Clinical trials: Primary Aldosteronism Due to Aldosterone Producing Adenoma
Hyperaldosteronism; Primary, Primary Aldosteronism Due to Aldosterone Producing Adenoma
Trial of Aldosterone-hybrid SteRoid for Guiding curablE Treatment of Primary Aldosteronism (TARGET-PA)
The goal of this project is to improve the diagnostic pathway for patients with primary aldosteronism, by validating non-invasive biomarkers coupled with routine computed tomography imaging.
- Trial name
- NCT07297745
- Testing
- Hybrid hormones
- Where
- 4 sites in Singapore
- Volunteers
- 120 people
- Sponsor
- Changi General Hospital
Primary Hyperaldosteronism, Primary Hyperaldosteronism Due to Adrenal Adenoma
Radiofrequency Endoscopic Ablation With Ultrasound Guidance: a Non-surgical Treatment for Aldosterone-producing Adenomas
High blood pressure (hypertension) causes strokes and heart attacks. While most patients need long-term treatment with pills, some have a cause which can be removed, curing the hypertension.
- Trial name
- FABULAS (NCT03405025)
- Testing
- Endoscopic ultrasound guided radiofrequency ablation, ultrasound
- Where
- 3 sites in United Kingdom
- Volunteers
- 28 people
- Sponsor
- University College, London
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
Prospective Study Assessing Blood Pressure and Other Outcomes Post-treatment in Patients With Primary Aldosteronism
Majority of patients with hypertension have primary hypertension (without an underlying cause). Secondary hypertension (due to an underlying disease) is important to recognize, as treatment can lead to cure of hypertension.
- Conditions
- Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)
- Trial name
- PA_PACES (NCT03174847)
- Testing
- Adrenalectomy, Mineralocorticoid Receptor Antagonists
- Where
- Singapore
- Volunteers
- 57 people
- Sponsor
- Changi General Hospital
Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism
Predicting Reduction of Hypertension After Adrenalectomy for Primary Aldosteronism: a Multicenter Analysis
Primary aldosteronism (PA) is the excessive endogenous production of the mineralocorticoid aldosterone. Although various rare forms of PA exist, the vast majority of cases are accounted by either an aldosterone-producing adenoma…
- Conditions
- Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism, Primary Aldosteronism Due to Conn Adenoma
- Trial name
- NCT04761354
- Testing
- Unilateral adrenalectomy
- Where
- 14 sites in United States, Australia and 3 more
- Volunteers
- 514 people
- Sponsor
- UMC Utrecht
Primary Aldosteronism Due to Aldosterone Producing Adenoma
MRA and ARB Treatment in Screening of Primary Aldosteronism
Current guidelines recommend withdrawal of treatments that affect the aldosterone/renin ratio (ARR) when screening for primary aldosteronism (PA).
- Trial name
- EMIRA (NCT04185857)
- Testing
- canrenone 50-100 mg orally once a day, olmesartan 10-20 mg orally once a day
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University Hospital Padova
Primary Aldosteronism Due to Aldosterone Producing Adenoma
Rapid Cortisol Assay in Adrenal Vein Sampling
Background: Adrenal vein sampling (AVS) is the gold standard test for the subtyping of primary aldosteronism (PA). This procedure is hampered by unsuccessful bilateral cannulation of adrenal veins, which can occur in up to two…
- Trial name
- I-PADUA (NCT03449797)
- Testing
- AVS performed with no intraprocedural rapid cortisol assay, AVS performed plus intraprocedural rapid cortisol assay
- Volunteers
- 200 people
- Sponsor
- University Hospital Padova
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
Outcome of Patients With Primary Aldosteronism
Majority of patients with hypertension have primary hypertension (without an underlying cause). Primary aldosteronism (PA) is the most common cause of secondary hypertension, and can be found in 5-10% of patients locally.
- Conditions
- Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral), Adrenalectomy; Status
- Trial name
- PA_Outcome (NCT04428827)
- Testing
- Unilateral adrenalectomy in patients with unilateral disease
- Where
- Singapore
- Volunteers
- 600 people
- Sponsor
- Changi General Hospital
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
Ipsilateral and Contralateral Index for the Interpretation of Adrenal Vein Sampling (AVS) in Primary Aldosteronism
Adrenal vein sampling (AVS) is currently considered the gold standard for subtype diagnosis of primary aldosteronism (PA). However, the percentage of unsuitable procedures due to the unsuccessful cannulation of one of the two…
- Conditions
- Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)
- Trial name
- NCT04378387
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Turin, Italy
Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Nodular Hyperplasia
First-in-human Evaluation of [18F]CETO
Purpose of this clinical phase 1 trial was to determine if para-chloro-2-[18F]fluoroethyletomidate positron emission computed tomography ([18F]CETO-positron emission computed tomography(PET)/computed tomography(CT)) can be used…
- Conditions
- Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Nodular Hyperplasia, Adrenal Cushing Syndrome, Non-Secretory Adrenal Adenoma
- Trial name
- NCT05361083
- Testing
- F18CETO
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Hyperaldosteronism
SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan.
