Clinical trials: Primary Parkinsonism
Sleep Disorders
Reducing Caregiver Stress and Sleep Disturbances in Patients With Progressive Dementia
People under stress, such as those caring for an ill family member, often have trouble with their sleep. The aim of this study is to see if reducing stress and changing a caregiver's sleep and wake patterns will improve his/her…
- Trial name
- NCT00178568
- Testing
- Stress Management and Healthy Sleep Practices
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kathy Kennedy
Parkinson Disease
Exercise Neuroprotection in Parkinson's Disease
The purpose of this study is to explore the relationships of exercise on inflammation in the body of older adults and people with Parkinson's disease (PD).
- Trial name
- PDex (NCT05854524)
- Testing
- Aerobic exercise
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Parkinson Disease
Constipation and Changes in the Gut Flora in Parkinson's Disease
The aim of this study is to investigate the link between gut health and Parkinson's disease
- Trial name
- GUT-PD (NCT05787756)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Parkinson Disease
Special Survey on PD Patients With Renal Dysfunction
The survey is conducted to collect safety and effectiveness information targeting patients who have both Parkinson's disease and renal dysfunction treated with Pramipexole in the daily clinical settings in Japan.
- Trial name
- NCT00613756
- Where
- 98 sites in Japan
- Volunteers
- 107 people
- Sponsor
- Boehringer Ingelheim
Parkinson's Disease, Sleep Fragmentation
Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease (Aim 2)
Parkinson's Disease (PD) is the second most common of the age-related neurodegenerative disorders, affecting over 1,900 adults per 100,000 over the age of 80 in the US.
- Trial name
- NCT05070013
- Testing
- Deep Brain Stimulation
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Nebraska
Parkinson's Disease
Safinamide in Levodopa Induced Dyskinesia in Parkinson's Disease Subjects
Approximately twenty four (24) subjects will participate in this research trial. The research trial will be conducted in approximately twelve (12) medical centers in the following countries: Germany, France, South Africa, Austria…
- Trial name
- Safinamide-LID (NCT01113320)
- Testing
- Safinamide
- Where
- 11 sites in Austria, Canada and 3 more
- Volunteers
- 26 people
- Sponsor
- Newron Pharmaceuticals SPA
Parkinson Disease
Stereotactic Intracerebral Injection of Allogenic IPSC-DAPs in Patients With Parkinson's Disease
Parkinson's disease is a progressive neurodegenerative disorder characterized by high morbidity due to the limited regenerative capacity of dopaminergic neurons in the brain.
- Trial name
- NCT07212088
- Testing
- ALC01 therapy
- Where
- China
- Volunteers
- 12 people
- Sponsor
- iCamuno Biotherapeutics Ltd.
Parkinson's Disease
Effectiveness, Tolerability and Safety of Rasagiline in Early Parkinson's Disease Patients Not Treated With Levodopa
Study to look at the effectiveness, tolerability and safety of two doses of Study Medication in Early Parkinson's Disease (PD) Patients who have not been treated with Levodopa.
- Trial name
- NCT00203060
- Testing
- Rasagiline Mesylate
- Volunteers
- 404 people
- Sponsor
- Teva Neuroscience, Inc.
Parkinson's Disease, Pathophysiology of Neuronal Oscillations Within Subthalamo-cortical Loops
Pathophysiology of Neuronal Oscillations Within Subthalamo-cortical Loops in Parkinson's Disease
Neuronal activity in circuits between the basal ganglia (BG) and motor cortical areas is abnormally synchronised and rhythmic. The oscillatory activity prevails at 8-30 Hz in untreated Parkinson's Disease (PD) and its amplitude…
- Trial name
- NCT01284686
- Testing
- subthalamo-cortical loops stimulation in a one-sided and bipolar way
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Parkinson's Disease
Tele-diagnostics for Remote Parkinson's Monitoring
The purpose of this research study is to design, implement, and clinically assess a portable, user worn system for monitoring Parkinson's disease (PD) motor symptoms.
- Trial name
- NCT01356056
- Testing
- Kinesia HomeView
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Great Lakes NeuroTechnologies Inc.
