Clinical trials: Primary Closure
Tongue Squamous Cell Carcinoma
Oncological Outcome of Contralateral Submental Artery Island Flap Versus Primary Closure in Tongue Squamous Cell Carcinoma
The purpose of this study is to compare the oncological and functional results of the contralateral submental flap with primary closure for reconstruction of tongue squamous cell carcinoma.
- Trial name
- NCT03440151
- Testing
- contralateral submental flap for tongue cancer defect, primary closure for tongue cancer defect
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Cairo University
Carotid Arteriosclerosis, Carotid Stenosis
Residual Stenosis and Restenosis Following Carotid Endarterectomy With Primary Closure, A Prospective Tracking Study
This prospective, multicenter observational study aims to evaluate the incidence, timing, and characteristics of residual and recurrent (restenosis) carotid artery stenosis following carotid endarterectomy (CEA) with primary…
- Conditions
- Carotid Arteriosclerosis, Carotid Stenosis, Brain Stroke
- Trial name
- RECEPT (NCT07057297)
- Where
- Czechia
- Volunteers
- 300 people
- Sponsor
- Charles University, Czech Republic
Cesarean Scar Defect (Isthmococele), Pelvic Pain
Single-Layer Versus Double-Layer Uterine Closure After Primary Cesarean Section
This study compares two surgical techniques for closing the uterus after cesarean section: single-layer versus double-layer closure.
- Conditions
- Cesarean Scar Defect (Isthmococele), Pelvic Pain, Spotting, Amenorrhea Secondary
- Trial name
- NCT07611331
- Testing
- Double-layer hysterorrhaphy at primary cesarean section, Single-layer hysterorrhaphy at primary cesarean section
- Where
- Tunisia
- Volunteers
- 384 people
- Sponsor
- Hédi Chaker Hospital
Primary Angle-Closure Glaucoma
The Multi-Omics Analysis of Lens Zonule Relaxation in The PACG Pathogenesis
Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and the control group, there are differentially expressed molecules in PACG patients with zonular laxity, and a potential mechanistic network can…
- Trial name
- NCT07539675
- Testing
- No Additional Experimental Intervention
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Zhongnan Hospital
Arthropathy of Knee
Analysis of Standard Versus Barbed Sutures in Primary Total Knee Arthroplasty.
The purpose of this prospective study is determine if barbed sutures are more efficient, have comparable complication rates, clinical outcomes, and cosmesis outcomes versus traditional knotted sutures when used in the closure of…
- Trial name
- NCT01320371
- Where
- 4 sites in United States
- Volunteers
- 363 people, healthy volunteers welcome
- Sponsor
- University of Utah
Glaucoma, Angle-Closure
Clinical Efficacy and Safety of Minimally Invasive Glaucoma Surgery on Primary Angle Closure Glaucoma
To evaluate the clinical efficacy (intraocular pressure reduction , success rate, the number of antiglaucoma medication) and safety of ab interno trabeculectomy (AIT) with Trabectome in Chinese PACG .
- Trial name
- NCT02964676
- Testing
- ab interno trabeculectomy with Trabectome, trabeculectomy
- Volunteers
- 246 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Migraine Headache, PFO - Patent Foramen Ovale
Migraine With Aura and Patent Foramen Ovale: Identification of Biomarkers to Select Patients In Whom Intervention Would Be Beneficial (MANET)
This is a multicenter prospective observational study aimed to asses whether a specific prothrombotic platelet phenotype can discern migraine patients with PFO (patent forame ovale) - related symptoms from patients with…
- Trial name
- MANET (NCT06046508)
- Testing
- blood samples collection
- Where
- 3 sites in Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centro Cardiologico Monzino
Appendicitis, Surgical Wound Infection
Primary Versus Delayed Wound Closure in Complicated Appendectomy (The HIEDI-Yemen Trial)
The goal of this clinical trial is to compare primary wound closure (PC) versus delayed primary closure (DPC) after standardized wound decontamination using the High-Efficiency Incision and Drainage with Irrigation (HIEDI)…
- Conditions
- Appendicitis, Surgical Wound Infection, Postoperative Complications, Wound Healing
- Trial name
- HIEDI-Yemen (NCT07688109)
- Testing
- Primary Closure with HIEDI, Delayed Primary Closure with HIEDI
- Where
- 3 sites in Yemen
- Volunteers
- 200 people
- Sponsor
- Sana'a University
Wound; Abdomen, Abdominal Wall
The Biomechanical Effects of Flaccid Paralysis Induced by Botulinum Toxin a After Damage Control Laparotomy
Damage control laparotomy (DCL) is a life saving maneuver used with success in trauma and acute general surgery patients. The technique involves source control of sepsis and hemorrhage with an abbreviated laparotomy.