Rationale: Primary hyperaldosteronism (PA) is the most frequent form of secondary hypertension. In PA autonomous hypersecretion of aldosterone by one or both adrenal glands causes hypertension that is often refractory to…
- Trial name
- SPARTACUS (NCT01096654)
- Testing
- Ct-scan or adrenal vein sampling
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Radboud University Medical Center
Primary Aldosteronism Due to Aldosterone Producing Adenoma
Renal Sympathetic Denervation From The Adventitia on Hypertension
Renal sympathetic denervation from the intima of renal arteries has become an important method for the treatment of resistant hypertension, but renal sympathetic nerve are mainly located in the adventitia, and there is no report…
- Trial name
- RSDAH (NCT02642445)
- Testing
- Renal Sympathetic Denervation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
Primary Aldosteronism and Surgically Curable Forms in Hypertension Patients Using 11C-Metomidate
10% of patients with hypertension potentially have the treatable condition - primary aldosteronism. Primary aldosteronism (PA) is caused by either bilateral adrenal disease (~40%), managed with lifelong medications; or unilateral…
- Trial name
- NCT03990701
- Testing
- 11C-Metomidate PET/CT Scan
- Where
- Singapore
- Volunteers
- 25 people
- Sponsor
- Changi General Hospital
Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)
Spatial Proteomics Profiles of Aldosterone-producing Adenoma and Unilateral Hyperplasia
Primary aldosteronism (PA) is a common cause of secondary hypertension, which is characterized by excessive aldosterone production by the adrenal gland.
- Trial name
- NCT05927961
- Testing
- histopathology
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Third Military Medical University
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
Application of Al18F-NOTA-Pentixafor PET/CT for Primary Aldosteronism
This prospective, single-center study investigates the biodistribution, dosimetry, safety, diagnostic performance of Al18F-NOTA-Pentixafor PET imaging in patients with primary aldosteronism.
- Trial name
- NCT06773663
- Testing
- Al18F-NOTA-Pentixafor PET/CT
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
A Novel and Efficient Biochemical Screening Strategy for Glucocorticoid-Remediable Aldosteronism: Combined 1-mg Overnight Dexamethasone Suppression Test and Steroid Profile
This prospective observational study evaluates a simplified biochemical screening strategy to differentiate Glucocorticoid-Remediable Aldosteronism (GRA) from Aldosterone-Producing Adenoma (APA).
- Trial name
- NCT07700888
- Testing
- 1 mg overnight dexamethasone inhibition test
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital
Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism
11C-Metomidate PET/CT for Endocrine Hypertension and Characterisation of Adrenal Tumours
10% of patients with hypertension potentially have the treatable condition - primary aldosteronism (PA). This is caused by either bilateral adrenal disease (~40%), managed with lifelong medications; or unilateral disease (~60%)…
- Conditions
- Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism, Adrenal Tumors
- Trial name
- NCT06100367
- Testing
- 11C-Metomidate PET/CT imaging at Clinical Imaging Research Centre
- Where
- 7 sites in Singapore
- Volunteers
- 97 people
- Sponsor
- Changi General Hospital
Primary Aldosteronism Due to Conn Adenoma, Radiofrequency Ablation Treatment
Radiofrequency Ablation Versus Adrenalectomy for Adenoma in Patients With Primary Aldosteronism and Hypertension
Primary aldosteronism (PA) is characterized by hypertension, frequent hypokalaemia, and an inappropriately high aldosterone-to-renin ratio (ARR).
- Conditions
- Primary Aldosteronism Due to Conn Adenoma, Radiofrequency Ablation Treatment, Adrenalectomy
- Trial name
- ADERADHTA2 (NCT07470580)
- Testing
- RFA -radiofrequency ablation, Adrenalectomy
- Where
- France
- Volunteers
- 134 people
- Sponsor
- University Hospital, Toulouse