Clinical trials: Primary Parkinsonism
Parkinson Disease
Study of the Effects of Three Exercise Programs in Parkinson's Disease
Introduction: Population aging is associated with increased prevalence of chronic diseases. Parkinson's disease (PD) is the second most common neurodegenerative disease in the world population, affecting motor function and…
- Trial name
- STEP (NCT02622737)
- Testing
- Functional training, Stationary bike, Exergaming
- Where
- Brazil
- Volunteers
- 79 people
- Sponsor
- Federal University of Bahia
Parkinson's Disease
Predictors of Motor Progression in Parkinson's Disease
Treatment resistant motor features, such as postural instability and freezing of gait are common in people with Parkinson's disease and major contributors to morbidity and mortality.
- Trial name
- NCT02769039
- Testing
- No intervention. Observational studies of sleep, movement and brain imaging
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Parkinson Disease, Acupuncture
Acupuncture for Management of Balance Impairment in Patients With Parkinson's Disease
This plan is to evaluate the effectiveness of scalp acupuncture, a modern acupuncture technique specialized to neurological disorders, in managing motor function and body balance for PD patients.
- Trial name
- NCT03178175
- Testing
- Acupuncture, Needle Insertion
- Where
- Taiwan
- Volunteers
- 4 people
- Sponsor
- Chang Bing Show Chwan Memorial Hospital
Parkinson Disease, Idiopathic Parkinson Disease
Placebo Controlled Study of Preladenant in Participants With Moderate to Severe Parkinson's Disease (P07037)
This is a study of the efficacy and safety of preladenant in adult participants with moderate to severe Parkinson's Disease (PD).
- Conditions
- Parkinson Disease, Idiopathic Parkinson Disease, Idiopathic Parkinson's Disease
- Trial name
- NCT01227265
- Testing
- Preladenant
- Volunteers
- 476 people
- Sponsor
- Merck Sharp & Dohme LLC
Parkinson's Disease (PD)
STN-tTIS With Different Intervention Intervals Versus Standard Medical Treatment for Parkinson's Disease
The goal of this clinical trial is to compare the efficacy and safety of different Intervention Intervals of subthalamic nucleus-targeted transcranial temporal interference stimulation (STN-tTIS) in patients with Parkinson…
- Trial name
- NCT07774312
- Testing
- STN-tTIS Once Weekly, STN-tTIS Twice Weekly, STN-tTIS Five Times Weekly
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ruijin Hospital
Parkinson Disease
Effect of Intermittent Oral Tube on Dysphagia in Parkinson's Disease Patients
The goal of this or clinical trial is to explore Intermittent Oro-esophageal Tube Feeding vs. Nasogastric Tube Feeding on nutritional status, dysphagia, and activities of daily living in patients with Parkinson's disease.
- Trial name
- NCT06328881
- Testing
- Comprehensive rehabilitation training, Intermittent Oro-esophageal Tube, Nasogastric tube
- Volunteers
- 80 people
- Sponsor
- Copka Sonpashan
Parkinson Disease
Determination of the Minimal Detectable Change of the Parkinson's Disease Questionnaire-8
This study is conducted to determine how many units of improvement the Parkinson's Disease Questionnaire-8 (PDQ-8), used to evaluate the quality of life of Parkinson's patients, should have to express a significant change in the…
- Trial name
- NCT06487364
- Testing
- Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Emre Şenocak
Parkinson Disease
Adaptive DBS to Offset STN Dysregulation During Exercise in PD
The investigators conduct a prospective study to evaluate the effects of exercise on Parkinson's Disease brain biomarkers detected with the PerceptTM PC neurostimulator.
- Trial name
- NCT06296810
- Testing
- aDBS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Fall, Aging
PRE.C.I.S.A - Fall Prevention and Promotion of Active and Healthy Aging
Randomized Controlled Trial (RCT) aiming at assessing the efficacy of an interdisciplinary multi-component and personalized multi-factorial intervention for reducing falls at one year post-enrolment in comparison to the usual…
- Conditions
- Fall, Aging, Parkinson Disease, Stroke
- Trial name
- PRECISA (NCT03592420)
- Testing
- Interdisciplinary multicomponent interventions, Usual care
- Where
- 2 sites in Italy
- Volunteers
- 366 people
- Sponsor
- Azienda Unita' Sanitaria Locale Di Modena
Parkinson's Disease (PD)
A Novel Digital Music-based Autonomous Personalized Walking Intervention to Improve Gait and Walking Automaticity in Parkinson Disease
The purpose of this research study is to examine the effects of a 3-month personalized community-based walking program using a digital music-based device designed for self-directed gait training in people with Parkinson disease…
- Trial name
- MyMusiQ (NCT07705373)
- Testing
- MR-005 (MedRhythms, Inc., Portland, ME)
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Boston University Charles River Campus
Tremor, Essential, Parkinson's Disease
Mapping the Target for the MRgFUS Treatment of Tremor
The purpose of this investigation is to determine the optimal DRT/VIM target location and its safety margins based on MR-SISET imaging features by comparing with postoperative lesions and clinical outcomes in patients with tremor…
- Trial name
- NCT04661241
- Testing
- Automatic DRT/VIM target-recognition method using MR-SISET and ML approaches, Routine clinical MRI protocol
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- NYU Langone Health
Alzheimer's Disease, Dementia With Lewy Bodies
Study Evaluating Intepirdine (RVT-101) on Gait and Balance in Subjects With Dementia
This study seeks to evaluate the effect of intepirdine (RVT-101) on gait and balance in patients with Alzheimer's Disease, Dementia with Lewy Bodies or Parkinson's Disease Dementia.
