Clinical trials: Primary Parkinsonism
Parkinson Disease
An Exploratory Study Investigating Safety, Tolerability and Pharmacokinetics of Ascending Doses of Lu AE04621 in Parkinson Disease Patients
To evaluate the safety, tolerability, pharmacokinetics, and efficacy of the Lu AE04621 and metabolite after ascending oral doses of Lu AE04621 in patients with Parkinson's Disease.
- Trial name
- NCT02649608
- Testing
- 0.04 mg Lu AE04621, 0.08 mg Lu AE04621, 0.2 mg Lu AE04621
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- H. Lundbeck A/S
Parkinson's Disease
Telephone-linked Home-based Exercise Training in PD
This project is investigating whether a home-based exercise program will reduce depression in patients with Parkinson's disease.
- Trial name
- NCT02898740
- Testing
- Structural exercise, Health education
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Parkinson Disease, Medication Compliance
Medication Responsiveness in Parkinson's Disease
Up till now, dopaminergic replacement is considered as the gold standard for the symptomatic treatment of motor symptoms in Parkinson's disease (PD).
- Conditions
- Parkinson Disease, Medication Compliance, Tapping Task, Smartphone
- Trial name
- NCT04185740
- Testing
- CloudUPDRS - Tapping Task
- Where
- Belgium
- Volunteers
- 33 people
- Sponsor
- KU Leuven
Parkinson Disease
A Randomized Controlled Trial of Nicotinamide Riboside Supplementation in Early Parkinson's Disease
NOPARK is a double-blinded randomized controlled phase II trial, with the aim to assess the efficacy of nicotinamide adenine dinucleotide (NAD)-replenishment therapy in the form of oral nicotinamide riboside (NR) in delaying the…
- Trial name
- NOPARK (NCT03568968)
- Testing
- Nicotinamide Riboside
- Where
- 11 sites in Norway
- Volunteers
- 410 people
- Sponsor
- Haukeland University Hospital
Parkinson's Disease, Cognitive Impairment
Atomoxetine Treatment for Cognitive Impairment in Parkinson's Disease (ATM-Cog)
The purpose of this study is to determine the safety and effectiveness of a drug called atomoxetine for the treatment of cognitive impairment for Parkinson 's disease.
- Trial name
- ATM-Cog (NCT01738191)
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical University of South Carolina
Idiopathic Parkinson's Disease and Lewy Body Disease
Single-center Study of Gustation in Idiopathic Parkinson's Disease and Lewy Body Disease Using Gustatory Evoked Potential Analysis
The aim of the PI-PEG study is to explore the taste functions of the following 3 groups of participants: healthy volunteers patients with early Parkinson's disease patients with incipient Lewy body disease.
- Trial name
- PI-PEG (NCT06439355)
- Testing
- Fasting blood test, Subject interview, Motor assessment
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Parkinson Disease
Evaluation of Neurocognitive Changes in Parkinson's Disease After Low Frequency Burst Stimulation
This study aims to determine whether direct brain stimulation of specific regions and ranges improves cognition in people with Parkinsons Disease (PD) who already have a deep brain stimulator implanted.
- Trial name
- NCT05307055
- Testing
- STN DBS - Theta Burst, STN DBS - Gamma
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Southern California
Parkinson's Disease
A Trial To Assess Switching From Ropinirole, Pramipexole Or Cabergoline To The Rotigotine Transdermal System In Idiopathic Parkinson's Disease
The purpose of this trial is to assess whether it is possible for subjects with idiopathic Parkinson's Disease to switch from ropinirole, pramipexole and cabergoline to rotigotine transdermal system (SPM 962) overnight without…
- Trial name
- NCT00242008
- Testing
- Rotigotine
- Where
- United States
- Sponsor
- UCB Pharma
Parkinson Disease
Social Self-Management of Parkinson's Disease
Parkinson's disease (PD) affects 1% to 2% of the US population over age 60, and its prevalence is increasing as the population ages.
- Trial name
- SocM-PD (NCT03938974)
- Where
- 2 sites in United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Tufts University
Mild Cognitive Impairment, Dementia
A Study of CST-2032 and CST-107 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's or Alzheimer's Disease
This is a Phase 2a, randomized, placebo-controlled, double-blind, crossover study to evaluate the effects CST-2032 administered with CST-107 on cognition in participants with Mild Cognitive Impairment (MCI) or mild dementia.
- Trial name
- NCT05104463
- Where
- 15 sites in United States, New Zealand
- Volunteers
- 64 people
- Sponsor
- CuraSen Therapeutics, Inc.
