Clinical trials: Primary Headache Disorder
Headache, Migraine
Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2
Before, during and after intravenous administration of PGE2 we score/measure headache, rCBF, blood flow in the middle cerebral artery and diameter of superficial temporal artery and correlate that to known pathophysiology of…
- Trial name
- NCT00374530
- Testing
- PGE2
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Headache, Migraine
Investigation of Vasodilation and Intensity of Headache Triggered by Glucagon Like Peptide-1 in Humans
Studying glucagon-like peptide-1 (GLP-1) induced vasodilatory effects on extra - and intracerebral arteries and headache in healthy volunteers and migraine patients without aura.
- Trial name
- NCT04232605
- Testing
- GLP-1 peptide
- Where
- Denmark
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine
The Effect of Sumatriptan and Placebo on CGRP Induced Headache
To develop a pragmatic migraine model the investigators will induce headache in healthy volunteers and in patients with migraine without aura with aCalcitonine Gene Related Peptide (CGRP).
- Trial name
- NCT03542357
- Testing
- Calcitonin Gene Related Peptide, Sumatriptan 50 mg
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine Headache, PFO - Patent Foramen Ovale
Migraine With Aura and Patent Foramen Ovale: Identification of Biomarkers to Select Patients In Whom Intervention Would Be Beneficial (MANET)
This is a multicenter prospective observational study aimed to asses whether a specific prothrombotic platelet phenotype can discern migraine patients with PFO (patent forame ovale) - related symptoms from patients with…
- Trial name
- MANET (NCT06046508)
- Testing
- blood samples collection
- Where
- 3 sites in Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centro Cardiologico Monzino
Cluster Headache
Role of Specific microRNAs in Cluster Headache
Cluster headache (CH) is a primary headache included in the trigeminal autonomic cephalalgias (TACs) according to the International Calssification of Headache Disorder, Third Edition.
- Trial name
- 5*1000 (NCT06503328)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Migraine
Effect of Single Oral Doses of Lasmiditan When Coadministered With Single Oral Doses of Sumatriptan in Healthy Participants
This is a randomized, double-blind, three-period, cross-over study to investigate the effect of sumatriptan (Imitrex) 100 mg on the pharmacodynamics and pharmacokinetics of lasmiditan 200 mg.
- Trial name
- NCT03076970
- Testing
- lasmiditan 200 mg, Sumatriptan
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Migraine Headache
Bioavailability of DHE Administered by I123 POD Device, IV Injection, and Migranal Nasal Spray in Healthy Adults
A Phase I clinical trial to compare the bioavailability of dihydroergotamine mesylate (DHE) following a single dose administration of INP104 (DHE administered by I123 Precision Olfactory Delivery (POD) Device Nasal Spray) to that…
- Trial name
- NCT03401346
- Testing
- INP104, Dihydroergotamine Mesylate (DHE), Migranal Nasal Spray
- Where
- Australia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Impel Pharmaceuticals
Migraine, Headache
The Role of CGRPand Nociceptin in Migraine
The release of the neuropeptide calcitonin gene-related peptide (CGRP) is thought to play a causative role in migraine. Nociceptin immunoreactivity and ORL-1 mRNA have been detected in human trigeminal ganglia where it was…
- Trial name
- NCT00155129
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Migraine, Upper Extremity
Scapular Muscle Activation and Shoulder Performance in Migraine
Migraine is a significant health problem due to its high prevalence and substantial contribution to disability. Individuals with migraine have been reported to exhibit myofascial trigger points, increased pain sensitivity, and…
- Conditions
- Migraine, Upper Extremity, Muscle Activity
- Trial name
- NCT07656922
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Migraine, Migraine Disease
A Prospective, Open-Label Study Evaluating the Effectiveness of Gepants for Acute Treatment of Migraine in the Emergency Department
Prospective, single-site, open-label, non-controlled pilot study consisting of two parallel trials. Participants will receive rimegepant or zavegepant for acute migraine treatment during a single Emergency Department visit, with…
- Conditions
- Migraine, Migraine Disease, Migraine in Adults, Migraine Headache
- Trial name
- NCT07667621
- Testing
- Rimegepant, Zavegepant
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Familial Hemiplegic Migraine, Migraine With Aura
Calcitonin Gene-related Peptide in Familial Hemiplegic Migraine (FHM) and Migraine With Aura (MA)
The aim of the present study is to explore the importance of migraine phenotype on the headache/migraine responses after CGRP in FHM-patients, MA-patients and healthy volunteers.
- Conditions
- Familial Hemiplegic Migraine, Migraine With Aura, Healthy
- Trial name
- CGRP-2008 (NCT00687947)
- Testing
- CGRP
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine Disorders
Resting-state Functional Connectivity Changes During Migraine Treatment
The purpose of this study is to determine whether reduced frequency of migraine attacks are associated with signal alternation and connectivity of cerebral cortex.
- Trial name
- NCT03484871
- Where
- South Korea
- Volunteers
- healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Migraine
Retinal Nerve Fiber Layer Thickness Changes in Migraine: A Meta-Analysis of Case-control Studies
Optical coherence tomography (OCT) is a non-invasive retinal imaging technology that can provide high-resolution cross-sectional images of the peripapillary retinal nerve fiber layer (RNFL) and measure its thickness.
- Trial name
- NCT02196532
- Testing
- Device: Optical coherence tomography
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yifan Feng
Primary Headache Disorder
Primary Headache and Psychological Factors, Mental Functioning and Attachment Modalities.
The World Health Organization (WHO) ranks headache among the top 20 causes of disability in the world. Primary headaches (with no known organic cause) account for 90% of these conditions.
- Trial name
- CEPRIVA (NCT03499392)
- Testing
- psychological tests
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon