Clinical trials: Primary Knee Arthroplasty
Osteoarthritis, Knee, Total Knee Arthroplasty
Oral Fluid vs IV Fluid After Primary TKA
The goal of this study is to compared efficacy of oral fluid and intravenous fluid after primary unilateral total knee arthroplasty.
- Conditions
- Osteoarthritis, Knee, Total Knee Arthroplasty, Oral Fluid Replacement
- Trial name
- NCT06288815
- Testing
- Oral fluid, IV fluid
- Where
- Thailand
- Volunteers
- 130 people
- Sponsor
- Thammasat University Hospital
Total Knee Replacement, Genicular Nerve Block
Genicular and Anterior Femoral Cutaneous Nerve Blocks for Total Knee Arthroplasty
The goal of this randomized controlled trial is to examine if there is a relationship between the addition of the genicular nerve block and anterior femoral cutaneous nerve block in providing analgesia and the use of oral and…
- Conditions
- Total Knee Replacement, Genicular Nerve Block, Opioid Use
- Trial name
- NCT05980546
- Testing
- Bupivacaine Injection, Dexamethasone injection, Fentanyl
- Where
- United States
- Volunteers
- 244 people
- Sponsor
- Hospital for Special Surgery, New York
Knee Osteoarthritis
Effectiveness of Inertial Sensors vs the Conventional Technique for the Execution of the Bone Resections in Primary TKA
Comparison of surgical technique for the execution of bone resections in total knee arthroplasty. Used technique are: a non-invasive extramedullary technique (EM technique) based on the use of inertial sensors for cutting guides…
- Trial name
- NCT04242303
- Testing
- Total knee replacement
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Istituto Ortopedico Rizzoli
Orthostatic Hypotension, Orthostatic Intolerance
Postoperative Incidence of Orthostatic Intolerance and Hypotension in Primary Unicompartmental Knee Arthroplasty (UKA)
Incidence and pathophysiologic hemodynamics of orthostatic intolerance and orthostatic hypotension in patients undergoing UKA
- Conditions
- Orthostatic Hypotension, Orthostatic Intolerance, Postoperative Complications
- Trial name
- NCT04195360
- Testing
- Standardized mobilization procedure
- Where
- Denmark
- Volunteers
- 42 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Primary Total Knee Arthroplasty
Quadriblock Versus "IPACK + Femoral Triangle Block + Obturator Nerve Block" in Total Knee Arthroplasty
Total knee arthroplasty (TKA) is one of the most common orthopedic surgical procedure and is associated with severe pain in the immediate postoperative period, thus limiting early recovery.
- Trial name
- QuITO (NCT04499716)
- Testing
- IPACK, Femoral triangle block, Obturator nerve block
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Clinique Medipole Garonne
Knee Arthritis
Perioperative Analgesia for Knee Arthroplasty (PAKA)
Peri-articular knee infiltration with Levobupivicaine 150mg, Morphine 10mg and Ketorolac 30mg reduces postoperative pain following primary total knee replacement compared with the current standard treatment of femoral nerve…
- Trial name
- PAKA (NCT01560767)
- Testing
- Femoral Nerve Block, peri-articular infiltration
- Where
- United Kingdom
- Volunteers
- 46 people
- Sponsor
- University of Warwick
Acute Pain, Regional Anesthesia Morbidity
Adductor Canal Catheter vs Local Infiltration of Analgesia for Total Knee Arthroplasty
The study is a prospective randomized controlled trial comparing local infiltration of analgesia in the knee joint and adductor canal catheters for postoperative analgesia following a primary Total Knee Arthroplasty (TKA).
- Trial name
- NCT02603900
- Testing
- ropivacaine, bupivacaine, Adductor Canal Catheter
- Where
- United States
- Sponsor
- Thomas Jefferson University
Osteoarthritis
A Migration and Bone Density Study Comparing 2 Types of Bone Cement in the OptiPac Bone Cement Mixing System
The goal of this scientific study is to determine whether there are differences in early migration and prosthesis-near bone density when a standard knee prosthesis is fixed with Refobacin Bone Cement R or with Refobacin Plus Bone…
- Trial name
- NCT00678236
- Testing
- Refobacin Bone Cement R, Refobacin Plus Bone Cement
- Where
- Denmark
- Volunteers
- 54 people
- Sponsor
- University of Aarhus
Primary Osteoarthritis of Knee Nos
Rate of Infection After Using Antibiotic Loaded Cement and Regular Cement in Total Knee Arthroplasty
Our study will be a prospective study To compare between the rate of infection after using antibiotic loaded cement and regular cement after total knee arthroplasty in primary knee osteoarthritis.this will be at assiut university…
- Trial name
- NCT06117839
- Testing
- using antibiotic loaded cement and regular cement after total knee arthroplasty in primary knee osteoarthritis.
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Assiut University
Osteoarthritis
A Comparison of the Design of Tibia Stems in Cemented Total Knee Arthroplasty - Wedge Stem Versus I-beam Stem.
The purpose of this study is to compare the early migration and periprosthetic bone changes of two cemented total knee arthroplasties with different tibial stem design.
- Trial name
- NCT00175136
- Testing
- Maxim TKA
- Where
- Denmark
- Volunteers
- 54 people
- Sponsor
- University of Aarhus
Total Knee Replacement
A Study to Compare Different Ways of Steroid Administration After Total Knee Implantation
We are going to evaluate the difference between perioperative intravenous steroid supplementation, perioperative periarticular steroid supplementation, and standard anaesthesia protocols.
- Trial name
- NCT04432012
- Testing
- Dexamethasone Sodium Phosphate 4 mg/ml intravenous, Dexamethasone Sodium Phosphate 4 mg/ml intra-articular
- Where
- Switzerland
- Volunteers
- 159 people
- Sponsor
- Christian Candrian
Post Operative Analgesia, Total Knee Arthroplasty
Supplementary Nerve Blocks Added to the Adductor Canal Block for Postoperative Pain Management in Primary Total Knee Arthroplasty: A Randomized Controlled Comparison of Sciatic, BiFeS, and IPACK Techniques
Postoperative pain following total knee arthroplasty (TKA) is a significant clinical problem that delays early mobilization, reduces patient satisfaction, and increases analgesic requirements.
- Trial name
- NCT07242170
- Testing
- Adductor canal block, BiFeS Block (Biceps Femoris Short Head Block), IPACK block
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Erzincan University
Osteoarthritis, Knee, Postoperative Pain
A Randomized Comparison of the Efficacy of the IPACK Block Versus the Popliteal Plexus Block for Posterior Knee Analgesia, in Patients Undergoing a Total Knee Arthroplasty and Receiving a Continuous Distal Femoral Triangle Block
Total knee arthroplasty (TKA) is commonly associated with significant postoperative pain, including pain arising from the posterior aspect of the knee.
- Trial name
- NCT07876310
- Testing
- Ultrasound-Guided iPACK Block, Ultrasound-Guided Popliteal Plexus Block, Ultrasound-Guided Continuous Femoral Triangle Block
- Volunteers
- 136 people
- Sponsor
- Clinica Santa Maria
Total Knee Arthroplasty, Venous Thromboembolism
Comparison of DOACs and LMWH for Thromboprophylaxis After Total Knee Arthroplasty
Yes. For these two fields, I would enter the following in English, based on your study protocol. 1. Brief Summary Copy and paste: This study aims to compare three thromboprophylaxis regimens in adults undergoing primary total…
- Trial name
- DOLOTHROK (NCT07869615)
- Testing
- Apixaban, Rivaroxaban, Enoxaparin (LMWH)
- Where
- Tunisia
- Volunteers
- 138 people
- Sponsor
- Military Hospital of Tunis
Arthroplasty, Replacement, Prevention of Venous Thromboembolism
Treatment of Patients Undergoing Primary Unilateral Elective Total Knee or Hip Replacement With Dabigatran Etexilate
To supplement the current evidence of the effect of Pradaxa® (dabigatran etexilate) on coagulation parameters, including a calibrated thrombin time test, in patients with moderate renal impairment undergoing elective total hip…
- Conditions
- Arthroplasty, Replacement, Prevention of Venous Thromboembolism, Moderate Renal Impairment (CrCl 30-50 mL/Min)
- Trial name
- NCT01184989
- Testing
- Dabigatran etexilate
- Where
- 10 sites in Austria, Canada and 4 more
- Volunteers
- 142 people
- Sponsor
- Boehringer Ingelheim
Osteoarthritis, Knee Replacement
Disability and Self-rated Health Following Primary Knee Replacement
Knee replacement is an effective treatment in late-stage osteoarthritis. It reduces pain and improves quality of life. There is, however, limited data concerning its results in older people and on its effect on how patients…
- Trial name
- NCT01236729
- Where
- Finland
- Volunteers
- 460 people
- Sponsor
- Coxa, Hospital for Joint Replacement
Osteoarthritis, Contracture
Reducing Recurrent Knee Flexion Contracture by Correcting Leg Length Discrepancy After Total Knee Arthroplasty for OA
Moving one's joints through their full range of motion (ROM) is crucial for health and wellbeing. Those who are unable to do so have difficulty carrying out simple activities like walking or feeding themselves.
- Trial name
- NCT02861521
- Testing
- Shoe lift
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- Ottawa Hospital Research Institute
Knee Osteoarthritis, Multimorbidity
Preoperative Multimorbidity and Functional Recovery After Total Knee Arthroplasty
This prospective observational cohort study aims to investigate the association between preoperative multimorbidity burden and functional recovery after primary total knee arthroplasty (TKA) in patients with knee osteoarthritis.
- Trial name
- NCT07882316
- Where
- Turkey (Türkiye)
- Volunteers
- 230 people
- Sponsor
- Balikesir Ataturk City Hospital
Primary Elective Hip Arthroplasty (THA), Primary Elective Total Knee Arthroplasty (TKA)
Digital Patient Journey Solution for Patients Undergoing Elective Hip and Knee Arthroplasty Dueto Primary Osteoarthritis
This is an interventional study which aims at assessing the effects of a digital patient journey solution in patients undergoing elective hip and knee arthroplasty due to primary osteoarthritis.
- Trial name
- NCT04083326
- Testing
- Digital Patient Journey Solution
- Where
- Finland
- Volunteers
- 69 people
- Sponsor
- VTT Technical Research Centre of Finland
Knee Osteoarthritis, Total Knee Arthroplasty
Hemoglobin Drop and Need for Blood Transfusion in Primary Knee Arthroplasty With or Without Drain Insertion
Total knee arthroplasty is a common operation performed to relieve pain and improve movement in patients with severe knee joint disease, such as osteoarthritis, rheumatoid arthritis, post-traumatic arthritis, or osteonecrosis.
- Trial name
- NCT07494708
- Testing
- Closed Suction Drain Insertion, No Drain Placement
- Where
- Pakistan
- Volunteers
- 102 people
- Sponsor
- Shifa International Hospital