Clinical trials: Primary Parkinsonism
Parkinson's Disease
Does Outpatient Palliative Care Improve Patient-centered Outcomes in Parkinson's Disease?
The purpose of this study is to improve outcomes for persons living with Parkinson's Disease (PD) and their family caregivers. The investigators hypothesize that outpatient interdisciplinary palliative care will improve…
- Trial name
- NCT02533921
- Testing
- Interdisciplinary outpatient palliative care, Standard of Care
- Where
- 3 sites in United States, Canada
- Volunteers
- 210 people
- Sponsor
- University of Colorado, Denver
Parkinson's Disease, Aging
Respiratory Load Magnitude Estimation in PD
The purpose of this study is to determine whether people with Parkinson's disease (PD) experience reduced perception of respiratory resistive loads versus healthy adults in the same age group.
- Trial name
- NCT02202057
- Testing
- Respiratory resistive load on inhalation, Fluoroscopic swallowing evaluation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Parkinson's Disease
Parkinson's Disease Isradipine Safety Study
The objective of this study is to establish the safety and tolerability of isradipine, sustained release preparation in patients with PD.
- Trial name
- NCT00753636
- Testing
- Dynacirc CR (Isradipine)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Northwestern University
Parkinson's Disease, Dystonia
Use of Interventional MRI for Implantation of Deep Brain Stimulator Electrodes
The purpose of this study is to gather observational data on an already FDA-approved implantation technique for deep brain stimulation (DBS) in which the entire surgery is performed within an MRI scanner ("interventional MRI", or…
- Trial name
- iMRI (NCT00792532)
- Testing
- interventional MRI for implantation of DBS electrodes, DBS electrodes
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of California, San Francisco
Parkinson Disease
Study of the Neuro-protective Effect of Granulocyte-colony Stimulating Factor on Early Stage Parkinson's Disease
The purpose of this study is to evaluate the effectiveness of neuroprotection from granulocyte colony-stimulating factor on Parkinson disease
- Trial name
- NCT01227681
- Testing
- G-CSF
- Where
- Taiwan
- Volunteers
- 4 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Parkinson Disease
Socio-Clinical Factors Associated With Self-Management in Parkinson's Disease
Self-management focuses on the behaviors that people with chronic disease use in order to maintain and improve their health and well-being and includes aspects such as medical and lifestyle management.
- Trial name
- NCT05211700
- Testing
- This is an observational study, there is no intervention in this study.
- Where
- Israel
- Volunteers
- 90 people
- Sponsor
- University of Haifa
Parkinson Disease
Protocol: Balance Training in Parkinson's Disease
Postural instability is a particularly incapacitating disorder, where loss of motor independence by Parkinson´s Disease (PD) patients marks a significant stage of disease onset.
- Trial name
- NCT02488265
- Testing
- Balance Training, Screening to prevent falls
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- University of Sao Paulo General Hospital
Parkinson's Disease
The Effect of Exercise on Individuals With Parkinson's Disease
The goal of this trial is to compare the effect of two different exercise programs on neuro-physiological, motor, functional, and quality-of-life issues in individuals with Parkinson's disease to determine which program is most…
- Trial name
- NCT00591344
- Testing
- Progressive resistance training, Modified Fitness Counts
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Illinois Chicago
Parkinson's Disease, Depression
Validation of the Hebrew Version of the Montreal Affective Voices.
Today, no non-verbal auditory stimuli that assess mental processing are available in Israel. The goal of this study is to make available a validated set of auditory stimuli in Israel.
- Trial name
- NCT01512732
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Parkinson's Disease
An Evaluation of the Pharmacokinetics and Pharmacodynamics of AP09004 in Patients With Parkinson's Disease
The purpose of this study is to evaluate blood level profiles of multiple oral doses of AP09004 vs. active control and to determine its safety and efficacy in Parkinson's patients.
- Trial name
- NCT00918177
- Testing
- AP09004, Carbidopa/Levodopa, immediate release
- Where
- 7 sites in Israel
- Volunteers
- 72 people
- Sponsor
- Intec Pharma Ltd.
Parkinson's Disease
Autologous Mesenchymal Stem Cell Transplant for Parkinson's Disease
This study is intended to look at the safety and efficacy of the use of autologous bone marrow derived stem cell transplant in patients with advanced Parkinson's disease.
- Trial name
- NCT00976430
- Testing
- Autologous Bone marrow derived stem cells transplant
- Where
- India
- Volunteers
- 5 people
- Sponsor
- Jaslok Hospital and Research Centre
Parkinson Disease
Rapid Cadence Cycling for Parkinson's Disease: A Study of Implementation and Efficacy in the Community Setting
Forced cadence cycling (FCC) in which individuals with Parkinson's Disease (PD) pedal with external augmentation at 80-90 revolutions per minute (rpm) has demonstrated significant motor improvement in prior clinical trials.
- Trial name
- NCT03675932
- Testing
- Rapid Cadence Cycling on a Solo-Rider Spin Bicycle
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Massachusetts General Hospital
Parkinson's Disease
A Multicenter, Open-label Trial to Assess Subject Preference of PARCOPA, Carbidopa/Levodopa Orally Disintegrating Tablets, Compared to Conventional Carbidopa/Levodopa Tablets in Subjects With Stable Parkinson's Disease
The objective of this trial was to assess subject preference for PARCOPA, carbidopa/levodopa Orally Disintegrating Tablets (ODT), compared with conventional carbidopa/levodopa tablets, in subjects with stable Parkinson's disease.
- Trial name
- NCT00139867
- Testing
- PARCOPA
- Where
- United States
- Sponsor
- UCB Pharma
Parkinson Disease
Pilot Study to Determine if Working Memory Training Aids Cognitive Functioning in Patients With Parkinson's Disease
This project will investigate the feasibility and preliminary effectiveness of an intensive and focused working memory training program for patients in the early stages of PD receiving dopaminergic therapy.
- Trial name
- PDWM (NCT01647698)
- Testing
- Adaptive working memory training task, Non-adaptive working memory training task (i.e. an active control task), No training
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Gail Eskes
Parkinson Disease
Effect of Melatonin on Oxidative Stress Parameters in Levodopa-Treated Parkinson's Disease Patients
In Bangladesh Melatonin is currently used for insomnia. Its potential therapeutic benefits beyond sleep regulation. This study aimss to evaluate the effects of melatonin supplementation on oxidative stress markers…
- Trial name
- NCT07375693
- Testing
- MELATONIN (MELATL07959)
- Where
- Bangladesh
- Volunteers
- 70 people
- Sponsor
- Bangladesh Medical University
Parkinson's Disease
Phase I, KM-819 in Healthy Subjects for Parkinson's Disease
This first in human, single-center, randomized, placebo-controlled, double blind, sequential group Phase 1 study in healthy subjects will be conducted to evaluate the safety, tolerability, PK, and PD following the escalation of…
- Trial name
- NCT03022799
- Testing
- KM-819
- Where
- South Korea
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Kainos Medicine Inc.
Parkinson's Disease (PD)
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Subcutaneous Infusions of ABBV-951 in Subjects With Parkinson's Disease
The purpose of the study is to assess the safety, tolerability, and pharmacokinetics of single, ascending doses of ABBV-951 administered as a subcutaneous bolus infusion followed by a continuous subcutaneous infusion in subjects…
- Trial name
- NCT03033498
- Testing
- ABBV-951
- Where
- 7 sites in United States
- Volunteers
- 29 people
- Sponsor
- AbbVie
Parkinson Disease Psychosis
Hallucinations in Parkinson's Disease
Investigation on how robotically mediated sensorimotor stimulation induces and triggers presence hallucinations in different clinical groups of parkinsonian patients, and in aged-matched controls
- Trial name
- NCT04592965
- Testing
- Clinical and neuropsychological assessments, Induction of PH and associated bodily states, Resting-state fMRI acquisition
- Where
- 6 sites in Spain, Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Olaf Blanke
Parkinson's Disease
Consortium On Risk for Early-onset Parkinson's Disease (CORE PD)
The purpose of this study is to investigate genetic and environmental risk factors that increase susceptibility to the development of early-onset Parkinson's disease (developed at or before age 50).
- Trial name
- NCT00104585
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Columbia University
Parkinson's Disease
Evaluation of a Biomarker Related to the GI Tract for the Diagnosis of Parkinson's Disease
The cause of Parkinson's disease (PD) is currently unknown. Both environmental and genetic factors have been found to contribute to PD pathogenesis.
- Trial name
- NCT01904240
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
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