- Conditions
- Alzheimer's Disease, Dementia With Lewy Bodies, Parkinson's Disease Dementia
- Trial name
- NCT02910102
- Testing
- RVT-101 35 mg
- Where
- 11 sites in United States
- Volunteers
- 38 people
- Sponsor
- Axovant Sciences Ltd.
Parkinson's Disease
A Pilot Clinical Trial With the Iron Chelator Deferiprone in Parkinson's Disease
Parkinson's disease (PD) is a common neurodegenerative disease affecting movement. Although drug treatments for PD are available they only treat the symptoms of the disease, fail to halt neuronal loss, and are associated with…
- Trial name
- DeferipronPD (NCT01539837)
- Testing
- Deferiprone 20mg, Deferiprone 30mg
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Imperial College London
PARKINSON DISEASE (Disorder), Parkinson Disease
Italian Translation and Validation of the GIDS-PD Scale for Parkinson's Disease
This study aims to translate and validate the Gastrointestinal Dysfunction Scale for Parkinson's Disease (GIDS-PD) into Italian to enable the assessment of gastrointestinal symptoms in Italian-speaking patients with Parkinson's…
- Trial name
- GIDS-PD_ITA (NCT07316751)
- Where
- 5 sites in Italy
- Volunteers
- 190 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Parkinson's Disease
Exercise for People With Parkinson's Disease
This randomized, controlled exercise intervention with three groups compares two exercise approaches to standard of care. Supervised interventions are administered for four months, with emphasis on patients adopting exercise…
- Trial name
- NCT01257945
- Testing
- Aerobic Exercise, Flexibility and Function exercise program, Home exercise program
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- University of Colorado, Denver
Parkinson's Disease
Crossover Target Engagement Study of Cholinergic Mechanisms of Gait Dysfunction in Parkinson's Disease (Project #3 - Experiment 3 [UdallP3E3])
With an appropriate oral dose of Varenicline (VCN) identified from experiments 1 \& 2 of the study (see NCT02933372), the investigators will administer VCN to Parkinson Disease (PD) participants to determine if VCN improves…
- Trial name
- UdallP3E3 (NCT04403399)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Michigan
Parkinson Disease
FitMi PD Home Therapy for Parkinson's Disease
The investigators will run an at-home usability study of a newly developed home exercise device (FitMi PD) for individuals with Parkinson's disease.
- Trial name
- NCT05655377
- Testing
- FitMi PD
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Flint Rehabilitation Devices, LLC
Parkinson Disease
Biofeedback Rehabilitation in Parkinson's Disease
Background: In this study, a new biofeedback system for balance and gait rehabilitation (Gamepad) was developed. The system, based on wearable inertial sensors, provides users with real-time visual and acoustic feedback about…
- Trial name
- GAMEPAD_PD (NCT02713971)
- Testing
- Gamepad system, Conventional physiotherapy
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Parkinson's Disease
A Single Period Investigation to Assess the Tolerability of Healthy Subjects to Oral Sinemet® (Levodopa/Carbidopa)
A Single Period Investigation to Assess the Tolerability of Healthy Subjects to Oral Sinemet® (Levodopa/Carbidopa) Doses Administered Using a Divided Dose Approach
- Trial name
- NCT02486432
- Testing
- Levodopa/Carbidopa (Sinemet)
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- NeuroDerm Ltd.
Parkinson Disease
Investigation of the Effects of LSVT-BlG Protocol on Balance, Gait, Fatigue and Quality of Life in Parkinson's Patients
Parkinson's disease is a progressive, degenerative neurological disease manifested by motor and non-motor symptoms. Treatment for Parkinson's disease is symptom-oriented.
- Trial name
- NCT06215898
- Testing
- LSVT-BIG Group via Telerehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Izmir Bakircay University
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