Clinical trials: Primary Parkinsonism
Parkinson's Disease
SEDPARK2: Post Marketing Surveillance to Observe Safety and Efficacy of Piribedil in Parkinson's Disease (PIR-002/K)
The objective of the Post Marketing Surveillance Study is to investigate the use of the non-ergot dopamine agonist piribedil (trade name: CLARIUM) in mono- and combination therapy in patients with Morbus Parkinson.
- Trial name
- NCT00727727
- Testing
- Piribedil
- Where
- 2 sites in Germany
- Volunteers
- 750 people
- Sponsor
- Desitin Arzneimittel GmbH
Parkinson Disease Dementia, Parkinson Disease
Community Outreach for Palliative Engagement -- Parkinson Disease
The purpose of this study is to learn more about the effectiveness of palliative care training for community physicians and telemedicine support services for patients and carepartners with Parkinson's disease and Lewy Body…
- Conditions
- Parkinson Disease Dementia, Parkinson Disease, Parkinson's Disease and Parkinsonism, Lewy Body Parkinsonism
- Trial name
- COPE-PD (NCT05222386)
- Testing
- Parkinson Disease Standard Care, Online Community-Supported Palliative Care
- Where
- United States
- Volunteers
- 632 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Parkinson Disease
A Prospective Longitudinal Assessment of PD Functional Impairment and Disability Via Mobile Health Technology
The purpose of this study is to compare data from a battery of novel mobile health technologies to standard-of-care validated patient questionnaires and clinician rating scales in Parkinson's disease patients.
- Trial name
- NCT05153356
- Testing
- Personal Kinetigraph, Kinesia 360
- Sponsor
- Rush University Medical Center
Parkinson Disease Dementia
To Evaluate the Safety of DBS in Patients With Primary Parkinson's Disease
To evaluate the safety of implantable rechargeable computer deep nerve stimulation system produced by Jiangsu Changyida Medical Technology Co., Ltd. for patients with primary Parkinson's disease
- Trial name
- NCT06494956
- Testing
- Implant device
- Volunteers
- 3 people
- Sponsor
- Jiangsu CED Medtech Co., Ltd
Parkinson's Disease
Topiramate as a Treatment for Levodopa-Induced Dyskinesia in Parkinson's Disease
A phase II double blind trial to evaluate the effects of the AMPA, glutamte antagonist, topiramate on levodopa-induced dyskinesia in Parkinson's disease
- Trial name
- NCT00296959
- Testing
- topiramate (drug)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Parkinson's Disease (PD)
Comparison of Two Different Dual-Task Training Methods in Patients With Parkinson's Disease
The aim of this study is to compare the effectiveness of motor-motor dual-task training and cognitive-motor dual-task training in patients with Parkinson's disease.The main questions it aims to answer are: Whether there is a…
- Trial name
- NCT07641569
- Testing
- Single Task Exercise Training, Motor-Motor Dual Task Exercise Training, Cognitive-Motor Dual Task Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Saglik Bilimleri Universitesi
Parkinson's Disease
Non-interventional, Retrospective, Multi-center Study to Evaluate Non-motor Symptoms in Advanced Parkinson Disease (PD) Patients Already Treated With Rotigotine
This is an observational, non-interventional and retrospective study in patients with advanced PD who have been treated with Rotigotine (Neupro®) as prescribed by physicians according to usual clinical practice in Spain.
- Trial name
- RETO-PD (NCT01504529)
- Where
- 59 sites in Spain
- Volunteers
- 391 people
- Sponsor
- UCB Pharma
Parkinson's Disease
Proof of Concept BeatPark
Physical activity has demonstrated its beneficial effect on functional capabilities and quality of life in patients with PD. However, the daily physical activity remains limited in these patients.
- Trial name
- BEATPARK 2 (NCT02647242)
- Testing
- Auto rehabilitation program of gait with Beat Health device.
- Volunteers
- 45 people
- Sponsor
- University Hospital, Montpellier
Parkinson Disease
Exercise to Improve Sleep in Parkinson's Disease
This study will investigate the impact of three common exercise modalities, cardiovascular, resistance, and multimodal (i.e., a combination of the previous two) training, on sleep quality and architecture in persons with…
- Trial name
- NCT05644327
- Testing
- Cardiovascular training (CT), Resistance training (RT), Multimodal training (MT)
- Where
- 3 sites in Canada
- Volunteers
- 150 people
- Sponsor
- McGill University
Overactive Bladder, Parkinson Disease
Neurogenic Overactive Bladder Treatment on Parkinson's Disease Through Back Tibial Nerve Electrostimulation
Dysfunctions of the lower urinary tract are non-motor symptoms common engines in Parkinson's disease (PD). Urodynamic changes in PD include overactive bladder (OB), characterized by urgency with or without urge incontinence …
- Trial name
- NOVTPD (NCT02583529)
- Testing
- Back Tibial Nerve Electrostimulation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Tatiane Gomes de Araujo
Alzheimer Dementia, Dementia, Vascular
Tailored Music Therapy for Dementia
This study evaluates the effect and process of individualized music therapy for home-dwelling persons with mild to moderate dementia. The music therapy is administered individually and includes a close caregiver.
