Clinical trials: Primary Headache Disorders
Migraine
Biomarker and Genetic Predictors of Erenumab Treatment Response
To explore the relationship between clinical response to erenumab and genetic biomarkers
- Trial name
- INTERROGATE (NCT04265755)
- Testing
- Erenumab
- Where
- 2 sites in Denmark, Iceland
- Volunteers
- 1,406 people
- Sponsor
- Amgen
Migraine
Bilateral Middle Meningeal Artery Lidocaine Infusion for Chronic Debilitating Migraines
The main purpose of this study is to evaluate the effectiveness of a new treatment in improving chronic migraine symptoms. This treatment involves a targeted lidocaine infusion into blood vessels in the skull to numb pain…
- Trial name
- NCT07061847
- Testing
- Lidocaine (drug), Lidocaine Procedure
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwell Health
Migraine
A Study Lasmiditan (LY573144) in a Single Migraine Attack in Japanese Participants With Migraine
This study will assess the efficacy and safety of lasmiditan in the acute treatment of a migraine attack in Japanese adult participants with or without aura.
- Trial name
- MONONOFU (NCT03962738)
- Testing
- Lasmiditan
- Where
- 34 sites in Japan
- Volunteers
- 846 people
- Sponsor
- Eli Lilly and Company
Migraine, Cluster Headache
Intranasal Cooling for Cluster Headache and Migraine
This study will be looking at the clinical efficacy of using a intranasal evaporative cooling device in providing relief of the symptoms of migraine and cluster headache.
- Trial name
- COOLHEAD (NCT01898455)
- Testing
- RhinoChill intranasal cooling
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Cumbria Partnership NHS Foundation Trust
Migraine, Episodic Migraine
Real-world Prospective Study on the Use of Anti-CGRP Drugs in Migraine
The goal of this observational study is to evaluate clinical differences in patients who received preventive treatment with medication targeting calcitonin gene-related peptide (CGRP) or its receptor: monoclonal antibodies…
- Conditions
- Migraine, Episodic Migraine, Chronic Migraine, Headache
- Trial name
- EUREkA (NCT07159750)
- Testing
- CGRP antibody or gepant
- Where
- 26 sites in United States, Argentina and 11 more
- Volunteers
- 700 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Migraine
Investigation of Functional Brain Features in Women with Migraine
This study aims to investigate whether the functional alterations in the brain of individuals with migraine appear before the peripheral vascular changes.
- Trial name
- NCT06470958
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine
AVPI Migraine Study
The study is designed as a multicenter, double-blind, randomized, sham-controlled trial to assess the safety and effectiveness of the Nocira AVPI Device for the acute treatment of migraine.
- Trial name
- NC06 (NCT05537818)
- Testing
- AVPI Device
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Nocira, LLC
Headache Disorders, Primary, Headache, Cervicogenic
Effect of Ultrasound-Guided Dry Needling Targeting Rectus Capitus Posterior Major on Individuals With Headaches
Headaches such as tension-type, migraine, and cervicogenic (neck-related) headaches are among the most common and disabling conditions worldwide.
- Trial name
- NCT07309874
- Testing
- Dry needling
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Texas Tech University Health Sciences Center
Migraine
Migraine--Investigational Treatment of Migraine With Noninvasive Brain Stimulation. (tDCS- Migraine)
The purpose of this study is to determine whether a painless and noninvasive procedure called Transcranial Direct Current Stimulation (tDCS) can be an effective therapy for the treatment of migraine and migraine-associated pain.
- Trial name
- NCT00521196
- Testing
- DC Stimulator (Transcranial Direct Current Stimulator)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Beth Israel Deaconess Medical Center
Migraine
Evaluation of MIG-SPRAY Treatment on Migraine
The goal of this clinical trial is to evaluate the real-world tolerability of the MIG-SPRAY device in adults aged 18-55 diagnosed with migraine (according to nternational Classification of Headache Disorders 3rd edition, code…
- Trial name
- MIG-S (NCT07100496)
- Testing
- MIG-SPRAY
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Clermont-Ferrand
Migraine Disorders, Chronic Migraine
Searching for Novel Biological Phenotypes in Migraine Patients Resistant to Treatments
The investigators aim to define the neurofunctional phenotype of migraine patients who did not respond to at least 3 preventive treatments, including monoclonal antibodies (mAbs) targeting calcitonin gene-related peptide (CGRP)…
- Conditions
- Migraine Disorders, Chronic Migraine, Episodic Migraine
- Trial name
- SPHERA_WP1_2 (NCT06562413)
- Testing
- MAbs
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Migraine Disorders
Transcutaneous Pulsed Radiofrequency in Migraine
The aim of the investigator is to compare the efficacy of greater occipital nerve block and transcutaneous pulsed radiofrequency treatment in migraine.
