Clinical trials: Primary Angioplasty
Cardiovascular Disease, Coronary Artery Disease
Italian Registry on Unprotected Left Main
The RITMO (Registro Italiano sul trattamento del Tronco coMune non protettO) observational study will appraise the prevalence, management strategy, and prognosis of unprotected left main coronary artery disease in Italy.
- Trial name
- RITMO (NCT00612053)
- Where
- Italy
- Volunteers
- 1,200 people
- Sponsor
- University of Turin, Italy
Myocardial Infarction
Fractional Flow Reserve (FFR) Stability in Non-Culprit Vessels at ST Elevation Myocardial Infarction(STEMI)
It has been shown that if it can be accomplished within a 90 minute "door to balloon" time, opening an artery in an acute heart attack situation (ST elevation myocardial infarction or STEMI) is best treated with balloon…
- Trial name
- NCT01065103
- Testing
- FFR (Fractional Flow Reserve)
- Where
- 2 sites in Canada
- Volunteers
- 48 people
- Sponsor
- Cardiology Research UBC
Arteriovenous Fistula Renal Dialysis Devices Obstruction
Primary Patency in Post-angioplasty Dysfunctional Arteriovenous Fistula in Renal Dialysis: Paclitaxel-releasing PTA Balloon Catheter vs PTA Balloon
In recent years the use of paclitaxel releasing percutaneous transluminal angioplastic (PTA) balloon catheter is spreading in vascular pathology, mainly in stenosis infrainguinal arteries.
- Trial name
- FISBAL (NCT02565953)
- Testing
- Paclitaxel-releasing PTA balloon catheter, PTA balloon catheter
- Where
- 4 sites in Spain
- Volunteers
- 134 people
- Sponsor
- Fundación Pública Andaluza Progreso y Salud
Acute Myocardial Infarction
Erythropoietin in Acute Myocardial Infarction
Erythropoietin (EPO) is a naturally occuring hormone which regulates the body's response to lack of oxygen and controls the number of red cells in the blood.
- Trial name
- NCT00149058
- Testing
- Erythropoietin
- Where
- 2 sites in United Kingdom
- Volunteers
- 124 people
- Sponsor
- Hammersmith Hospitals NHS Trust
Orthostatic Hypotension, Dysautonomic, Orthostatic Intolerance
The STAND-UP Study
Orthostatic hypotension (OH) and orthostatic intolerance (OI) are common conditions where blood pressure drops when standing up, causing dizziness, fainting, or fatigue.
- Trial name
- NCT07195903
- Testing
- Angioplasty or stenting
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- St. Francis Hospital, New York
Contrast Induced Nephropathy
Hydration and Contrast-Induced Nephropathy in Primary Angioplasty
The purpose of this study is to determine whether hydration with sodium bicarbonate is more effective than hydration with sodium chloride to prevent contrast induced nephropathy in patients undergoing Primary Coronary…
- Trial name
- NCT00770614
- Testing
- sodium bicarbonate solution, Isotonic saline
- Where
- Italy
- Volunteers
- 450 people
- Sponsor
- Ospedale Misericordia e Dolce
Acute Kidney Injury
Aminophylline and Contrast Induced Nephropathy in Acute Myocardial Infarction
The purpose of this study is to determine whether additional therapy with Aminophylline to hydration with sodium bicarbonate and administration of N-acetylcysteine is more effective to prevent contrast induced acute kidney injury…
- Trial name
- NCT01594489
- Testing
- Aminophylline, Hydration plus N-acetylcisteine
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Ospedale Misericordia e Dolce
Acute Myocardial Infarction
The Melatonin Adjunct in the Acute myocaRdial Infarction Treated With Angioplasty
Background: Experimental studies have documented the beneficial effects of the endogenously produced antioxidant, melatonin, in reducing tissue damage and limiting cardiac pathophysiology in models of experimental…
- Trial name
- MARIA (NCT00640094)
- Testing
- melatonin
- Where
- 3 sites in Spain
- Volunteers
- 272 people
- Sponsor
- Alberto Domínguez Rodríguez
Acute Myocardial Infarction
REgister of Myocardial Infarction Patients Treated by the NOVAra STE-MI Network
Myocardial infarction (MI) outcomes strictly depend on the time to reponed the infarct-related coronary artery. Networks have been activated in the last years in many countries to achieve fast track access of patients with…
- Trial name
- RENOVAMI (NCT01760382)
- Testing
- Primary PCI
- Where
- Italy
- Volunteers
- 700 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Anterior Wall Acute Myocardial Infarction
Evaluation of the Delivery of Optimized Supersaturated Oxygen Therapy to Treat Patients With an Acute Heart Attack
The purpose of this study is to evaluate the feasibility of the delivery of SuperSaturated Oxygen (SSO2) Therapy for 60 minutes selectively into the left main coronary artery (LMCA).