Parkinson's Disease
Multi-disciplinary Rehabilitation Program for Advanced Parkinson's Patients in the Community
The present study examines the effectiveness of the rehabilitation program in the framework of the "Ezra LeMarpeh" project for Parkinson's patients. The Ezra LeMarpeh Association, founded by Rabbi A. E.
- Trial name
- NCT03406754
- Testing
- rehabilitation programs
- Where
- 2 sites in Israel
- Volunteers
- 60 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Advanced Stage Parkinson's Disease
An Open-Label Extension Trial to Assess the Safety of Long-Term Treatment of Rotigotine in Advanced-Stage Parkinson's Disease
The objective of this open-label extension is to assess the safety and tolerability of long-term treatment of the rotigotine patch in subjects with advanced-stage idiopathic Parkinson's disease
- Trial name
- NCT00501969
- Testing
- Rotigotine
- Where
- 53 sites in Australia, Austria and 15 more
- Volunteers
- 395 people
- Sponsor
- UCB Pharma
Parkinson Disease (PD)
Comparison of Benzhexol and Procyclidine for Tremor in Tremor-Predominant Parkinson's Disease
The goal of this clinical trial is to compare benzhexol and procyclidine for improving tremor in adults with tremor-predominant Parkinson's disease who are taking levodopa.
- Trial name
- NCT07810296
- Testing
- Benzhexol, Procyclidine
- Where
- Pakistan
- Volunteers
- 88 people
- Sponsor
- safia bano
Parkinson's Disease
The Effectiveness of Motor-motor and Motor-cognitive Dual-task Training Interventions on Balance in People With Parkinson's Disease: a Feasibility Study
This study aims to test the feasibility and acceptability of home-based motor-motor dual-task training and motor-cognitive dual-task training interventions, and balance-related outcome measures which may be used in an anticipated…
- Trial name
- NCT05710588
- Testing
- motor-motor dual-task training, motor-cognitive dual-task training
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Plymouth
Parkinson Disease
GLP1R in Parkinson's Disease
The purpose of the study is to test the neuroprotective and anti-inflammatory properties of semaglutide in idiopathic Parkinson's disease (PD)
- Trial name
- GIPD (NCT03659682)
- Testing
- Semaglutide
- Volunteers
- 120 people
- Sponsor
- Oslo University Hospital
Parkinson Disease
Robotic Rehabilitation of Upper Limb in PD
It has been shown that robot-assisted therapy may be considered an effective and reliable method for the delivery of highly repetitive training useful to boost neuroplasticity.
- Trial name
- NCT03893786
- Testing
- Robotic Rehabilitation
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
PARKINSON DISEASE (Disorder)
Exploratory Clinical Trial of UX-DA003 Injection for the Treatment of Patients With Parkinson's Disease
This clinical study is designed to explore the safety and tolerability of UX-DA003. It will also explore if UX-DA003 works to improve motor function in subjects with Parkinson's disease.
- Trial name
- NCT07911670
- Testing
- UX-DA003
- Where
- China
- Volunteers
- 12 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Parkinson Disease
High-Intensity Respiratory Muscle Training in Individuals With Parkinson's Disease
Background: Individuals with PD commonly have a significant reduction in respiratory muscle strength and inspiratory muscle endurance, and it can intensify with the disease progression.
- Trial name
- NCT05608941
- Testing
- Respiratory muscle training, Control
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- Federal University of Minas Gerais
Tremor
The Effect of Lesion Characteristics in MRgFUS on Tremor in Essential Tremor and Parkinson's Disease
The study will investigate Essential Tremor and Parkinson's Disease patients who underwent Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS).
- Trial name
- MRgFUS (NCT03300193)
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Parkinson Disease
Quantification of Beta Activity in Routine EEG Recordings in Parkinson's Disease Patients
The investigators are studying the relationship between a certain oscillatory brain rhythm (13-30 cycles/sec) that emerges prominently in patients with Parkinson's disease and symptoms of slowness of movement.
- Trial name
- PD-EEG (NCT03103347)
- Volunteers
- 27 people
- Sponsor
- Duke University
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