Clinical trials: Primary Parkinsonism
Parkinson's Disease
Development of a Novel 18F-DTBZ PET Imaging as a Biomarker to Monitor Neurodegeneration of PARK6 and PARK8 Parkinsonism
The primary objective of this protocol is to access the utility of 18F-DTBZ PET imaging as an in vivo biomarker to monitor neurodegeneration of both PD mouse models and PD patients.
- Trial name
- NCT01759888
- Testing
- 18F-DTBZ
- Where
- Taiwan
- Volunteers
- 49 people
- Sponsor
- Chang Gung Memorial Hospital
Parkinson Disease
Study of Dysarthria, and the Appearance of Non-dopaminergic Signs in Idiopathic PARKinson's Disease
Pilot study: Longitudinal follow up of the PRODY-GI cohort for parkinson's disease (PD) Observational study of upper and lower axial symptoms' occurence in 30 PD patients in on and off drug conditions, 30 aged matched control…
- Trial name
- Prodygi-II (NCT03517059)
- Where
- France
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Parkinson Disease
OpiCapone Effect on Motor Fluctuations and pAiN
The aim of this study is to investigate the efficacy of 50 mg opicapone when administered with the existing treatment of levodopa (L-dopa) plus a dopa decarboxylase inhibitor (DDCI), in Parkinson's disease (PD) patients with…
- Trial name
- OCEAN (NCT04986982)
- Testing
- Opicapone 50 mg
- Where
- United Kingdom
- Volunteers
- 144 people
- Sponsor
- Bial - Portela C S.A.
Parkinson's Disease
A Clinical Trial of LY3962681 in Healthy Volunteers and in Patients With Parkinson's Disease
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics/pharmacodynamics (PK/PD) of LY3962681 in healthy volunteers and patients with Parkinson's disease.
- Trial name
- PROSPECT-PD (NCT06565195)
- Testing
- LY3962681
- Where
- 16 sites in United States, Germany and 3 more
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Prevail Therapeutics
Parkinson's Disease
Trial Comparing Functional Outcomes of Awake vs. Asleep Deep Brain Stimulation (DBS) for Parkinson's Disease
The purpose of the proposed study is to demonstrate that the functional outcomes of DBS surgery utilizing the "asleep" technique are not inferior to those reported for traditional "awake" DBS technique.
- Trial name
- NCT02401308
- Testing
- Deep Brain Stimulation surgery
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Freezing of Gait, Parkinson's Disease
Etiology-Phenotype-Outcome Pathway Study on Freezing of Gait (FOG)
This study is a prospective, multicenter, observational cohort (patient registry) designed to better understand freezing of gait (FOG), a disabling walking problem that can occur in Parkinson's disease and other related…
- Conditions
- Freezing of Gait, Parkinson's Disease, Parkinsonism, Vascular Parkinsonism
- Trial name
- NCT07386015
- Testing
- Observational Data Collection
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Tianjin Huanhu Hospital
Parkinson's Disease
Efficacy and Safety of the Iron Chelator Deferiprone in Parkinson's Disease
Few available drugs can slow the progression of neurodegenerative pathologies such as Parkinson's disease (PD). One of the recent hypotheses concerning the reduction of oxidative stress and neuron death features a harmful effect…
- Trial name
- FAIR-PARK-I (NCT00943748)
- Testing
- deferiprone
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Lille
Parkinson Disease
Can tDCS Enhance Efficacy of Rehabilitative Intervention for Freezing of Gait in Parkinson's Disease?
Freezing of gait in Parkinson's disease (PD) is a major cause of disability and falls and responds often incompletely to conventional therapy. The pathogenesis remains largely unknown and therapeutic alternatives are needed.
- Trial name
- NCT02205216
- Testing
- Active tDCS, Rehabilitation Therapy
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Parkinson Disease
Moving Through Glass: An Augmented Reality Device Application for Persons With Parkinson's Disease
Recently, Mark Morris Dance Group, and created Moving Through Glass (MTG), a project that was funded by Google, as a portable, round-the-clock extension of the internationally acclaimed Dance for Parkinson's Disease (PD)®.
- Trial name
- NCT03214926
- Testing
- Moving Through Glass intervention
- Volunteers
- 7 people
- Sponsor
- Syracuse University
Parkinson's Disease
Rasagiline as Add on to Dopamine Agonists in the Treatment of Parkinson's Disease
To assess the efficacy of rasagiline 1 mg as a first add-on treatment to dopamine agonist therapy in early Parkinson Disease (PD) patients, , not optimally controlled on dopamine agonists as compared to placebo.
- Trial name
- ANDANTE (NCT01049984)
- Testing
- Rasagiline
- Where
- 58 sites in United States
- Volunteers
- 328 people
- Sponsor
- Teva Neuroscience, Inc.
