Clinical trials: Primary
Primary Hypophosphatemic Rickets
Therapeutic Use of Oral Sodium Phosphate (Z-521) in Primary Hypophosphatemic Rickets
The purpose of this study is to investigate the efficacy and safety of oral phosphate (Z-521) in subjects with primary hypophosphatemic rickets.
- Trial name
- NCT01237288
- Testing
- Z-521
- Where
- 4 sites in Japan
- Volunteers
- 16 people
- Sponsor
- Zeria Pharmaceutical
Pain, Postoperative, Satisfaction
Comparing Ropivacaine Adductor Canal Blockade by Surgeon Versus Anesthesiologist
The purpose of this study is to evaluate the efficacy of two methods of administering an adductor canal block (ACB) following total knee arthroplasty (TKA); intraoperative surgeon performed intra-articular adductor canal block…
- Trial name
- NCT03864588
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Rothman Institute Orthopaedics
Adenocarcinoma of Unknown Primary, Adult Cholangiocarcinoma
Genetic Analysis-Guided Dosing of FOLFIRABRAX in Treating Patients With Advanced Gastrointestinal Cancer
This phase I/II trial studies the side effects of genetic analysis-guided dosing of paclitaxel albumin-stabilized nanoparticle formulation, fluorouracil, leucovorin calcium, and irinotecan hydrochloride (FOLFIRABRAX) in treating…
- Conditions
- Adenocarcinoma of Unknown Primary, Adult Cholangiocarcinoma, Gallbladder Carcinoma, Gastric Adenocarcinoma
- Trial name
- NCT02333188
- Testing
- Paclitaxel Albumin-Stabilized Nanoparticle Formulation, Leucovorin Calcium, Irinotecan Hydrochloride
- Where
- 8 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Chicago
Type 2 Diabetes, Telemedicine
Telemedicine Influence in the Follow up of the Type 2 Diabetes Patient
The purpose of this study is to evaluate the impact of a a real time teleassistance system in the clinical evolution of type 2 diabetic patients on self monitoring blood glucose in the Public National Primary Care System.
- Conditions
- Type 2 Diabetes, Telemedicine, Self Monitoring Blood Glucose, Primary Care
- Trial name
- NCT00527254
- Testing
- Telemedicine system
- Where
- Spain
- Volunteers
- 328 people
- Sponsor
- Province of Malaga Health Department
Epithelial Ovarian Cancer, Fallopian Tube Cancer
Intraperitoneal Therapy For Ovarian Cancer With Carboplatin Trial
The purpose of this study is: Phase A: To confirm the feasibility of paclitaxel administered by intravenous (IV) infusion weekly plus concurrent carboplatin administered by intraperitoneal (IP) injection once every 3 weeks…
- Conditions
- Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma
- Trial name
- iPocc (NCT01506856)
- Testing
- Paclitaxel(intravenous) + Carboplatin(intravenous), Paclitaxel(intravenous) + Carboplatin(intraperitoneal)
- Where
- 62 sites in United States, Hong Kong and 4 more
- Volunteers
- 655 people
- Sponsor
- Gynecologic Oncology Trial & Investigation Consortium
Cessation, Smoking
Effectiveness of an Intervention in Primary Care to Promote Smoking Cessation in Pregnant Women
The purpose of this study is to evaluate the effectiveness of the behavior treatment accompanied by self-help materials in Primary health care, across the intervention of the midwifes in the pregnancy follow-up visits.
- Trial name
- GESTABAC (NCT01872156)
- Testing
- Intervention GESTABAC, Control Group
- Where
- Spain
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Gerencia de Atención Primaria, Madrid
Primary Tauopathy Corticobasal Degeneration Syndrome (CBD)
Expanded Access to ABBV-8E12
This is an expanded access program (EAP) for eligible participants. This program is designed to provide access to ABBV-8E12 prior to approval by the local regulatory agency. Availability will depend on territory eligibility.
- Trial name
- NCT03744546
- Testing
- ABBV-8E12
- Sponsor
- AbbVie
Chronic Obstructive Pulmonary Disease
A Study for the Assessment of the Words Used by Patients and Physicians to Express the Symptoms of Chronic Obstructive Pulmonary Disease (COPD)
Chronic obstructive pulmonary disease (COPD) is characterized by a progressive decline in lung function and increased symptoms such as breathlessness/dyspnoea, cough and expectoration.
- Trial name
- COPD Language (NCT01219946)
- Where
- 32 sites in Greece
- Volunteers
- 700 people
- Sponsor
- AstraZeneca
Instrumentation Time
Comparative Evaluation of Instrumentation Time Using Pediatric Rotary Versus Hand (Flare) File Systems
The study will be conducted to evaluate instrumentation time, obturation quality, and child's behavior using pediatric rotary versus hand flare file systems in treatment of primary molars.
- Trial name
- NCT05665803
- Testing
- Pediatric rotary files, Manual flare files
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Cairo University
Postural Tachycardia Syndrome
Crossover Study of Propranolol vs Ivabradine in POTS
1.0 BACKGROUND Postural tachycardia syndrome (POTS) is a disorder of chronic orthostatic intolerance characterized by symptoms of palpitations, lightheadedness, chest discomfort, shortness of breath, blurred vision, and mental…
- Trial name
- NCT04186286
- Testing
- Ivabradine 4-week course, Propranolol 4-week course
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Primary Malignant Brain Tumor, Glioblastoma (GBM)
FearLess in NeuroOncology
The overarching goal of this project is to assess the feasibility, acceptability, and appropriateness of recruitment methods, target population, and a waitlist design to finalize the protocol of FearLess in primary malignant…
- Conditions
- Primary Malignant Brain Tumor, Glioblastoma (GBM), Astrocytoma, Oligodendroglioma
- Trial name
- NCT06989086
- Testing
- Fearless in Neuro-Oncology
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Virginia Commonwealth University
Type 1 Diabetes
ENCRT-103-hPI: Evaluation of an Immune-protected ENCRT-103-hPI Containing Primary Human Islets in Adults With Type 1 Diabetes, With and Without Standard-of-care Portal Vein Islet Infusion.
This study will evaluate the safety and performance of ENCRT-103-hPI, which is a cargo of primary islets inside Encellin's ENC-103-CED.
- Trial name
- NCT07680673
- Testing
- ENCRT-103-hPI encompasses the ENC-103 device, which will be implanted once loaded with primary islet cargo.
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- Encellin
Hereditary Angioedema
EAP for Deucrictibant Immediate-release
This is an expanded access program (EAP) designed to allow access to deucrictibant immediate-release (IR) capsule for eligible participants with hereditary angioedema (HAE) in the United States (US) and US territories who lack…
- Trial name
- NCT07759141
- Testing
- Deucrictibant IR
- Sponsor
- Pharvaris Netherlands B.V.
Hypercholesterolemia, Dyslipidemia
Long-Term Extension Study of Pitavastatin in Patients With Primary Hypercholesterolemia or Combined Dyslipidemia
This study is a long-term follow-up protocol for patients who participated in study NK-104-3.01EU or study NK-104-3.02EU.
- Trial name
- NCT00325780
- Testing
- Pitavastatin
- Where
- 186 sites in Denmark, Finland and 11 more
- Volunteers
- 1,355 people
- Sponsor
- Kowa Research Europe
Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Ovarian Carcinoma
Lenvatinib, Pembrolizumab, and Paclitaxel for Treatment of Recurrent Endometrial, Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
This phase II clinical trial studies the effect of lenvatinib, pembrolizumab, and paclitaxel in treating patients with endometrial, epithelial ovarian, fallopian tube, or primary peritoneal cancer that has come back (recurrent).
- Conditions
- Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Ovarian Carcinoma, Platinum-Resistant Primary Peritoneal Carcinoma, Recurrent Endometrial Carcinoma
- Trial name
- NCT04781088
- Testing
- Lenvatinib, Paclitaxel, Pembrolizumab
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Floor Backes, MD
Obesity, Overweight
Balance: A Pragmatic Trial of a Digital Health Intervention to Prevent Weight Gain in Primary Care
Up to 50% of obese patients are not interested in, or ready for, weight loss. Clinical practice guidelines clearly recommend that these patients avoid gaining weight.
- Conditions
- Obesity, Overweight, Overnutrition, Nutrition Disorders
- Trial name
- D0479 (NCT03003403)
- Testing
- Intervention Program
- Where
- United States
- Volunteers
- 443 people, healthy volunteers welcome
- Sponsor
- Duke University
Osteoarthrosis, ERAS
Nursing Intervention for the Reduction of Anxiety During the Process of Primary Total Hip Arthroplasty Within the Optimized Recovery Program.
Osteoarthrosis (OA) is a chronic, degenerative disease characterized by joint wear and tear. It is a major cause of pain, disability and decreased quality of life.
- Conditions
- Osteoarthrosis, ERAS, Anxiety, Nurse
- Trial name
- NIRARATC (NCT05882227)
- Testing
- video, Traditional information
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- University of Barcelona
Healthy
Metabolic Availability of Methionine From Chickpeas in Adult Men
The research study is being done so we can determine the quality of the protein present in Canadian chickpeas. Amino acids are the building blocks of protein and protein quality is determined by the amount of amino acids present…
- Trial name
- NCT03339154
- Testing
- Dietary Intakes
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Primary Mediastinal Large B-cell Lymphoma (PMBCL)
Primary Mediastinal Large B-cell Lymphoma With CNS Involvement
This is a retrospective, multicenter study focused on patients with a known diagnosis of PMLBCL which experienced a CNS relapse during the course of their disease to obtain information about the clinical characteristics, the…
- Trial name
- NCT06024694
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- IRCCS San Raffaele
Non-Neoplastic Hematologic and Lymphocytic Disorder
Treosulfan and Fludarabine Phosphate Before Donor Stem Cell Transplant in Treating Patients With Nonmalignant Inherited Disorders
This phase II clinical trial studies how well treosulfan and fludarabine phosphate with or without low dose radiation before donor stem cell transplantation works in treating patients with nonmalignant (noncancerous) diseases.
- Trial name
- NCT00919503
- Testing
- Allogeneic Bone Marrow Transplantation, Anti-Thymocyte Globulin, Cyclosporine
- Where
- 6 sites in United States
- Volunteers
- 98 people
- Sponsor
- Fred Hutchinson Cancer Center
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