- Trial name
- NCT01495962
- Testing
- Botulinum Toxin Type A
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Mayo Clinic
Rectal Cancer
Biological Mesh Closure of the Pelvic Floor After Extralevator Abdomino Perineal Resection for Rectal Cancer
Rationale: Approximately 800 abdominoperineal resections (APR) are performed for rectal cancer each year in the Netherlands. The extralevator approach (eAPR) reduces the rate of positive margins and improves oncological outcome…
- Trial name
- BIOPEX (NCT01927497)
- Testing
- Biological mesh assisted perineal closure, Primary perineal closure
- Where
- Netherlands
- Volunteers
- 104 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Total Knee Arthroplasty
Perfusion Assessment of Wound Closure Techniques in Primary Total Knee Arthroplasty
This study will assess which of the three most common methods of wound closure in primary total knee arthroplasty (staples, interrupted vertical mattress, or running subcuticular suture) provide the best wound vascular perfusion.
- Trial name
- NCT01924403
- Testing
- Staple Closure, Vertical Mattress Closure, Running Subcuticular Closure
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Wound Infection
A Randomized Trial of Ostomy Closure Techniques
Stoma closure has been associated with a high rate of surgical site infection (SSI). The rate for SSI following stoma closure has been noted to be 7-41%; a rate that is higher than expected for a clean-contaminated operative…
- Trial name
- NCT01713452
- Testing
- Purse string closure, Primary closure
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Minnesota
Primary Median Laparotomy
Multi-center Study to Evaluate the Safety and Efficacy of Aesculap MonoMax® for Abdominal Wall Closure
MonoMax will be used for a continuous all-layer (except skin) suture to close abdominal wall after midline incision. The primary objective of this trial is to demonstrate that the frequency of wound infection and the frequency of…
- Trial name
- ISSAAC (NCT00572507)
- Testing
- MonoMax®
- Where
- 4 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Aesculap AG
Glaucoma; Drugs
Efficacy of Tafluprost as an Adjunct to Medical Therapy for Residual Glaucoma After Trabeculectomy
A 6-month, parallel-group study of the safety and efficacy of tafluprostin for Chinese patients with posttrabeculectomy residual primary angle-closure glaucoma or posttrabeculectomy residual primary open angle glaucoma.
- Trial name
- NCT03595865
- Testing
- tafluprostin
- Volunteers
- 60 people
- Sponsor
- wangdabo
Pilonidal Sinus Disease, Sacrococcygeal Pilonidal Sinus
Primary Closure vs Open Technique for Pilonidal Sinus
The purpose of this randomized controlled trial is to compare two commonly used surgical techniques for the treatment of pilonidal sinus disease: excision with primary closure and excision with open (lay-open) technique.
- Conditions
- Pilonidal Sinus Disease, Sacrococcygeal Pilonidal Sinus, Chronic Infected Sinus Tract, Post-surgical Wound Healing
- Trial name
- NCT07311707
- Testing
- Primary Suturing of Surgical Wound, Open Surgical Wound Management
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Khyber Teaching Hospital
Migraine
Clopidogrel For the Prevention of New Onset Migraine Headache Following Transcatheter Closure of Atrial Septal Defects
The addition of clopidogrel on top of aspirin may reduce the occurrence of new-onset migraine headache episodes following transcatheter ASD closure.
- Trial name
- CANOA (NCT00799045)
- Testing
- Clopidogrel
- Where
- Canada
- Volunteers
- 220 people
- Sponsor
- Laval University
Primary Open-Angle Glaucoma, Primary Angle-Closure Glaucoma
Combined Phacoemulsification-Goniotomy in Primary Open-Angle and Primary Angle-Closure Glaucoma
This study evaluates whether combining cataract surgery (phacoemulsification) with incisional goniotomy effectively lowers intraocular pressure (IOP) and reduces the need for glaucoma medications in patients with coexisting…
- Conditions
- Primary Open-Angle Glaucoma, Primary Angle-Closure Glaucoma, Cataract
- Trial name
- NCT07821827
- Testing
- Combined Phacoemulsification and Goniotomy
- Volunteers
- 70 people
- Sponsor
- Assiut University
Glaucoma
IOP Pattern in Primary Angle Closure and Primary Angle Closure Glaucoma Patients, Before and After LPI
The purpose of the study is to determine the relationship of the intraocular pressure patterns recorded during 2 sessions using Triggerfish, before and after elective laser peripheral iridotomy in angle closure glaucoma patients
- Trial name
- NCT01906151
- Testing
- SENSIMED Triggerfish®
- Where
- France
- Sponsor
- Sensimed AG
PFO, Cognitive
Multimodal Brain Function in Migraine Patients With Patent Foramen Ovale
This investigator-initiated, single-center prospective study is designed to clarify how patent foramen ovale (PFO) relates to brain function abnormalities in patients with drug-refractory migraine with aura (MA), and whether…
- Conditions
- PFO, Cognitive, Cognitive Functions, Migraine
- Trial name
- NEURO-PFO (NCT07343154)
- Volunteers
- 45 people
- Sponsor
- Second Xiangya Hospital of Central South University
Foramen Ovale, Patent, Migraine
Effectiveness and Safety of Transcatheter Patent Foramen Ovale Closure for Migraine
The purpose of the study is to evaluate effectiveness and safety of transcatheter patent foramen ovale closure for migraine.
- Trial name
- EASTFORM (NCT02127294)
- Testing
- transcatheter patent foreman ovale closure
- Where
- China
- Volunteers
- 258 people
- Sponsor
- Yi Yang