Clinical trials: Primary Immune Regulatory Disorder
Antiphospholipid Syndrome (APS)
Effect of Telitacicept on Antibody Titers in Primary APS Patients
The purpose of this study is to evaluate the regulatory effect of Telitacicept on antibody titers in primary antiphospholipid syndrome patients carrying high-risk antiphospholipid antibody profiles.
- Trial name
- NCT06315530
- Testing
- Telitacicept+SOC, SOC
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Glomerulonephritis, IGA
Role of Regulatory T Cells in Pathogenesis of Primary IgA Nephropathy
Along structural IgA abnormalities, hyperproduction of IgA is thought to play a role in the pathogenesis of primary IgA nephropathy.
- Trial name
- NCT00521508
- Testing
- gene transcription and cytometry
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Antiphospholipid Syndrome (APS)
Effect of Belimumab on Antibody Titers in Primary APS Patients
The purpose of this study is to evaluate the regulatory effect of Belimumab on the antiphospholipid antibody (aPL) as well as to observe related past and new clinical events in primary antiphospholipid syndrome patients.
- Trial name
- NCT06747312
- Testing
- Belimumab+SOC, SOC
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Migraine Disorders, Pain
The Role of Cytokines and Regulatory T Lymphocytes in Migraine Pathophysiology.
Migraine is a frequent and debilitating neurologic disorder. It is more frequent in women, and more prevalent in patients with autoimmune and/or inflammatory diseases such as multiple sclerosis (MS), rheumatoid arthritis (RA)…
- Conditions
- Migraine Disorders, Pain, Autoimmune Diseases, Multiple Sclerosis
- Trial name
- SIIM (NCT06426316)
- Testing
- Blood test
- Where
- France
- Volunteers
- 396 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Ebola Virus Disease, Marburg Virus Disease
Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults
Primary Objective: To evaluate the safety and tolerability of cAd3-EBO-S and cAd3 Marburg vaccines when administered Intramuscular (IM) at a dose of 1 x 10^11 particle units (PU) to healthy adults.
- Trial name
- NCT04723602
- Testing
- cAd3-Marburg, cAd3-EBO-S
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Chronic Migraine
Suppressive Functions of Regulatory T Cells in Migraine
Migraine is a frequent, disabling condition, of great social and economical impact worldwide. This condition is more frequent in women and subjects with autoimmune and/or inflammatory diseases.
- Trial name
- SIIM-reg (NCT07067112)
- Testing
- Blood sampling, questionnaire and phone call
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand