Clinical trials: Primary Parkinsonism
Parkinson Disease, Parkinson's Disease
An Open-label Continuation Study Evaluating the Long-term Safety of Extended Release Ropinirole XL (Formerly CR) in Parkinson''s Disease
To evaluate the safety profile of ropinirole XL during long-term treatment in subjects with early and advanced Parkinson's disease
- Trial name
- NCT00632736
- Testing
- Ropinirole XL (formerly CR)
- Where
- 75 sites in United States, Belgium and 7 more
- Volunteers
- 419 people
- Sponsor
- GlaxoSmithKline
Essential Tremor, Parkinson Disease
Using Wearable and Mobile Data to Diagnose and Monitor Movement Disorders
The purpose of the research is to better understand the motor behavior of individuals in health and disease. The specific purpose of this project is to identify if we can utilize a smartphone to diagnose different movement…
- Conditions
- Essential Tremor, Parkinson Disease, Huntington Disease, Dystonia, Primary
- Trial name
- NCT04231487
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Rutgers, The State University of New Jersey
Parkinson Disease
Efficacy and Safety of TJ0113 Capsule in Patients With Parkinson's Disease
A randomized, double-blind, placebo parallel-controlled Phase II clinical trial to evaluate the efficacy and safety of TJ0113 capsule in patients with early-stage Parkinson's disease
- Trial name
- NCT06596005
- Testing
- TJ0113 200mg, TJ0113 400mg
- Where
- China
- Volunteers
- 149 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Parkinson's Disease (PD), Movement Disorders
Efficacy of Probiotics for Parkinson Disease (PD)
In previous clinical studies, PS128 has been reported to ameliorate motor deficits in Parkinson's disease (PD). PS23 has been reported to delay some age-related disorders.
- Conditions
- Parkinson's Disease (PD), Movement Disorders, Depression, Anxiety
- Trial name
- NCT06118294
- Testing
- probiotics
- Where
- Taiwan
- Sponsor
- Changhua Christian Hospital
Parkinson Disease
Evaluation of a Decision Aid for Deep Brain Stimulation Surgery for Parkinson's Disease
The goal of this clinical trial is to learn if a Decision Aid can help patients with Parkinson's disease make a decision about undergoing Deep Brain Stimulation surgery.
- Trial name
- NCT06446505
- Testing
- Deep Brain Stimulation Decision Aid
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Colorado, Denver
Parkinson's Disease
Varenicline Treatment for Excessive Daytime Sleepiness in Parkinson's Disease
The effect of varenicline, an alpha4beta2 nicotinic receptor partial agonist on excessive daytime sleepiness in Parkinson's disease will be studied in a randomized, double blind, placebo-controlled clinical trial with a…
- Trial name
- VESPA (NCT02473562)
- Testing
- Varenicline
- Where
- 2 sites in Netherlands
- Volunteers
- 22 people
- Sponsor
- Amsterdam UMC, location VUmc
TMS Protocols in the Treatment of PD
Standardization and Optimization of TMS Protocols for the Treatment of PD With Depression or Cognitive Impairment
The goal of this study is to determine whether transcranial magnetic stimulation (TMS) is an effective treatment in Parkinson's disease patients with depression or cognitive impairment.
- Trial name
- NCT03552861
- Testing
- repetitive transcranial magnetic stimulation(rTMS)
- Where
- 10 sites in China
- Volunteers
- 252 people
- Sponsor
- Guangdong Provincial People's Hospital
Parkinson's Disease
Interleaving Stimulation Improves Dyskinesia in Parkinson's Disease
This study is designed as a prospective, randomized, double-blind, controlled study to assess putative differences in the effect of interleaving stimulation and empirical stimulation with regards to post-operation dyskinesia…
- Trial name
- NCT06239454
- Testing
- interleaving stimulation, empirical stimulation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Huashan Hospital
Parkinson's Disease, Multiple System Atrophy
Efficacy of Therapeutic Interventions for Orthostatic Hypotension in Parkinson's Disease and Multiple System Atrophy
Patients with Parkinson's Disease or Multiple System Atrophy (MSA), and symptoms of orthostatic hypotension, are eligible for the study.
- Conditions
- Parkinson's Disease, Multiple System Atrophy, Orthostatic Hypotension
- Trial name
- NCT00103597
- Testing
- Fludrocortisone, Domperidone, Conservative Measures for Orthostatic Hypotension
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- Royal Brisbane and Women's Hospital
Parkinson Disease
Assessment of Methods Used in Evaluating Balance Rehabilitation in Parkinson's Patients
Balance rehabilitation holds an important place in the treatment of Parkinson's patients. Before and after treatment, patients are evaluated using various measurement methods.
- Trial name
- NCT06562686
- Where
- Turkey (Türkiye)
- Volunteers
- 83 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Parkinson Disease (PD)
Enhancing Nursing Students' Empathy and Learning in Parkinson's Disease Through High-Fidelity Simulation and Blended Learning
The goal of this randomized controlled trial is to evaluate the effectiveness of a multimodal Parkinson's disease-focused intervention on empathy levels and perceived theoretical-practical learning in third-year undergraduate…
- Trial name
- NCT07503418
- Testing
- Blended-learning capsules, High-Fidelity Physical Simulation, Simulated Home Environment
- Where
- Spain
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Cadiz
Sleep Disturbances, Parkinsons's Disease
Effects of Rasagiline on Sleep Disturbances in Parkinson's Disease
As the MAO-B inhibitor rasagiline is able to improve motor skills it might have positive effects on sleep disruption by reducing nocturnal akinesia.
- Trial name
- RaSPar (NCT01442610)
- Testing
- Rasagiline
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Technische Universität Dresden
Parkinson&Amp;#39;s Disease
A Study to Evaluate Efficacy, Safety and Tolerability of Hydroxychloroquine in Subjects With Parkinson's Disease
The purpose of this study is to determine if hydroxychloroquine is safe to take and whether there is potential for it to slow the progression of PD symptoms.
- Trial name
- NCT06816810
- Testing
- Hydroxychloroquine (HCQ)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Ottawa Hospital Research Institute
Parkinson's Disease
Apomorphine Nasal Powder in the Treatment of Parkinson's Disease "Off" Periods.
To determine the safety and tolerability of repeated dosing with Apomorphine Nasal Powder in subjects with Parkinson's Disease.
- Trial name
- NCT00346827
- Testing
- Apomorphine Nasal Powder
- Volunteers
- 36 people
- Sponsor
- Britannia Pharmaceuticals Ltd.
Parkinson Disease (PD), Idiopathic Parkinson's Disease
Assessment of the Safety, Immunogenicity, and Pharmacodynamics of TRB-001 in Patients With Early Idiopathic Parkinson's Disease
This is a randomized, placebo-controlled, double-blind, dose-finding phase 1b study with the purpose to assess the safety, immunogenicity and pharmacodynamics of TRB-001 in early idiopathic Parkinson's Disease patients.
- Trial name
- NCT07840027
- Testing
- TRB-001
- Where
- Austria
- Volunteers
- 36 people
- Sponsor
- Tridem Bioscience FlexCo
Parkinson Disease, Idiopathic Parkinson Disease
PA Behavior and HRQoL in Parkinson's Disease Patients Patients: Role of Social Cognitive Variables
The primary aim of the study will be to examine Social Cognitive Theory (SCT) correlates, of physical activity (PA) participation and health-related quality of life (HRQoL) in Parkinson's disease participants.
- Conditions
- Parkinson Disease, Idiopathic Parkinson Disease, Idiopathic Parkinson's Disease, Parkinson Disease, Idiopathic
- Trial name
- PDQ (NCT05575479)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Ohio State University
Parkinson Disease, Physical Activity
Physical Training Induced Plasticity of Motor Control Mechanisms in Parkinson's Disease Patients
There are experimental evidences of the important role of exercise in the PD, that induces similar effects to pharmacotherapy. So far, the mechanisms of the impact of these changes on the brain subcortical and cortical regions…
- Trial name
- NCT03753503
- Testing
- exercise, conventional physical therapy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wroclaw University of Health and Sport Sciences
Parkinson Disease
i-BiSSkApp for Swallowing Rehabilitation in Parkinson's Disease
Aspiration pneumonia due to dysphagia is a leading cause of death in Parkinson's disease (PD). Dysphagia intervention in the United States involves evaluation at onset of dysphagia symptoms followed by short-term therapy.
- Trial name
- NCT05837520
- Testing
- i-BiSSkApp (tablet application) with swallowing therapy, Traditional behavioral swallowing therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of South Florida
Parkinson Disease
Integration of Auditory, and Deep Brain Stimulation to Enhance Deep Sleep in Parkinson's Disease
The study is an open-label trial to validate the local field potential (LFP) activity in the subthalamic nucleus (STN) for slow-wave detection during acoustic stimulation during nighttime sleep in Parkinson's disease patients…
- Trial name
- NCT05184270
- Testing
- Acoustic stimulation
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- Christian Baumann
Parkinson Disease, Constipation
Probiotics-prebiotic Fiber Therapy in Parkinson's Disease Patients With Constipation
A double blinded randomised placebo controlled trial to evaluate the efficacy of probiotics on constipation symptoms and whole gut transit time in patients with Parkinson's disease.PD patients with constipation were randomized to…
- Trial name
- NCT04451096
- Testing
- Probiotics with prebiotic
- Where
- Malaysia
- Volunteers
- 48 people
- Sponsor
- National University of Malaysia
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.