Clinical trials: Primary Arthritis
Hip Osteoarthritis, Knee Osteoarthritis
Determining the Impact of a Physiotherapist-Led Primary Care Model for Hip and Knee Pain - A Pilot Trial
This is a pilot cluster randomized controlled trial to to evaluate the individual and health system impacts of implementing a new physiotherapist-led primary care model for hip and knee pain in Canada.
- Trial name
- NCT05736133
- Testing
- Physiotherapist-led primary care model for hip and knee pain, Usual physician-led primary care model for hip and knee pain
- Where
- Canada
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Jordan Miller, PT, PhD
Healthy Volunteers, Sjögren's Syndrome
A Study to Evaluate the Effects of ASP5502 in Healthy Adults and Adults With Primary Sjögren's Syndrome
Primary Sjögren's syndrome (pSS) is a condition when the body's immune system attacks glands that produce fluids, such as the tear and saliva glands. This leads to dry eyes and a dry mouth.
- Trial name
- NCT06544642
- Testing
- ASP5502
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Global Development, Inc.
Chronic Pain, Acute Pain
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary…
- Conditions
- Chronic Pain, Acute Pain, Post Operative Pain, Fibromyalgia, Primary
- Trial name
- NCT05754190
- Testing
- SOMA pain manager smartphone application
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Brown University
Primary Generalized (Osteo)Arthritis, Post-traumatic Arthrosis of Other Joints, Upper Arm
Simpliciti IDE Trial; Replacing the Humeral Head in Total Shoulder Arthroplasty
The purpose of this study is to demonstrate safety and efficacy of the Simpliciti Shoulder System in total shoulder arthroplasty.
- Trial name
- NCT01390038
- Testing
- Simpliciti™ Shoulder System
- Where
- 14 sites in United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Stryker Trauma and Extremities
Osteoarthritis, Hip
Femoral Remodeling Following Total Hip Arthroplasty With OMNI Apex Modular™ and OMNI Apex ARC™ Stem Compared to Competitive Designs
This study compares the change in bone density which occurs after hip replacement with different femoral stem devices.
- Trial name
- NCT01359540
- Testing
- OMNI Apex Modular™ Hip Device, OMNI Apex ARC™ Hip Device
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Spokane Joint Replacement Center
Chronic Pain, Osteoarthritis
Acupuncture Approaches for Chronic Pain
Chronic pain is a major public health problem that places many burdens on individuals, including impairment of physical and psychological functioning, lost productivity, and side effects of medications used to treat pain.
- Conditions
- Chronic Pain, Osteoarthritis, Neck Pain, Back Pain
- Trial name
- AADDOPT-2 (NCT02456727)
- Testing
- Group/Community Acupuncture, Individual Acupuncture
- Where
- United States
- Volunteers
- 779 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
Reducing Orthostatic Intolerance With Oral Rehydration in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients
We and others have shown that many younger patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have orthostatic intolerance (OI), i.e., they can't tolerate prolonged standing.
- Conditions
- Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Systemic Exertion Intolerance Disease (SEID), Postural Tachycardia Syndrome (POTS)
- Trial name
- NCT02854683
- Testing
- Normal Saline, Oral Rehydration Solution
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Sjogren's Syndrome
Ro60 Expression in Macrophages in Sjogren's Disease
Context: The Ro60 protein associates with YRNAs (or RNYs) to form the RoRNP complex, which regulates RNA surveillance and maturation.
- Trial name
- RoMioSS (NCT06324968)
- Testing
- Positive serology for anti-SSA
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Sjogren's Syndrome
Immune Profile of Saliva and Serum of Patients With Primary Sjögren´s Syndrome
Primary Sjögren's syndrome (pSS) is a chronic systemic inflammatory disease, which mainly affects the lacrimal and salivary glands, leading to sicca syndrome.
- Trial name
- pSS (NCT03711214)
- Testing
- Periodontal scaling
- Where
- 3 sites in Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Progression of Rheumatoid Arthritis, Osteoarthritis of Multiple Joints
To Examine Whether or Not the Primary Causes of OA or RA Might be Bone Alterations
Generally, osteoarthris (OA) is considered as primarily cartilage disease. However, as we and others have previously reported, a portion of OA might be caused primarily by bone alterations.
- Trial name
- NCT02327650
- Testing
- The examinations for bones in joints of OA and RA patients
- Where
- 2 sites in Japan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shinshu University
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Sjogren's Syndrome
The Functioning of Immune and Hormonal Systems in Patients With Sjogren's Syndrome and in Healthy Volunteers
This study aims to learn more about how the immune and hormonal systems function in patients with Sjogren's syndrome, a disease in which the immune system does not function properly.
- Trial name
- NCT00001953
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Diabetic Retinopathy, Macular Degeneration
Advancing Understanding of Transportation Options
This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa
- Trial name
- AUTO (NCT04141891)
- Testing
- Driving Decision Aid, Older Drivers Website
- Where
- 3 sites in United States
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Migraine Disorders, Pain
The Role of Cytokines and Regulatory T Lymphocytes in Migraine Pathophysiology.
Migraine is a frequent and debilitating neurologic disorder. It is more frequent in women, and more prevalent in patients with autoimmune and/or inflammatory diseases such as multiple sclerosis (MS), rheumatoid arthritis (RA)…
- Conditions
- Migraine Disorders, Pain, Autoimmune Diseases, Multiple Sclerosis
- Trial name
- SIIM (NCT06426316)
- Testing
- Blood test
- Where
- France
- Volunteers
- 396 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Patient Satisfaction, Hip Osteoarthritis
Dual Mobility Cup: Does it Improve Patient's Satisfaction After Total Hip Arthroplastry?
Although the success of total hip arthroplasty, many patients were dissatisfied postoperatively. Patient's reported outcome measures become of a great importance in assessment of the results after joint replacement.
- Trial name
- NCT04333316
- Testing
- large head, dual mobility cup
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Tanta University
Gout
Assessment of Primary Care Providers' Knowledge and Beliefs Regarding Gout Management
This is a questionnaire study aimed at learning about physicians' views on the treatment of Gout.
- Trial name
- NCT01151709
- Where
- United States
- Volunteers
- 838 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Osteoarthritis
Comparison of Anesthetic Techniques on Total Hip Arthroplasty
To compare analgesia and orthopedic rehabilitation milestones in patients receiving either spinal anesthesia (local anesthetic plus opioid) or general endotracheal anesthesia with lumbar plexus block.
- Trial name
- NCT01359865
- Testing
- Lumbar Plexus Block
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Osteoarthritis, Hip
Peri-Operative Testosterone Administration in Primary Total Hip Arthroplasty
It is often observed that patients following total hip replacement have a hard time with rehabilitation, as patients commonly lose muscle mass and strength around the surgical site.
- Trial name
- NCT06608914
- Testing
- Nandrolone decanoate, Saline
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- American Hip Institute
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Diabetes, Chronic Kidney Diseases
Benchtop NMR Spectroscopy for Assessment of Clinical Human Pathologies (BRANCH-P STUDY)
This research programme seeks to combine the resources of NHS primary care, with the leading spectroscopic work in low-magnetic fields of the Wilson Group (Nottingham Trent University) to demonstrate the potential for benchtop…
- Conditions
- Diabetes, Chronic Kidney Diseases, Cancer, Bowel Disease
- Trial name
- BRANCH-P (NCT05473325)
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Willows Health