Clinical trials: Primary Angle-Closure Glaucoma
Primary Open-Angle Glaucoma, Primary Angle-Closure Glaucoma
Combined Phacoemulsification-Goniotomy in Primary Open-Angle and Primary Angle-Closure Glaucoma
This study evaluates whether combining cataract surgery (phacoemulsification) with incisional goniotomy effectively lowers intraocular pressure (IOP) and reduces the need for glaucoma medications in patients with coexisting…
- Conditions
- Primary Open-Angle Glaucoma, Primary Angle-Closure Glaucoma, Cataract
- Trial name
- NCT07821827
- Testing
- Combined Phacoemulsification and Goniotomy
- Volunteers
- 70 people
- Sponsor
- Assiut University
Primary Open Angle Glaucoma (POAG), Juvenile Open Angle Glaucoma
Testing a Reading Module to Improve Reading Skills and Quality of Life in Glaucoma Patients
The goal of this interventional study is to test the effectiveness of reading rehabilitation module towards reading speed and error, and quality of life in glaucoma patients.The main questions it aims to answer are: 1.
- Conditions
- Primary Open Angle Glaucoma (POAG), Juvenile Open Angle Glaucoma, Normotensive Glaucoma, Primary Angle Closure Glaucoma
- Trial name
- NCT07741812
- Testing
- Reading Rehabilitation Module
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- Universiti Sains Malaysia
Primary Angle-Closure Glaucoma
Predicting the Risk of Partial Ciliary Block After Cataract and Goniosynechialysis Surgery in Primary Angle-Closure Disease
Primary angle-closure disease (PACD) is a major cause of vision loss, often treated with a combined surgery that removes the eye's natural lens (cataract surgery) and physically opens the eye's drainage system…
- Trial name
- PCB-Risk (NCT07549438)
- Volunteers
- 1,150 people
- Sponsor
- Peking University People's Hospital
Primary Angle-Closure Glaucoma
The Multi-Omics Analysis of Lens Zonule Relaxation in The PACG Pathogenesis
Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and the control group, there are differentially expressed molecules in PACG patients with zonular laxity, and a potential mechanistic network can…
- Trial name
- NCT07539675
- Testing
- No Additional Experimental Intervention
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Zhongnan Hospital
Primary Angle-Closure Glaucoma
Vitreous Zonule in Primary Angle-Closure Glaucoma
This study aims to investigate the role of the vitreous zonule (VZ) in the pathogenesis of primary angle-closure glaucoma (PACG) and to explore the feasibility of three-dimensional ultrasound biomicroscopy (3D-UBM) for imaging…
- Trial name
- NCT07523139
- Where
- China
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Primary Angle-closure Glaucoma
Kahook Dual Blade Goniotomy in Chronic Primary Angle-Closure Glaucoma
This prospective randomized controlled trial, conducted by the Ophthalmology Department of Peking University People's Hospital, aims to compare the intraocular pressure (IOP)-lowering efficacy and safety of two surgical…
- Trial name
- NCT07517302
- Testing
- Kahook Dual Blade (KDB) goniotomy, phacoemulsification with intraocular lens implantation combined with goniosynechialysis
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Peking University People's Hospital
Acute Ocular Hypertension Glaucoma, Intraocular Hypertension
Effect of Infusion Warming on Mannitol Infusion Pain in Patients With Acute Ocular Hypertension
Acute ocular hypertension is a common ophthalmic emergency that often requires rapid reduction of intraocular pressure. Intravenous mannitol is widely used for this purpose, but infusion-related pain and local venous irritation…
- Conditions
- Acute Ocular Hypertension Glaucoma, Intraocular Hypertension, Primary Angle-Closure Glaucoma
- Trial name
- NCT07495449
- Testing
- Infusion Warming Device, Routine Non-Warmed Mannitol Infusion
- Where
- China
- Volunteers
- 142 people
- Sponsor
- Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong
Primary Angle Closure Glaucoma
Comparison of Phaco Surgery With Goniosynechialysis Versus Trabeculectomy in Glaucoma Treatment
The goal of this clinical trial is to learn whether phacoemulsification combined with goniosynechialysis (Phaco-GSL) is as effective and safe as trabeculectomy in treating patients with primary angle-closure glaucoma.
- Trial name
- NCT06952153
- Testing
- Phacoemulsification with Goniosynechialysis, Trabeculectomy with 5FU
- Where
- Vietnam
- Volunteers
- 82 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Primary Open Angle Glaucoma, Pseudoexfoliative Glaucoma
Advanced Glaucoma Progression Study
Glaucoma is one of the leading causes of blindness in the world. The key to prevention of visual loss from glaucoma is early detection of the disease or its progression and timely treatment.
