Clinical trials: Primary Headache Disorders
Migraine, Migraine With Aura
A Study of the PK and Safety of Single Doses of STS101, DHE Injection and Nasal Spray in Healthy Subjects
Single-center, single-dose, open-label, 5-period crossover (in each part), pharmacokinetic and safety study.
- Conditions
- Migraine, Migraine With Aura, Migraine Without Aura
- Trial name
- NCT05337254
- Testing
- Dihydroergotamine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Satsuma Pharmaceuticals, Inc.
Headache Disorders, Primary, Migraine
Trigeminal Brainstem Mapping
To what extent the somatotopy of the 3 branches of the trigeminal nerve (V1,V2,V3) as well as the greater occipital nerve (GON) in the brainstem but also in the thalamus and the insula can be mapped using functional imaging and…
- Trial name
- NCT03999060
- Testing
- Electric Current Stimulation
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Headache, Migraine
Acetazolamide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow
In this study the investigators will research the hypothesis that the drug Acetazolamide induce headache and dilation of cerebral arteries and increase the cerebral blood flow in the areas of the brain supplied by these arteries.
- Trial name
- NCT01750723
- Testing
- Acetazolamide
- Where
- 2 sites in Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine Disorders
Trigeminal Brainstem Mapping 2: Higher Cortical Strucureas as Well as Subnuclei of the Spinal Trigeminal Nucleus
In previous studies clustering of the three branches of the trigeminal nerve in brainstem were shown, cerebellum and periaqueductal gray.
- Trial name
- NCT06535880
- Testing
- Electric Current Stimulation
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Headache, Migraine
The Effect of PACAP27 on the Extra- and Intracerebral Arteries Assessed by Magnetic Resonance Angiography (MRA) on Healthy Volunteers
Studying Pituitary adenylate cyclase-activating peptide 27 (PACAP27) effects on extra- and intracerebral arteries assessed by MRA on healthy volunteers.
- Trial name
- NCT03560024
- Testing
- PACAP27
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine
Human Electrophysiological Model to Quantify the CGRP-related Axon Reflex of Trigeminal Afferents
The proposed project aims at establishing Calcitonin gene-related peptide (CGRP)-Related Axon Reflex of Trigeminal Afferents as a neurophysiological biomarker for migraine.
- Trial name
- MiPro-CGRP (NCT04796766)
- Testing
- High frequency stimulation (HFS), Low-frequency sinusoidal transcutaneous stimulation (sLFS)
- Where
- Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Migraine, Vestibular Migraine
Analysis of Vestibular Compensation Following Clinical Intervention for Vestibular Schwannoma
Multiple sensory cues are typically generated by discrete events, and while they do not reach the cerebrum simultaneously, the brain can bind them temporally if they are interpreted as corresponding to a single event.
- Conditions
- Migraine, Vestibular Migraine, Vestibular Schwannoma, Motion Sickness
- Trial name
- NCT04196933
- Testing
- Temporal Binding Adaptation - PSS training, Temporal Binding Adaptation - PSS adaptation with VI stimulation, Chronic Motion-modulated Stimulation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Cerebral Microangiopathy, CADASIL
Impact of tDCS on Cerebral Autoregulation
The aim of the study is to investigate whether there is a polarity-specific influence of tDCS on cerebral vasomotor reactivity monitored by transcranial doppler sonography.
- Conditions
- Cerebral Microangiopathy, CADASIL, Migraine With Aura, ICA Stenosis
- Trial name
- NCT01865604
- Testing
- Anodal tDCS, Cathodal tDCS
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Migraine
BIOmarkers of MIGraine: a Proof of Concept Study Based on the Stratification of Responders to CGRP Monoclonal Antibodies
Migraine is the 2nd most disabling neurological disease. It affects 14.7% of the population (children and adults) of whom 80% are female. In the European Union, the total annual cost of migraine is of 111 billion euros.
- Trial name
- BIOMIGA (NCT04503083)
- Where
- 3 sites in Germany, Italy and 1 more
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Migraine, Chronic Headache
Does Topiramate Adjust the Excitability of the Brain in Migraine Sufferers?
The purpose of the study is to determine by the use of non-invasive magnetic stimulation if the medication Topiramate adjusts the excitability of the migraine sufferer's brain.
- Trial name
- NCT00286923
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Emerald City Headache Organization
Tension-Type Headache
Muscle Strength in Shoulder and Neck Muscles in Tension Type Headache Patients. Effect of Specific Strength Training
Background: Tension Type Headache (TTH) is highly frequent and is of great socio-economic importance. Andersen et al. 2008 has shown that maximal muscle strength is reduced in women with trapezius myalgia.
- Trial name
- NCT02984826
- Testing
- Strength training, Ergonomic and posture
- Where
- Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Healthy Volunteers, Headache, Migraine, Hemodynamics, VIP, SPECT, Ultrasound
Experimental Headache Induced by Vasoactive Intestinal Polypeptide
We hypothesized that infusion of VIP may induce headache in healthy subjects and that VIP induced headache may be associated with dilatation of intra- and extracerebral blood vessels.
- Trial name
- NCT00255320
- Testing
- VIP
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Reversible Cerebral Vasoconstriction Syndrome
Triggers And Risk Factors to Develop a Reversible Cerebral Vasoconstriction Syndrome
This study will be the first to evaluate the role played by potential precipitating factors and risk factors in Reversible Cerebral Vasoconstriction Syndrome (RCVS) through of prospective selection of carefully characterised…
- Trial name
- TARDIS (NCT04179383)
- Testing
- Constitution of a biobank
- Where
- France
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Migraine, Obesity
Diet and Migraine Study
The purpose of this study is to look at two different diets (a low carbohydrate diet and a low fat diet) for migraine prevention in overweight or obese persons with migraine.
- Trial name
- NCT01859052
- Testing
- Low carbohydrate diet, Low calorie low fat diet, AHA diet recommendations
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Primary Headache Disorder
Primary Headache and Psychological Factors, Mental Functioning and Attachment Modalities.
The World Health Organization (WHO) ranks headache among the top 20 causes of disability in the world. Primary headaches (with no known organic cause) account for 90% of these conditions.
- Trial name
- CEPRIVA (NCT03499392)
- Testing
- psychological tests
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Migraine, Epilepsy
High-field MR Imaging in Migraine, Visual Snow and Epilepsy
In this project, the aim is to recruit patients with drug resistant epilepsy and those suffering from migraine. Interestingly, patients suffering from epilepsy are also more often reporting to suffer from migraine.
- Conditions
- Migraine, Epilepsy, Visual Snow Syndrome
- Trial name
- NCT05524493
- Testing
- Structural MRI, Quantitative MRI, Diffusion MRI
- Where
- 2 sites in Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Headache Disorders
Assessing the Diagnostic Accuracy of an On-line Questionnaire for Diagnosis of Primary Headache Disorders
Purpose of the study is to assess the diagnostic accuracy of an on- line questionnaire in comparison to a semi-structured interview administered by a trained interviewer.
- Trial name
- NCT03304886
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Stanford University
Headache, Migraine
The Effect of Adenosine on Cranial Hemodynamic, Headache and Migraine Induction Properties.
Adenosine is a nucleoside that plays a role in both vascular and nociceptive systems, and it has been proposed that adenosine may cause headache in particularly sensitive subjects.
- Trial name
- NCT04577443
- Testing
- Adenosine, Saline
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine Headache
A Double-Blind Placebo-Controlled Trial of Rozerem in Migraine Headaches
To study the effect of Rozerem, a high affinity MT1 and MT2, low affinity 5-HT2B receptor agonist used for insomnia, as a migraine prophylactic agent.
- Trial name
- NCT00391755
- Testing
- ramelteon
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Charlottesville Neuroscience
Migraine, Migraine Headache
Migraine Attack Pain Phase Prediction Study
The study of the ability to predict pain in a migraine attack, through premonitory symptoms and through an ambulatory monitoring device through real-time recording of hemodynamic variables, is one of the strategic lines of…
- Conditions
- Migraine, Migraine Headache, Migraine Disorders, Migraine Without Aura
- Trial name
- PREDI-CRISIS (NCT06459635)
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa