Clinical trials: Primary Parkinsonism
Lewy Body Disease, Parkinson Disease Dementia
Learning to PERSEVERE: Peer Mentor Support and Caregiver Education in Lewy Body Dementia
The investigators propose to adapt, improve, and implement a peer mentor support and caregiver education (PERSEVERE) program to improve LBD-specific caregiving mastery.
- Conditions
- Lewy Body Disease, Parkinson Disease Dementia, Dementia With Lewy Bodies
- Trial name
- NCT04649164
- Testing
- Peer mentor support and caregiver intervention, Focus group to provide feedback on educational materials and mentoring program
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Parkinson's Disease
Pharmacokinetic Study in Healthy Males
The purpose of this study is to investigate the pharmacokinetics of levodopa, carbidopa, 3-OMD and ODM-104 after repeated doses of 3 levodopa formulations given in combination with carbidopa and ODM-104.
- Trial name
- NOCOF (NCT02312232)
- Testing
- levodopa, carbidopa, ODM-104
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Orion Corporation, Orion Pharma
Parkinson Disease (PD)
L-THEANINE AND MEDITERRANEAN DIET ON RBD, GI FUNCTION, AND INFLAMMATION IN PARKINSON'S DISEASE
Parkinson's disease is a progressive neurological disorder associated with severe dopaminergic neuron loss in the substantia nigra pars compacta.
- Trial name
- NCT07682532
- Testing
- Dietary Supplement
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Medipol University
PARKINSON DISEASE (Disorder)
Effect of Rasagiline on Balance in Parkinson's Disease as Measured by Computerized Posturography
This study evaluates the effect of rasagiline on balance in Parkinson's disease. Participants taking study medication which is rasagiline or sugar pill will undergo a computerized balance test on and off medication.
- Trial name
- NCT07077187
- Testing
- computerized dynamic posturography, Rasagiline 1 mg capsule
- Sponsor
- New York Medical College
Parkinson Disease
The University of Alabama at Birmingham (UAB) Neuroinflammation in Parkinson's Disease-TSPO- Positron Emission Tomography (PET) Substudy
The primary objective of this substudy is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET ligand [18F]DPA-714 in participants enrolled in the UAB Innate and…
- Trial name
- NCT03457493
- Testing
- DPA-714-PET/MRI, 5-year Follow-up DPA-714-PET/MRI, DPA-714 Metabolite Analysis
- Where
- United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Parkinson's Disease
PK, PD and Safety of Multiple Doses of V1512 Tablets in PD Patients Compared to Standard Levodopa/Carbidopa Oral Tablets
The purpose of the study is to determine if the pharmacokinetic profile of V1512 is similar or better than existing medications for the treatment of Parkinson's Disease
- Trial name
- NCT00491998
- Testing
- V1512, V1512 and Entacapone
- Where
- Italy
- Volunteers
- 27 people
- Sponsor
- Vernalis (R&D) Ltd
Parkinson Disease, Freezing of Gait
Motor Adaptation to Split-Belt Treadmill in Parkinson's Disease
Freezing of Gait (FOG) is a disabling symptom common in advanced Parkinson's Disease. FOG is an independent contributor to fall risk and is only partially relieved by medication.
- Trial name
- NCT03725215
- Testing
- Split-Belt Treadmill Training
- Where
- 2 sites in Belgium, Germany
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- KU Leuven
REM Sleep Behavior Disorder
Gut Microbiota Across Early Stages of Synucleinopathy: From High-risk Relatives, REM Sleep Behavior Disorder to Early Parkinson's Disease
With the global ageing population, neurodegenerative disorders including synucleinopathy are major burdens to patients, carers and society.
- Trial name
- NCT03645226
- Testing
- Colonoscopy
- Where
- 2 sites in Hong Kong
- Volunteers
- 441 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Parkinson Disease
The Use of Telerehabilitation to Improve Movement Outcomes for Patients With Parkinson Disease
The goal of this pilot randomized clinical trial was to assess the feasibility of telerehabilitation (TR) for patients with Parkinson\'s Disease (PD). The main questions it aims to answer are: 1.
- Trial name
- NCT06246747
- Testing
- In clinic physical therapy, Telerehabilitation only
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Wizecare
Parkinson's Disease
Using [18F]FDOPA PET/CT to Monitor the Effectiveness of Fetal Dopaminergic Grafts in Parkinson Disease Patients
While positron emission tomography/computed tomography (PET/CT) can assist in the diagnosis of Parkinson disease (PD), it can also potentially help monitor treatment options for PD.