Parkinson's Disease, Parkinsonism
Molecular Analysis of Human Neural Stem Cells
The aim of this study is to develop and optimize methods to isolate, propagate and differentiate adult human neural stem cells from patients with degenerative neurological disorders like Parkinson's disease.
- Trial name
- NCT01329926
- Testing
- Harvesting of neural stem cells
- Where
- United States
- Sponsor
- NeuroGeneration
Parkinson Disease
taVNS in Mild to Moderate Parkinson's Disease
The purpose of this study is to find out whether a non-invasive form of nerve stimulation called transcutaneous vagus nerve stimulation (taVNS) is safe and effective in people with Parkinson's Disease.
- Trial name
- taVNS (NCT04157621)
- Testing
- Active taVNS
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Medical University of South Carolina
Idiopathic Parkinson's Disease
Dopamine Effect on Inhibitory Control
The effect of Levodopa medication on inhibitory control in Parkinson's patients is extremely debated despite the fact that this has potential clinical and therapeutic implications.
- Trial name
- DEI (NCT03665493)
- Testing
- PD patients H&Y=1.5-2 Medications ON, PD patients H&Y=1.5-2 Medications OFF, Healthy age-matched controls
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Giovanni Mirabella
Parkinson Disease
A Pharmacokinetic Study of Levodopa and Carbidopa Intestinal Gel in Subjects With Advanced Parkinson's Disease
A Pharmacokinetic Study of Levodopa and Carbidopa Intestinal Gel in Subjects with Advanced Parkinson's Disease.
- Trial name
- NCT01484990
- Testing
- Levodopa-Carbidopa
- Volunteers
- 19 people
- Sponsor
- AbbVie
Parkinson's Disease
Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD
The purpose of this randomized, double-blind, placebo-controlled study is to assess the efficacy of BIA 28-6156 over placebo in delaying clinical meaningful motor progression over 78 weeks in subjects with Parkinson's disease who…
- Trial name
- ACTIVATE (NCT05819359)
- Testing
- BIA 28-6156 10 mg, BIA 28-6156 60 mg
- Where
- 95 sites in United States, Canada and 9 more
- Volunteers
- 237 people
- Sponsor
- Bial R&D Investments, S.A.
Parkinson Disease
i-BiSSkApp for Swallowing Rehabilitation in Parkinson's Disease
Aspiration pneumonia due to dysphagia is a leading cause of death in Parkinson's disease (PD). Dysphagia intervention in the United States involves evaluation at onset of dysphagia symptoms followed by short-term therapy.
- Trial name
- NCT05837520
- Testing
- i-BiSSkApp (tablet application) with swallowing therapy, Traditional behavioral swallowing therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of South Florida
Urinary Retention, Neurogenic Bladder
Connected Catheter (C2P) Study for Bladder Management
The objective of this study is to evaluate the safety and essential performance of the C2P System in males with neurogenic lower urinary tract dysfunction (NLUTD), both in an acute clinical setting and an extended period of home…
- Trial name
- NCT03626324
- Testing
- C2P
- Where
- 8 sites in United States
- Volunteers
- 27 people
- Sponsor
- Spinal Singularity
Parkinson Disease
Brain Activity During Gait in Parkinson's
Lay Summary: Walking problems, such as slow and short steps, are very common in Parkinson's disease and lead to increased falls risk, as well as reduced mobility and quality of life.
- Trial name
- BARC-PD (NCT04863560)
- Testing
- Auditory Cueing, Visual Cueing, tactile Cueing
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 80 people
- Sponsor
- Northumbria University
Healthy Volunteers, Parkinson's Disease Patients
Preparation and Feasibility of Exams for Expected Studies
Feasibility study: the examinations carried out as part of this protocol aim to carry out all the acquisitions and simulations of use, necessary for the development of the clinical research protocols to come to Clinatec (in…
- Conditions
- Healthy Volunteers, Parkinson's Disease Patients, Para/Tetraplegic Patients
- Trial name
- PRELUDE (NCT05698810)
- Testing
- CE marked Medical Device MagnetoEncephaloGraphy (MEG) usability, CE marked Medical Device Magnetic Resonance Imaging (MRI) usability, CE marked Medical Device ElectroEncephaloGraphy (EEG) usability
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Parkinson Disease
Personality, as a Predictive Factor of Therapeutic Response on Quality of Life After Continuous Perfusion of Dopaminergic Drugs, in Parkinson's Disease
The aim of the study is to evaluate if patients' personality could be considerate as predictive factor of quality of life after the establishment of continuous infusion of dopaminergic treatments to observe if there are…
- Trial name
- PSYCHO-PERF (NCT03793491)
- Testing
- TCI scale, PDQ-39 scale
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Toulouse
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