- Conditions
- Alzheimer Dementia, Dementia, Vascular, Dementia, Lewy Body, Dementia Parkinson's Disease
- Trial name
- NCT03011723
- Testing
- Resource oriented music therapy
- Where
- Norway
- Volunteers
- 11 people
- Sponsor
- University of Bergen
Parkinson Disease, Constipation
Probiotics-prebiotic Fiber Therapy in Parkinson's Disease Patients With Constipation
A double blinded randomised placebo controlled trial to evaluate the efficacy of probiotics on constipation symptoms and whole gut transit time in patients with Parkinson's disease.PD patients with constipation were randomized to…
- Trial name
- NCT04451096
- Testing
- Probiotics with prebiotic
- Where
- Malaysia
- Volunteers
- 48 people
- Sponsor
- National University of Malaysia
Parkinson Disease
Hallux Mobilization in Patients With Parkinson's Disease
Parkinson's disease is a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain; the…
- Trial name
- HalluxPD001 (NCT02098642)
- Testing
- MIRT, Mobilization of the metatarsophalangeal joint of the hallux
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Parkinson Disease
Priming Through Timing. Using Opposing Strategies to Enhance Motor Learning for Individuals With Parkinson's Disease
The purpose of this study is to determine how using auditory cues of a metronome at various frequencies impacts the gait mechanics and balance in people with Parkinson's disease when walking over ground and on a treadmill.
- Trial name
- NCT03660605
- Testing
- Rhythmic Auditory Stimulation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of North Carolina, Chapel Hill
Symptomatic Neurogenic Orthostatic Hypotension
Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension
To evaluate the time to treatment intervention in patients with Parkinson's Disease (PD), Multiple System Atrophy (MSA), Pure Autonomic Failure (PAF), Non-Diabetic Autonomic Neuropathy (NDAN) or Dopamine Beta Hydroxylase (DBH)…
- Trial name
- RESTORE (NCT02586623)
- Testing
- Droxidopa capsules
- Where
- 168 sites in United States
- Volunteers
- 453 people
- Sponsor
- H. Lundbeck A/S
Parkinson Disease
Cognitive Testing Online in Parkinson's Disease
This is a feasibility and pilot study. Though large-scale online neurocognitive testing is increasingly being done in psychiatry, there are no such efforts in Parkinson's research.
- Trial name
- NCT05025254
- Testing
- Neurocognitive testing
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- McGill University
Tremor, Essential, Parkinson's Disease
Mapping the Target for the MRgFUS Treatment of Tremor
The purpose of this investigation is to determine the optimal DRT/VIM target location and its safety margins based on MR-SISET imaging features by comparing with postoperative lesions and clinical outcomes in patients with tremor…
- Trial name
- NCT04661241
- Testing
- Automatic DRT/VIM target-recognition method using MR-SISET and ML approaches, Routine clinical MRI protocol
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- NYU Langone Health
Parkinson's Disease, Deep Brain Stimulation
Tandem DBS for Parkinson's Disease: A Pilot Study Utilizing STN/GPi + Hypothalamic Stimulation
Does dual hemispheric stimulation of the subthalamic nucleus (STN) and fornix/hypothalamus potentially improve cognitive function in patients with Parkinsons disease.
- Trial name
- NCT01563341
- Testing
- Deep brain stimulation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Mayo Clinic
Parkinson Disease
Unlocking Movement Potential: Enhancing Parkinson's Disease Treatment With Robotic EksoSkeleton
The goal of this study is to see how well therapy with the Eksobionic Exoskeleton (Esko) works for people with Parkinson's disease (PWPD). Esko is a robotic device that provides high repetition and intensity training.
- Trial name
- NCT06225830
- Testing
- Eksobionics Eksoskeleton NR
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Albert Einstein Healthcare Network
Parkinson Disease
Training Based On Declarative Memory Cues Improved Gait In Patients With Parkinson's Disease
Deficits in automatic motor control, characteristic of Parkinson's disease (PD), contribute to progressive impairment in gait performance.
- Trial name
- NCT02600728
- Testing
- Experimental Training, Control Training
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo General Hospital
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