- Trial name
- NCT02538315
- Testing
- [18F]FDOPA PET/CT
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- University of Saskatchewan
Parkinson Disease
Investigating the Safety of srTMS in the Treatment of Parkinson's Disease
Super rapid transcranial magnetic stimulation (srTMS) is a method of brain stimulation that may be able to change the electrical activity of the nerve cells of the brain.
- Trial name
- NCT00063284
- Testing
- Magstim Rapid Magnetic Stimulator
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson's Disease
18F-DTBZ for l Diagnosis of Parkinson's Disease and Monitoring the Severity of Disease by VMAT2 PET Imaging
The primary objective of this protocol is to analyze the sensitivity and specificity of 18F-DTBZ PET to the differential diagnosis of Parkinson's Disease (PD) and normality.
- Trial name
- 8F-DTBZ (NCT01283347)
- Testing
- 18F-DTBZ
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
PARKINSON DISEASE (Disorder)
Retraining Gait in Parkinson's Disease Via a Personalised App
Introduction Parkinson's disease (PD) limits mobility by worsening gait/walking and increasing fall risk. Falls lead to injuries and reduce confidence in performing everyday tasks.
- Trial name
- CuePD-Extend (NCT07584993)
- Testing
- CuePD, Control material
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Northumbria University
Parkinson's Disease
Mesenchymal Stem Cells Transplantation to Patients With Parkinson's Disease
The study is a phase I/II trial designed to establish the safety and efficacy of intravenous administration of autologous bone marrow derived mesenchymal stem cells to patients with Parkinson's disease.
- Trial name
- NCT01446614
- Testing
- bone marrow derived mesenchymal stem cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Parkinson Disease
Effects of Bilateral GPI DBS on Freezing of Gait in PD
This study aims to evaluate the effect of deep brain stimulation in the the globus pallidus (Gpi) on freezing of gait in patients with Parkinson's disease.
- Trial name
- PD GPI DBS (NCT03227250)
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Haiyan Zhou
Central Nervous System Disease, Basal Ganglia Disease
Bilateral Pallidal Stimulation in Patients With Advanced Parkinson's Disease-LATESTIM
Deep brain stimulation (DBS) is an established treatment for advanced complicated Parkinson's disease (PD). Several controlled randomized studies have given proof of an advantage for operated patients as compared to medically…
- Conditions
- Central Nervous System Disease, Basal Ganglia Disease, Movement Disorders, Neurodegenerative Disorders
- Trial name
- LATESTIM (NCT02823158)
- Testing
- Deep brain stimulation (DBS) of Globus Pallidus internus (GPi) and Best medical treatment (BMT), Best medical treatment
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Parkinson Disease, Cognitive Deficit in Attention
The Effect of Different Types of Focus Instructions in Parkinson's Rehabilitation
Parkinson's disease is the most common progressive neurodegenerative movement disorder. Common movement impairments in Parkinson's include balance and walking difficulties.
- Conditions
- Parkinson Disease, Cognitive Deficit in Attention, Feedback, Psychological, Gait, Festinating
- Trial name
- NCT06615115
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Parkinson Disease, Proprioceptive Disorders
Proprioception and Meditation
In past work is has been shown that yoga can be as effective as a standard balance or Tai Chi protocol; however, there is an inability to distinguish between the mind and body contributions of yoga training.
- Conditions
- Parkinson Disease, Proprioceptive Disorders, Movement Disorders
- Trial name
- NCT03079817
- Testing
- Yoga Meditation, Proprioceptive Drills
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Miami
Parkinson's Disease
Remote Dynamic Cycling for the Customized Off-site Rehab in Parkinson's Disease
This research will develop novel and accessible way to deliver effective and customized rehab to those suffering from common and devastating neurodegenerative condition called Parkinson's disease.
- Trial name
- PDBIKE (NCT05298150)
- Testing
- Dynamic cycling, Forced cycling
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Parkinson Disease
LFP Beta aDBS Feasibility Study
The purpose of this study is to use local field potentials as control signals for adjusting DBS stimulation settings under varying patient states and to assess patient outcomes.
- Trial name
- NCT03446833
- Testing
- The LFP Beta aDBS System
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- MedtronicNeuro
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