- Trial name
- NCT01630707
- Testing
- SuperSaturated Oxygen (SS02) Therapy
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- TherOx
Acute ST-segment Elevation Myocardial Infarction
EARLY Routine Catheterization After Alteplase Fibrinolysis vs. PPCI in ST-Segment-Elevation MYOcardial Infarction
The EARLY-MYO (EARLY routine catheterization after alteplase fibrinolysis vs. primary PCI in acute ST-segment elevation MYOcardial infarction) is an investigator-initiated, prospective, multicenter, randomized (1:1), open-label…
- Trial name
- EARLY-MYO (NCT01930682)
- Testing
- Alteplase, Early post-fibrinolytic catheterisation, Primary PCI
- Where
- China
- Volunteers
- 344 people
- Sponsor
- RenJi Hospital
Myocardial Infarction, Ischemia
FIT (Fast Infarction Treatment): Complete Revascularization During Primary Percutaneous Coronary Intervention (PCI) Can be Achieved Safely With an Improved Clinical Outcome During the Indexed Hospitalization.
Few reports described outcomes of complete compared with infarct related artery (IRA) only revascularization in patients with ST elevation myocardial infarction (STEMI) and multivessel coronary disease (CAD).
- Conditions
- Myocardial Infarction, Ischemia, Heart Failure, Necrosis
- Trial name
- FIT (NCT01160900)
- Testing
- Coronary angioplasty all lesions
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Azienda Ospedaliera San Camillo Forlanini
Popliteal Artery
Endovascular Treatment of Popliteal Artery - Balloon Angioplasty Versus Primary Stenting
1. Does primary stenting have a lower 12-month restenosis rate than PTA alone in the treatment of atherosclerotic lesions of the popliteal artery? Alternative hypothesis: "Primary stenting with the Edwards LifeStent is associated…
- Trial name
- ETAP (NCT00712309)
- Testing
- Lifestent, balloon-angioplasty (PTA)
- Where
- 2 sites in Germany
- Volunteers
- 250 people
- Sponsor
- Herz-Zentrums Bad Krozingen
Myocardial Infarction
Safety and Efficacy Study of Eptifibatide in Primary Percutaneous Coronary Intervention (PCI)
Rationale: ST-elevation myocardial infarction (STEMI) is usually triggered by rupture of an atherosclerotic plaque that then accumulates platelets and fibrin and leads to an occlusive coronary thrombus.
- Trial name
- NCT00251823
- Testing
- Eptifibatide facilitated PCI
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Coronary Artery Disease
Angioplasty of Left Main - lAriboisiere Registry
In patients with unprotected left main disease (ULMD), angioplasty is emerging as an alternative technique. The investigators aimed to determine the rate of major cardiovascular events in patients treated by angioplasty for ULMD…
- Trial name
- ALMA (NCT01725373)
- Where
- France
- Volunteers
- 125 people
- Sponsor
- Hopital Lariboisière
ST Elevation Myocardial Infarction
Cardiovascular Patient Outcomes and Research Team Primary PCI Registry
The proposed study is a registry of patients treated with primary angioplasty for acute myocardial infarction. The aim of this registry is to define the outcomes of patients treated for acute, ST-segment myocardial infarction…
- Trial name
- CPORT (NCT02201264)
- Where
- 14 sites in United States
- Volunteers
- 6,726 people
- Sponsor
- Johns Hopkins University
Acute Myocardial Infarction
Optical Coherence Tomography Assessment of Gender diVersity In Primary Angioplasty. The OCTAVIA Trial
Recent studies suggest important gender differences in the pathophysiology and prognosis of ST-segment elevation myocardial infarction (STEMI).
- Trial name
- OCTAVIA (NCT01377207)
- Testing
- Primary PCI
- Where
- 14 sites in Italy
- Volunteers
- 140 people
- Sponsor
- Italian Society of Invasive Cardiology
STEMI
Randomized Placebo-controlled Trial of Inhaled iNO in Acute ST-segment Elevation MI Treated by Primary Angioplasty
Reperfusion of ischemic myocardium, termed ischemia/reperfusion during the treatment of MI may result in paradoxical myocardial injury compromising myocardial salvage and left ventricular functional recovery.
- Trial name
- ENAMOR (NCT00854711)
- Testing
- inhaled nitric oxide
- Where
- Israel
- Volunteers
- 7 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
ST-elevation Myocardial Infarction
Primary Reperfusion Secondary Stenting Trial
The purpose of this research project is to improve how we treat heart attacks. The study will assess whether it might not be better to wait a few hours before implanting the coronary stent into the coronary artery rather than…
- Trial name
- PRIMACY (NCT01542385)
- Testing
- Stent
- Where
- 16 sites in Canada, France
- Volunteers
- 307 people
- Sponsor
- Montreal Heart Institute
Anterior Wall Acute Myocardial Infarction
Evaluation of Intracoronary Hyperoxemic Oxygen Therapy in Anterior Acute Myocardial Infarction Patients (IC-HOT)
The primary objective of the study is to collect confirmatory data supporting the safety and effectiveness of SSO2 Therapy in treatment of anterior acute myocardial infarction (AMI) patients who have undergone successful…
- Trial name
- IC-HOT (NCT02603835)
- Testing
- SSO2 Therapy
- Where
- 15 sites in United States
- Volunteers
- 100 people
- Sponsor
- TherOx