trial name
- NCT02650284
- Testing
- Stryker Triathlon Primary Total Knee System, Restoris MCK Multicompartmental Knee System
- Where
- Australia
- Volunteers
- 18 people
- Sponsor
- Stryker South Pacific
Primary Dysmenorrhea
Moxibustion for Primary Dysmenorrhea
Hypothesis: Moxibustion is effective for managing primary dysmenorrhea. Aim: To attest the effectiveness and safety of moxibustion for primary dysmenorrhea. Design: A randomized controlled trial.
- Trial name
- NCT01972906
- Testing
- moxibustion, Ibuprofen Sustained Release Capsules
- Where
- China
- Volunteers
- 152 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Brain and Central Nervous System Tumors, Neuroblastoma
Radiolabeled Monoclonal Antibody Therapy After Radiation Therapy in Treating Patients With Primary Brain Tumors
RATIONALE: Monoclonal antibodies can locate tumor cells and deliver tumor-killing substances, such as radioactive iodine, to them without harming normal cells.
- Trial name
- NCT00003484
- Testing
- carmustine, irinotecan hydrochloride, surgical procedure
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Darell D. Bigner, MD, PhD
Osteoarthritis (OA) of the Knee
Postoperative Pain and Analgesic Requirements After Preoperative Methadone for Primary TKA
The goal of this prospective, randomized study is to compare the outcomes of two cohorts of patients undergoing primary Total Knee Arthroplasty (TKA) and to determine whether a single dose of methadone administered preoperatively…
- Trial name
- NCT06691633
- Testing
- Preoperative Methadone, Preoperative Oxycodone
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Louisville
Clinical Stage IV Cutaneous Melanoma AJCC v8, Melanoma of Unknown Primary
Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-200M for the Treatment of Melanoma Brain Metastases
This phase I trial finds out the side effects and possible benefits of stereotactic radiosurgery and immune checkpoint inhibitors with NovoTTF-100M for the treating of melanoma that has spread to the brain (brain metastases).
- Conditions
- Clinical Stage IV Cutaneous Melanoma AJCC v8, Melanoma of Unknown Primary, Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma
- Trial name
- NCT05341349
- Testing
- Ipilimumab, Nivolumab, Pembrolizumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Emory University
Primary Liver Transplant
Mycophenolate Mofetil Maintenance Therapy for Liver Transplantation
The rationale for this study is to determine if Campath-1H can be used in liver transplant recipients to induce a state of immunological unresponsiveness that would not only eliminate the need for calcineurin inhibitors…
- Trial name
- NCT00849238
- Testing
- mycophenolate mofetil
- Sponsor
- University of Wisconsin, Madison
Immune Thrombocytopenia, Treatment
Daratumumab Versus Rituximab in the Management of Pediatric Primary Immune Thrombocytopenia (ITP)
This randomized, open-label study aim to compare the efficacy and safety of Daratumumab (anti-CD38 monoclonal antibody) with Rituximab in pediatric ITP patients.This study will be conducted in pediatric ITP patients who had not…
- Trial name
- NCT07362238
- Testing
- Rituximab, Daratumumab
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Primary Central Nervous System Lymphoma
Orelabrutinib Maintenance Therapy After ASCT in Primary Central Nervous System Lymphoma
A multicenter, randomized, prospective clinical study of the efficacy and safety of Orelabrutinib maintenance therapy after Autologous Stem Cell Transplantation (ASCT) in patients with primary central nervous system lymphoma.
- Trial name
- NCT05334238
- Testing
- Orelabrutinib
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Ruijin Hospital
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