Clinical trials: Primary Open-Angle Glaucoma
Open-angle Glaucoma, Low Tension Glaucoma
Waveform Analysis of the Doppler Curve of Ophthalmic Arteries in Glaucoma Patients
Color Doppler Imaging (CDI) has been providing information about ocular blood flow over the past decades. This non-invasive procedure based on ultrasound technique has identified increased resistance and decreased systolic blood…
- Trial name
- NCT01487655
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Vitamin D Deficiency, Primary Open- Angle Glaucoma
Associations of Vitamin D Deficiency and Vitamin D Receptor Polymorphisms With the Risk of Primary Open-angle Glaucoma
This study investigated whether vitamin D receptor gene polymorphism is altered in primary open-angle glaucoma subjects carrying the risk allele and vitamin D deficiency is an important factor in the development of glaucoma.
- Trial name
- NCT02539745
- Testing
- Vitamin D receptor polymorphic analysis, Serum levels of 1a, 25-Dihydroxyvitamin D3
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Lv Yingjuan
Primary Open Angle Glaucoma
Nicotinamide and Pyruvate for Open Angle Glaucoma: A Randomized Clinical Study
The objective of this study is to determine if a combination of oral nicotinamide and pyruvate (N\&P) can maintain eye health as compared to placebo while standard-of-care intraocular pressure-lowering glaucoma medications are…
- Trial name
- NCT05695027
- Testing
- Dietary supplements - Nicotinamide and Pyruvate
- Where
- 3 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Columbia University
Primary Open Angle Glaucoma, Myopia
Diagnostic Innovations in Glaucoma Study
The overarching goal of our research study is to evaluate changes in visual function and optic nerve topography (the structure of the back of the eye) in patients with glaucoma (increased susceptibility to pressure inside the eye…
- Trial name
- DIGS (NCT00221897)
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Glaucoma
Polymorphisms in the Human Matrix Metalloproteinase Genes MMP1, MMP3, and MMP9: Genetic Risk Factors of Primary Open Angle Glaucoma?
Matrix metalloproteinases (MMPs) fulfill diverse important molecular functions and play pivotal roles in development, tissue morphogenesis, repair, aging, and inflammatory processes.
- Trial name
- NCT00312403
- Testing
- Blood Sample
- Where
- Austria
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Ocular Hypertension, Primary Open Angle Glaucoma
Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AKB-9778 Ophthalmic Solution
The purpose of this Phase 1b study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of AKB-9778 ophthalmic solution (eye drops) administered for 7 days in adults.
- Trial name
- NCT04284514
- Testing
- AKB-9778 Ophthalmic Solution
- Where
- 2 sites in United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Aerpio Therapeutics
Primary Open Angle Glaucoma
African Descent and Glaucoma Evaluation Study
According to the National Eye Institute, Glaucoma affects about three million Americans. Among Blacks in the United States, open- angle glaucoma is the leading cause of irreversible visual loss.
- Trial name
- ADAGES (NCT00221923)
- Where
- 3 sites in United States
- Volunteers
- 1,540 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Primary Open-angle Glaucoma
GORE Glaucoma Drainage Implant Clinical Study Dominican Republic
The objective of this early feasibility clinical study is to evaluate the safety and effectiveness of several different GORE Glaucoma Drainage Implant configurations in subjects with primary open-angle glaucoma that is…
- Trial name
- NCT05557058
- Testing
- Gore Glaucoma Device Implant (GORE GDI)
- Where
- Dominican Republic
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- W.L.Gore & Associates
Primary Open-angle Glaucoma
Efficacy and Tolerability of Preservative-free 0.0015% Tafluprost in Glaucoma Patients
The aim of this work is to evaluate efficacy and tolerability of preservative containing 0.0015% tafluprost and preservative-free 0.0015% tafluprost.
- Trial name
- NCT03104621
- Testing
- Benzalkonium chloride (BAK), 0.0015% tafluprost
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Retinal Blood Flow
The Effect of Dronabinol on Ocular Hemodynamics in Patients With Primary Open Angle Glaucoma
Glaucoma is among the leading causes for irreversible blindness worldwide. While lowering intraocular pressure (IOP) remains the mainstay of therapy, there are still some patients who progress despite well-controlled IOP.
- Trial name
- NCT04596826
- Testing
- Dronabinol 5 MG, Dronabinol 10 MG
- Where
- Austria
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Primary Open Angle Glaucoma, Ocular Hypertension
The Efficacy of Selective Laser Trabeculoplasty
Selective laser trabeculoplasty (SLT) is a new method to reduce intraocular pressure in eyes with open angle glaucoma or ocular hypertension. SLT may also be effective for cases with previously failed ALT procedures.
- Conditions
- Primary Open Angle Glaucoma, Ocular Hypertension, Pseudo-Exfoliative Glaucoma, Pigment Dispersion Glaucoma
- Trial name
- NCT00347893
- Testing
- Selective laser trabeculoplasty
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Glaucoma Research & Education Group
Glaucoma, Open-angle
The Effectiveness of YAG Iridotomy in Preventing Peripheral Anterior Synechia After CLASS in Primary Open Angle Glaucoma
To investigate the effectiveness of YAG laser iridotomy in preventing peripheral anterior synechia after CO2 Laser-Assisted Sclerectomy Surgery and the long-term effect of reducing intraocular pressure
- Trial name
- NCT04912362
- Testing
- YAG iridotomy
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Obstructive Sleep Apnoea, Primary Open Angle Glaucoma
PAIR Study-PAP And IOP Relationship: Study 1
Lowering of the pressure in the eye (intraocular pressure, IOP) is the only proven treatment for Primary Open-angle Glaucoma (POAG).
- Trial name
- PAIR (NCT03127813)
- Testing
- Application of continuous positive airway pressure (CPAP)
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Papworth Hospital NHS Foundation Trust
Glaucoma
Functional Brain Changes of Primary Open-angle Glaucoma Patients
Structural and functional brain changes of primary open-angle glaucoma patient will be examined with fMRI. POAG patients and control group were examined with 3.0T magnetic resonance imaging.
- Trial name
- NCT02570867
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Qing Zhou
Primary Open Angle Glaucoma
How Does Your Genetic Make-up (Profile) Influence Your Glaucoma?
Glaucoma is a group of diseases in which visual loss occurs because of damage to the optic nerve. Research has shown that certain genes may cause glaucoma in some cases.
- Trial name
- NCT00626847
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Primary Open Angle Glaucoma, Normal Tension Glaucoma
Correlation of Orbital Cerebrospinal Fluid Pressure and Retinal Venous Outflow in Primary Open-angle Glaucoma
A spontaneous venous pulsation over the optic disc is an ophthalmological sign that can potentially be found in up to 98% of healthy individuals.
- Trial name
- NCT01795014
- Where
- Belgium
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Primary Open Angle Glaucoma
The Antioxidant Effect of Routine Vascular Therapy for Normal Tension Glaucoma Patients
To quantify oxidative stress in circulating leukocytes of normal tension glaucoma patients, prior to and one month after routine vascular therapy.
- Trial name
- NCT00465348
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Single-nucleotide Polymorphism (SNP) for Glaucoma
Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients
A single-nucleotide polymorphism (SNP) analysis of DNA obtained from peripheral blood of the glaucoma patients and the normal control will be performed to find genetic marker for primary open angle glaucoma.
- Trial name
- NCT01025024
- Testing
- SNP analysis of the DNA
- Where
- South Korea
- Volunteers
- 1,224 people, healthy volunteers welcome
- Sponsor
- Chungnam National University
Open Angle Glaucoma
Correlation Between Optical Coherence Tomography Angiography and Photopic Negative Response in Patients With Glaucoma
Open angle glaucoma (OAG) is considered a common cause of irreversible vision loss worldwide. It is an optic neuropathy associated with progressive loss and degeneration of the retinal ganglion cell layer (RGC) and its axons…
- Trial name
- NCT05104294
- Testing
- Optical Coherence Tomography- Angiography, Photopic negative response
- Where
- Egypt
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Benha University
Subjects With Primary Open-angle Glaucoma (POAG)
Prospective Evaluation of Open-angle Glaucoma Subjects on Two Topical Hypotensive Medication Treated With Two iStents
The purpose of this study is to assess efficacy and safety of two iStents for the reduction of intraocular pressure associated with primary open-angle glaucoma.
- Trial name
- NCT01252888
- Testing
- iStents
- Where
- Armenia
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Glaukos Corporation