Parkinson Disease
Safety and Efficacy Study of CEP-1347 in the Treatment of Parkinson's Disease
The purpose of this study is to establish safety for CEP-1347 and to determine an efficacious dose in the treatment of Parkinson's disease.
- Trial name
- NCT00040404
- Testing
- CEP-1347 10mg, CEP1347 25mg, CEP-1347 50mg
- Where
- 66 sites in United States, Canada and 1 more
- Volunteers
- 806 people
- Sponsor
- Cephalon
Parkinson Disease
Effects of Cervical Stabilization Exercises and Vibration Application in Individuals With Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disease that causes a progressive decrease in motor functions, which is caused by the influence of dopaminergic pathways in the substantia nigra (SN).
- Trial name
- NCT05837715
- Testing
- Chattanooga Stabilizer pressure biofeedback, VibraSens - Focal Vibration Therapy (TechnoConcept - France), Telerehabilitation
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Parkinson Disease, Surgery
The Effects Of DBS Of Subthalamıc Nucleus On Functionality In Patıents With Parkinson's Disease: Short-Term Results
Parkinson's disease is a progressive chronic neurodegenerative disease. In cases where drug treatment is insufficient and drug use is not possible due to drug side effects, highly effective and low-risk surgical treatment options…
- Conditions
- Parkinson Disease, Surgery, Respiration; Decreased, Muscle Weakness
- Trial name
- NCT03797976
- Testing
- MIP and MEP
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Mustafa Kemal University
Parkinson's Disease
Impact of Walking Practice on Persons With PD
The purpose of this study is to investigate the impact of a specifically designed leg brace on walking endurance in individuals with Parkinson's disease.
- Trial name
- NCT02113189
- Testing
- Walking program with ankle brace, Individualized walking program, Walking program with custom braces.
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Texas Southwestern Medical Center
Parkinson Disease, Mild Cognitive Impairment
Superior Parietal iTBS for PD-MCI
The goal of this study is to determine the whether a short-term, high-dose form of non-invasive brain stimulation (intermittent theta burst stimulation; iTBS) is a promising and safe treatment for mild cognitive impairment in…
- Trial name
- NCT07701785
- Testing
- Accelerated intermittent theta-burst stimulation (iTBS) rTMS to right superior parietal lobule (rSPL)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical University of South Carolina
Parkinson Disease
Transcranial Direct Current Stimulation of the Primary Motor Cortex to Treat Levodopa-induced Dyskinesias
The main objective of the study is to evaluate the efficacy of 10 sessions of transcranial direct current stimulation of the primary motor cortex to reduce levodopa-induced dyskinesia
- Trial name
- NCT05752240
- Testing
- Transcranial direct current stimulation
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Parkinson's Disease
MIRT and Rotigotine in the Early Stage of PD
To test whether a multidisciplinary intensive rehabilitation treatment (MIRT) slowed down the progression of the disease in Parkinson's disease (PD) "de novo" patients, all treated with Rotigotine, in a randomized controlled…
- Trial name
- MIRT-RT (NCT02100176)
- Testing
- Multidisciplinary intensive rehabilitation treatment, Rotigotine
- Where
- 2 sites in Italy
- Volunteers
- 40 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Parkinson's Disease
A Phase 3 Study of TVP-1012 (1 mg) in Early Parkinson's Disease Patients
The purpose of this study is to evaluate the efficacy and safety of TVP-1012 (1 mg/day) administered to Japanese patients with early Parkinson's disease.
- Trial name
- NCT02337725
- Testing
- TVP-1012
- Where
- 55 sites in Japan
- Volunteers
- 244 people
- Sponsor
- Takeda
Advanced Stage Parkinson's Disease
A Pilot Study to Assess Efficacy and Safety of Pardoprunox as Adjunct Therapy to L-dopa in the Treatment of Patients With Parkinson's Disease Experiencing Motor Fluctuations and Dyskinesia.
This is a multicenter, randomized, double blind, pramipexole-controlled parallel group study of pardoprunox as adjunctive treatment to levodopa.
- Trial name
- NCT00903838
- Testing
- pardoprunox, pramipexole
- Where
- 9 sites in Germany, Italy and 1 more
- Volunteers
- 37 people
- Sponsor
- Abbott Products
Parkinson Disease
Blood Biomarker in Early Parkinson's Disease
Currently, there are no cures or disease modifying therapies for Parkinson's disease (PD). This is partially due to the inability to detect the disease before it has progressed to a stage where there are clinical manifestations.
- Trial name
- NCT03384797
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Duke University
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