- Conditions
- Primary Open Angle Glaucoma, Pseudoexfoliative Glaucoma, Chronic Angle Closure Glaucoma
- Trial name
- AGPS (NCT01742819)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of California, Los Angeles
Optic Neuropathy, NAION - Non-Arteritic Ischemic Optic Neuropathy
Clinical Study of FB1001 in Patients
This study is designed for single-center, open-label, dose escalation phase I trial to evaluate the safety and tolerability of a single/multiple intravitreal injection of FB1001 in patients with APACG(Acute Primary Angle-Closure…
- Conditions
- Optic Neuropathy, NAION - Non-Arteritic Ischemic Optic Neuropathy, APAC - Acute Primary Angle Closure, Glaucoma, Angle-Closure
- Trial name
- NCT06506305
- Testing
- FB1001
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Primary Angle-Closure Glaucoma
Liwan Eye Study: the Fourth Follow-up
Primary angle-closure glaucoma (PACG) is one of the major causes of blindness affecting more than 20 million patients worldwide.
- Trial name
- NCT06333470
- Testing
- Primary angle closure diseases
- Volunteers
- 600 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Primary Angle Closure Glaucoma
The Effect of Phacoemulsification on Intraocular Pressure in Primary Angle Closure Glaucoma (PACG) Patients At Phanat Nikhom Hospital, Chonburi Province
BACKGROUND: Primary angle closure glaucoma (PACG) is one of a leading cause of blindness worldwide including Thailand. This problem impact to the overall health of people and health care system.
- Trial name
- NCT06252246
- Testing
- Phacoemulsification machine
- Where
- Thailand
- Volunteers
- 121 people
- Sponsor
- Phanatnikhom Hospital
Primary Angle Closure Glaucoma
Correlation Between Angle Closure Glaucoma Data and Lens Zonule Status
The goal of this observational study is to discuss the correlation between primary angle-closure glaucoma and the state of the suspended ligament of the lens and the pathogenesis of PACG by measuring the biological data of…
- Trial name
- NCT06184620
- Where
- China
- Volunteers
- 263 people, healthy volunteers welcome
- Sponsor
- Guangfu Dang
Primary Angle Glaucoma Closure Suspect
Danish Angle Closure Prevention Trial
To determine whether primary angle closure suspects (PACS) in a Caucasian population benefit from prophylactic laser iridotomy.
- Trial name
- DAP (NCT06077253)
- Testing
- Iridotomy
- Where
- 5 sites in Denmark
- Volunteers
- 242 people
- Sponsor
- University of Aarhus
Glaucoma,Primary Open-Angle ,Primary Angle Closure
Comparison of Optical Coherence Tomography Angiography Microvascular Changes in Primary Open Angle and Primary Angle Closure Glaucoma
This work aims to study the peripapillary and macular microvascular changes in primary open angle and primary angle closure glaucoma using Optical Coherence Tomography Angiography (OCTA).
- Trial name
- NCT06000176
- Testing
- Optical coherence tomography angiography
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Omar Said
Primary Angle Glaucoma Closure Suspect
Superior vs Temporal Laser Peripheral Iridotomy in Primary Angle Closure Suspects (PACS)
Basic Study Design: Prospective, randomized, single-center, single-blinded study to compare dysphotopsias and pain recollection immediately 2 weeks, and 3 months after LPI in PACS patients who have a clear indication for…
- Trial name
- NCT04741919
- Testing
- Yag Laser peripheral Iridotomy
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Primary Angle Closure Glaucoma
Trabeculectomy Versus Peripheral Iridectomy Plus Goniotomy in Advanced PACG
A multicenter, parallel, open, non-inferior randomized controlled trial is conducted to compare the effectiveness and safety of trabeculectomy and peripheral iridectomy plus goniotomy (TVG) in the treatment of advanced primary…
- Trial name
- TVG (NCT05163951)
- Testing
- Trabeculectomy, SPI+GSL+GT
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Sun Yat-sen University
Glaucoma, Glaucoma, Open-Angle
Longitudinal Study on Glaucoma Surgery Using XEN® Gel Stent
To evaluate the safety and efficacy of the XEN® Gel Stent in mild to moderate glaucoma patients undergoing glaucoma surgery.
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Glaucoma, Angle-Closure, Glaucoma, Primary Open Angle
- Trial name
- NCT03151577
- Testing
- XEN® Gel Stent implantation
- Volunteers
- 150 people
- Sponsor
- Swiss Vision Network
Primary Angle Closure Glaucoma, Primary Angle Closure
Hydrus Microstent and Lens Extraction for the Treatment of Primary Angle-Closure Glaucoma
This study is a prospective evaluation of the Hydrus Microstent for the treatment of Primary Angle Closure (PAC) and Primary Angle Closure Glaucoma (PACG) with adjunctive cataract.
- Trial name
- NCT04622605
- Testing
- Trabecular bypass and Schlemm's canal stent
- Where
- Philippines
- Volunteers
- 31 people
- Sponsor
- Asian Eye Institute
Primary Angle Closure Glaucoma
Evaluation of Ocular Biometry in PACD With Two Swept Source Optical Coherence Tomography Devices
Purpose: To investigate agreement between 2 swept source OCT biometers, IOL M.aster700 and Anterion, in various ocular biometry and intraocular lens (IOL) calculations of primary angle-closure disease (PACD).
- Trial name
- NCT05052242
- Testing
- primary angle closure disease
- Where
- Thailand
- Volunteers
- 45 people
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand