Clinical trials: Primary Headache Disorder, open to volunteers
Cluster Headache
Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Cluster Headache
Cluster headache is a primary headache condition characterized by clusters of one-sided, high-intensity pain attacks. The headache may be episodic or chronic. Treatment options are limited and their effects unsatisfactory.
- Trial name
- BASIC (NCT03944876)
- Testing
- Botulinum toxin type A
- Where
- 5 sites in Germany, Italy and 3 more
- Volunteers
- 112 people
- Sponsor
- Norwegian University of Science and Technology
Migraine
The Effects of Physiotherapy in Migraine
The aim of this study is to investigate the effects of a physiotherapy program including cervical muscle training and transcutaneous auricular vagus nerve stimulation (taVNS) on pain, functional status, quality of life…
- Trial name
- NCT07657377
- Testing
- Physiotherapy program
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ankara Yildirim Beyazıt University
Migraine, Traumatic Brain Injury
Efficacy of Xeomin for Migraines in Patients With Traumatic Brain Injuries vs. Anomalous Health Incidents
This cohort study aims to compare the efficacy of Xeomin injections for migraine management in patients with a history of Traumatic Brain Injury (TBI) versus those with a history of Anomalous Health Incidents (AHI).
- Conditions
- Migraine, Traumatic Brain Injury, Anomalous Health Incidents
- Trial name
- NCT07267819
- Testing
- Xeomin (incobotulinumtoxinA)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Uniformed Services University of the Health Sciences
Migraine Disorders
Treatment of Episodic Migraine With AURICular Neuromodulation
Migraine is a ubiquitous pathology affecting approximately 1 billion individuals and being the leading cause of morbidity worldwide before the age of 50.
- Trial name
- MENAURIC (NCT06623188)
- Testing
- Auricular neuromodulation
- Where
- 3 sites in France
- Volunteers
- 106 people
- Sponsor
- Hôpital Européen Marseille
Headache Disorders, Dizziness
Headache Ear Auditory Dizziness Sinus (HEADS) Registry
The Headache, Ear, Auditory, Dizziness, Sinus (HEADS) Registry is a study over time of individuals living in the United States who experience sinus, vestibular, auditory, and headache symptoms.
- Conditions
- Headache Disorders, Dizziness, Vestibular Diseases, Sinus Disease
- Trial name
- HEADS (NCT07754266)
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Association of Migraine Disorders
Acute Headache, Migraine
High- vs Standard-Dose Intravenous Magnesium for Acute Headache
Headache is one of the most common reasons for consultation in emergency departments and represents a significant cause of disability, particularly in patients with migraine and other primary headache disorders.
- Conditions
- Acute Headache, Migraine, Tension-type Headache, Cluster Headache
- Trial name
- MAGHEAD (NCT07779486)
- Testing
- Magnesium Sulfate 2 grams, Magnesium Sulfate 4 G, Paracetamol 1 g
- Where
- Tunisia
- Volunteers
- 300 people
- Sponsor
- University of Monastir
Myalgia, Muscle Pain
Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin
The main aim of the presented project will be to examine the concentration of selected receptors (CB1, CB2, TRPV-1) showing affinity for binding to cannabidol (CBD) and cannabinol (CBN) in blood samples collected from people with…
- Conditions
- Myalgia, Muscle Pain, Orofacial Pain, Headache, Tension
- Trial name
- NCT06405646
- Testing
- Blood CB1, CB2, TRPV-1 concentration measurement
- Where
- Poland
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Migraine Disease, Patent Foramen Ovale
Migraine Headaches Elimination With Patent Foramen Ovale-Directed Therapy
Migraine is a common and often disabling condition, but its exact causes are not fully understood. Some people with migraines have a small opening in the heart wall called a patent foramen ovale (PFO).
- Trial name
- COMFORT-PFO (NCT07629635)
- Testing
- Prasugrel 5mg, Transcatheter Closure of Patent Foramen Ovale
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Columbia University
COVID-19, Long COVID
Effectiveness of Transcranial Direct Current in Patients With Persistent COVID-19 With Headaches and Chronic Pain.
This study aims to verify the efficacy/effectiveness of treatment with transcranial direct current stimulation (TDCS) in patients with Long Covid who experience headaches, migraines, and chronic pain, such as arthralgia and…
- Conditions
- COVID-19, Long COVID, Long Covid19, SARS CoV 2 Infection
- Trial name
- NCT05780450
- Testing
- Transcranial Direct Current Therapy (tDCS)
- Where
- 2 sites in Spain
- Volunteers
- 87 people
- Sponsor
- Fundación Universidad Católica de Valencia San Vicente Mártir
Migraine, Alexithymia
Studio TIARA: Alessitimia ed Emicrania Cronica
The aim of this observational, cross-sectional study is to investigate the relationship between alexithymia and migraine frequency (considering alexithymia a condition that can influence the severity of the clinical phenotype of…
- Trial name
- TIARA (NCT06891053)
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Azienda Sanitaria Locale di Alessandria
MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)
This is a parallel arm non-randomized dose-escalation, open-label basket exploratory phase 1 clinical trial where Mitochondrial encephalopathy, lactic acidosis, stroke-like episodes (MELAS) and Leber's hereditary optic…
- Trial name
- NCT06792500
- Testing
- Glycerol Tributyrate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- George Washington University
Pregnancy, Migraine
External Trigeminal Nerve Stimulation for Migraine Treatment in Pregnancy
This online registry aims to understand the potential benefits and safety of external trigeminal nerve stimulation for the treatment of migraine in pregnant women.
- Conditions
- Pregnancy, Migraine, Headache, Postpartum
- Trial name
- NCT06788977
- Testing
- external Trigeminal Nerve Stimulation
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- Cefaly Technology
Chronic Migraine
Prophylactic Treatment With Atorvastatin for Chronic Migraine (ChronicStatinMig)
The main objective of this study is to see whether the favorable preventative effect of Atorvastatin 40mg per day in episodic migraine, that was found previously in three smaller randomized controlled cross-over studies, can be…
- Trial name
- NCT06485336
- Testing
- Atorvastatin 40mg
- Where
- 6 sites in Norway
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Migraine
Chronology and Sequence of Premonitory Symptoms
The purpose of this study is to prospectively investigate the temporal sequence of premonitory symptoms across multiple migraine attacks.
- Trial name
- CHRONOpS (NCT07681466)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Roma La Sapienza
Migraine
Substance P-Induced Migraine Attacks Without Aura
Substance P is a neuropeptide implicated in the pathogenesis of headache. This study investigates whether its administration can trigger migraine attacks in individuals with migraine without aura.
- Trial name
- NCT06959004
- Testing
- Substance P
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
Migraine With Aura
Acid-Sensing Ion Channel and Migraine Disease Proof of Concept Study on the Efficacy of Amiloride in the Prophylaxis of Migraine Aura
Recent data suggest involvement of Acid-Sensing Ion Channel channels in the pathophysiology of migraine making these channels a therapeutic target of migraine disease.
- Trial name
- APAM (NCT04063540)
- Testing
- Amiloride
- Where
- 5 sites in France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Chronic Migraine Headache
Low-Intensity Focused Ultrasound Targeting the Dorsolateral Prefrontal Cortex for Preventive Treatment of Chronic Migraine
Chronic migraine is a disabling neurological disorder characterized by frequent headache attacks and significant impairment of quality of life.
- Trial name
- NCT07857109
- Testing
- Low-Intensity Focused Ultrasound Stimulation
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Chinese PLA General Hospital
Migraine
Coping Skills for Migraine: A 6-Month Program
This study aimed to investigate the effects of client-centered coping skills training on pain, quality of life, disability level, and coping skills in individuals with migraine over a 6-month follow-up period.
- Trial name
- NCT07163559
- Testing
- coping skills training
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hacettepe University
Migraine With Aura, Migraine Aura
Induction of Migraine Attacks With Aura Using Pituitary Adenylate Cyclase Activating Polypeptide-38
Pituitary Adenylate Cyclase Activating Polypeptide-38 (PACAP-38) is a key neuropeptide in migraine pathophysiology and treatment.
- Trial name
- NCT07342296
- Testing
- Pituitary Adenylate Cyclase Activating Polypeptide-38 (PACAP-38)
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
Migraine Disorder, Low Back Pain
Sleep Hygiene Education to Improve Sleep in Chronic Migraine and Back Pain
The goal of this clinical trial is to learn whether sleep hygiene education can improve sleep quality and reduce pain in adults with migraine and/or chronic lower back pain.
- Conditions
- Migraine Disorder, Low Back Pain, Chronic Pain, Sleep Disorder (Disorder)
- Trial name
- NCT07425964
- Testing
- Sleep Hygiene Education
- Volunteers
- 100 people
- Sponsor
- Aalborg University