- Trial name
- NCT05499689
- Testing
- Bupivacaine Hydrochloride, Transcutaneous pulsed radiofrequency qurrent
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Diskapi Teaching and Research Hospital
Migraine, Headache
Registry for Migraine - Structural and Functional MRI Before and After Erenumab Treatment
This study aims to investigate structural and functional cerebral changes using magnetic resonance imaging before and after treatment with erenumab in patients with migraine.
- Trial name
- REFORM (NCT04674020)
- Testing
- Erenumab
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Danish Headache Center
Chronic Cluster Headache
Efficacy of Modified Atkins Ketogenic Diet in Chronic Cluster Headache: a Prospective Case Series
Atkins diet is a nutritional regimen characterized by ad libitum protein and fat intake, but carbohydrate restriction. It is followed by millions of people around the word as a life-style, but in the last years was proposed as a…
- Trial name
- CCHD (NCT03244735)
- Testing
- Atkins diet
- Where
- Italy
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Migraine
Chronic Pain and Conditioned Pain Modulation After on Line-behavioral Approach
Chronic pain is a disabling condition associated with progressive changes and decline in psychological wellbeing. According with a modern conceptualization, pain has to be considered a biopsychosocial disorder where biological…
- Trial name
- Be-Home-Pain (NCT04859374)
- Testing
- Mindfullness, treatment as usual (TAU) (pharmacological)
- Volunteers
- 35 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Migraine
Music and Imagery for Veterans With Migraine Headache
The purpose of this study is to determine feasibility and acceptability of telehealth music imagery for migraine (Aim 1) and to explore whether there are clinically meaningful changes in headache frequency and associated…
- Trial name
- IMAGINE (NCT06440876)
- Testing
- Music and Imagery
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Richard L. Roudebush VA Medical Center
Migraine
Study to Test Rizatriptan in the Early Treatment of Acute Migraine (0462-081)
The purpose of this study is to test the effectiveness of rizatriptan benzoate in the early treatment of an acute migraine attack.
- Trial name
- NCT00516737
- Testing
- Comparator: rizatriptan benzoate
- Volunteers
- 207 people
- Sponsor
- Organon and Co
Migraine Disorders, Migraine With Aura
The FreMRI Study: Advanced MRI on Migraine Patients Treated With Fremanezumab
The goal of this open-label, single-blind, controlled-trial is to evaluate brain changes evaluated with diffusion Magnetic Resonance Imaging (MRI) and functional MRI in patients with high-frequency episodic migraine and chronic…
- Conditions
- Migraine Disorders, Migraine With Aura, Migraine Without Aura, Brain Diseases
- Trial name
- FreMRI (NCT06244823)
- Testing
- Fremanezumab Prefilled Syringe
- Where
- Spain
- Volunteers
- 87 people
- Sponsor
- Hospital Clínico Universitario de Valladolid
Migraine
Topiramate, Amitriptyline Monotherapy and Combination Therapy in Migraine Prophylaxis
The goal of this clinical trial is to compare the efficacy and safety of Topiramate, Amitriptyline Monotherapy and Combination Therapy in Migraine Prophylaxis in outddor migraine patients attending headache clinic.
- Trial name
- NCT05759845
- Testing
- Topiramate 25Mg Tab, Amitriptyline 25 Mg Oral Tablet, topiramate 25mg plus amitriptyline 25mg
- Where
- Bangladesh
- Volunteers
- 150 people
- Sponsor
- Dr. Reaz Mahmud
Patent Foramen Ovale
Internal Microstructure of Patent Foramen Ovale Related to Stroke
This study aims to (1) investigate the internal microstructure of patent foramen ovale related to cryptogenic stroke, transient ischemic attack or migraine and determine the effectiveness of transcatheter closure in these…
- Trial name
- IMPORT (NCT04686253)
- Testing
- not appliable
- Where
- 2 sites in China
- Volunteers
- 1,200 people
- Sponsor
- China National Center for Cardiovascular Diseases
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